Inhalation toxicology, oxidative stress and cardiopulmonary diseases.
NY State Regents Scholarship; UCI Committee of 1000 Award
Dr. Michael T. Kleinman is a Professor of Occupational and Environmental Medicine in the Department of Medicine at the University of California, Irvine (UCI), where he has been since 1982. He was previously employed by the U.S. Atomic Energy Commission (AEC) as an environmental scientist and he directed the Aerosol Exposure and Analytical Laboratory at Rancho Los Amigos Hospital in Downey, CA. He is a toxicologist and has been studying the health effects of exposures to environmental contaminants 40 years. He holds a M.S. in Chemistry (Biochemistry) from the Polytechnic Institute of Brooklyn and a Ph.D. in Environmental Health Sciences from New York University. He is also the Co-Director of the Air Pollution Health Effects Laboratory in the Department of Medicine at University of California, Irvine. He has published about 110 articles in peer-reviewed journals dealing with environmental contaminants and their effects on cardiopulmonary and immunological systems and on global and regional distribution of environmental contaminants including heavy metals and radioactive contaminants from nuclear weapons testing and manufacture. He has directed more than 50 controlled exposure studies of human volunteers and laboratory animals to ozone and other photochemical oxidants, carbon monoxide, ambient particulate matter and laboratory-generated aerosols containing chemically or biologically reactive metals such as lead, cadmium, iron and manganese. His current studies examine the role of toxic organic components of ambient particles in the development of inflammation and oxidative stress that leads to damage of the heart, lung and brain. He served on two National Academy committees to examine issues in protecting deployed U.S. Forces from the effects of chemical and biological weapons. Dr. Kleinman’s current research focuses on neurological and cardiopulmonary effects of inhaled particles, including nanomaterials and ultrafine, fine and coarse ambient particles in humans and laboratory animals. His recent health effects studies have demonstrated that inhalation of combustion-generated particles can promote airway allergies and accelerate the development of cardiovascular disease and that these effects may be associated with organic and elemental carbon components of the ultrafine fraction of the ambient aerosol. His studies have also demonstrated that inhalation of ambient particles is associated with persistent inflammation in the brain and that particles associated with manganese can alter dopamine and serotonin levels in the brain and can cause changes in nerve structure during brain development. Dr. Kleinman has developed exposure guidelines for toxic contaminants in workplace and ambient environments as a member of the ACGIH TLV committee and as a member of the California Health Effects Advisory Committee (which proposes PELs for CalOSHA. He has also served on EPA CASAC panels for PM, NO2 and CO, was a co-author of the WHO indoor air quality guidelines for CO (now in draft), and chairs the Air Quality Advisory Committee for California (which has a charge for the state similar to that of CASAC).
Li, N., Harkema, J. R., Lewandowski, R. P., Wang, M., Bramble, L. A., Gookin, G. R., Ning, Z., Kleinman, M. T., Sioutas, C. and Nel, A. E. 2010 Ambient ultrafine particles provide a strong adjuvant effect in the secondary immune response: implication for traffic-related asthma flares. Am J Physiol Lung Cell Mol Physiol 299: L374-383.
Wu J, Edwards R, He XE, Liu Z, Kleinman M. 2010 Spatial analysis of bioavailable soil lead concentrations in Los Angeles, California. Environ Res 110(4): 309-317.
Simkhovich BZ, Kleinman MT, Kloner RA. 2009. Particulate air pollution and coronary heart disease. Current Opinion in Cardiology 24(6): 604-609.
Campbell A, Araujo JA, Li HH, Sioutas C, Kleinman M. 2009. Particulate Matter Induced Enhancement of Inflammatory Markers in the Brains of Apolipoprotein E Knockout Mice. Journal of Nanoscience and Nanotechnology 9(8): 5099-5104.
Kleinman MT, Araujo J, Nel A, Sioutas C, Campbell A, Cong PQ, Li A, Bondy SC, Inhaled ultrafine particulate matter affects CNS inflammatory processes and may act via MAP kinase signaling pathways, Toxicol Lett 178, 127-130, 2008.
Simkhovich BZ, Kleinman, MT, Kloner RA, Air pollution and cardiovascular injury: epidemiology, toxicology and mechanisms, J. Amer. Coll. Cardiol. 52:719-726, 2008.
Kleinman, MT, Sioutas, C, Froines, J, Fanning, E, Hamade, A, Meacher, D and Oldham, M., Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice: relevance of particle composition and size, Inhal. Toxicol., 19 Suppl 1: 117-126, 2007
Kleinman, M.T., Hyde, D., Bufalino, C., Basbaum, C., Bhalla, D.K. and Mautz, W.J Toxicity of Chemical Components of Fine Particles Inhaled by Aged Rats: Effects of Concentration. J. Air and Waste Management Assoc.53: 1080-1087, 2003.
Kleinman, M.T., Chang, M, Sioutas, C. and Cassee, F. Fine and coarse ambient particles suppress macrophage function. Toxicol. Letters 151-158, 2003.
Hall JV; Winer AM; Kleinman MT; Lurmann FW; Brajer V; Colome SD. Valuing the health benefits of clean air. Science, 1992 Feb 14, 255(5046):812-7.
Kleinman, M.T., Chang, M, Sioutas, C. and Cassee, F. 2002, Fine and coarse ambient particles suppress macrophage function. Toxicol. Letters 3:197-208.
Kleinman, M.T., Bufalino, C, Rasmussen, R. Hyde, D., Bhalla, D.K. and Mautz, W.J. Toxicity of chemical components of ambient fine particulate matter (PM2.5) inhaled by aged rats. J. Appl. Toxicol. 357-364, 2000.
Kleinman, M.T. Health Effects of Carbon Monoxide, in Environmental Toxicants, 2nd Edition M. Lippmann, ed. Van Nostrand Reinhold, publishers, New York, Jan. 2000.
Solomon, C., Christian, D. L., Chen, L. L., Welch, B. S., Kleinman, M. T., Dunham, E., Erle, D. J. and Balmes, J. R. Effect of serial-day exposure to nitrogen dioxide on airway and blood leukocytes and lymphocyte subsets. European Respiratory Journal 15:922-928, 2000.
Bondy, S.C., Ali, S.F. and Kleinman, M.T. Exposure of mice to tobacco smoke attenuates the toxic effects of methamphetamine on dopamine systems. Toxicol. Letters 118:43-46, 2000.
Chen Y, Douglass T, Jeffes EW, Xu Q, Williams CC, Arpajirakul N, Delgado C, Kleinman M, Sanchez R, Dan Q, Kim RC, Wepsic HT, Jadus MR. Living T9 glioma cells expressing membrane macrophage colony-stimulating factor produce immediate tumor destruction by polymorphonuclear leukocytes and macrophages via a "paraptosis"-induced pathway that promotes systemic immunity against intracranial T9 gliomas. Blood 100:1373-1380, 2002.
Jenkins, B.M., Mehlschau, J.J., Williams, R.B., Solomon, C., Balmes, J., Kleinman, M. And Smith, J. Rice Straw Smoke Generation System for Controlled Human Inhalation Exposures. Aerosol Sci. And Technol. 37: 437-454, 2003.
Opperhuizen, A., Buringh, E. And Kleinman, M.T. Compliance with PM standards in the European Union: A Netherlands case study. Environ. Management 53: 24-32, 2003
Brain and Lung Tumor Foundation (Kleinman, Subcontract PI) 07/01/04-06/30/11
Effects of air pollution exposure on genetic markers of tumor development
California Air Resources Board (Kleinman, PI) (4/1/08-1/31/11)Contribution of vapor phase reactive organic compounds in ambient air to cardiopulmonary health effects.
California Air Resources Board (Kleinman, PI) (2/1/10-3/31/13)Neurotoxic Effects of Inhaled Fine Particles in APOE-/- mice.
New York Academy of Sciences
American Chemical Society
American Association for Aerosol Research
Air and Waste Management Association
Society of Toxicology
Industrial hygiene and exposure assessment
UCI Comprehensive Cancer Center
Center for Occupational and Environmental Health