| Bruce J. Tromberg | |
Positions: |
Professor, College of Medicine, Biomedical Engineering The Henry Samueli School of Engineering Director, Laser Microbeam and Medical Program, Beckman Laser Institute and Medical Clinic School of Medicine Director, Beckman Laser Institute 
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Degrees: |
B.A., Vanderbilt University, Chemistry Ph.D., Chemistry,, Univ. of Tenn., Oak Ridge Nat. Lab. |
Research |
Lasers, near infrared spectroscopy, non-invasive diagnostics, photomedicine, biomedical optics, photodynamic therapy |
Abstract: |
Optical Spectroscopy and Selective Photochemistry in Cells and Tissues. My research involves the development of optical techniques to non-invasively monitor and perturb physiological processes in tissues and cells. In order to describe the optical characteristics of thick tissues we have developed a method, known as Photon Migration, that can be used to quantitatively measure light scattering and absorption on a picosecond timescale. We have devised biophysical models and constructed instrumentation for measuring parameters such as hemoglobin oxygenation, tissue water content, relative blood volume, and cell size/shape. We are currently applying this technology to non-invasive functional imaging of tumors and dysplastic lesions in human breast, brain, cervix, and uterus. Complementary strategies based on photodynamic inactivation are used to selectively treat cancers upon diagnosis. |
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Zoumi, A. Yeh, A. Tromberg, B.J. Imaging Cells And Extracellular Matrix In Vivo Using Second-Harmonic Generation And Two-Photon Excited Fluorescence, PNAS, 99, 11014 – 11019, 2002. Shah, N., Cerussi, A., Eker, C., Espinoza, J., Butler, J., Fishkin, J., Hornung, R., Tromberg, B. Non-Invasive Functional Optical Spectroscopy of Human Breast Tissue. . Proceedings of the National Academy of Science, 98, 4420-4425, 2001. |
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Fishkin, J. B., Coquoz, O., Anderson, E. R., Brenner, M., Tromberg, B. J. Frequency-domain photon migration measurements of normal and malignant tissue optical properties in a human subject. Applied Optics. 36: 10-20, (1997). |
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Tromberg, B.J., Coquoz, O., Fishkin, J.B., Pham, T., Anderson, E.R., Butler, J., Cahn, M., Gross, J.D., Venugopalan, V., Pham, D. Non-Invasive Measurements of Breast Tissue Optical Properties Using Frequency-Domain Photon Migration. Phil. Trans. Royal Society London B. 352, 661-668 (1997). |
Address |
University of California Beckman Laser Institute Mail Code: 1475 Irvine, CA 92612-1475 |
Phone: | (949)824-8705, 8367, 4713 |
Fax: | (949)824-8413 |
Email: | bjtrombe@uci.edu |
| www.bli.uci.edu/research/bjt/bjt.html |
| Updated | 07/09/2009 |
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