Stephanie Y. Lu
                                Professor, Department of Ophthalmology & Visual Sciences
School of Medicine
                School of Medicine
                            M.D., University of California, San Diego (UCSD), 2004
                        
B.S., University of California, Los Angeles (UCLA), 1997, Biochemistry
                
            B.S., University of California, Los Angeles (UCLA), 1997, Biochemistry
                    Phone: Patient Appointments: (949) 824-2020; Academic Office: (949) 824-9483
                    
Fax: (949) 824-8050
Email: sylu@hs.uci.edu
            
                Fax: (949) 824-8050
Email: sylu@hs.uci.edu
                    University of California, Irvine
                    
Gavin Herbert Eye Institute
850 Health Sciences Road
Mail Code: 4375
Irvine, CA 92697
                
                Gavin Herbert Eye Institute
850 Health Sciences Road
Mail Code: 4375
Irvine, CA 92697
                    Research Interests
                    
                    
                
                            Age-related macular degeneration, diabetic retinopathy, macular hole, epiretinal membrane, macular dystrophy
                    
                
                    Websites
                    
                        
                
                
                    Academic Distinctions
                    
                    
                
                            Board Certified in Ophthalmology
                    
                
                    Publications
                    
                        
                
                                Nasim Salimi; Kevin Schneider; Marilyn Chwa; Andrea Bao; Stephanie Y Lu; Baruch D Kuppermann; Cristina M Kenney. Assessment of potential adverse effects of Ciprofloxacin in AMD cybrid cell lines.. Investigative Ophthalmology & Visual Science June 2020, Vol.61, 3696. doi: ARVO Annual Meeting Abstract  |   June 2020.
                        
                        
                                Israelsen P.; Tsao S.; Vu T.T.; Lu SY, Early Anatomic Outcomes of Intravitreal Bevacizumab for Diabetic Macular Edema with Renal Disease: A Real-World Study at a single Veterans Affairs Hospital. Investigative Ophthalmology & Visual Science July 2019, Vol.60, 3643. doi: ARVO Annual Meeting Abstract  |   July 2019
                        
                        
                                Patel TH, Norman L, Chang S, Abedi S, Liu C, Chwa M, Atilano S, Thaker K, Lu SY, Jazwinski SM Micell MV, Udar N, Bota D, Kenney MC                                                             
European mtDNA Variants Are Associated With Differential Responses to Cisplatin, an Anticancer Drug: Implications for Drug Resistance and Side Effects. Frontiers in Oncology, July 2019, doi: 10.3389/fonc.2019.00640
                        European mtDNA Variants Are Associated With Differential Responses to Cisplatin, an Anticancer Drug: Implications for Drug Resistance and Side Effects. Frontiers in Oncology, July 2019, doi: 10.3389/fonc.2019.00640
                                Shen E, Tsao S, Kuppermann BD, Lu SY. A case of multifocal central serous chorioretinopathy from a progestin-only contraceptive device. New Frontiers in Ophthalmology 2019 doi: 10.15761/NFO.1000235. Case Report ISSN: 2397-2092. Volume 5: 1-3. Published: June 27, 2019
                        
                        
                                Nashine S, Cohen P, Chwa M, Lu SY, Nesburn AB, Kuppermann BD, Kenney MC. Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage. Cell Death Dis. 2017 Jul 20;8(7):e2951. doi: 10.1038/cddis.2017.348.
                        
                        
                                Ngai P, Muniz-Castro H, Lu SY. Submacular Hemorrhage Following Cataract Surgery in a Patient with Long Axial Length. New Front Ophthalmol. June 26, 2017 doi: 10.15761/NFO.1000166 Volume 3(3): 1-4.
                        
                        
                                Nashine S, Chwa M, Kazemian M, Thaker K, Lu SY, Nesburn A, Kuppermann BD, Kenney MC. Differential Expression of Complement Markers in Normal and AMD Transmitochondrial Cybrids. PLoS One. 2016 Aug 3;11(8):e0159828. doi: 10.1371/journal.pone.0159828. eCollection 2016.  PMID: 27486856(Impact factor 3.5)
                        
                        
                                Patel A, Nguyen C, Lu SY, Central retinal vein occlusion: A review of current Evidence-based treatment options. Middle East African Journal of Ophthalmology, Volume 23, Issue 1, Jan/March 2016, page(s): 44-48.
                        
                        
                                Bressler SB, Almukhtar T, Bhorade A, Bressler NM, Glassman AR, Huang SS, Jampol LM, Kim JE, Melia M; Diabetic Retinopathy Clinical Research Network Investigators (including Lu SY). Repeated intravitreous ranibizumab injections for diabetic macular edema and 	the risk of sustained elevation of intraocular pressure or the need for ocular hypotensive treatment. JAMA Ophthalmol. 2015 May;133(5):589-97.
                        
                        
                                Haider A, Bababeygy SR and Lu SY. Cystoid Macular Edema and Macular Pigmentation Associated with nab-Paclitaxel Therapy.  Retinal Cases Brief Reports, 2015 Summer; 9(3):220-2
                        
                        
                                Haider A, Bababeygy SR, Lu SY. Cystoid Macular Edema Following Silicone Oil Tamponade For Retinal Detachment Surgery. Austin J Clin Ophthalmol. Feb 2015;2(1): 1042.
                        
                        
                                Lu SY, Azada MC, Ou S-H. Ignatius.
Case Report. Choroidal metastasis response to crizotinib in a ROS1-rearranged NSCLC patient. Lung Cancer 2015 Feb;87(2):207-9
                Case Report. Choroidal metastasis response to crizotinib in a ROS1-rearranged NSCLC patient. Lung Cancer 2015 Feb;87(2):207-9
                    Grants
                    
                        
                
                            Lu S, sub-investigator:A Phase II, Randomized, Single-Masked, Sham-Controlled Study of the Safety, Tolerability and Evidence of Activity of Intravitreal APL-2 Therapy in Patients with Geographic Atrophy (GA)
                        
                        
                            Lu S, sub-investigator:A Two-Year, Randomized, Double-Masked, Multicenter, Three-Arm Study Comparing the Efficacy and Safety of RTH258 versus Aflibercept in Subjects with Neovascular Age-Related Macular Degeneration (RTH258-C001)
                        
                        
                            Lu S, sub-investigator: A PHASE RANDOMIZED, DOUBLE-MASKED, PLACEBO-CONTROLLED MULTICENTER CLINICAL TRIAL DESIGNED TO EVALUATE THE SAFETY AND EXPLORATORY EFFICACY OF LUMINATE® (ALG-1001) IN INDUCING PVD IN SUBJECTS WITH NON-PROLIFERATIVE DIABETIC RETINOPATHY
                        
                        
                            Lu S, sub-investigator: A PHASE III, MULTICENTER, RANDOMIZED, DOUBLE-MASKED, SHAM-CONTROLLED STUDY TO ASSESS THE EFFICACY AND SAFETY OF LAMPALIZUMAB ADMINISTERED INTRAVITREALLY TO PATIENTS WITH GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION
                        
                        
                            Lu S, sub-investigator: A Multi-Center, Two-Stage, Open-Label Phase 1 and Randomized, Active Controlled, Masked Phase II Study to Evaluate the Safety and Efficacy of Intravitreal Implantation of NT-503-3 Encapsulated Cell Technology Compared with Eylea® for the Treatment of Recurrent Subfoveal Choroidal Neovascualarization (CNV) Secondary to Age-Related Macular Degeneration (AMD)
                        
                        
                            Lu S, sub-investigator: A PHASE 3 RANDOMIZED, DOUBLE-MASKED, CONTROLLED TRIAL TO ESTABLISH THE SAFETY AND EFFICACY OF INTRAVITREOUS ADMINISTRATION OF FOVISTATM (ANTI PDGF-B PEGYLATED APTAMER) ADMINISTERED IN COMBINATION WITH EITHER AVASTIN® OR EYLEA® COMPARED TO AVASTIN® OR EYLEA® MONOTHERAPY IN SUBJECTS WITH SUBFOVEAL NEOVASCULAR AGE-RELATED MACULAR DEGENERATION
                        
                        
                            Lu S, sub-investigator:A PHASE 2, DOUBLE-MASKED, RANDOMIZED, DOUBLE-MASKED, CONTROLLED, MULTIPLE-DOSE, REGIMEN-RANGING STUDY OF THE EFFICACY AND SAFETY OF INTRAVITREAL REGN2176-3 IN PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION
                        
                
                    Professional Societies
                    
                        
                
                            American Academy of Ophthalmology
                        
                        
                            American Society of Retina Specialists
                        
                        
                            Association for Research in Vision and Ophthalmology
                        
                        
                            Orange County Medical Association
                        
                        
                            Association of University Professors of Ophthalmology
                        
                        
                            Club Vit
                        
                        
                            California Medical Association
                        
                
                    Other Experience
                    
                            
                
                                Fellowship in Vitreoretinal Surgery and Diseases
UC Irvine
                            
                UC Irvine
                    Research Centers
                    
                        
            
                            Gavin Herbert Eye Institute
                        
                
                    Link to this profile
                    
https://faculty.uci.edu/profile/?facultyId=5754
                https://faculty.uci.edu/profile/?facultyId=5754
                    Last updated
                    
05/16/2025
            05/16/2025