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Thomas Poulos
2206 Natural Sciences 1
Mail Code: 3900
Irvine, CA 92697
PHONE:
(949)824-7020 lab: 4322
FAX:
(949) 824-3280
E-MAIL:
poulos@uci.edu
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Thomas Poulos |
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Chancellor's Professor of Biochemistry, Chemistry, and Pharmaceutical Sciences |
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PH.D., University of California, San Diego, 1972, Biology |
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Research Interests
Protein crystallography, protein enginering, heme enzyme structure and function.
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Faculty/lab web: http://crystal.bio.uci.edu/~poulos/lab_website/intro.html |
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Graduate Programs: Structural Biology and Molecular Biophysics Chemical Biology Medicinal Chemistry and Pharmacology |
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Professional Society
Protein Society
American Chemical Society
Ameican Crystallographic Association
Biophysical Society
Amer. Society of Pharmacology and Experimental Therapeutics
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Other Experience |
| Updated: Last Updated: 10/16/2009 |
Li C, Li H, Zhou S, Sun E, Yoshizawa J, Poulos TL, Gershon PD (2009). Polymerase translocation with respect to single-stranded nucleic acid: looping or wrapping of primer around a poly(A) polymerase. Structure 17, 680-689.
Ioanoviciu A, Meharenna YT, Poulos TL, Ortiz de Montellano, PR (2009) DevS oxy complex stability identifies this heme protein as a gas sensor in Mycobacterium tuberculosis dormancy. Biochemistry 48, 5839-5848.
Ji H, Sidartha T, Igarashi J, Li H, Derrick M, Martasek P, Roman LJ, Vasques-Vivar J, Poulos TL, Silverman RB (2009) Selective Neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy Annals Neurol. 65 209-217.
Ji, H. Li H. Martasek P, Roman LJ, Poulos, TL, Silverman RB (2009). Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping. J. Med. Chem. 52, 779-797.
Igarashi J, Li H, Jamal J, Ji H, Fang H, Lawton GR, Silverman RB, Poulos TL (2009) Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors J. Med Chem. 52, 2060-2066.
Li H, Das A, Sibhatu H, Jamal J, Sligar SG, Poulos TL (2008) Exploring the electron transfer properties of nitric oxide synthase by reversal of the FMN redox potential. J. Biol. Chem. 283 34762-34772.
Meharenna YT, Oertel P, Bhaskar B, Poulos TL (2008) Engineering ascorbate peroxidase activity into cytochrome c peroxidase Biochemistry 47, 10324-10332.
Fasan R, Meharenna YT, Snow CD, Poulos TL, Arnold FH (2008). Evolutionary history of the mergence of a specialized cytochrome P450. J. Mol. Biol. 383. 1069-1080.
Gruia FG, Ionascu D, Kubo M, Ye X, Dawson J, Osborn RL, Sligar SG, Denisov I, Das A, Poulos TL, Terner J, Champion PM (2008). Low-frequency dynamics of Caldariomyces fumago chloroperoxidase probed by femtosecond coherence spectroscopy. Biochemistry 47, 5156-5167.
Ji H, Stanton BZ, Igarashi J, Li H, Martasek P, Roman LJ, Poulos TL, Silverman RB (2008) Minimal pharmacophoric elements and fragment hopping, an approach directed at molecular diversity and isozyme selectivity. Design of selective neuronal nitric oxide synthase inhibitors. J. Amer. Chem. Soc. 130, 3900-3914.
Meharenna YT, Slessor KE, Cavaignac SM, Poulos TL, De Voss JJ (2008) The critical role of substrate-protein hydrogen bonding in the control of regioselective hydroxylation in P450cin J. Biol. Chem. 283, 10804-1081.
Ho WW, Li H, Nishida CR, Ortiz de Montellano PR, Poulos TL (2008) Crystal structure and properties of CYP231A2 from the thermoacidophilic archaeon Picrophilus torridus Biochemistry 47, 2071-2079
Seo J, Igarashi J, Li H, Martasek P, Roman LJ, Poulos TL, Silverman RB (2007).Structure-Based Design and Synthesis of N(omega)-Nitro-l-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water. J Med Chem. 50, 2089-2099.
Borjigin, M, Li H, Lanz ND, kerby RL, Roberts GP, Poulos TL (2007). Structure-Based Hypothesis on the Activation of the CO-sensing Transcription Factor CooA. Acta Crys D63, 282-287.
