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Ping H. Wang
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Positions:
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Professor, Medicine
School of Medicine
Biological Chemistry
School of Medicine
Director, Center for Diabetes Research and Treatment
Research Centers and Institutes
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Degrees:
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M.D., Kaohsiung Medical College
S.M.,, Harvard University
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Research
Interests: |
Insulin-like growth factor, Heart, Diabetes, Diabetes Complications
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Publications:
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Shan Y, Liu T, Su H, Samsamshariat A, Mestril R, Wang PH. Hsp10 and Hsp60 modulate Bcl-2 family and mitochondria apoptosis signaling induced by doxorubicin in cardiac muscle cells. J Mol Cell Cardiol 2003;35:1135-43.
Shan Y, Yang T, Mestril R, Wang PH. HSP10 and HSP60 Suppresses ubiquitination of IGF-1 receptor and augments IGF-1 receptor signaling in cardiac muscle – Implications on decreased myocardial protection in diabetic cardiomyopathy. J Biol Chem 2003;278:45492-8.
Li T, Chen Y, Liu T,Jia J, Hampson S, Shan Y, Kibler D, Wang PH. Using DNA microarray to identify Sp1 as a transcriptional regulatory element of insulin-like growth factor-1 in cardiac muscle cells. Circulation Research 2003;93:1202-9.
Hoffman AR, Strasburger CJ, Zagar A, Blum WF, Kehely A, Hartman ML; T002 Study Group. Efficacy and tolerability of an individualized dosing regimen for adult growth hormone replacement therapy in comparison with fixed body weight-based dosing. J Clin Endocrinol Metab. 2004;89(7):3224-33.
Jang GM, Leong LE, Hoang LT, Wang PH, Gutman GA, Semler BL. Structurally distinct elements mediate internal ribosome entry within the 5’ noncoding region of a voltage-gated potassium channel mRNA. J Biol Chem. 2004;279(46):47419-30
Wang PH. Growing pains in the pursuit of diabetes prevention. Lancet, 2004;363(9413):910.
Chen H, Shan Y, Yang T, Lin H, Chen J, Lin, S, Wang PH. Insulin Deficiency Down-Regulated Hsp60 and IGF-1 Receptor Signaling in Diabetic Myocardium. Diabetes 2005;54(1):175-81.
Wang PH. IGF-1 is a matter of heart. Growth Hormone and IGF Research. 2005; 15: 89-94.
Su H, Samsamshariat A, Fu J, Shan Y, Chen Y, Piomelli D, Wang PH. Oleylethanolamide Activates Ras-Erk Pathway and Improves Myocardial Function in Doxorubicin-induced Heart Failure. Endocrinology 2006; 147:827-834.
Chen H, Jia J, Su H, Lin H, Chen J, Lin S, Yang J, Lai H, Mestril R, Wang PH. Down-Regulation of the Constitutively Expressed Hsc70 in Diabetic Myocardium is Mediated by Insulin Deficiency. J. Endocrinology 2006;190(2):433-40.
Lai H, Liu T, Ting C, Yang J, Huang L, Wallace D, Kaiser P, Wang PH. Regulation of IGF-1 Receptor Signaling in Diabetic Cardiac Muscle: Dysregulation of Cytosolic and Mitochondria Hsp60. Am J Physiology (Endocrinol and Metab), In Press.
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Address |
University of California
C240 Medical Sciences 1
Mail Code: 4086
Irvine, CA 92697
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Phone: | (949) 824-6981 |
Fax: | (949) 824-2200 |
Email: | phwang@uci.edu |
| Updated |
12/03/2006
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