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 Paolo Casali

University of California

3208 Hewitt Hall
 Mail Code: 4120
 Irvine, CA 92697

PHONE: (949) 824-9648
FAX: (949) 824-2305

E-MAIL: pcasali@uci.edu

 

Paolo Casali
Donald L Bren Professor of Medicine, Molecular Biology & Biochemistry
School of Medicine
 Director, Institute for Immunology
Research Centers and Institutes
M.D., University of Milan, School of Medicine & Surgery, 1974
Specialty in Allergy and Clinical Immunology, University of Milan, School of Medicine & Surgery, 1976, Immunology
Specialty in Medical Microbiology, University of Milan, School of Medicine & Surgery, 1984, Microbiology
Doctorat in Immunologie, University of Geneva, Switzerland, 1979, Immunology
Research Interests
Molecular and Cellular Immunology, Molecular Genetics, Autoimmunity

Faculty/lab web:
http://casalilab.bio.uci.edu
 
Graduate Programs:
 Immunology and Pathogenesis
 
Professional Society AAI, AAAS, ASCI
 
Other Experience
Editor-in-Chief, AUTOIMMUNITY
Updated: Last Updated: 06/05/2009

  SELECTED PUBLICATIONS (2000-2009)

Park, S.-R., T. Mai, Z. Pal, J. Zhang, A. Al-Qahtani, E.J. Pone, Z. Xu, H. Zan and P. Casali. 2009. The HoxC4 homeodomain transcription factor binds to the AICDA/Aicda promoter to induce AID expression, immunoglobulin class switch DNA recombination and somatic hypermutation. Nature Immunol., in press.

Zan, H., J. Zhang, S. Ardeshna, M. Greenberg, Z. Xu, S.-R. Park and P. Casali. 2009. Lupus-prone MRLfaslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin heavy chain locus: Concurrent upregulation of somatic hypermutation and class switch DNA recombination. Autoimmunity 42:89-103.

Zan, H. and P. Casali. 2008. AID- and Ung-dependent generation of resected double-strand DNA breaks in immunoglobulin class switch DNA recombination: a postcleavage role for AID. Mol. Immunol. 46:45-61.

Elkon, K. and P. Casali. 2008. Structure and function of autoantibodies: nature and significance. Nature Clin. Pract. Rheum.4:491-498.

Atassi, M.Z. and P. Casali. 2008. Molecular mechanisms of autoimmunity. Autoimmunity 41:122-132.

Al-Qhatani, A., Z. Xu, H. Zan, C. Walsh and P. Casali. 2008. A role for Drak2 in the germinal center reaction and the antibody response. Autoimmunity 41:341-352.

Xu, Z., E. J. Pone, A. Al-Qahtani, S.-R. Park, H. Zan, and P. Casali 2007. Regulation of aicda expression and AID activity. Crit. Rev. Immunol. 27: 367-397.

Xu, Z., H. Zan, Z. Pal and P. Casali. 2007. DNA replication to aid somatic hypermutation. Adv. Exp. Med. Biol. 596: 111-128.

Duquerroy, S., E.A. Stura, S. Bressanelli, S.M. Fabiane, M.C. Vaney, D. Beale, M. Hamon, P. Casali, F.A. Rey, B.J. Sutton and M.J. Taussig. 2007. Crystal structure of a human autoimmune complex between IgM rheumatoid factor RF61 and IgG1 Fc reveals a novel epitope and evidence for affinity maturation. J. Mol. Biol. 368: 1321-1331.

Casali, P., Z. Pal, Z. Xu and H. Zan. 2006. DNA repair in antibody somatic hypermutation. Trends Immunol. 27:313-321.

Wu, X., C.Y. Tsai, M. Patam, H. Zan, S.M. Lipkin and P. Casali. 2006. A role for the MutL mismatch repair Mlh3 protein in immunoglobulin class switch DNA recombination and somatic hypermutation. J. Immunol. 176: 5426-5437.

Komori, A., Z. Xu, X. Wu, H. Zan and P. Casali. 2006. Biased dA/dT somatic hypermutation as regulated by the heavy chain intronic iEm enhancer and 3'Ea enhancers in human lymphoblastoid B cells. Mol. Immunol. 43: 1817-1826.

Zan, H., N. Shima, Z. Xu, A. Al-Qahtani, A.J. Evinger, III, Y. Zhong, J.C. Schimenti and P. Casali. 2005. The translesion DNA polymerase q plays a dominant role in immunoglobulin gene somatic hypermutation. EMBO J. 24:3757-3769.

Xu, Z., Z. Fulop, Y. Zhong, A.J. Evinger, III, H. Zan, and P. Casali. 2005. DNA lesions and repair in Immunoglobulin class switch DNA recombination and somatic hypermutation. Ann. N.Y. Acad. Sci. 1050: 146-162.

Casali, P. and H. Zan. 2004. Class switching and myc translocation: how does DNA break? Nature Immunol. 5: 1101-1103.

Kim, E., C.R. Edmonston, X. Wu, A. Schaffer and P. Casali. 2004. The HoxC4 homeodomain protein mediates activation of the immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells: relevance to class switch DNA recombination. J. Biol. Chem. 279: 42258-42269.

Liu, S., A. Cerutti, P. Casali* and M.K. Crow*. 2004. Ongoing immunoglobulin class switch DNA recombi-nation in lupus B cells: analysis of switch regulatory regions. Autoimmunity 37: 431-443. [*equal contrib.]

Wu, X., H. Zan, A. Komori, J. Feng, E.C. Kim and P. Casali. 2003. Immunoglobulin somatic hypermutation: double-strand DNA breaks, AID and error-prone DNA repair. J. Clin. Immunol. 23: 235-246.

Schaffer, A, E. Kim, H. Zan, L. Testoni, S. Salamon, A. Cerutti and P. Casali. 2003. Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified and conserved ATTT cis-elements. J. Biol. Chem. 278: 23141-23150.

He, B., N. Raab-Traub, A. Chadburn, E.J. Schattner, D.K. Knowles, P. Casali and A. Cerutti. 2003. The EBV oncoprotein LMP1 cooperates with BAFF and APRIL to induce IgH class switch DNA recombination and enhance lymphoma B cell survival. J. Immunol. 171: 5215-5224.

Riboldi, P., W. Ikematsu, B. Brambilla, C. Caprani, M . Gerosa and P. Casali. 2003. Diversity and somatic hypermutation of the Ig VHDJH, Vk-Jk and Vl-Jl gene segments in lymphoma B cells. Relevance to the origin of the neoplastic B cell clone. Human Immunol. 64: 69-81.

Diaz, M. and P. Casali. 2002. Somatic immunoglobulin hypermutation. Curr. Opin. Immunol. 14: 235–240.

Cerutti, A., H. Zan, E. Kim, S. Shah, E.J. Schattner, A. Schaffer and P. Casali. 2002. Ongoing in vivo immunoglobulin class switch DNA recombination in chronic lymphocytic leukemia B cells. J. Immunol. 169: 6594-603.

Litinskiy, M.B., B. Nardelli, D.M. Hilbert, A Schaffer, P. Casali and A. Cerutti. 2002. Dendritic cells induce CD40-independent immunoglobulin class switching by stimulating B cells through BlyS and APRIL. Nat. Immunol. 3: 822-829.

Gurrieri, C., P. McGuire, H. Zan, X.-J. Yan, A. Cerutti, E. Albesiano, S. Allan, V. Vinciguerra, K. Rai, M. Ferrarini, N. Chiorazzi* and P. Casali*. 2002. Chronic lymphocytic leukemia B cells undergo somatic hypermutation and intraclonal Ig VHDJH gene diversification J. Exp. Med. 196: 629-639. [*equal contrib.]

Zan, H., A. Komori, Z. Li, A. Cerutti, M. Flajinik, M. Diaz and P. Casali. 2001. The translesion DNA polymerase z plays a major role in Ig and bcl-6 somatic hypermutation. Immunity 14: 643-653.

Cerutti, A., E. C. Kim, S. Shah, E. J. Schattner, H. Zan, A. Schaffer and P. Casali. 2001. Dysregulation of CD30+ T cells by leukemia impairs isotype switching in normal B cells. Nat. Immunol. 2: 150-156.

Zan, H., Z. Li, K. Yamaji, P. Dramitinos, A. Cerutti and P. Casali. 2000. BCR engagement and T cell contact induce bcl-6 hypermutation in human B cells: identity with Ig hypermutation. J. Immunol. 165: 830-839.

Li, Z., E.W. Schettino, E. Padlan, H. Ikematsu and P. Casali. 2000. Structure-function analysis of a lupus anti-DNA autoantibody: central role of the heavy chain complementarity-determining region 3 Arg in binding double- and single-stranded DNA. Eur. J. Immunol. 30: 2015-2026.

Cerutti, A., A. Schaffer, S. Shah, R. Goodwin, H. Zan and P. Casali. 2000. Engagement by CD153 (CD30L) by CD30+ T cells inhibits class switch DNA recombination and antibody production in human IgM+ IgD+ B cells. J. Immunol. 165: 786-794.
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