Jerry L. McCullough

picture of Jerry L. McCullough

Professor Emeritus
School of Medicine

Ph.D., Yale University, 1970, Pharmacology
B.S., Indiana University, 1965, Chemistry

Phone: (949) 824-5516
Fax: (949) 824-5407

University of California, Irvine
102A Med Surge I
Mail Code: 2400
Irvine, CA 92697
Research Interests
Clinical Research, Dermatopharmacology, topical drug development, in vitro and in vivo skin penetration models, psoriasis, skin cancer, photoaging, photodynamic therapy
Research Abstract
Dr. McCullough is interested in pharmacologic studies of dermatologic diseases including psoriasis and cancer. These studies are aimed at understanding the mechanisms of action of known drugs and developing safer and more effective forms of therapy. Dr. McCullough provides administrative support for the Dermatology Clinical Research Center.
McCullough, JL, Bertino, JR: Dihydrofolate reductase from mouse liver and spleen. Biochemical Pharmacology 20:561-574, 1971.

Bertino, JR, O'Brien, P, McCullough, JL: Inhibition of growth of leukemia cells by enzymic folate depletion. Science 172:161-162, 1971.

McCullough, JL, Nixon, P, Bertino, JR: Kinetic investigation of the reaction mechanism of dihydrofolate reductase from L1210 Cells. Annals of the New York Academy of Sciences 186:486-495, 1971.

Bertino, JR, Levitt, M, McCullough, JL, Chabner, B: New approaches to chemotherapy with folate antagonists: Use of leucovorin rescue and enzymic folate depletion. Annals of the New York Academy of Sciences 186:486-495, 1971.

McCullough, JL, Chabner, BA, Bertino, JR: Purification and properties of carboxypeptidase G1. Journal of Biological Chemistry 246:7207-7213, 1971.

McCullough, JL, Maren, TH: Dihydropteroate synthesis from Plasmodium berghei: Isolation, properties, and Inhibition by dapsone and sulfadiazine. Journal of Antimicrobial Agents and Chemotherapy 3:665-669, 1973.

Weinstein, GD, McCullough, JL: Cytokinetics in diseases of epidermal hyperplasia. Annual Review of Medicine 24:345-351, 1973.

McCullough, JL, Maren, TH: Inhibition of dihydropteroate synthesis from E coli by sulfones and sulfonamides. Molecular Pharmacology 10:140-145,1974.

McCullough, JL, Weinstein, GD: Effect of lipid soluble esters of methotrexate on DNA synthesis in human skin. Journal of Investigative Dermatology 63:464-466, 1974.

Weinstein, GD, McCullough, JL: Comparative effects of methotrexate esters on normal and psoriatic skin. Archives of Dermatology 111:471-475, 1975.

McCullough, JL, Weinstein, GD: Mouse vaginal assay for topically effective chemotherapeutic agents. Journal of Investigative Dermatology 65:394-399, 1975.

McCullough, JL, Snyder, D, Weinstein, GD, Friedland, AN, Stein, B: Factors affecting human percutaneous penetration of methotrexate and its analogues in vitro. Journal of Investigative Dermatology 66:103-107, 1976.

Weinstein, GD, McCullough, JL: Cytokinetics and chemotherapy of psoriasis. Journal of Investigative Dermatology 67:26-30, 1976.

McCullough, JL, Weinstein, GD, Hynes, JB: In vitro screening of biochemical activity of new folic acid antagonists in skin. Journal of Investigative Dermatology 68:362-365, 1977.

McCullough, JL, Schreiber, SH, Ziboh, V A: Cell proliferation kinetics of epidermis in the essential fatty acid deficient rat. Journal of Investigative Dermatology 70:318-320, 1978.

Newburger, AE, Weinstein, GD, McCullough, JL: Biological and biochemical reactions of methotrexate in psoriasis. Journal of Investigative Dermatology 60:183-186, 1978.

Lord, JT, Ziboh, VA, McCullough, JL: Alteration of prostaglandin binding by hyperproliferative skin membrane fractions. Prostaglandins and Medicine 2:21-31, 1979.

McCullough, JL, Weinstein, GD: The role of cell kinetics in the chemotherapy of hyper-proliferative skin diseases: A review. Journal of Pharmacology and Therapeutics 7:601-615, 1979.

Weinstein, GD, McCullough, JL, Eaglstein, WH, Golub, A: A clinical screening program for topical chemotherapeutic drugs in psoriasis. Archives of Dermatology 117:388-393, 1981.

Hartman, ME, McCullough, JL, Weinstein, GD: Mechanism of chemotherapeutic drug action in mouse vaginal epithelium: Predictive capability for topical anti-psoriatic drugs. Archives of Dermatology 117:399-403, 1981.

Lowe, NJ, Stoughton, RB, McCullough, JL, Weinstein, GD: Topical drug effects on normal and proliferating epidermal cell models: A comparison with responses in psoriatics. Archives of Dermatology 117:394-398, 1981.

Nguyen, TT, Ziboh, VA, Uematsu, S, McCullough, JL, Weinstein, GD: New model of a scaling dermatosis: Induction of hyperproliferation in hairless mice with eico-5,9,11-trienoic acid. Journal of Investigative Dermatology 76:384-387, 1981.

Ziboh, VA, Nguyen, TT, McCullough, JL, Weinstein, GD: Possible role of prostaglandins in scaly dermatosis. Progress Lipid Research 20:857-866, 1981.

Meck, RA, Ingram, M, Meck, J, McCullough, JL, Wu, M, Yunis, A: Establishment and cell cycle kinetics of a human squamous cell carcinoma in nude mice and in vitro. Cancer Research 41:1076-1085, 1981.

Ball, M, McCullough, JL, Weinstein, GD: Percutaneous absorption of methotrexate: Effect on epidermal DNA synthesis in hairless mice. Journal of Investigative Dermatology 79:7-10, 1982.

McCullough, JL, Weinstein, GD, Lemus, LL, Rampone, W, Jenkins, J: Development of a topical hematoporphyrin derivative formulation; Characterization of photosensitization effects in vivo. Journal of Investigative Dermatology 81:528-532, 1983.

McCullough, JL, Weinstein, GD, Rosenblum, M, Jenkins, J: Percutaneous penetration of methylglyoxal bis (guanylhydrazone); Effects on hairless mouse epidermis in vivo. Journal of Investigative Dermatology 81:388-392, 1983.

Ziboh, VA, McCullough, JL, Weinstein, GD: Alteration of endogenous arachidonic acid metabolism: Possible involvement in scaly skin dermatosis. Proceedings Nigerian Academy of Science, pp. 4-15, 1983.

Rettenmaier, M A, Berman, ML, DiSaia, PJ, Burns, RG, McCullough JL, Weinstein, GD, Berns, MW: Gynecologic uses of photoradiation therapy. Progress in Clinical and Biological Research 170:767-775, 1983.

Weinstein, GD, McCullough, JL, Ross, PR: Cell proliferation in normal epidermis. Journal of Investigative Dermatology:623-628, 1984.

Berns, MW, Rettenmaier, M, McCullough, J, Coffey, J, Wile, A, Berman, M, DiSaia, P, Weinstein, G: Response of psoriasis to red laser light (630 nm) following systemic injection of hematoporphyrin derivative. Lasers in Surgery and Medicine 4:73-77, 1984.

McCullough, J, Peckham, P, Klein, J, Weinstein, G, Jenkins, J: Regulation of epidermal proliferation by combination of difluoromethyl ornithine (DFMO) and methylglyoxal bis guanylhydrazone (MGBG). Journal of Investigative Dermatology 85:518-521, 1985.

Weinstein, GD, McCullough, JL, Ross, PA: Cell kinetic basis for pathophysiology of psoriasis. Journal of Investigative Dermatology 85:579-583, 1985.

Biren, C, Barr, R, McCullough, J, Black, K, Hewitt, C: Prolonged viability of human skin xenografts in rats by cyclosporine (CSA). Journal of Investigative Dermatology 86:611-614, 1986.

Klein, J, McCullough, JL, Weinstein, GD: Topical tritiated thymidine for determining epidermal growth fraction in vivo. Journal of Investigative Dermatology 86:406-409, 1986.

Rampone, W, McCullough, J, Weinstein, G, Towers, G, Berns, M: Characterization of photosensitizing effects by topical delivery of alpha-terthienyl and UVA. Journal of Investigative Dermatology 87:354-357, 1986.

Stanbridge, EJ, Ross, P, McCullough, JL: A novel approach for obtaining monoclonal antibodies that react with differentiation-specific antigens using human hybrid cells. Cancer Research 46:4759-4764, 1986.

Ganderup, G, Newburger, AE, McCullough, JL: Growth kinetics of primary and metastatic human melanoma xenografts in nude mice. Journal of Investigative Dermatology 87:537-539, 1986.

Berns, MW, McCullough, JL: Porphyrin sensitized phototherapy (PDT). Archives of Dermatology 122:871-874, 1986.

Goodman, M, Biren, C, McCullough, J, Barr, R: A model of human melanoma in cyclosporine immune suppressed rats. Journal of Investigative Dermatology 88:141-144, 1987.

McCullough, JL, Weinstein, GD, Douglas, J, Berns, MW: Photosensitizers in dermatology. Journal of Photochemistry and Photobiology 46:77-82, 1987.

Chapkin RS, Ziboh, VA, McCullough, JL: Dietary influences of evening primrose and fish oil on the skin of essential fatty acid deficient guinea pigs. Journal of Nutrition 117:1360-1370, 1987.

Peckham, PE, Weinstein, GD, McCullough, JL: The treatment of severe psoriasis: A national survey. Archives of Dermatology 123:1303-1307, 1987.

Nelson, JS, McCullough, JL, Berns, MW: Photodynamic therapy of malignant melanoma. Journal National Cancer Institute 80:56-60, 1988.

McCullough, JL, Weinstein, GD, Ross, P, Barr, RJ, Stanbridge, EJ: Identification of differentiation-specific antigens in psoriatic versus normal skin. International Journal of Dermatology 27:628-632, 1988.

McCullough, JL, Weinstein GD, Berns, MW: Topical hematoporphyrin derivative (HPD) photodynamic therapy for psoriasis. Laser Research In Medicine, Dentistry & Surgery 64:35-39, 1988.

Weinstein, GD, McCullough, JL, Olsen, E: Topical methotrexate in psoriasis. Archives of Dermatology 125:227-230, 1989.

Biren, C, Ganderup, GS, Lemus, L, McCullough, JL, Barr, RJ: Topical cyclosporine (CSA): Effect on allergic contact dermatitis in guinea pigs. Contact Dermatitis 20:10-16, 1989.

Salm, M, McCullough, JL, Weinstein, GD: Vasoactive pharmacologic responses of human skin xenografts in cyclosporineBtreated rats. Skin Pharmacology 2:168-174, 1989.

Roberts, WG, Smith, KM, McCullough, JL, Berns, MW: Photosensitization and photodestruction of various sensitizers in photodynamic therapy. Photochemistry and Photobiology 49:431-438, 1989.

Weinstein, GW, Jeffes, E, McCullough, JL: Cytotoxic and immunologic effects of methotrexate in psoriasis. Journal of Investigative Dermatology 95:49S-51S, 1990.

Kwiatkowska, B, McCullough, JL, Ross, P, Weinstein, GD, Stanbridge, E: Specificity of human keratinocyte x HeLa cell hybrid murine monoclonal antibodies. International Journal of Dermatology 30:860-863, 1991.

Nelson, JS, McCullough, JL, Glenn, TC, Wright, WH, Liaw L, Jacques, SL: MidBinfrared laser ablation of stratum corneum enhances in vitro percutaneous transport of drugs. Journal of Investigative Dermatology 97:874-879, 1991.

Goodman, M, White, G, McCormick, A, McCullough, J, Weinstein, G: Cyclosporin (CSA) for psoriasis: A cell cycle derived dosage schedule, Journal American Academy of Dermatology 27:584-598, 1992.

Qian, QF, McCullough, JL: Effects of methotrexate on immune cells in psoriatic esions. Chinese Journal of Dermatology 26:20-22, 1993.

Jeffes, EWB, McCullough, J, McCormick, A, Almanzor, J, Liu, G, Dang, M, Voss, K, Voss, J, Schlotzhauer, A, Weinstein, G: Methotrexate therapy of psoriasis: I. Differential sensitivity of proliferating lymphoid and epithelial cells to the effects of MTX. Journal of Investigative Dermatology 104:183-188, 1995.

Liem, W., Weinstein, GD, McCullough, JL: Topical therapy for psoriasis: Results of survey to U.S. dermatologists. Cutis: 55:306-310, 1995.

Steiner, R, Tromberg, BJ, Wyss, P, Krasieva, T, Chandanani, N, McCullough, J, Berns, MW, Tadir, Y: Rat reproductive performance following photodynamic therapy with topically administered Photofrin. Human Reproduction. 10:227-233, 1995.

Jeffes, EW, Lee, S, Said, S, Sabahi, M, McCullough, JL, Herrod, R, Alzona, C, Linden, K, Soundararajan, D., Edwards, S, Weinstein, GD: Elevated numbers of proliferating mononuclear cells in the peripheral blood of psoriatic patients correlate with disease severity. Journal of Investigative Dermatology 105:733-738, 1995.

Fehr, MK, Chapman CF, Krasieva T, Tromberg, B, McCullough, JL, Berns MW, Tadir, Y: Selective photosensitization of vulvar condylomata acuminata following topical application of 5-aminolevulinic acid. American Journal of Obstetrics & Gynecology 174:951-957, 1995.

Monk BJ, Brewer, C, VanNostrand, K, Berns MW, McCullough, JL, Manetta, A, Tadir, Y: Photodynamic therapy using topically applied dihematoporphyrin ether in the treatment of cervical intraepithelial neoplasia. Gynecologic Oncology 64:70-75, 1997.

Jeffes, EWB, McCullough JL, Weinstein G, Fergin P, Nelson S, Berns M, Shull T, Simpson K, Bukaty L, Fong N: Photodynamic therapy of actinic keratosis with topical 5-aminolevulinic Acid (ALA): A pilot dose-ranging study. Archives of Dermatology 133:727-732, 1997.

Neev, J, Nelson JS, Critelli M, McCullough JL, Cheung E, Carrasco WA, Rubenchik AM, Da Silva LB, Perry MD, Stuart BC. Ablation of human nail by pulsed lasers. Lasers in Surgery and Medicine 21:186-192, 1997.

Powell, TJ, Ben-Bassat, H; Klein, BY, Chen H, Shenoy, N, McCullough, J, Narog, B, Grazit, G, Chen, I, Hartzstark, Z, Chauat, M, Lefitzki, R, Tang, C, McMahon, J, Shawver, L, Levitzki, A: Growth inhibition of psoriatic keratinocytes by quinazoline tyrosine kinase inhibitors. British Journal of Dermatology 141:802-810, 1999.

McCullough, JL, Furfuryladenine-A New Antiaging Topical: Research and Clinical Experience. In: Skin & Allergy News : Developments in Topical Skin Treatments: An Update. Skin Disease Education Foundation Symposium, 1999.

McCullough, JL, Shull, TF: Reducing wrinkles and other signs of aging. Dermatology Nursing 12: 385-394, 2000.

Jeffes, EWB, McCullough, JL, Weinstein, GD, Kaplan, R, Glazer, SD, Taylor, J.R.:: Photodynamic therapy of actinic keratosis with topical 5-aminolevulinic acid and fluorescent blue light. Journal of American Academy of Dermatology 45:96-104, 2001.

Eliseo, AJ, McCullough, JL: Topical Bactericides: Wetting Agents. UCI Excellence in Research Journal 04/2001.

Gans, EH, Christensen, M, McCullough, JL, Rizer, R: A study of benzoyl peroxide gel containing zinc lactate and glycolic acid for treatment of acne. Cosmetic Dermatology 15:33-36, 2002.

McCullough, JL, Weinstein, GW: Clinical study to assess the safety and efficacy of topical kinetin 0.10% (Kinerase®) for photodamaged skin. Cosmetic Dermatology 15:29-32, 2002.

Jung, S, (McCullough, JL- Faculty Mentor): Novel compounds for skin penetration enhancement. UCI Undergraduate Research Journal Volume 5: 25-29, 2003.

Khan, MH, Choi, B, Chess, S, Kelly K, McCullough, JL, Nelson JS: Optical clearing of the human skin in vivo: implications for light-based diagnostic imaging and therapeutics. Lasers Surgery Medicine 34:83-85, 2004.

McCullough, JL, Kelly K.M.: Prevention and treatment of skin aging. Annals NY Academy Science 1067: 323-331, 2006.

Wu, JJ, Weinstein, GD, Kricorian GJ, Kormelli, T, McCullough, JL: Topical kinetin 0.1% lotion for improving the signs and symptoms of acne rosacea. Clinical and Experimental Dermatology Sept. 14: 1-4, 2007

McCullough JL, Garcia RL, Reece B: A clinical study of topical Pyratine 6™ (0.10%) for improving the appearance of photodamaged skin. Journal of Drugs in Dermatology 7: 131-135, 2008.

Tremaine AM, McCullough JL: Botulinum toxin type A for the management of blabellar rhytids. Clinical, Cosmetic and Investigative Dermatology 3: 15-23, 2010
Professional Society
American Academy of Dermatology
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