Stephen Claude Bondy

picture of Stephen Claude Bondy

Professor, Medicine
School of Medicine

Professor, Pharmacology
School of Medicine

M.A., Cambridge
Ph. D., Birmingham, England

Phone: (949) 824-8077
Fax: (949) 824-2070

University of California, Irvine
Center for Occupational and Environmental Health
Department of Medicine, University of California, Irvine
100 Theory, Suite 100
Mail Code: 1830
Irvine, CA 92617
Research Interests
Brain aging; Environmental and dietary agents that promote or retard such aging
Academic Distinctions

“Transgenic Crops” UCI Occupational Heath Residency Didactics, 2016.
“Melatonin, Cancer and Aging” UCI Department of Medicine Research Retreat, Orange, 2017.
“Melatonin can Delay Onset and Progression of Cancer” 3rd World Congress on Oncology and Radiology, San Francisco, 2017.

2017: Organizing Committee, 3rd World Congress on Oncology and Radiology, San Francisco, USA.

1997-2017 Initial Review Board of Medical and Scientific Advisory Council, Alzheimer’s Association.

2008-2020 Hong Kong University Grants Committee. State Key Laboratory Reviewer.

2007-2019: NIH/NIEHS Special Emphasis Review Panel of Extramural Loan Repayment Program.

2018-2019 UCI Formal Investigations Committee.

2016-2018: Academic Integrity Review Board, UCI.

2017-2018: Medical Scientist Training Program Interview Committee

2017: Program Committee, 3rd World Congress on Oncology and Radiology, San Francisco, 2017.

2018: REPRISE database of expert reviewers of the Italian Ministry of Education, Universities and Research.

2018-2021: UCI Council on Research, Computing and Library Resources (CORCL).

2018-2019: Chair, Committee for 5 Year Review and Continuation Proposal for the UCI Center for Complex Biological Systems (CCBS).

2018: Lead CORCL Reviewer. UCI Center for Virus Research Sunset Review.

2018: Lead CORCL Reviewer. UCI Cancer Research Institute Sunset Review.

2018-2019: Reserve Council on Academic Personnel (RCAP)

Occupational Medicine & Health Affairs
Current Aging Science

2017: Institute of Hematology, “In vitro effects of new antibiotics against clinical isolates of Salmonella enteric subspecies” Baqai Medical University , Karachi, Pakistan.
2018: Sadaf Muhammad Ibrahim, Department of Pharmacology, Baqai Medical University, Karachi, Pakistan.” the Anti-diabetic effect of Guaiacum officinale in streptozotocin induced male Albino rats”.
2018: Muhammad Akbar Mughal, M. D., Department of Physiology, Baqai Medical University, Karachi, Pakistan. “Relationship between C1418T segment of Thrombomodulin Gene Polymorphism with Coronary Artery Disease Patients In General Adult Population of Karachi, Pakistan”.
2019: Tariq Javed. Department of Zoology, University of Karachi, Pakistan. “Toxicological studies of Salvadora persica and Guaiacum officinalis extracts against Maize weevil, Sitophilus zeamais, in comparison with neonicotinoids.

2018: Rebecca Johnson, EHS Graduate Program, UCI.
2018: Nicole Chmielewski Stivers, EHS Graduate Program, UCI.
2018: Janielle Vidal, EHS Graduate Program, UCI
2018: Sarah Smith, EHS Graduate Program, UCI.
Research Abstract
Research focuses on the role of environmental factors in the initiation or potentiation of neurodegenerative diseases. In this context the emphasis is on the contribution of inflammatory events to neural aging. The potential slowing of brain aging by antioxidants and antiinflammatory agents such as melatonin, is also under investigation. Such retardation could reduce the incidence of specific age-related neurodegenerative disorders such as Parkinson's and Alzheimer's diseases.

Bondy, S. C. and Campbell, A. Water quality and brain function. Int. J. Env. Res. Pub. Hlth. 14, pii: E2, 2018. PMID: 29267198.

Bondy, S. C. Melatonin: Beneficial Aspects and Underlying Mechanisms. In: Melatonin: Medical Uses and Role in Health and Disease. Nova Press, Hauppauge NY, pp. 277-294, (Eds. Correia, L. and Meyers, G), 2018. ISBN: 978-1-53612-987-

Hsu, H.W., Bondy, S. C., Kitazawa, M. Environmental heavy metal exposure, cellular mechanisms, and Alzheimer’s disease. Toxicol. Sci. 163:338-345, 2018. PMID: 29409005.

Bondy, S. C. and Campbell, A. Z. Mechanisms underlying tumor suppressive properties of melatonin. In Melatonin from an Antioxidant to a Classic Hormone or a Tissue Factor: Experimental and Clinical Aspects. Special Issue of Int. J. Mol. Sci. 19: 2205, 2018. doi:10.3390/ijms19082205.

Prasad, K. N. and Bondy, S. C. Dietary fibers and their fermented short-chain fatty acids in prevention of human disease. Bioactive Carbohydrates and Dietary Fibre 2018. doi: 10.1016/j.mad.2018.10.003.

Prasad, K.N. and Bondy, S. C. Oxidative and inflammatory events in prion disease: can they be therapeutic targets? Current Aging Sci., 2019 doi: 10.2174/1874609812666190111100205
Pending: R21 AG061707 P.I: Campbell, A. 4/1/20-3/31/23. The Use of Primary Human Cell Model for Molecular Understanding of the Protective Properties of Melatonin in the Aged Brain. Bondy, S. C. (Consultant). Pending: R41 CA247009 P.I: Lambros, M. 12/1/19-11/30/20, Using Targeted Lipid Nanoparticles to Deliver Chemotherapeutic Agents. . Bondy, S. C. (Consultant).
Professional Societies
Society for Neuroscience
Toxicology Society
American Aging Association
International Neurotoxicology Association
Graduate Programs
Environmental Toxicology

Pharmacological Sciences

Research Center
Irvine Center for Occupational & Environmental Medicine
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