Ellena M. Peterson

picture of Ellena M. Peterson

Professor, Pathology
School of Medicine
Associate Dean, Admissions and Outreach
School of Medicine
Associate Director, Medical Microbiology, Pathology

Ph.D., Georgetown University, 1978, Microbiology and Immunology

Phone: (949) 824-4169, 7450
Fax: (949) 824-2160
Email: epeterso@uci.edu

University of California, Irvine
D440 Medical Sciences I
Mail Code: 4800
Irvine, CA 92697-480
Research Interests
Chlamydia Vaccine Development, Type Three Secretion System and the Rapid Detection of Infectious Agents
Academic Distinctions
Fellow, American Academy of Microbiology

John Budd Golden Microscope Teaching Award for the Outstanding Pathology Resident Professor. June, 2010

Excellence in Medical Student Teaching Award, May, 2013
Research Abstract
Research interests in the clinical/applied area are the development of rapid procedures for the detection of clinically relevant pathogenic bacteria, viruses and fungi with particular interest in sexually transmitted pathogens. In the basic research area, attempts are being made to define the key structural elements of the pathogen Chlamydia at the molecular level that are important in eliciting a protective host immunological response. These include exploring components of the outer membrane of this pathogen and more recently, the type three secretion system.
Selected Publications

Slepenkin, A., L. M. de la Maza. and E. M. Peterson. Interaction between Components of the Type III Secretion System of Chlamydiaceae. J. Bacteriology, 187: 473-479, 2005.

Pal, S., E. M. Peterson and L. M. de la Maza. Vaccination with the Chlamydia trachomatis major outer membrane protein can elicit an immune response as protective as that resulting from inoculation with live bacteria. Infect. Immun. 73: 8153-8160, 2005.

Slepenkin A., P.-A Enquist., U. Hägglund., L. M. de la Maza, M. Elofsson and E. M. Peterson. Reversal of the Anti-Chlamydial Activity of Putative Type Three Secretion Inhibitors by Iron. Infect. Immun., 75: 3478-3489, 2007.

Sun, G., S. Pal, A. K. Sarcon, S. Kim, E. Sugawara, H. Nikaido, M. Cocco, E. M. Peterson and L.M. de la Maza. Structural and functional analyses of the major outer membrane protein of Chlamydia trachomatis. J. Bacteriol, 189: 6222-6235, 2007.

Schro¨der, NWJ, T. R. Crother, Y. Naiki, S. Chen, M. H. Wong, A. Yilmaz, A Slepenkin, D. Schulte, Randa Alsabeh, T. M. Doherty, E. Peterson, A. E. Nel, and M. Arditi. Innate Immune responses during respiratory infection with a bacterial pathogen induce allergic airway sensitization. J Allergy Clin Immunol, 122:595-602, 2008.

Naiki Y, Sorrentino R, Wong MH, Michelsen KS, Shimada K, Chen S, Yilmaz A, Slepenkin A, Schröder NW, Crother TR, Bulut Y, Doherty TM, Bradley M, Shaposhnik Z, Peterson EM, Tontonoz P, Shah PK, Arditi M. TLR/MyD88 and LXRalpha Signaling Pathways Reciprocally Control Chlamydia Pneumoniae-Induced Acceleration of Atherosclerosis. J. Immunol, 181:7176-7185, 2008.

Shimada K, Chen S, Dempsey PW, Sorrentino R, Alsabeh R, Slepenkin AV, Peterson E, Doherty TM, Underhill D, Crother TR, Arditi M. The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection. PLoS Pathog. 2009 Apr;5(4):e1000379. Epub 2009 Apr 10. Erratum in: PLoS Pathog. 2009 Apr;5(4). doi: 10.1371/annotation/f3aa682e-3bc2-4a05-ac7f-05c6cfe1bbd7. PLoS Pathog. 2009 Apr;5(4).

Kari Laszlo, William M. Whitmire, Deborah D. Crane, Nathalie Reveneau, John H. Carlson, Morgan M. Goheen, Ellena M. Peterson, Sukumar Pal, Luis M. de la Maza, and Harlan D. Caldwell. Chlamydia trachomatis Native Major Outer Membrane Protein Induces Partial Protection in Non-Human Primates: Implication for a Trachoma Transmission Blocking Vaccine. J. Immunology 182: 8063-8070, 2009.

Sun, G., S. Pal, J. Weiland, E. M. Peterson and L.M. de la Maza. Protection against an intranasal challenge by vaccines formulated with native and recombinant preparations of the Chlamydia trachomatis major outer membrane protein. Vaccine, 27:5020-5025, 2009.

Di Russo Case, E. E. M. Peterson and M. Tan. Promoters for Chlamydia Type III Secretion Genes Show a Differential Response to DNA Supercoiling that Correlates with Temporal Expression Pattern. J. Bacteriol., 192:2569-74, 2010.

Chu, Hencelyn, Anatoly Slepenkin, Mikael Elofsson, Pia Keyser, Luis M. de la Maza and Ellena M. Peterson. Candidate vaginal microbicides with activity against Chlamydia trachomatis and Neisseria gonorrhoeae. International J. of Antimicrobial Agents 36:145-150, 2010.

Reynolds, Courtney, Victor Quan; Diane Kim, Ellena Peterson, Julie Dunn, Matthew Whealon, Leah Terpstra, Hildy Meyers, Michele Cheung; Bruce Lee, Susan S. Huang. Methicillin-Resistant Staphylococcus aureus (MRSA) Carriage in 10 Nursing Homes in Orange County, California. Infection Control Hosp Epidemiol, J. Urology 32: 91-93, 2011.

Liss MA, Alexandra Chang ,Rosanne Santos, Amy Nakama-Peeples , Ellena M. Peterson, Kathryn Osann , John Billimek, Richard J. Szabo and Atreya Dash. Prevalence and Significance of Fluoroquinolone-Resistant Escherichia coli in Patients Undergoing Transrectal Ultrasound Guided Prostate Needle Biopsy. The J. Urology, 185: 1283-1288, 2011.

Liss, Michael, Amy Peeples and Ellena M. Peterson. Detection of Fluoroquinolone Resistant Organisms from Rectal Swabs Using Selective Media Prior to a Transrectal Prostate Biopsy. J Clin Micro, 49: 116-118, 2011

Slepenkin, Anatoly, Hencelyn Chu, Mikael Elofsson, Pia Keyser, and Ellena M. Peterson. Protection of mice from a Chlamydia trachomatis vaginal infection using a salicylidene acylhydrazide, a potential microbicide. J. Infect. Dis, 204: 1313-1320, 2011.

Ur-Rehman, Tofeeq, Anatoly Slepenkin, Hencelyn Chu, Anders Blomgren, Markus K Dahlgren, Caroline E Zetterstrom, Ellena M Peterson, Mikael Elofsson and Asa Gylfe. Pre-clinical pharmacokinetics and anti-chlamydial activity of salicylidene acylhydrazide inhibitors of bacterial type III secretion. J. Antibiotics, 66:1-8, 2012.

Hua Nguyen Trang D., Kaye D. Evans, Rosalinda A. Goh, Grace L. Tan, Ellena M. Peterson. Comparison of media, temperature and length of incubation for the detection of vancomycin-resistant Enterococcus. J. Clin Microbiol, 50: 2503, 2012.

Murphy CR, Eells SJ, Quan V, Kim D, Peterson E, Miller LG, Huang SS. Methicillin-Resistant Staphylococcus aureus Burden in Nursing Homes Associated with Environmental Contamination of Common Areas. J Am Geriatr Soc. Jun;60(6):1012-8, 2012

Forthal, Donald N., Tran B. Phan, Anatoly V. Slepenkin, Gary Landucci, Hencelyn Chu, Mikael Elofsson, and Ellena M. Peterson. In vitro anti-HIV-1 activity of salicylidene acylhydrazide compounds. International J. Antimicrobial Agents, 40(4):354-60, 2012.

Liss, Michael A., Ellena Peterson and James Johnson. Prevalence of ST131 Among Fluoroquinolone-Resistant Escherichia coli Obtained from Rectal Swabs Prior to Transrectal Prostate Biopsy. Urology 81 (3):548-555, 2013.

Liss, Michael, Kristen Nakamura, and Ellena Peterson. A Comparison of Broth Enhancement to Direct Plating for the Screening of Rectal Cultures for Ciprofloxacin Resistant E. coli. J Clin Micro, 51(1):249-52, 2013.
Professional Societies
American Society for Microbiology
American Venereal Disease Association
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