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 Michael J. Buchmeier

University of California

3205 Mc Gaugh Hall
 University of California Irvine
 Mail Code: 3900
 Irvine, CA 92697

PHONE: (949) 824-5781
FAX: 949-824-1714

E-MAIL: m.buchmeier@uci.edu

 

Michael J. Buchmeier
Professor Div. of Infectious Diseases, Dept. of Medicine, Dept. of Molecular Biology and Biochemistry, Center for Virus Research
Research Centers and Institutes
Ph.D., McMaster University, 1976, Virology and Immunology
M.S., Washington State University, 1973, Bacteriology and Public health
B.S., Washington State University, 1970, Bacteriology and Public health
Research Interests
Arenaviruses, Coronaviruses, Biology of RNA Viruses, Viral Pathogenesis, Structural Biology of Viruses, Biology of Zoonotic and Emerging Viruses, Biodefense

 
Graduate Programs:
 Cellular and Molecular Biosciences Virology
 
Professional Society Fellow of the American Academy of Microbiology Fellow of the AAAS Fellow of the Pluto Society American Society for Virology International Committee on Virus Taxonomy International Society for Neurovirology International Society for Neuroimmunology American Association of Immunologists
 
Abstract
Professor Buchmeier is interested in the pathogenesis and control of emerging Viral infections, the structure and function of viral proteins and glycoproteins,in antiviral drug design, and the mechanisms by which viruses interact with the host during persistent infection. Also of interest are the ways in which viruses contribute to a variety of autoimmune and neurodegenerative diseases.


Other Experience
Scientific Advisory Board, Telik inc, 1987—2003

Scientific Advisory Board, AVI Biopharma, 2005—2008

Member, Recombinant Advisory Committee (RAC), NIH, 2008—2013

Member, Microbiology and Immunology Review Committee, NIH-NIAID, 2000—2005

Member, Experimental Virology Study section, NIH, 1991—1995

Graduate Research Fellowship Review Panel (Biology), National Science Foundation, 1999—2001

Peer Review Committee A, National Multiple Sclerosis Society, 2000—2006
Updated: Last Updated: 10/08/2008

  Neurovirology: Viruses and the Brain
Michael J. Buchmeier and Iain L. Campbell, eds.
Academic Press, New York, 2001.
isbn 0-12-039856-7

92. Rempel, J.D., Murray, S., Meisner, J., and Buchmeier, M.J. Differential regulation of innate and adaptive immune responses in viral encephalitis. Virology, 2004 318: 381-392

93. Rempel, J.D., Murray, S.J., Meisner, J., Buchmeier, M.J. Mouse hepatitis virus neurovirulence: evidence of a linkage between S glycoproteins expression and immunopathology. Virology, 2004 318: 45-54.

94. Neuman, B.W., Stein, D.A., Kroeker, A.D., Paulino, A.D., Moulton, H. M., Iversen, P.L., and Buchmeier, M.J. Antisense Morpholino Oligomers Directed Against the 5”-End of the Genome Inhibit coronavirus Proliferation and Growth. J. Virol. 2004 June; 78(11): 5891-9.

95. Neuman, B.W., Adair, B.D., Burns, J.M., Milligan, R.A., Buchmeier, M.J. and Yeager, M. Complementarity in the Supramolecular Deisgn of Arenaviruses and Retroviruses Revealed by Electron Cryo-Microscopy. J Virol. 2005 March; 79(6): 3822-3830.

96. Rempel, J.D., Quina, L.A., Blakely-Gonzales, P.K., Buchmeier,M.J., and Gruol, D.L. Viral Induction of Central Nervous System Innate Immune Responses. J. Virol. 2005 Apr; 79(7): 4369-81.

97. Sampath, R., Hofstadler, S.A., Blyn, L.B., Eshoo, M.W., Hall, T.A., Massire, C. Levene, H.M., Hannis, J.C., Harrel, P.M., Neuman, B., Buchmeier, M.J., Jiang, Y., Ranken, R., Drader, J.J., Samant, V., Griffey, R.H., M cNeil, J. A., Crook, S.T., and Ecker, D.J. Rapid Identification and Surveillance of Emerging Infectious Diseasaes: A Coronavirus Example. Emerg. Infect. Dis., 2005 March; 11(3): 373-9.

98. Neuman, B.W., Stein, D.A., Kroeker, A.D., Churchill, M.J., Kim, A.M., Dawson, P., Moulton, H.M., Bestwick, R.K., Iversen, P.L., and Buchmeier, M.J. Inhibition, Escape and Attenuation of SARS Coronavirus Treated with Antisense Morpholino Oligomers. J. Virol. 2005 79(15): 9665-76.

99. Rodriguez-Carreno, M. P., Nelson, M. S., Botten, J., Smith-Nixon, K., Buchmeier, M. J., Whitton, J. L., Evaluating the immunogenicity and protective efficacy of a DNA vaccine encoding Lassa virus nucleoprotein. Virology, 2005 335: 87-98.

100. Peti, W., Johnson, M.A., Herrmann, T. , Neuman, B.W., Buchmeier, M.J. , Nelson, M. , Joseph, J. , Pagel, R. , Stevens, R. C. , Kuhn, P. and Wüthrich, K. Structural Genomics of the SARS Coronavirus: NMR Structure of the Protein nsP7. J. Virol. 2005 Oct; 79(20): 12905-13.

101. Saikatendu, Joseph, J. S. , Subramanian, V. , Neuman, B. W. , Buchmeier, M. J. , Stevens, R. C. ,and Kuhn, P. Structural basis of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) ADP-Robpse-1” – phosphate (Appr-1P) dephosporylation by a conserved domain of nsP3 K. Structure (Camb). 2005 Nov;13(11): 1665-75.

102. Neuman, B.W., Adair, B.D., Yoshioka, C., Quispe, J.D., Orca, G., Kim, A.M., Kuhn, P., Milligan, R.A., Yeager, M., and Buchmeier, M.J. Supramolecular Architecture of Severe Acute Respiratory Syndrome Coronavirus Revealed by Electron Cryomicroscopy. J. Virol. 2006 Aug. 80(16): 7918-28.

103. Joseph JS, Saikatendu KS, Subramanian V, Neuman BW, Brooun A, Griffith M, Moy K, Yadav MK, Velasquez J, Buchmeier MJ, Stevens RC, and Kuhn P. Crystal structure of non structural protein-10 (nsP10) from the SARS Coronavirus reveals a novel fold with two zinc-binding motifs. J. Virol. 2006 Aug. 80(16): 7894-7901.

104. Botten, J, Alexander, J, Pasquetto, V, Sidney, J, Barrowman, P, Ting, J, Peters, B, Southwood, S, Stewart, B, Rodriguez-Carreno, MP, Mothe, B, Whitton, JL, Sette, A, and Buchmeier, MJ. Identification of Protective Lassa Virus Epitopes That Are Restricted by HLA-A2. J. Virol. 2006 Sept. 80(17): 8351-61.

105. Reignier, T, Oldenburg, J, Noble, B, Lamb, E, Romanowski, V, Buchmeier, MJ, and Cannon, PM. Receptor use by pathogenic arenaviruses. Virology. 2006 Sep 15;353(1):111-20.

106. Burrer R, von Herrath MG, Wolfe T, Rempel JD, Iglesias A, Buchmeier MJ. Autoantibodies exacerbate the severity of MHV-induced encephalitis. Adv Exp Med Biol. 2006;581:399-402.

107. Neuman BW, Adair BD, Yoshioka C, Quispe JD, Milligan RA, Yeager M, Buchmeier MJ. Ultrastructure of SARS-CoV, FIPV, and MHV revealed by electron cryomicroscopy. Adv Exp Med Biol. 2006;581:181-5.

108. Neuman BW, Stein DA, Kroeker AD, Moulton HM, Bestwick RK, Iversen PL, Buchmeier MJ. Inhibition and escape of SARS-CoV treated with antisense morpholino oligomers. Adv Exp Med Biol. 2006;581:567-71.

109. Burrer, R., Buchmeier, M.J., Wolfe, T., Ting, J. P. C., Feuer, R., Iglesias, A., and von Herrath, M. G. Exacerbated pathology of viral encephalitis in mice with CNS-specific autoantibodies. 2007 Am J Pathol. Feb;170(2):557-66.

110. Bui HH, Botten J, Fusseder N, Pasquetto V, Mothe B, Buchmeier MJ, Sette A. Protein sequence database for pathogenic arenaviruses. Immunome Res. 2007 Feb 8;3:1.

111. Botten, J., Whitton, J. L., Barrowman, P., Sidney, J., Whitmire, J. K., Alexander, J., Ting, J., Bui, H., Sette, A., and Buchmeier, M. J. HLA-A2-restricted protection against lethal lymphocytic choriomeningitis. J Virol. 2007 Mar;81(5):2307-17.

112. Saikatendu KS, Joseph JS, Subramanian V, Neuman BW, Buchmeier MJ, Stevens RC, Kuhn P. Ribonucleocapsid formation of SARS-CoV through molecular action of the N-terminal domain of N protein. J Virol. 2007 Apr;81(8):3913-21.

113. Kotturi MF, Peters B, Buendia-Laysa F Jr, Sidney J, Oseroff C, Botten J, Grey H, Buchmeier MJ, Sette A. The CD8+ T-cell response to lymphocytic choriomeningitis virus involves the L antigen: uncovering new tricks for an old virus. J Virol. 2007 May:81(10):4928-40.

114. Burrer, R., Neuman, B.W., Ting, J.P.C., Kroeker, A.D., Stein, D.A., Moulton, H.M., Bestwick, R.K., Iversen, P.L., Kuhn, P., and Buchmeier, M.J. Antiviral effects of antisense morpholino oligomers in murine hepatic and pulmonary coronavirus infection models. J Virol. Jun;81(11):5637-48.

115. Saunders, A. S., Ting, J.P.C., Meisner, J., Neuman, B.W., Perez, M., de la Torre, J.C., Buchmeier, M.J. Mapping the landscape of the Lymphocytic Choriomeningitis Virus stable signal peptide reveals novel functional domains. J Virol. 2007 Jun;81(11):5649-57.

116. Joseph JS, Saikatendu KS, Subramanian V, Neuman BW, Buchmeier MJ, Stevens RC, Kuhn P.
Crystal structure of a monomeric form of SARS-CoV endonuclease nsp15 suggests a role for hexamerization as an allosteric switch. J Virol. 2007 Jun;81(12):6700-8.


117. Mothe, B. R., Stewart, B., Oseroff, C., Bui, H., Stogiera, S., Garcia, Z., Dow, C., Rodriguez-Carreno, M., Kotturi, M., Pasquetto,. V., Botten, J., Crotty, S., Janssen, E., Buchmeier, M. J., and Sette, A. Chronic LCMV infection actively down regulates CD4+ T-cell responses directed against a broad range of epitopes. J. of Immunol. 2007, 179:1058-67.

118. Moulton, H.M., Fletcher, S., Neuman, B.W., McClorey, G., Stein, D.A., Abes, S., Wilton, S.D., Buchmeier, M.J., Lebleu, B., Iversen, P.L. Cell-penetrating peptide-morpholino conjugates alter pre-m RNA splicing of DMD (Duchenne muscular dystrophy) and inhibit murine coronavirus replication in vivo. Biochem Soc Trans. 2007 Aug;35(Pt 4):826-8.

119. Capul, A.A., Perez, M., Burke, E., Kunz, S., Buchmeier, M.J., de la Torre, J.C. Arenavirus Z-GP association requires Z myristoylation but not functional RING or L domains. J. Virol. 9451-60, 2007.

120. Serrano P, Johnson MA, Almeida MS, Horst R, Herrmann T, Joseph JS, Neuman BW, Subramanian V, Saikatendu KS, Buchmeier MJ, Stevens RC, Kuhn P, Wuthrich K. NMR Structure of the N-terminal Domain of the Nonstructural Protein 3 from the SARS Coronavirus. J Virol. Nov;81(21):12049-60. 2007.

121. Neuman BW, Joseph JS, Saikatendu KS, Serrano P, Chatterjee A, Johnson MA, Liao L, Klaus JP, Yates JR 3rd, Wüthrich K, Stevens RC, Buchmeier MJ, Kuhn P.
Proteomics analysis unravels the functional repertoire of coronavirus nonstructural protein 3.
J. Virol. 5279-94. 2008.

122. Buchmeier MJ, Kuhn P New tools to battle emerging viruses.
Curr Opin Microbiol. 2008 Jul 18. [Epub ahead of print]

123. Kotturi MF, Scott I, Wolfe T, Peters B, Sidney J, Cheroutre H, von Herrath MG, Buchmeier MJ,
Grey, H, Sette A. Naive precursor frequencies and MHC binding rather than the degree of epitope diversity shape CD8+ T cell immunodominance.
J. Immunol. 2008 Aug 1;181(3):2124-33.
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