Larry E. Overman

picture of Larry E. Overman

Distinguished Professor of Chemistry


Ph.D., University of Wisconsin, 1969


B.A., Earlham College, 1965

Phone: (949) 824-7156
Fax: (949) 824-2210
Email: leoverma@uci.edu

University of California, Irvine
4042A Frederick Reines Hall
Mail Code: 2025
Irvine, CA 92697
Research Interests
Organic, Inorganic, Organometallic and Chemical Biology
URL
Academic Distinctions
Ryoji Noyori Prize, Society of Synthetic Organic Chemistry, Japan, 2015; Roger Adams Award in Organic Chemistry, American Chemical Society, 2015; UCI Medal, University of California, Irvine, 2011; American Chemical Society, Herbert C. Brown Award for Creative Research in Synthetic Methods, 2010; Tetrahedron Prize for Creativity in Organic Chemistry, 2008; The Nagoya Medal of Organic Chemistry, 2007; International Society of Heterocyclic Chemistry Senior Award, 2005; American Chemical Society Arthur C. Cope Award, 2003; UC Irvine Distinguished Faculty Lectureship Award for Research, 2002–2003; Yamada Prize, 2002; Japan Society for the Promotion of Science Fellowship, 2000; S. T. Li Prize for Achievements in Science and Technology, 1999; Centenary Medal, Chemical Society, U.K., 1997; American Chemical Society Award for Creative Work in Synthetic Organic Chemistry, 1995; Guggenheim Fellowship, 1993–1994; Javits Neuroscience Investigator Award, 1985–1992; 1992–1999, American Chemical Society Arthur C. Cope Scholar Award, 1989; Visiting Miller Research Fellow, U.C. Berkeley, 1989; Alexander von Humboldt U.S. Senior Scientist Award, 1985–1987; Camille and Henry Dreyfus Teacher-Scholar Award, 1976–1981; U.C. Irvine School of Physical Sciences Distinguished Teaching Award, 1981; U.C. Irvine Alumni Association Distinguished Research Award, 1979; Alfred P. Sloan Foundation Fellow, 1975–1977
Appointments
NIH Postdoctoral Fellow, Columbia University, 1969–1971
Joined UCI Faculty in 1971
Research Abstract
Professor Overman's research interests center on the invention of new reactions and strategies in organic synthesis and the total synthesis of natural products and their congeners. Total synthesis targets of our laboratory include agents displaying a variety of pharmacological activities. We are involved also in collaborative programs in the areas of cancer biology, learning and memory, and tropical parasitic diseases.
Available Technologies
Publications
"Forging C(sp3)–C(sp3) Bonds with Carbon-Centered Radicals in the Synthesis of Complex Molecules"
S. P. Pitre, N. A. Weires, L. E. Overman
Journal of the American Chemical Society 2019, 141, doi/10.1021/jacs.8b11790
 
“Total Synthesis of (–)-Chromodorolide B By a Computationally-Guided Radical Addition/Cyclization/Fragmentation Cascade”
D. J. Tao, Y. Slutskyy, M. Muuronen, A. Le, P. Kohler, L. E. Overman
Journal of the American Chemical Society 2018, 140, 3091–3102
 
“1,6-Addition of Tertiary Carbon Radicals Generated From Alcohols or Carboxylic Acids by Visible-Light Photoredox Catalysis”
S. Y. Abbas, P. Zhao, L. E. Overman
Organic Letters 2018, 20, 868–871
 
“Short Enantioselective Total Syntheses of Cheloviolenes A and B and Dendrillolide via Convergent Fragment Coupling Using a Tertiary Carbon Radical”
M. R. Garnsey, Y. Slutskyy, C. R. Jamison, P. Zhao, J. Lee, Y. H. Rhee, L. E. Overman
Journal of Organic Chemistry 2018, 83, 6958–6976
 
“Versatile Construction of 6-Substituted cis-2,8-Dioxabicyclo[3.3.0]octan-3-ones. Short Enantioselective Total Syntheses of Cheloviolenes A and B and Dendrillolide C”
Y. Slutskyy, C. R. Jamison, P. Zhao, J. Lee, Y. H. Rhee, L. E. Overman
Journal of the American Chemical Society 2017, 139, 7192–7195
 
“Fragment Coupling and Formation of Quaternary Carbons by Visible-Light Photoredox Catalyzed Reaction of tert-Alkyl Hemioxalate Salts and Michael Acceptors”
C. R. Jamison, Y. Slutskyy, L. E. Overman
Organic Syntheses 2017, 94, 167–183
 
"Fragment Coupling With Tertiary Radicals Generated By Visible-Light Photocatalysis"
C. R. Jamison and L. E. Overman
Accounts of Chemical Research 2016, 49, 1578–1586
 
“Total Synthesis of (–)-Chromodorolide B”
D. J. Tao, Y. Slutzkyy, and L. E. Overman
Journal of the American Chemical Society 2016, 138, 2186–2189
 
"Palladium(II)-Catalyzed Enantioselective Reactions Using COP Catalysts"
J. S. Cannon and L. E. Overman
Accounts of Chemical Research 2016, 49, 2220–2231
 
"NT1721, a novel epidithiodiketopiperazine, exhibits potent in vitro and in vivo efficacy against acute myeloid leukemia"
C. M. Kowolik, M. Lin, J. Xie, L. E. Overman and D. A. Horne
Oncotarget 2016, 7, 86186–86197
 
“H3K9me3 Inhibition Improves Memory, Promotes Spine Formation and Increases BDNF Levels in the Aged Hippocampus”
S. Snigdha, G. A. Prieto, A. Petrosyan, B. M. Loertscher, A. P. Dieskau, L. E. Overman,
and C. Cotman
Journal of Neuroscience 2016, 36, 3611–3622.
Professional Societies
National Academy of Sciences
American Academy of Arts & Sciences
AAAS
American Chemical Society
Last updated
12/31/2018