Larry E. Overman

picture of Larry E. Overman

Professor, Chemistry
School of Physical Sciences
Distinguished Professor of Chemistry

Ph.D., University of Wisconsin, 1969

B.A., Earlham College, 1965

Phone: (949) 824-7156
Fax: (949) 824-2210

University of California, Irvine
4042A Frederick Reines Hall
Mail Code: 2025
Irvine, CA 92697
Research Interests
Organic, Inorganic, Organometallic and Chemical Biology
Academic Distinctions
Roger Adams Award in Organic Chemistry, American Chemical Society, 2015; UCI Medal, University of California, Irvine, 2011; American Chemical Society, Herbert C. Brown Award for Creative Research in Synthetic Methods, 2010; Tetrahedron Prize for Creativity in Organic Chemistry, 2008; The Nagoya Medal of Organic Chemistry, 2007; International Society of Heterocyclic Chemistry Senior Award, 2005; American Chemical Society Arthur C. Cope Award, 2003; UC Irvine Distinguished Faculty Lectureship Award for Research, 2002–2003; Yamada Prize, 2002; Japan Society for the Promotion of Science Fellowship, 2000; S. T. Li Prize for Achievements in Science and Technology, 1999; Centenary Medal, Chemical Society, U.K., 1997; American Chemical Society Award for Creative Work in Synthetic Organic Chemistry, 1995; Guggenheim Fellowship, 1993–1994; Javits Neuroscience Investigator Award, 1985–1992; 1992–1999, American Chemical Society Arthur C. Cope Scholar Award, 1989; Visiting Miller Research Fellow, U.C. Berkeley, 1989; Alexander von Humboldt U.S. Senior Scientist Award, 1985–1987; Camille and Henry Dreyfus Teacher-Scholar Award, 1976–1981; U.C. Irvine School of Physical Sciences Distinguished Teaching Award, 1981; U.C. Irvine Alumni Association Distinguished Research Award, 1979; Alfred P. Sloan Foundation Fellow, 1975–1977
NIH Postdoctoral Fellow, Columbia University, 1969–1971
Joined UCI Faculty in 1971
Research Abstract
Professor Overman's research interests center on the invention of new reactions and strategies in organic synthesis and the total synthesis of natural products and their congeners. Total synthesis targets of our laboratory include agents displaying a variety of pharmacological activities. We are involved also in collaborative programs in the areas of cancer biology, learning and memory, and tropical parasitic diseases.
Available Technologies
"Fragment Coupling With Tertiary Radicals Generated By Visible-Light Photocatalysis"
C. R. Jamison and L. E. Overman
Accounts of Chemical Research 2016, 49, 1578–1586
“Total Synthesis of (–)-Chromodorolide B”
D. J. Tao, Y. Slutzkyy, and L. E. Overman
Journal of the American Chemical Society 2016, 138, 2186–2189
“Short Enantioselective Total Syntheses of trans-Clerodane Diterpenoids: Convergent Fragment Coupling Using a trans-Decalin Tertiary Radical Generated from a Tertiary Alcohol Precursor”
Y. Slutskyy, C. R. Jamison, G. L. Lackner, D. S. Müller, A. P. Dieskau, N. L. Unteidt, and L. E. Overman
Journal of Organic Chemistry 2016, 81, 7029–7035.
"Palladium(II)-Catalyzed Enantioselective Reactions Using COP Catalysts"
J. S. Cannon and L. E. Overman
Accounts of Chemical Research 2016, 49, 2220–2231
“Generation of the Methoxycarbonyl Radical by Visible-Light Photoredox Catalysis and Its Conjugate Addition with Electron-Deficient Olefins”
Y. Slutskyy and L. E. Overman*
Organic Letters 2016, 18, 2564–2567
“Diastereoselective Coupling of Chiral Acetonide Trisubstituted Radicals with Alkenes”
D. J. Tao, M. Muuronen, Y. Slutskyy, A. Le, F. Furche, and L. E. Overman
Chemistry – A European Journal 2016, 22, 8786–8790
"NT1721, a novel epidithiodiketopiperazine, exhibits potent in vitro and in vivo efficacy against acute myeloid leukemia"
C. M. Kowolik, M. Lin, J. Xie, L. E. Overman and D. A. Horne
Oncotarget 2016, 7, 86186–86197
“H3K9me3 Inhibition Improves Memory, Promotes Spine Formation and Increases BDNF Levels in the Aged Hippocampus”
S. Snigdha, G. A. Prieto, A. Petrosyan, B. M. Loertscher, A. P. Dieskau, L. E. Overman,
and C. Cotman
Journal of Neuroscience 2016, 36, 3611–3622.
“Analogues of Marine Guanidine Alkaloids Are in Vitro Effective against Trypanosoma cruzi and Selectively Eliminate Leishmania (L.) infantum Intracellular Amastigotes”
L. F. Martins, J. T. Mesquita, E. G. Pinto, T. A. Costa-Silva,
S. E. T. Borborema, A. J. G. Junior, B. J. Neves, C. H. Andrade,
Z. A. Shuhaib, E. L. Bennett, G. P. Black, P. M. Harper, D. M. Evans, H. S. Fituri, J. P. Leyland, C. Martin, T. D. Roberts, A. J. Thornhill, S. A. Vale, A. Howard-Jones, D. A. Thomas, H. L. Williams, L. E. Overman, R. G. S. Berlinck, P. J. Murphy, and A. G. Tempone
J. Nat. Prod. 2016, 79, 2202–2210
Professional Societies
National Academy of Sciences
American Academy of Arts & Sciences
American Chemical Society
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