Baruch D. Kuppermann

picture of Baruch D. Kuppermann

Roger F. Steinert Endowed Professor; Chair, Department of Ophthalmology; Director, Gavin Herbert Eye Institute
School of Medicine

M.D., University of Miami, Florida, 1985
Ph.D., California Institute of Technology, 1983, Neuroscience

Phone: Appointments (949) 824-2020; Academic Office (949) 824-8089
Fax: (949) 824-4015

University of California, Irvine
Gavin Herbert Eye Institute
850 Health Sciences Road
Mail Code: 4375
Irvine, CA 92697
Research Interests
1) Ocular Manifestations of AIDS 2) Risk factors for the development of retinopathy of prematurity post partum 3) Photodynamic therapy for the treatment of choroidal melanomas
Research Abstract
Baruch D. Kuppermann, MD, PhD is the Roger F. Steinert Professor, Chair of the Department of Ophthalmology, and Director of the Gavin Herbert Eye Institute at the University of California, Irvine. He also holds a joint appointment with the Department of Biomedical Engineering at UC Irvine.

After earning his PhD in neuroscience at the California Institute of Technology and his medical degree at the University of Miami in Florida, Dr. Kuppermann completed his internship at the Los Angeles County/University of Southern California Medical Center and his residency in ophthalmology at the University of Southern California Doheny Eye Institute in Los Angeles. In addition, he completed fellowships in retina and vitreous at St. Joseph Medical Center in Baltimore, Maryland and at the University of California, San Diego.

His laboratory research focuses on assessing the toxicity of drugs on retinal cells in culture, including various vital stains, steroids, and anti-VEGF compounds. More recently, the lab has modified its focus to study the effect of mitochondrial genetics on retinal diseases such as age-related macular degeneration and diabetic macular edema. He is also active in the development of drug delivery systems for the posterior segment through collaborative work with the Department of Biomedical Engineering at UC Irvine. Dr. Kuppermann has published extensively in the peer-reviewed literature, has been a visiting professor at a number of universities in the United States and Europe, and has given several named lectureships. He is also extensively involved in clinical research, having served as Principal Investigator in many trials evaluating new drugs and technologies for the treatment of age-related macular degeneration, diabetic retinopathy, and retinal vein occlusion.

Dr. Kuppermann is listed as one of the best doctors in America, as well as one of the "Best Ophthalmologists in Orange County" by Orange Coast Magazine. He is a peer reviewer for the American Journal of Ophthalmology, Archives of Ophthalmology, Investigative Ophthalmology and Visual Science, Journal of Infectious Diseases, Lancet, Ophthalmology, Retina, and Survey of Ophthalmology.
Peer-reviewed publications, 2016-2018
Hamid MA, Mehta MC, Kuppermann BD. Multimodal imaging in a patient with Prader-Willi syndrome. Int J Retina Vitreous. 2018 Nov 30;4:45. doi: 10.1186/s40942-018-0147-6. eCollection 2018.
Sharma A, Reddy P, Kuppermann BD, Bandello F, Lowenstein A. Biosimilars in ophthalmology: "Is there a big change on the horizon?" Clin Ophthalmol. 2018 Oct 24;12:2137-2143. doi: 10.2147/OPTH.S180393. eCollection 2018. Review.
Sapkal AU, Nashine S, Mansoor S, Sharma VR, Ramirez CA, Migon RZ, Gupta NK, Chwa M, Kuppermann BD, Kenney MC. Protective Effects of 17ß-Estradiol on Benzo(e) pyrene[B(e)P]-induced Toxicity in ARPE-19 cells. J Ophthalmic Vis Res. 2018 Oct-Dec;13(4):419-425. doi: 10.4103/jovr.jovr_16_18.
Hamid MA, Moustafa MT, Càceres-Del-Carpio J, Kuppermann BD, Kenney MC. Effects of Antiangiogenic Drugs on Expression Patterns of Epigenetic Pathway Genes. Ophthalmic Surg Lasers Imaging Retina. 2018 Oct 15;49(10):S29-S33. doi: 10.3928/23258160-20180814-05.
Tsao SW, Gabriel R, Thaker K, Kuppermann BD, Kenney MC. Effects of Brimonidine on Retinal Pigment Epithelial Cells and Müller Cells Exposed to Amyloid-Beta 1-42 Peptide In Vitro. Ophthalmic Surg Lasers Imaging Retina. 2018 Oct 15;49(10):S23-S28. doi: 10.3928/23258160-20180814-04.
Nashine S, Cohen P, Nesburn AB, Kuppermann BD, Kenney MC. Characterizing the protective effects of SHLP2, a mitochondrial-derived peptide, in macular degeneration. Sci Rep. 2018 Oct 11;8(1):15175. doi: 10.1038/s41598-018-33290-5.
Singer MA, Miller DM, Gross JG, Greven CM, Kapik B, Bailey C, Ghanchi F, Kuppermann BD. Visual Acuity Outcomes in Diabetic Macular Edema With Fluocinolone Acetonide 0.2 µg/Day Versus Ranibizumab Plus Deferred Laser (DRCR Protocol I). Ophthalmic Surg Lasers Imaging Retina. 2018 Sep 1;49(9):698-706. doi: 10.3928/23258160-20180831-08.
Sharma A, Dongre P, Bellala K, Reddy P, Kuppermann BD, Francesco B. Role of retinal image-based counseling in the treatment of peripheral retinal lesions. Eye (Lond). 2018 Aug 17. doi: 10.1038/s41433-018-0196-y. [Epub ahead of print].
Riazi-Esfahani M, Kuppermann BD, Kenney MC. The Role of Mitochondria in AMD: Current Knowledge and Future Applications. J Ophthalmic Vis Res. 2017 Oct-Dec;12(4):424-428. doi: 10.4103/jovr.jovr_182_17.
Moustafa MT, Ramirez C, Schneider K, Atilano SR, Limb GA, Kuppermann BD, Kenney MC. Protective Effects of Memantine on Hydroquinone-Treated Human Retinal Pigment Epithelium Cells and Human Retinal Müller Cells. J Ocul Pharmacol Ther. 2017 Oct;33(8):610-619. doi: 10.1089/jop.2016.0129.
Nashine S, Cohen P, Chwa M, Lu S, Nesburn AB, Kuppermann BD, Kenney MC. Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage. Cell Death Dis. 2017 Jul 20;8(7):e2951. doi: 10.1038/cddis.2017.348.
Regillo CD, Callanan DG, Do DV, Fine HF, Holekamp NM, Kuppermann BD, Singer MA, Singh RP. Use of Corticosteroids in the Treatment of Patients With Diabetic Macular Edema Who Have a Suboptimal Response to Anti-VEGF: Recommendations of an Expert Panel. Ophthalmic Surg Lasers Imaging Retina. 2017 Apr 1;48(4):291-301. doi: 10.3928/23258160-20170329-03.
Estrago-Franco MF, Moustafa MT, Riazi-Esfahani M, Sapkal A, Piche-Lopez R, Patil J, Sharma A, Falatoonzadeh P, Chwa M, Luczy-Backman G, Kuppermann BD, Kenney MC. Effects of Benzo(e)pyrene on Reactive Oxygen/Nitrogen species and Inflammatory Cytokines Induction in Human RPE Cells and Attenuation by Mitochondrial-involved Mechanism. J Ophthalmic Vis Res. 2016 Oct-Dec; 11 (4): 385–393. DOI: 10.4103/2008-322X.194091.
Nashine S, Chwa M, Kazemian M, Thaker K1, Lu S, Nesburn A, Kuppermann, BD, Kenney, MC. Differential Expression of Complement Markers in Normal and AMD Transmitochondrial Cybrids. PLoS One. 2016 Aug 3;11(8):e0159828. doi: 10.1371/journal.pone.0159828. eCollection 2016.
Thaker K, Chwa M, Atilano SR, Coskun P, Cáceres-Del-Carpio J, Udar N, Boyer DS, Jazwinski SM, Miceli MV, Nesburn AB, Kuppermann BD, Kenney MC. Increased expression of ApoE and protection from amyloid-beta toxicity in transmitochondrial cybrids with haplogroup K mtDNA. Neurobiol Dis. 2016 Apr 22;93:64-77. doi: 10.1016/j.nbd.2016.04.005. Epub 2016 Apr 22.
Ramírez C, Cáceres-Del-Carpio J, Chu J, Moustafa MT, Chwa M, Limb GA, Kuppermann BD, Kenney MC. Brimonidine Can Prevent In Vitro Hydroquinone Damage on Retinal Pigment Epithelium Cells and Retinal Müller Cells. J Ocul Pharmacol Ther. 2016 Mar;32(2):102-8. doi: 10.1089/jop.2015.0083. Epub 2015 Dec 1.
Cáceres-del-Carpio J, Costa RD, Haider A, Narayanan R, Kuppermann BD. Corticosteroids: Triamcinolone, Dexamethasone and Fluocinolone. Dev Ophthalmol. 2016;55:221-31. doi: 10.1159/000431198. Epub 2015 Oct 26.
Non-peer reviewed publications, 2016-2018
Kenney MC, Kuppermann BD: Mitochondrial Genetics in AMD. The powerhouse of the cell holds potential for the treatment of age-related disease. Retina Today. May/June 2017.
Kuppermann BD: What happens to your eyes if you stare at the eclipse? Eclipse article August 01, 2017. UC Irvine Health.
Narayanan R, Kuppermann BD: Intracellular Edema. Dev Ophthalmol. 2017;58:21-26. doi: 10.1159/000455266. Epub 2017 Mar 28.
Narayanan R, Kuppermann BD: Hot Topics in Dry AMD. Current Pharmaceutical Design, 2017, Vol. 23, No. 4 543.
Narayanan R, Kuppermann BD. Corticosteroids and Anti-Complement Therapy in Retinal Diseases. S.M. Whitcup, D.T. Azar (eds.), Pharmacologic Therapy of Ocular Disease Springer. Handbook of Experimental Pharmacology, 242; 2016 Nov 5. 309-318. DOI 101007/164-2016-22.
Kuppermann BD: Breaking Bridges With Integrin Therapy. This class of drugs may have potential to treat several diseases. Trials are ongoing. New Retina MD. October 2016. 35-36. Issue 3.
“Safety and Efficacy of Abicipar Pegol (AGN-150998) in Patients with Neovascular Age-related Macular Degeneration”. Allergan. March 2016 – May 2020.
“An Extension Study of JC-01 Evaluating Long-Term Safety of Intravitreal Injection of Human Retinal Progenitor Cells (jCell) in Adult Subjects with Retinitis Pigmentosa (RP) (JC-01E)”. CIRM. 2017-2019.
“A Phase 2, Randomised, Double-Masked, Sham-Controlled, Multicentre Study to Evaluate the Efficacy and Safety of Ocriplasmin in Inducing Total Posterior Vitreous Detachment (pvd) in Subjects with Non-Proliferative Diabetic Retinopathy (NPDR) (Circle)”. Thrombogenics. January 2017- December 2019.
“Phase III Study of the Efficacy and Safety of Squalamine Lactate Ophthalmic Solution, 0.2% Twice Daily in Subjects with Neovascular Age-Related Macular Degeneration”. Ohr. January 2017 – December 2020.
“A Phase 3, Double-Masked, Randomized, Study of the Efficacy and Safety of Intravitreal Aflibercept Injection in Patients with Moderately Severe to Severe Nonproliferative Diabetic Retinopathy”. Regeneron. February 2017 – January 2020.
“SAPPHIRE: A Randomized, Masked, Controlled Trial to Study the Safety and Efficacy of Suprachoroidal CLS-TA in Conjunction with Intravitreal Aflibercept in Subjects with Retinal Vein Occlusion”. Clearside Biomedical, Inc. September 2017-May 2020.
Professional Societies
American Academy of Ophthalmology
Association of University Professors of Ophthalmology
American Ophthalmological Society
American Society of Retina Specialists
Club Jules Gonin
European Society of Retina Specialists
Macula Society
Pan American Association of Ophthalmology
Retina Society
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