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 Thomas E. Lane

University of California

Gross Hall Room 2006
Mail Code: 3900
Irvine, CA 92697

PHONE: (949) 824-5878
FAX: (949) 824-8551

E-MAIL: tlane@uci.edu

 

Thomas E. Lane
Professor and Chancellor's Fellow, Molecular Biology and Biochemistry
School of Biological Sciences
Director, Multiple Sclerosis Research Center, Molecular Biology and Biochemistry
School of Biological Sciences

B.S., Ball State University, 1988
Ph.D. 1993, University of California, Los Angeles

Research Interests
multiple sclerosis, demyelination, chemokines, inflammation, virology, immunology

Faculty/lab web:
http://darwin.bio.uci.edu/~faculty/lane
 
Graduate Programs:
Virology Immunology and Pathogenesis Neurobiology
 
Professional Society American Society of Virology The American Association of Immunologists American Society for Microbiology International Society for Neuroimmunology
 
Abstract
Research in my laboratory is focused on neuroinflammatory diseases of the central nervous system (CNS). In particular, we are interested in the molecular and cellular mechanisms governing neuroinflammation in animal models of the human demyelinating disease multiple sclerosis (MS) and spinal cord injury. In addition, we are examining the therapeutic potential of neural stem cells (NSCs) in promoting tissue repair following surgical engraftment into mice with an established demyelinating disease. Aspects related to NSC-mediate repair include defining the signaling cues utilized by engrafted cells to migrate to areas of demyelination, determining what factor(s) regulate cell lineage fate differentiation, and developing new methods to prevent allograft rejection of NSCs.


Other Experience
Updated: Last Updated: 02/17/2011

  Sy, M., M. Kitazawa, R. Medeiros, L. Whitman, D. Cheng, T.E. Lane, and F.M. LaFerla. (2011). Inflammation induced by infection potentiates tau pathology in transgenic mice. American J. Pathology, In press.

Kohler, A., K. De Filippo, M. Hasenberg, C. Nitschke, E. Nye, M.P. Hosking, T.E. Lane, L. Mann, R.M. Ransohoff, A.E. Hauser, W. Winter, B. Schraven, H. Geiger, N. Hogg, and M. Gunzer. (2011). Thrombopoietin-stimulated megakaryocytes control neutrophil motility and mobilization from bone marrow by release of CXCR2 ligands. Blood, In press.

Held, K.S., O. Steward, C. Blanc, and T.E. Lane. (2010). Impaired immune responses following spinal cord injury leads to reduced ability to control viral replication. Exp. Neurol. 226(1):242-53.

Liu, L., L. Darnall, T. Hu, K. Choi, T.E. Lane, and R.M. Ransohoff. (2010). Myelin repair is accelerated by inactivating CXCR2 on nonhematopoietic cells. J. Neuroscience, 30(27):9074-83.

Tirotta, E., K.S. Carbajal, C.S. Schaumburg, L. Whitman, and T.E. Lane (2010). Cell replacement therapies to promote remyelination in a viral model of demyelination. J. Neuroimmunology, 224(1-2):101-7.

Denes, A., N.Humphreys, T.E. Lane, R. Grencis, and N. Rothwell. (2010). Chronic systemic infection exacerbates ischaemic brain damage via a CCL5 (RANTES) mediated proinflammatory response. J. Neuroscience. 30(30):10086-95.

Hosking, M.P., E. Tirotta, R.M. Ransohoff, and T.E. Lane. (2010). CXCR2 signaling protects oligodendrocytes and restricts demyelination in a mouse model of viral-induced demyelination. PLoS One. 5(6):e11340.

Carbajal, K.S., C. Schaumburg, R. Strieter, J. Kane, and T.E. Lane. (2010). Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple sclerosis. Proc Natl Acad Sci U S A, 107(24):11068-73.

Hosking, M.P. and T.E. Lane (2010). The role of chemokines during viral infection of the CNS. Pearl Article: PLoS Pathogens. 6(7):e1000937.

Hosking, M.P. and T.E. Lane (2010). The pathogenesis of murine coronavirus infection of the central nervous system. Crit. Rev. Immuno. 30(2):119-130.

Liu, L., A. Belkadi, L. Darnall, T. Hu, C. Drescher, A.C. Cotleur, D. Padovani-Claudio, T. He, K. Choi, T.E. Lane, R.H. Miller, and R.M. Ransohoff. (2010). CXCR2+ neutrophils play an essential role in cuprizone-induced demyelination: relevance to multiple sclerosis. Nature Neuroscience. 13(3):319-326.

Hosking, M.P. and T.E. Lane. (2009). The biology of persistent infection: Inflammation and demyelination following murine coronavirus infection of the central nervous system. Current Immuno. Rev. 5(4):267-276.

Hosking, M.P., L. Liu, R.M. Ransohoff, and T.E. Lane. (2009). A protective role for ELR+ chemokines during acute viral encephalomyelitis. PLoS Pathogen.5(11)e1000648.

Drennen, M.B., A. Franki, P. Dewint, K. Van Beneden, S. Seeuws, S.A. van de Pavert, E.C. Reilly, G. Verbruggen, T.E. Lane, R.E. Mebius, D. Deforce, and D. Elewaut. (2009). Cutting Edge: The chemokine receptor CXCR3 retains invariant natural killer T cells in the thymus. J. Immunology, 183(4):2213-2216.

Hatch, M.N., C.S. Schaumburg, T.E. Lane*, and H.S. Keirstead*. (2009). Endogenous remyelination is induced by transplant rejection in a viral model of multiple sclerosis. J. Neuroimmunology. 212(1-2):74-81.

Stiles, L.N., M.T. Liu, J.A.C. Kane, and T.E. Lane (2009). CXCL10 and trafficking of virus-specific T cells during coronavirus demyelination. Autoimmunity.42(6):484-491.

Whitman, L.M., H. Zhou, S. Perlman, and T.E. Lane (2009). IFN-gamma mediates suppression of coronavirus replication in glial-committed progenitor cells. Virology, 384(1):209-215.

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