Baruch D. Kuppermann

picture of Baruch D. Kuppermann

Roger F. Steinert Professor and Chair, Department of Ophthalmology
School of Medicine
Director, Gavin Herbert Eye Institute
School of Medicine
Joint Appointment, Professor, Department of Biomedical Engineering
The Henry Samueli School of Engineering

M.D., University of Miami, Florida, 1985
Ph.D., California Institute of Technology, 1983, Neuroscience

Phone: Appointments (949) 824-2020; Academic Office (949) 824-8089
Fax: (949) 824-4015

University of California, Irvine
Gavin Herbert Eye Institute
850 Health Sciences Road
Mail Code: 4375
Irvine, CA 92697
Research Interests
1) Pathophysiology of age related macular degeneration using cell culture models of the retina 2) Developing and evaluating drug delivery systems for retinal diseases 3) Clinical trial development for retinal diseases including diabetic retinopathy
Research Abstract
Baruch D. Kuppermann, MD, PhD is the Roger F. Steinert Professor, Chair of the Department of Ophthalmology, and Director of the Gavin Herbert Eye Institute at the University of California, Irvine. He also holds a joint appointment with the Department of Biomedical Engineering at UC Irvine.

After earning his PhD in neuroscience at the California Institute of Technology and his medical degree at the University of Miami in Florida, Dr. Kuppermann completed his internship at the Los Angeles County/University of Southern California Medical Center and his residency in ophthalmology at the University of Southern California Doheny Eye Institute in Los Angeles. In addition, he completed fellowships in retina and vitreous at St. Joseph Medical Center in Baltimore, Maryland and at the University of California, San Diego.

His laboratory research focuses on assessing the toxicity of drugs on retinal cells in culture, including various vital stains, steroids, and anti-VEGF compounds. More recently, the lab has modified its focus to study the effect of mitochondrial genetics on retinal diseases such as age-related macular degeneration and diabetic macular edema. He is also active in the development of drug delivery systems for the posterior segment through collaborative work with the Department of Biomedical Engineering at UC Irvine. Dr. Kuppermann has published extensively in the peer-reviewed literature, has been a visiting professor at a number of universities in the United States and Europe, and has given several named lectureships. He is also extensively involved in clinical research, having served as Principal Investigator in many trials evaluating new drugs and technologies for the treatment of age-related macular degeneration, diabetic retinopathy, and retinal vein occlusion.

Dr. Kuppermann is listed as one of the best doctors in America, as well as one of the "Best Ophthalmologists in Orange County" by Orange Coast Magazine. He is a peer reviewer for the American Journal of Ophthalmology, Archives of Ophthalmology, Investigative Ophthalmology and Visual Science, Journal of Infectious Diseases, Lancet, Ophthalmology, Retina, and Survey of Ophthalmology.
Peer-reviewed publications, 2017-2020
Nashine S, Nesburn AB, Kuppermann BD, Kenney MC. Role of Resveratrol in Transmitochondrial AMD RPE Cells. Nutrients. 2020 Jan 6;12(1). pii: E159. doi: 10.3390/nu12010159. PMID: 31935891
Cáceres-Del-Carpio J, Moustafa MT, Toledo-Corral J, Hamid MA, Atilano SR, Schneider K, Fukuhara PS, Costa RD, Norman JL, Malik D, Chwa M, Boyer DS, Limb GA, Kenney MC, Kuppermann BD. In vitro response and gene expression of human retinal Müller cells treated with different anti-VEGF drugs. Exp Eye Res. 2020 Jan 3;191:107903. doi: 10.1016/j.exer.2019.107903. [Epub ahead of print] No abstract available. PMID: 31904361
Sharma A, Faridi H, Kumar N, Parachuri N, Sharma R, Kuppermann B, Bandello F, Loewenstein A, Regillo C. Immunogenicity and efficacy after switching from original Ranibizumab to a Ranibizumab biosimilar: a real-world data. Eye (Lond). 2019 Dec 16. doi: 10.1038/s41433-019-0745-z. [Epub ahead of print] No abstract available. PMID: 31844168
Sharma A, Bilong Y, Patil J, Katte JC, Ahmad Khaqan H, Kumar Gupta N, Patel A, Sundaramoorthy SK, Madhusudan RJ, Vidhya N, Lekha T, Shah PK, Saravanan VR, Dharwadkar SS, Rishi P, Franco MFE, Chelo D, Kagmeni G, Assumpta Bella L, Kuppermann BD. MIIRetCam (Make In India Retina Camera) assisted retinal imaging in paediatric patients: Useful, artefacts, learning curve. J Fr Ophtalmol. 2020 Jan;43(1):e35-e38. doi: 10.1016/j.jfo.2019.09.003. Epub 2019 Dec 16. No abstract available. PMID: 31837894
Sharma A, Kumar N, Bandello F, Loewenstein A, Kuppermann BD. Need of education on biosimilars amongst ophthalmologists: Combating the nocebo effect. Eye (Lond). 2019 Nov 29. doi: 10.1038/s41433-019-0722-6. [Epub ahead of print] No abstract available. PMID: 31784703
Sharma A, Kumar N, Kuppermann BD, Bandello F, Lowenstein A. Faricimab: expanding horizon beyond VEGF. Eye (Lond). 2019 Nov 6. doi: 10.1038/s41433-019-0670-1. [Epub ahead of print] No abstract available. PMID: 31695160
Sharma A, Kumar N, Kuppermann BD, Francesco B. Re: Campochiaro et al.: The Port Delivery System with ranibizumab for neo-vascular age-related macular degeneration: results from the randomized phase 2 Ladder clinical trial (Ophthalmology. 2019; 126:1141-1154). Ophthalmology. 2019 Nov;126(11):e87-e88. doi: 10.1016/j.ophtha.2019.06.019. No abstract available. PMID: 31635710
Sharma A, Kumar N, Kuppermann BD, Bandello F, Loewenstein A. Ophthalmic biosimilars and biologics-role of endotoxins. Eye (Lond). 2019 Oct 16. doi: 10.1038/s41433-019-0636-3. [Epub ahead of print] No abstract available. PMID: 31619778
Sharma A, Kuppermann BD, Bandello F, Lanzetta P, Zur D, Park SW, Yu HG, Saravanan VR, Zacharias LC, Barreira AK, Iglicki M, Miassi F, Veritti D, Tsao S, Makam D, Jain N, Lowenstein A. Intraocular pressure (IOP) after intravitreal dexamethasone implant (Ozurdex) amongst different geographic populations-GEODEX-IOP study. Eye (Lond). 2019 Sep 30. doi: 10.1038/s41433-019-0616-7. [Epub ahead of print] PMID: 31570814
Sharma A, Kumar N, Kuppermann BD, Bandello F. Abicipar pegol: the non-monoclonal antibody anti-VEGF. Eye (Lond). 2019 Sep 30. doi: 10.1038/s41433-019-0670-8. [Epub ahead of print] No abstract available. PMID: 31570812
Sharma A, Kumar N, Kuppermann BD, Bandello F. Brolucizimab-leading an era of structural revolution for long-term VEGF suppression. Eye (Lond). 2019 Sep 19. doi: 10.1038/s41433-019-0583-z. [Epub ahead of print] No abstract available. PMID: 3157892
Sharma A, Kumar N, Kuppermann BD, Lowenstein A, Bandello F. Brolucizumab: is extended VEGF suppression on the horizon? Eye (Lond). 2019 Sep 16. doi: 10.1038/s41433-019-0582-0. [Epub ahead of print] No abstract available. PMID: 31527765
Nashine S, Subramaniam SR, Chwa M, Nesburn A, Kuppermann BD, Federoff H, Kenney MC. PU-91 drug rescues human age-related macular degeneration RPE cells; implications for AMD therapeutics. Aging (Albany NY). 2019 Sep 2. doi: 10.18632/aging.102179. [Epub ahead of print] PMID: 31477635
Sharma A, Kumar N, Kuppermann BD, Francesco B, Lowenstein A. Ophthalmic biosimilars: Lessons from India. Indian J Ophthalmol. 2019 Aug;67(8):1384-1385. doi: 10.4103/ijo.IJO_430_19. No abstract available. PMID: 31332154
Sharma A, Parachuri N, Kumar N, Kuppermann BD, Bandello F, Loewenstein A, Regillo CD. Subfoveal Neurosensory Detachment Flattening and Observe (SNF-Ob): A Novel Approach in Diabetic Macular Edema Management: A Potential Cost-Effective Treatment Strategy to Be Explored. Ophthalmol Retina. 2019 Jul 10. pii: S2468-6530(19)30458-0. doi: 10.1016/j.oret.2019.06.016. [Epub ahead of print] No abstract available. PMID: 31451440
Sharma A, Kumar N, Kuppermann BD, Bandello F, Loewenstein A. Understanding biosimilars and its regulatory aspects across the globe: an ophthalmology perspective. Br J Ophthalmol. 2019 Jul 17. pii: bjophthalmol-2019-314443. doi: 10.1136/bjophthalmol-2019-314443. [Epub ahead of print] Review. PMID: 31315829
Sharma A, Goyal A, Bilong Y, Shah P, Banker A, Kumar N, Sharma R, Kuppermann BD, Bandello F. Comparison of a Smartphone-Based Photography Method with Indirect Ophthalmoscopic Assessment in Referable Retinopathy of Prematurity: A Smart Retinopathy of Prematurity Model Pilot Study. Ophthalmol Retina. 2019 Jun 22. pii: S2468-6530(19)30313-6. doi: 10.1016/j.oret.2019.06.006. [Epub ahead of print]. PMID: 31422107
Nashine S, Nesburn AB, Kuppermann BD, Kenney MC. Age-related macular degeneration (AMD) mitochondria modulate epigenetic mechanisms in retinal pigment epithelial cells. Exp Eye Res. 2019 Jun 18:107701. doi: 10.1016/j.exer.2019.107701. [Epub ahead of print]. PMID: 31226340
Sharma A, Kumar N, Parachuri N, Kuppermann BD, Francesco B, Regillo CD. Ranibizumab port delivery system (RPDS): realising long awaited dream of prolonged VEGF suppression. Eye (Lond). 2019 Jun 5. doi: 10.1038/s41433-019-0479-y. [Epub ahead of print]. PMID: 31165769
Sharma A, Kumar N, Kuppermann BD, Francesco B, Loewenstein A. Biotherapeutics and immunogenicity: ophthalmic perspective. Eye (Lond). 2019 Apr 9. doi: 10.1038/s41433-019-0434-y. [Epub ahead of print]. PMID: 30967643
Sharma A, Kumar N, Kuppermann BD, Francesco B, Loewenstein A. Biologics, biosilimars, and biobetters: different terms or different drugs? Eye (Lond). 2019 Mar 7. doi: 10.1038/s41433-019-0391-5. [Epub ahead of print] No abstract available. PMID: 30846867
Nashine S, Kanodia R, Nesburn AB, Soman G, Kuppermann BD, Kenney MC. Nutraceutical effects of Emblica officinalis in age-related macular degeneration. Aging (Albany NY). 2019 Feb 21;11(4):1177-1188. doi: 10.18632/aging.101820. PMID: 30792375
Hamid MA, Mehta MC, Kuppermann BD. Multimodal imaging in a patient with Prader-Willi syndrome. Int J Retina Vitreous. 2018 Nov 30;4:45. doi: 10.1186/s40942-018-0147-6. eCollection 2018.
Sharma A, Reddy P, Kuppermann BD, Bandello F, Lowenstein A. Biosimilars in ophthalmology: "Is there a big change on the horizon?" Clin Ophthalmol. 2018 Oct 24;12:2137-2143. doi: 10.2147/OPTH.S180393. eCollection 2018. Review.
Sapkal AU, Nashine S, Mansoor S, Sharma VR, Ramirez CA, Migon RZ, Gupta NK, Chwa M, Kuppermann BD, Kenney MC. Protective Effects of 17ß-Estradiol on Benzo(e) pyrene[B(e)P]-induced Toxicity in ARPE-19 cells. J Ophthalmic Vis Res. 2018 Oct-Dec;13(4):419-425. doi: 10.4103/jovr.jovr_16_18.
Hamid MA, Moustafa MT, Càceres-Del-Carpio J, Kuppermann BD, Kenney MC. Effects of Antiangiogenic Drugs on Expression Patterns of Epigenetic Pathway Genes. Ophthalmic Surg Lasers Imaging Retina. 2018 Oct 15;49(10):S29-S33. doi: 10.3928/23258160-20180814-05.
Tsao SW, Gabriel R, Thaker K, Kuppermann BD, Kenney MC. Effects of Brimonidine on Retinal Pigment Epithelial Cells and Müller Cells Exposed to Amyloid-Beta 1-42 Peptide In Vitro. Ophthalmic Surg Lasers Imaging Retina. 2018 Oct 15;49(10):S23-S28. doi: 10.3928/23258160-20180814-04.
Nashine S, Cohen P, Nesburn AB, Kuppermann BD, Kenney MC. Characterizing the protective effects of SHLP2, a mitochondrial-derived peptide, in macular degeneration. Sci Rep. 2018 Oct 11;8(1):15175. doi: 10.1038/s41598-018-33290-5.
Singer MA, Miller DM, Gross JG, Greven CM, Kapik B, Bailey C, Ghanchi F, Kuppermann BD. Visual Acuity Outcomes in Diabetic Macular Edema With Fluocinolone Acetonide 0.2 µg/Day Versus Ranibizumab Plus Deferred Laser (DRCR Protocol I). Ophthalmic Surg Lasers Imaging Retina. 2018 Sep 1;49(9):698-706. doi: 10.3928/23258160-20180831-08.
Sharma A, Dongre P, Bellala K, Reddy P, Kuppermann BD, Francesco B. Role of retinal image-based counseling in the treatment of peripheral retinal lesions. Eye (Lond). 2018 Aug 17. doi: 10.1038/s41433-018-0196-y. [Epub ahead of print].
Riazi-Esfahani M, Kuppermann BD, Kenney MC. The Role of Mitochondria in AMD: Current Knowledge and Future Applications. J Ophthalmic Vis Res. 2017 Oct-Dec;12(4):424-428. doi: 10.4103/jovr.jovr_182_17.
Moustafa MT, Ramirez C, Schneider K, Atilano SR, Limb GA, Kuppermann BD, Kenney MC. Protective Effects of Memantine on Hydroquinone-Treated Human Retinal Pigment Epithelium Cells and Human Retinal Müller Cells. J Ocul Pharmacol Ther. 2017 Oct;33(8):610-619. doi: 10.1089/jop.2016.0129.
Nashine S, Cohen P, Chwa M, Lu S, Nesburn AB, Kuppermann BD, Kenney MC. Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage. Cell Death Dis. 2017 Jul 20;8(7):e2951. doi: 10.1038/cddis.2017.348.
Regillo CD, Callanan DG, Do DV, Fine HF, Holekamp NM, Kuppermann BD, Singer MA, Singh RP. Use of Corticosteroids in the Treatment of Patients With Diabetic Macular Edema Who Have a Suboptimal Response to Anti-VEGF: Recommendations of an Expert Panel. Ophthalmic Surg Lasers Imaging Retina. 2017 Apr 1;48(4):291-301. doi: 10.3928/23258160-20170329-03.
“SAPPHIRE: A Randomized, Masked, Controlled Trial to Study the Safety and Efficacy of Suprachoroidal CLS-TA in Conjunction with Intravitreal Aflibercept in Subjects with Retinal Vein Occlusion”. Clearside Biomedical, Inc. September 2017-January 2019.
“An Extension Study of JC-01 Evaluating Long-Term Safety of Intravitreal Injection of Human Retinal Progenitor Cells (jCell) in Adult Subjects with Retinitis Pigmentosa (RP) (JC-01E)”. CIRM. 2017-2019.
“A Phase 2, Randomised, Double-Masked, Sham-Controlled, Multicentre Study to Evaluate the Efficacy and Safety of Ocriplasmin in Inducing Total Posterior Vitreous Detachment (pvd) in Subjects with Non-Proliferative Diabetic Retinopathy (NPDR) (Circle)”. Thrombogenics. January 2017- December 2019.
“A Phase 3, Double-Masked, Randomized, Study of the Efficacy and Safety of Intravitreal Aflibercept Injection in Patients with Moderately Severe to Severe Nonproliferative Diabetic Retinopathy”. Regeneron. February 2017 – January 2020.
“Safety and Efficacy of Abicipar Pegol (AGN-150998) in Patients with Neovascular Age-related Macular Degeneration”. Allergan. March 2016 – May 2020.
“Phase III Study of the Efficacy and Safety of Squalamine Lactate Ophthalmic Solution, 0.2% Twice Daily in Subjects with Neovascular Age-Related Macular Degeneration”. Ohr. January 2017 – December 2020.
Professional Societies
American Academy of Ophthalmology
Association of University Professors of Ophthalmology
American Ophthalmological Society
American Society of Retina Specialists
Club Jules Gonin
European Society of Retina Specialists
Macula Society
Pan American Association of Ophthalmology
Retina Society
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