SITE MENU

FACULTY MENU

picture of Markus Walter Ribbe
 Markus Walter Ribbe

University of California

2236 McGaugh Hall
Mail Code: 3900
Irvine, CA 92697

PHONE: (949) 824-9509
FAX: (949) 824-8551

E-MAIL: mribbe@uci.edu

 

Markus Walter Ribbe
Chancellor’s Professor, Molecular Biology and Biochemistry
School of Biological Sciences
Chancellor’s Professor, Chemistry
School of Physical Sciences

Ph.D., University of Bayreuth, Germany, 1998, Microbiology/Biochemistry

Research Interests
Bioinorganic Chemistry, Assembly & Function of Metalloproteins

 
Graduate Programs:
Structural Biology and Molecular Biophysics
 
Professional Society American Chemical Society, Society of Biological Inorganic Chemistry, Association for the Advancement of Science (AAAS),
 
Other Experience
Herman Frasch Foundation Fellow 2007

Elected Fellow, American Academy of Microbiology 2012

Elected Fellow, American Association for the Advancement of Science 2012

Elected Chair, Iron-Sulfur Enzymes Gordon Conference 2014

Updated: Last Updated: 11/26/2014

  Publications 2009 - present:

Lee, C.C.; Hu, Y.; Ribbe, M.W. (2014)
"Catalytic reduction of CN-, CO and CO2 by nitrogenase cofactors in lanthanide-driven reactions."
Angew. Chem. Int. Ed. Engl., in press.

Hu, Y.; Ribbe, M.W. (2014)
"Nitrogenase and Homologs."
J. Biol. Inorg. Chem., in press.

Lee, C.C.; Ribbe M.W.; Hu, Y. (2014)
"Cleaving the N,N Triple Bond: The Transformation of N2 to NH3 by Nitrogenases."
Met. Ions Life Sci., 14, 147-176.

Rebelein, J.G.; Hu, Y.; Ribbe, M.W. (2014)
"Reduction of CO2 by Nitrogenases."
Angew. Chem. Int. Ed. Engl., 43, 11543-11546.

Hu, Y.; Ribbe, M.W. (2014)
"A Journey into the Active Center of Nitrogenase."
J. Biol. Inorg. Chem., 19, 731-736.

Rupnik, K.; Lee, C.C.; Wiig, J.A.; Hu, Y.; Ribbe, M.W.; Hales, B.J. (2014).
"Non-Enzymatic Synthesis of the P-Cluster in the Nitrogenase MoFe Protein: Evidence for the Involvement of All-Ferrous [Fe4S4]0 Intermediates."
Biochemistry, 53, 1108-1116.

Ribbe, M.W.; Hu, Y.; Hodgson, K.O.; Hedman, B. (2014).
"Biosynthesis of nitrogenase metalloclusters."
Chem. Rev., 114, 4063-4080.

Wiig, J.A.; Lee, C.C.; Hu, Y.; Ribbe, M.W. (2013).
"Tracing the Interstitial Carbide of the Nitrogenase Cofactor during Substrate Turnover."
J. Am. Chem. Soc., 135, 4982-4983.

Ni, F.; Lee, C.C.; Hwang, C.S.; Hu, Y.; Ribbe, M.W.; McKenna, C.E. (2013).
"Reduction of Fluorinated Cyclopropene by Nitrogenase."
J. Am. Chem. Soc., 135, 10346-10352.

Lancaster, K.M.; Hu, Y.; Bergmann, U.; Ribbe, M.W.; Debeer, S. (2013).
"X-ray spectroscopic observation of an interstitial carbide in NifEN-bound FeMoco precursor."
J. Am. Chem. Soc., 136, 610-612.

Hu, Y.; Ribbe, M. W. (2013).
"Biosynthesis of the iron-molybdenum cofactor of nitrogenase."
J. Biol. Chem., 288, 13173-13177.

Hu, Y.; Ribbe, M.W. (2013).
"Nitrogenase Assembly."
Biochim. Biophys. Acta, 1827, 1112-1122.

Moser, J.; Lange, C.; Krausze, J.; Rebelein, J.; Schubert, W.D.; Ribbe, M.; Heinz, D.W.; Jahn, D. (2013).
"Structure of ADP•AlF3-Stabilized Protochlorophyllide Oxidoreductase Complex."
Proc. Natl. Acad. Sci. USA, 110, 2094-2098.

Wiig, J.A.; Hu, Y.; Lee, C.C.; Ribbe, M.W. (2012).
"Radical SAM-dependent Carbon Insertion into Nitrogenase M-cluster."
Science, 337, 1672-1675.
Featured as “Perspectives” by Boal, A.K.; Rosenzweig, A.C. (2012). "A Radical Route for Nitrogenase Carbide Insertion." Science, 337, 1617-1618.

Rupnik, K.S.; Hu, Y.; Lee, C.C.; Wiig, J.A.; Ribbe, M.W.; Hales, B.J. (2012).
"P+ State of Nitrogenase P-Cluster Exhibits Electronic Structure of a [Fe4S4]+ Cluster."
J. Am. Chem. Soc., 134, 13749-13754.

Lee, C.C.; Hu, Y.; Ribbe, M.W. (2012).
"ATP-Independent Substrate Reduction by Nitrogenase P-cluster Variant."
Proc. Natl. Acad. Sci. USA, 109, 6922-6926.

Lee, C.C.; Hu,Y.; Ribbe, M.W. (2012).
"ATP-Independent Hydrocarbon Formation Catalyzed by Isolated Nitrogenase Cofactors."
Selected as "Hot Paper".
Angew. Chem. Int. Ed. Engl., 51, 1947-1949.

Hu, Y.; Lee, C.C.; Ribbe, M.W. (2012).
"Vanadium Nitrogenase: A Two-Hit Wonder?"
Dalton Trans., 41, 1118-1127.

Hu, Y.; Ribbe, M.W. (2011).
"Biosynthesis of the Metalloclusters of Molybdenum Nitrogenase."
Microbiol. Mol. Biol. Rev., 75, 664-677.

Hu, Y.; Lee, C.C.; Ribbe, M.W. (2011).
"Extending the Carbon Chain: Hydrocarbon Formation Catalyzed by Vanadium/Molybdenum Nitrogenases."
Science, 333, 753-755.

Fay, A.W.; Blank, M.A.; Lee, C.C.; Hu, Y.; Hodgson, K.O.; Hedman, B.; Ribbe, M.W. (2011).
"Spectroscopic Characterization of Isolated FeMoco Precursor from NifEN."
Selected as VIP (Very Important Paper).
Angew. Chem. Int. Ed. Engl., 50, 7787-7790

Blank, M.A.; Lee, C.C.; Hu, Y.; Hodgson, K.O.; Hedman, B.; Ribbe, M.W. (2011).
"Structural Models of the [Fe4S4] Clusters of Homologous Nitrogenase Fe Proteins."
Inorg. Chem., 50, 7123-7128.

Lee, C.C.; Hu, Y.; Ribbe, M.W. (2011).
"Tracing the Hydrogen Source of Hydrocarbons Formed by Vanadium Nitrogenase."
Selected as VIP (Very Important Paper).
Angew. Chem. Int. Ed. Engl., 50, 5545 –5547.

Wiig, J.A.; Hu, Y.; Ribbe, M.W. (2011).
"NifEN-B complex of Azotobacter vinelandii is fully functional in nitrogenase FeMo cofactor assembly."
Proc. Natl. Acad. Sci. USA, 108, 8623–8627.

Kaiser, J.T.; Hu, Y.; Wiig, J.A.; Rees, D.C.; Ribbe, M.W. (2011).
"Structure of precursor bound NifEN: a nitrogenase FeMo cofactor maturase/insertase."
Science, 331, 91-94.

Rupnik, K.; Lee, C.C.; Hu, Y.; Ribbe, M.W., Hales, B.J. (2011).
"[4Fe4S]2+ Clusters Exhibit Ground-State Paramagnetism."
J. Am. Chem. Soc., 133, 6871-6873.

Hu, Y.; Ribbe, M.W. (2011).
"Biosynthesis of Nitrogenase FeMoco."
Coord. Chem. Rev., 255, 1218-1224.

Rupnik, K.; Hu, Y.; Fay, A.W.; Ribbe, M.W.; Hales, B.J. (2011).
"VTVH-MCD Spectroscopic Study of NifEN-Bound Precursor and 'FeMoco'."
J. Biol. Inorg. Chem., 16, 325-332.

Hu, Y.; Ribbe, M. W. (2011).
"Historic overview of nitrogenase research."
Methods Mol. Biol., 766, 3-7.

Lee, C. C.; Fay, A. W.; Wiig, J. A.; Ribbe, M. W.; Hu, Y. (2011).
"Assembly of nitrogenase MoFe protein."
Methods Mol. Biol., 766, 31-47.

Wiig, J. A.; Lee, C. C.; Fay, A. W.; Hu, Y.; Ribbe, M. W. (2011).
"Purification of nitrogenase proteins."
Methods Mol. Biol., 766, 93-103.

Fay, A. W.; Lee, C. C.; Wiig, J. A.; Hu, Y.; Ribbe, M. W. (2011).
"Protocols for cofactor isolation of nitrogenase."
Methods Mol. Biol., 766, 239-248.

Lancaster, K.M.; Roemelt, M.; Ettenhuber, P.; Hu, Y.; Ribbe, M.W.; Neese, F.; Bergmann, U.; DeBeer, S. (2011).
"Evidence for an interstitial carbide atom in the FeMo cofactor of nitrogenase from valence to core X-ray emission spectroscopy."
Science, 334, 974-977.

Fay, A.W.; Blank, M.A.; Lee, C.C.; Hu, Y.; Hodgson, K.O.; Hedman, B.; Ribbe, M.W. (2010).
"Characterization of Isolated Nitrogenase FeVco."
J. Am. Chem. Soc., 132, 12612-12618.

Lee, C.C.; Hu, Y.; Ribbe, M.W. (2010).
"Vanadium Nitrogenase Reduces CO."
Science, 329, 642.

Hu, Y.; Ribbe, M.W. (2010)
"Decoding Nitrogenase Mechanism: The Homolog Approach."
Acc. Chem. Res., 43, 475-484.

Hu, Y.; Fay, A.W.; Lee, C.C.; Wiig, J.A.; Ribbe, M.W. (2010).
"Dual Functions of NifEN: Insights into the Evolution and Mechanism of Nitrogenase."
Dalton Trans., 39, 2964-2971.

Fay, A.W.; Blank, M.A.; Yoshizawa, J.M.; Lee, C.C.; Wiig, J.A.; Hu, Y.; Hodgson, K.O.; Hedman, B.; Ribbe, M.W. (2010).
"Formation of a homocitrate-free iron-molybdenum cluster on NifEN: Implications for the role of homocitrate in nitrogenase assembly."
Dalton Trans., 39, 3124-3130.

Yoshizawa, J.M.; Fay, A.W.; Lee, C.C.; Hu, Y.; Ribbe, M.W. (2010).
"Insertion of Heterometals into the NifEN-associated Iron-molybdenum Cofactor Precursor"
J. Biol. Inorg. Chem., 15, 421-428.

Lee, C.C.; Blank, M.A.; Fay, A.W.; Yoshizawa, J.M.; Hu, Y.; Hodgson, K.O.; Hedman, B.; Ribbe, M.W. (2009).
"Stepwise Formation of P-cluster in Nitrogenase MoFe Protein."
Proc. Natl. Acad. Sci. USA, 106, 18474-18478.

Hu, Y.; Yoshizawa, J.M.; Fay, A.W.; Lee, C.C.; Wiig, J.A.; Ribbe, M.W. (2009).
"Catalytic Activities of NifEN: Implications for Nitrogenase Evolution and Mechanism."
Proc. Natl. Acad. Sci. USA, 106, 16962-16966.

Schwarz, G.; Mendel, R.R.; Ribbe, M.W. (2009).
"Molybdenum Cofactors, Enzymes and Pathways."
Nature, 460, 839-847.

Yoshizawa, J.M.; Blank, M.A.; Fay, A.W.; Lee, C.C.; Wiig, J.A.; Hu, Y.; Hodgson, K.O.; Hedman, B.; Ribbe, M.W. (2009).
"Optimization of FeMoco Maturation on NifEN."
J. Am. Chem. Soc., 131, 9321-9325.

Wätzlich, D.; Bröcker, M.J.; Uliczka, F.; Ribbe, M.; Virus, S.; Jahn, D.; Moser, J. (2009).
"Chimeric nitrogenase-like enzymes of (bacterio)chlorophyll biosynthesis."
J. Biol. Chem., 284, 15530-15540.

Lee, C.C.; Hu, Y.; Ribbe, M.W. (2009).
"Unique Features of the Nitrogenase VFe Protein from Azotobacter vinelandii."
Proc. Natl. Acad. Sci. USA, 106, 9209-9214.

Cotton, M.S.; Rupnik, K.; Broach, R.B.; Hu, Y.; Fay, A.W.; Ribbe, M.W.; Hales, B.J. (2009).
"VTVH-MCD Study of the delta-nifB-delta-nifZ MoFe Protein from Azotobacter vinelandii."
J. Am. Chem. Soc., 131, 4558-4559.

FACULTY