Imaging Genetics, Adult stem cells, CNS circuitry, neurotrophic factors, prosthetic interfaces, addiction, neuroananatomy, basal ganglia, limbic system, dopamine, Schizophrenia, Parkinson's and Alzheimer's disease, art, law, culture, and the brain
Honorary Doctorate, St Michael's College
Academic Hall of Fame, St Michael's College (1st in 100 yr history of the college)
Fulbright Scholar in East Africa
NIH Career Development Award
Teacher of the Year (several) in College of Medicine
Chair of the UCI Faculty/Academic Senate 1998-1999,
Chair of the UCI College of Medicine Faculty 1992-1994
My research program is primarily in four areas, including adult stem cells, chemical neuroanatomy and circuitry, higher brain functions, and brain imaging.
Human Brain Imaging - Extensive collaborations with clinical and basic researchers on imaging genetics studies of depression, schizophrenia, tobacco use, language disorders, personality, intelligence, male-female differences in cognition, consciousness and anesthesia, human cortical development, sleep, emotional memory, imaging genetic studies of psychiatric disorders, modeling of neural circuits, and law, culture, and the brain.
Stem Cells and Neurotrophic factors - We have been studying the localization, development, and function of neurotrophic factors in the mammalian brain. We have studied EGF, TGFalpha, TGFbeta, and FGF and have focused on the TGFa family of growth factors since 1982. Experimental approaches include in situ nucleic acid hybridization, immunocytochemistry, minipump infusions, neurotoxic lesions, behavioral pharmacology, fluorescence histochemistry, and retrograde tracing. Present focus is on in vivo regeneration from endogenous stem cells in the brain, and their application to neurodegenerative diseases, stroke, and trauma in humans and have just begun a study to create new neural interfaces for advanced prosthetic limbs and neural chips.
Chemical Neuroanatomy- We study of the distribution and connections of chemically defined circuits in the brain and have detailed the dopamine and norepinephrine system, as well as the distribution of opioid peptide and growth factor systems, especially in the basal ganglia, limbic system, and cortex in the developing and adult brain.
Higher Brain Functions- I am interested in the neural circuitry and genetics of creativity, artistic talent, psychopathology, criminal behavior, and levels of consciousness.
Methods for treating neurological deficits by intrastriatal administration of transforming growth factor alpha (TGF-a) Patent number: 7790669
Neural probe array and method of use (Artificial limbs)
Methods for treating a neurological disorder by peripheral administration of a trophic factor
Methods for treating neurological deficits
Publication number: 20110071078
Method for correlating differential brain images and genotypes; genes that correlate with differential brain images
Methods for treating neurological deficits
Patent number: 8158578
Philipp Gunz, Amanda K. Tilot, Katharina Wittfeld, Alexander Teumer Chin Yang, Shaplan, Theo G.M. van Erp, Michael Dannemann, Benjamin Vernot, Simonandez, H Brunner, Wolfgang Enard, James Fallon, Norbert Hosten, Uwe Vo¨lker, Antonio Profico, Fabio DiVincenzo, Giorgio Manzi, Janet Kelso, Beate St. Pourcain, Jean-Jacques Hublin, Barbara Franke, Svante Pa¨a¨bo, Fabio Macciardi, Hans J. Grabe, Simon E. Fisher.
Neandertal introgression sheds light on modern human endocranial globularity. 2018 Current Biology 29 1-8.
Chong-Hwa Hong, Charles, James H Fallon, Karl J Friston, James C Harris (2018) Rapid eye movements in sleep furnish a unique probe into consciousness. Frontiers in Psychology, section Theoretical and Philosophical Psychology.
Gehricke J-G, Fallon J.H. et al. (2017)The brain anatomy of attention-deficit/ hyperactivity disorder in young adults – a magnetic resonance imaging study. PLOS One 12(4) 1-21.
Guffanti G, Gaudi S,Fallon JH, et al Macciardi F. (2016). LINE1 Insertions as a Genomic Risk Factor for Schizophrenia: Preliminary Evidence From an Affected Family. Am J Med Genet Part B 9999:1–12.
Gaudi, S, Guffanti, G., Fallon, J, Macciardi, F (2016) Epigenetic mechanisms and brain circuits of positive emotions: a role for Transposable Elements. J Comparative Neurology. 524: 2944-2954
Jean-G. Gehrickea, James Swanson, James Fallon, Cyrus Caburian, Sophie Duong, L. Tugan Muftuler, Timothy Wigal, Robert Moyzis (2015) Increased brain activity to unpleasant stimuli in individuals with the DRD4-7R genotype. Psychiatry Research: Neuroimaging 231: 58-63
Guffanti, G, Potkin, SG, Gaudi, S., Fallon, JH, Macciardi, F, (2014) Transposable Elements and Psychiatric Disorders: a review of current findings and a look into the next future. American J Medical Genetics 9999 1-16.
Guffanti G, Torri F, Rasmussen J, Clark AP, Knowles JA, Lakatos A, Turner JA, Fallon JH, Saykin AJ, Weiner M, Initiative AtAsDN, Vawter MP, Potkin SG, Macciardi F. (2013). Increased CNV-Region Deletions in Mild Cognitive Impairment (MCI) and Alzheimer’s disease (AD) Subjects in the ADNI Sample. Genomics. 102(2):112–122.
Hong, C. Fallon, JH, et al (2013) fMRI Study of default-mode network with video-timed rapid eye movements in sleep.
Guffanti, G., Federica Torri, Jerod Rasmussen, Clarke A., Knowles J., Anita Lakatos, Jessica A. Turner, James H. Fallon, Sara Lupoli, Andrew Saykin, Michael Weiner, Steven G. Potkin, Fabio Macciardi, F, and ADNI, the Alzheimer’s Disease Neuroimaging Initiative (2013) Increased CNV-Region Deletions in MCI and AD Subjects in the ADNI Sample. Genomics. In Press.
Hyo Jong Lee, Theo G.M. van Erp, Jessica A. Turner, Gregory McCarthy, Bryon A. Mueller, Vince D. Calhoun, James T. Voyvodic, Adrian Preda, Jerod Rasmussen, Michele Diaz, Nicholas Vu, Judith Ford, Dan Mathalon, James Fallon, FBIRN9, Gregory G. Brown, Steven G. Potkin
(2012) Diminished Dorsolateral Prefrontal Cortex Response to Emotional Distraction during Working Memory Maintenance in Schizophrenia Patients. Schizophrenia Bulletin.
Aurora K. R. LePort, Aaron T. Mattfeld, Heather Dickinson-Anson, James H. Fallon, Craig E. L. Stark, Frithjof R. Kruggel, Larry Cahill, James L. McGaugh (2012) Behavioral and Neuroanatomical Investigation of Highly Superior Autobiographical Memory (HSAM) Neurobiology of Learning and Memory.
Macciardi, F.M. and Fallon, J.H. Are we ready for Imaging Genetics predictions at the individual level? International Imaging Genetics (2012)
Guerra-Crespo1*, M, A. Boronat-García1, A.K. De la Herrán-Arita1, J.R. García-Montes1, G. Maya-Espinosa1, J.H. Fallon2 and R. Drucker-Colín (2012) Neural stem cells as exogenous and endogenous promising therapy approaches in stroke. INTECH
Keator,D.B., Fowlkes, C., Fallon, J., Potkin, S., Ihler, A.(2010) Alzheimer’s Disease Classification using PET and Oriented Hierarchical Filtering. Organization of Human Brain Mapping, Barcelona, Spain.
Rasmussen1, J., Anita Lakatos1, Theo G.M. van Erp1, Frijthof Kruggel2, David B. Keator1, James Fallon1, Steven G. Potkin1 and Alzheimer’s Disease Neuroimaging Initiative. (2012) Empirical derivation of the denominator region for computing degeneration sensitive 18fluorodeoxyglucose ratios in Alzheimer’s Disease based on the ADNI study. Biochem Biophysics Acta 2012 1822: 467-466.
Keator D.B.1,2, Fallon J.H.2, Lakatos A.2, Fowlkes C.C.1, Potkin S.G.2, Ihler A.1 (2012) Feed-forward Hierarchical Model of the Ventral Visual Stream Applied to Functional Brain Image Classification.
Potkin SG, Macciardi F, Guffanti G, Fallon JH, Wang Q, Turner JA, Lakatos A, Miles MF, Lander A, Vawter MP, Xie X. (2009) Identifying gene regulatory networks in schizophrenia. Neuroimage.53:839–847.
Guerra-Crespo, M, Gleason, D., Sistos, A., and Fallon, J.H. (2010) Intranasal Administration of PEGylated Transforming Growth Factor-alpha Improves Behavioral Deficits in a Chronic Stroke Model. Journal of Stroke and Cerebrovascular Diseases. 19:3-9.
Kim, M, Manoach, Calhoun, V. Tura, E. D, Fallon, J.H., Potkin, S.G., and Turner, J (2010) Working memory circuitry in schizophrenia shows widespread cortical inefficiency and compensation. Shizophrenia Research. 117: 42-51.
Cho, ZH, Editor..Fallon, JH. 7 Tesla MRI Brain Atlas: In Vivo Atlas with Cryomacrotome Correlation. Springer
Kikinis, Z, Fallon, J.H., , M. Niznikiewicz3, P. Nestor C. Wible, C. Davidson, L. Bobrow, P. Pelavin1 B. Fischl, A. Yendiki, R.W. McCarley, R. Kikinis, M. Kubicki, M.E. Shenton (2010) Gray matter volume reduction in rostral middle frontal gyrus in patients with chronic schizophrenia. Schizophrenia Research [In Press].
Keator,D.B., Fowlkes, C., Fallon, J., Potkin, S., Ihler, A.(2010) Alzheimer’s Disease Classification using PET and Oriented Hierarchical Filtering. Organization of Human Brain Mapping.
Kim, M.A., Tura, E., Potkin. S.G., Fallon, J.H. , Manoach, D.S., Calhoun, V.D., FBIRN, Turner, J.A. (2009) Working memory circuitry in schizophrenia, as revealed by partial least squares analysis. Biological Psychiatry
Potkin, S.G., Guffanti, G. Lakatos, A., Turner, J., Kruggel, F. Fallon, J.H., Saykin, A, Orro, A., Lupoli, S., Salvi, E., Weiner,M., Macciardi, F.,(2009) Hippocampal Atrophy as a Quantitative Trait in a Genome-wide Association Study Identifying Novel Susceptibility Genes for Alzheimer's Disease. PloS ONE. Aug 7;4(8):e6501.
Guerra-Crespo, M, D. Gleason, A. Sistos, T.Toosky, I. Solaroglu, J.H. Zhang, P.J. Bryant and Fallon J.H.(2009) Transforming Growth Factor-alpha Induces Neurogenesis and Behavioral Improvement in a Chronic Stroke Model. Neuroscience 160: 470-483.
Potkin, S.G., Turner, J.A., Fallon, J.H., Laurielleo, J., Guffanti, G., Lakatos, A., Macciardi, F., FBIRN (2009) A Genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. Schizophrenia Bulletin. Jan;35(1):96-108. Epub 2008 Nov 20.
Gehricke, J.G., Potkin, S.G., Leslie, F.M., Loughlin, S.E., Whalen, C. K., Jamner, L.D., Mbogori, J. and Fallon, J.H. (2009) Nicotine-induced brain metabolism associated with anger provocation. Behavioral and Brain Functions. 5:19
Gleason, D, Fallon JH, Guerra, M, Liu, J-C, Bryant, PJ (2008) Ependymal Stem Cells Divide Asymmetrically and Transfer Progeny into the Subventricular Zone when Activated by Injury. Neuroscience (in press).
Potkin SG, Turner JA, Fallon JA, Lakatos A, Keator DB, Guffanti G, Macciardi F. (2009)
Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia.Mol Psychiatry. 2009 Apr;14(4):416-28. Epub 2008 Dec 9.
Potkin, S.G. 1*, Jessica A. Turner1, James A. Fallon1, Anita Lakatos1, David B. Keator1, Guia Guffanti2, Fabio Macciardi2*, FBIRN1 (2008) Gene Discovery Through Imaging Genetics: Identification of Two Novel Genes Associated with Schizophrenia. . International Congress on Schizophrenia Research. Apr;14(4):416-28. Epub 2008 Dec 9.
Fallon, J.H. and Keator, D.B. (2008) Commentary on In Silico Modeling System: A National Research Resource for Simulation of Complex Brain Disorders. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. Jan;5(1):5-6
Hong, C.,Harris, J.C., Pearlson, G.D., Kim, J-S., Calhoun, V.D., Fallon, J.H.,Golay, X., Gillen, J.S., Zijl, P.C..M., Zee, D.S., Pekar, J.J. (2008) fMRI Evidence for Multisensory Recruitment Associated with Rapid Eye Movements during Sleep. Human Brain Mapping (in press)
Labus, JS , B.N. Naliboff, J. Fallon, S.M. Berman, B. Suyenobu, J.A. Bueller, M. Mandelkern and E.A. Mayer (2008) Sex differences in brain activity during aversive visceral stimulation and its expectation in patients with chronic abdominal pain: A network analysis. NeuroImage 41:3, 1032-1043.
Tura, E., Turner, J.A., Fallon, J.A., Potkin, S.G. (2008) Multivariate analyses suggest genetic impacts on neurocircuitry in schizophrenia. Neuroreport Apr 16;19(6):603-7.
Wu JC, Gillin JC, Buchsbaum MS, Schachat C, Darnall LA, Keator DB, Fallon JH, Bunney WE. (2008) Sleep deprivation PET correlations of Hamilton symptom improvement ratings with changes in relative glucose metabolism in patients with depression. J Affect Disord. 107(1-3):181-6. Epub 2007 Nov 26.
Amen, D.G., Prunella, J.R., Fallon, J.H., Amen, B., Hanks, C (2008) High Resolution Brain SPECT Imaging In Completed Suicides. J Neuropsychiatry and Clinical Neurosciences. Clin Neurosci. 2009 Fall;21(4):430-9.
Su, J., Guerra-Crespo, M. & Fallon, J. H. (2007). The therapeutic potential of transforming growth factor a as a treatment for chronic stroke. Journal of Investigative Medicine 55, S151-S151.
Petrovic, V, Fallon, H, & Kuester, F (2007) Visualizing Whole-Brain DTI Tractography with GPU-based Tuboids and LoD Management IEEE
Gehricke JG, Loughlin SE, Whalen CK, Potkin SG, Fallon JH, Jamner LD, Belluzzi JD, Leslie FM. (2007) Smoking to self-medicate attentional and emotional dysfunctions. Nicotine Tob Res. 2007 Nov;9 Suppl 4:S523-36.
Fallon, J.H., Keator, D.B., Mbogori,, J. , Taylor, D., and Potkin, S.G. (2004) Gender: A major determinant of brain response to nicotine. International Journal of Neuropharmacology. (December, 2004).
Fallon, JH (2006) Neuroanatomical background to understanding the brain of the young psychopath. Ohio State Journal of Criminal Law. 3:34 341-367.
Fallon, JH, Keator, D, Mbgori, J., Turner, J., and Potkin, SG (2004) Hostility predicts susceptibility to nicotine dependence. Cognitive Brain Research 18:142-148.
Fallon JH, Reid JR, Kinyamu RM, Opole IO, Opole R, Baratta J, Korc M, Endo T, Duong A, Nguyen G, Karkehebadhi M, Twardzik D, Loughlin SE (2000) In vivo induction of massive proliferation, directed migration, and differentiation of neural cells in the adult mammalian brain. Proc. Natl. Acad. Sci. 26(97): 14686-14691.
Fallon, JH, Opole, IO, Potkin, SG (2003) The Neuroanatomy of Schizophrenia: Circuitry and Neurotransmitter Systems. Clinical Neuroscience. Research. 3:77-107.
Wakana, S, Panzenboeck, M., Fallon, JH, Hua, K. Zhang , J., Jiang, H. Dubey, P., Blitz, A., van Zijl, P., Mori, S. (2006) Tractography-based Quantitative Analyses of White Matter Anatomy: Tracking Protocol, Reproducibility and Tract-Specific Quantification of Cerebral Hemisphere. Neuroimage.(in press)
Shankle, WR, Hara, J, O’Heany,T, Bjornsen, L, Gade, G., Leport, P., Ali, M., Rayhaun, A., Kim, J., Malkazian, D., Raimo, M., Reyes, L. Amen, D., Fallon, JH, Kim, R., Rudy, R. (2006) NeuroSPECT Demonstrates Increased Cortical Function in Alzheimer’s Disease Patients For At Least Two Years After Omental Transposition Neurosurgery. Alasbimn Online Journal. Number 31(Article N° AJ31-1). http://www2.alasbimnjournal.cl/alasbimn/CDA/imprime/0,1208,PRT%253D15971,00.html
Wu, J.C., Gillis, J.C., Buchsbaum , M.S., Chen, P., Keator , D.B., Wu, N.K. Darnall, L.A., Fallon, J.H., BunneyW.E. (2006) Frontal lobe metabolic decreases with sleep deprivation not totally reversed by recovery sleep. Neuropsychopharmacology. (in press).
Melonakos J, Al-Hakim, R., Fallon, J.H., and Tannenbaum, A. (2006) Knowledge-Based Segmentation of Brain MRI Scans Using the Insight Toolkit. Insight Journal (NAMIC/BIRN).
Turner, J.A., Smyth, P., Macciardi, F., Fallon, J.H., Kennedy, J.L., Potkin, S.G. (2006) Imaging phenotypes and genotypes in schizophrenia. Neuroscience 4 (1)
Bose S, Mok AC, Fallon JH, Potkin SG. (2006) Three-month change in cerebral glucose metabolism in patients with nonarteritic ischemic optic neuropathy. Graefes Arch Clin Exp Ophthalmol. 2006 Jan 13;1-4.
Tuszynski, M.H., Thal, L., Pay, M., Hoi-Sang, U., Bakay, R., Salmon, D., Blesch, A., Vahlsing, L., Ho, G., Tong, G., Potkin, S., Fallon, J.H., Mufson, E., Kordower, J., Gall, C., Connor, J. (2005) A Phase I Clinical Trial of Nerve Growth Factor Gene Therapy for Alzheimer’s Disease. Nature.
Society for Neuroscience
Chair and Member, Scientific Advisory Board and Corporate Board
NeuroRepair (Chair) American Land Forces Institute (Vice Chair) Vatican Arts and Technology Council, CPP (Chair) NeoSync Creative Leaps International Solo Artists Inc. The George Greenstein Institute of NeuroSomatic Arts and Science. Joint Chiefs of Staff/Joint Command DARPA COLGEN Pentagon Joint Forces Command chief SME (Subject Matter Expert) on Cognition and Warfare NIH Nanodevelopment Center member, Louisiana International Film Festival Advisory Board 2010—pres
In Extremis Warrior Task Force Member
Interdepartmental Neuroscience Program