Harold W. Moore

picture of Harold W. Moore

Professor Emeritus, Chemistry
School of Physical Sciences

PH D 1963, University of Illinois

Phone: (949) 824-2659
Fax: (949) 824-2659
Email: halmoore@uci.edu

University of California, Irvine
1105 Natural Science II
Mail Code: 4675
Irvine, CA 92697
Research Interests
Organic Chemistry
Academic Distinctions
School of Physical Sciences Distinguished Teaching Award
UCI Alumni Association Distinguished Teaching Award
Edward A. Dickson Emeritus Chair, 2004-2007
2009 Outstanding Emeritus Award
1963-65, Postdoctoral Research Associate, Stanford Research Institute
Professor, UCI, 1965
Chair, Department of Chemistry 1970-73, 1982-85
Dean, School of Physical Sciences 1985-94
Research Professor 1994-2001
Emeritus Professor 2001-present
Research Abstract
The main objective of our research is the discovery of new reactions of synthetic and mechanistic interest. This exploratory program is complemented by target-specific syntheses. In this regard, selected natural products that are structurally amenable to function as bioreductive alkylating agents, and thus potential anticancer agents, are of particular interest. In addition, we are interested in the design and synthesis of non-natural products that will selectively cleave DNA but only subsequent to an activating chemical step.

We have published over 200 papers in these general areas. A few selected examples are given below.
"Bioactivation as a Model for Drug Design. Bioreductive Alkylation", Moore, H. W.
Science 1977, 197, 527

"A New Tandem Synthetic Routes to Angular Triquinanes. Synthesis of the Waihoensene Ring System," Erg├╝den, J.; Moore, H. W. Organic Letters 1999, 1, 375.

"Synthsis of Angular Triquinanes From 1-Alkynylbicyclo[3.2.0]hept-2-en-7-ones---A Tandem oxy-Cope Ring Expansion/Transannular Ring Clossure Reaction". Verma, S.; Fleischer, E. B.; Moore, H. W., Journal of Organic Chemistry, 2000, 65, 8564

"Cyclolbutenone Ethylenedithioacetals and Their Ready Electrocyclic Ring Opening", Regenhardt, W.; Schaumann, E.; Moore, H. W., Synthesis, 2001, No. 7, 1076

"Rearrangements of Cyclobutenones. Electrocyclic Ring Closure and Thermal Ring Expansions of 3-Allenyl- and 3-Alkynyl-2-dienyl-4,4-dimethoxycyclobutenones", Hergueta, A. R.; Moore, H. W., Journal of Organic Chemistry, 2001, 67, 1388.

"Formation of Reactive o-Quinone Methides From the Reaction of Trimetylsilyl(methyl-substituted 1,4-Benzoquinones with Nucleophiles", J. E. Ezcurra, K. Karabelas and H. W. Moore, Tetrahedron, 2005, 61, 275
"Synthesis of Angularly-Fused Benzocyclobutenedione Monoketals--Useful Synthetic Intermediates to Angucyclines," Tiedemann, R.; Heileman, M. J.; Schaumann, E.; Moore, H. W. Journal of Organic Chemistry 1999, 64, 2170.
"New Metathesis Methodology Leading to Angularly-Fused Polycyclic Quinones and Related Compounds," Heileman, M. J.; Teidemann, R.; Moore, H. W. Journal of the American Chemical Society 1998, 120, 3801.
"Ring Expansions of Cyclobutenones. Unusual Reactions of 2-(2-Ethenylphenyl)-4,4-dimethoxycyclobutenones," Heileman, M. J.; Moore,H. W. Tetrahedron Letters 1998, 39, 3643.
"Dimethyl Squarate and its Conversion to 3-Ethenyl-4-methoxycyclobutene-1,2-dione and 2-Butyl-6-ethenyl-5-methoxy-1,4-benzoquinone," Liu, H.; Tomooka, C. S..; Simon lL. Xu, Benjamin R. Yerxa, Robert W. Sullivan, Yifeng Xiong and Harold W. Moore, Organic Synthesis 1999, 76, 189.
"Rearrangements of Cyclobutenones. Synthesis of N-Methyl-7,8-dihydrobenzophenanthridine-9,12-didols and Related Compounds," Hergueta, A. R.; Moore, H. W. Journal of Organic Chemistry 1999, 64, 5979.
"Synthesis and Thermal Rearrangements of 4-Allyl-4-arylcyclobutenones," Tiedemann, R.; Turnbull, P; Moore, H. W. Journal of Organic Chemistry 1999, 64, 4030.
4-Iminocyclobutenones: Synthesis and Building-Blocks of Aminohydroquinones and Annulated Quinonines, Oppermann, G.; Stranberg, M.; Moore, H. W.; Schaumann, E.; Adiwidjaja, G.; Synthesis, 2010, No 12, pp 2027-2038
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