Thomas Poulos

University of California

2206 Natural Sciences 1
Mail Code: 3900
Irvine, CA 92697

PHONE: (949)824-7020 lab: 4322
FAX: (949) 824-3280



Thomas Poulos
Chancellor's Professor of Biochemistry, Chemistry, and Pharmaceutical Sciences

PH.D., University of California, San Diego, 1972, Biology

Research Interests
Protein crystallography, protein engineering, heme enzyme structure and function.

Faculty/lab web:
Graduate Programs:
Chemical Biology Medicinal Chemistry and Pharmacology
Professional Society Protein Society American Chemical Society Ameican Crystallographic Association Biophysical Society Amer. Society of Pharmacology and Experimental Therapeutics
Other Experience
Updated: Last Updated: 01/09/2014

  Madrona Y, Hollingsworth SA, Khan B, Poulos TL (2013). P450cin active site water: implications for substrate binding and solvent accessibility. Biochemistry 52, 5039-5050

Sevrioukova IF, Poulos TL (2013) Dissecting Cytochrome P450 3A4-ligand interactions using ritonavir analogues. Biochemistry 52, 4474-4481.

Sevrioukova IF, Poulos TL (2013). Pyridine-substituted desoxyritonavir is a more potent inhibitor of cytochrome P450 3A4 than ritonavir. J. Med. Chem. 9, 3733-3741.

Tripathi S, Li H, Poulos TL (2013). Structural basis for effector control and redox partner recognition in cytochrome P450. Science 340, 1227-1230.

Li H, Jamal J, Chreifi G, Venkatesh V, Abou-Ziab H, Poulos TL. (2013). Dissecting the Kinetics of the NADP+ - FADH2 Charge Transfer Complex and Flavin Semiquinones in Neuronal Nitric Oxide Synthase. J. Inorg. Biochem. 124, 1-10.

Jasion VS, Poulos TL (2012). Leishmania major peroxidase is a cytochrome c peroxidase. Biochemistry 51, 2453-2460

Sevrioukova IF, Poulos TL (2012) Interaction of human P4503A4 with ritonavir analogs. Arch. Biochem. Biophys. 520, 108-116

Publications from Pubmed