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picture of Christopher C.W. Hughes
 Christopher C.W. Hughes

University of California

Dept. Mol. Biol. & Biochem.
 3219 McGaugh Hall
 Mail Code: 3900
 Irvine, CA 92697

PHONE: (949)824-8771
FAX: (949) 824-8551

E-MAIL: cchughes@uci.edu

 

Christopher C.W. Hughes
Professor & Chair, Molecular Biology and Biochemistry
School of Biological Sciences
 Professor, Biomedical Engineering
The Henry Samueli School of Engineering
B.Sc (Hon)., University of London, 1981, Biochemistry
Ph.D., University of London, 1988
Research Interests
Blood vessel development, angiogenesis in cancer

Faculty/lab web:
http://darwin.bio.uci.edu/~cchughes/
 
Graduate Programs:
 Cancer Biology Biotechnology
 
Professional Society North American Vascular Biology Organization
 
Abstract
Growth of new blood vessels (angiogenesis) is an important process both in the healthy individual and in disease. Angiogenesis is becoming a hot area of research for cancer biologists as recent data suggest that blocking new blood vessel growth can slow tumor growth by cutting off the supply of oxygen and nutrients.

We have identified several genes involved in regulating the multiple steps of angiogenesis and are developing reagents to specifically interfere with these processes For more information see our website: http://darwin.bio.uci.edu/~cchughes/

Patents: Doubly chimeric human T cell-microvessel SCID mice: a small animal model of human allograft rejection


Other Experience
Updated: Last Updated: 07/02/2009

  Mestas J, and Hughes CCW. 2004. Of mice and not men: differences between mouse and human immunology. J. Immunol. 172: 2731-2738

Griffith GK, Miller C, Sainson RCA, Calvert JW, Jeon NL, Hughes CCW, and George SC. 2005. Diffusion limits of an in vitro thick prevascularized tissue. Tissue Eng. 11: 257-266.

Sainson RCA, Aoto J, Nakatsu MN, Holderfield M, Conn E, Koller E, and Hughes CCW. 2005 Re-iterative Notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis FASEB J 19: 1027-9

Holderfield MT, Henderson Anderson AM, Kokubo H, Chin MT, Johnson RL, and Hughes CCW. 2006 HESR1/CHF2 suppresses VEGFR2 transcription independent of binding to E-boxes. Biol. Biochem. Res. Comm. 346: 637-648

Ghajar CM, Blevins KS, Hughes CCW, George SC, and Putnam AJ. 2006 Mesenchymal stem cells enhance angiogenesis in mechanically viable prevascularized tissues via early MMP upregulation. Tissue Engineering 10: 2875-2888.

Wu B, Crampton SP, and Hughes CCW. 2007. Wnt signaling induces MMP expression and regulates T cell transmigration. Immunity 26: 227-239.

Pedram A, Razandi M, Sainson RC, Kim JK, Hughes CCW, Levin ER. 2007. A conserved mechanism for steroid receptor translocation to the plasma membrane. J. Biol. Chem. 282: 22278-88.

Ghajar CM, Harris JW, Suresh V, Chen X, Jeon NL, Hughes CCW, Putnam AJ, George SC. 2008. The Effect of Matrix Density on the Regulation of 3-D Capillary Morphogenesis. Biophys. J. 94: 1930-41

Sainson RCA, Johnston DA, Chu HC, Holderfield MT, Nakatsu MN, Crampron SP, Davis J, Conn E, and Hughes CCW. 2008 TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype. Blood 111: 4997-5007

Holderfield MT and Hughes CCW. 2008 Crosstalk between VEGF, Notch and TGF? in vascular morphogenesis. Circulation 102: 637-52

Hughes CCW 2008. Endothelial-stromal interactions in angiogenesis. Curr. Opinion Hematol. 15: 204-209

Nakatsu MN and Hughes CCW 2008. An optimized three-dimensional in vitro model for the analysis of angiogenesis. Methods in Enzymology 443: 65-82

Chen X, Aledia, AS, Ghajar CM, Griffith CK, Putnam AJ, Hughes CCW, and George SC. 2009 Prevascularization of a fibrin-based tissue construct accelerates the formation of functional anastomosis with host vasculature. Tissue Engineering 15: 1363-71.

Johnston DA, Dong B, and Hughes CCW. 2009 Induction of jagged-1 in endothelial cells is NF?B dependent. Gene 435: 36-44.
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