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Ronald C. Shank
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Positions:
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Professor, Community & Environmental Medicine
School of Medicine
Chair, Director, Graduate Program in Environmental Toxicology
School of Medicine
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Degree:
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PH.D., Massachusetts Institute of Technology
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Academic
Distinctions
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Gold Medal, Chulabhorn Research Institute, Bangkok, Thailand
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Research
Interests: |
Molecular mechanisms in DNA damage by chemical carcinogens, and biochemical activation of environmental carcinogens
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Research
Abstract:
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Dr. Shank studies chemical carcinogenesis and biochemical toxicology. His research focuses on the toxicokinetics of DNA adduct formation and on molecular mechanisms in the competition for binding sites in DNA by small and bulky chemical carcinogens. These studies are highly relevant to the current problem in toxicology of extrapolating from results of in vitro and animal experiments to assess risks in human populations exposed to low environmental levels of carcinogenic chemicals.
Dr. Shank is also extensively involved in organizing and participating in training courses in environmental toxicology and technology in Southeast Asia, sponsored by the UN Development Programme. The courses are well-established (12 years) in Thailand and were offered in Vietnam in 1998.
Dr. Shank also directs the Graduate Program in Environmental Toxicology, leading to the Master of Science and Doctor of Philosophy degrees in Environmental Toxicology. Detailed information on the program can be obtained from http://www.com.uci.edu/envtox.
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Publications:
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Ross, M.K., Mathison, B.H., Said, B. and Shank, R.C., 5-Methylcytosine in CpG sites and the reactivity of nearest neighboring guanines tpward the carcinogen aflatoxin B1-8,9-epoxide. Biochem. Biophys. Res. Comm., 254: 114-119, 1999.
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Said, B., Matsumoto, D.C., Hamade, A.K., and Shank, R.C. Mutagenic activity and DNA adduct formation by 1,2-epoxy-3-(p-nitrophenoxy)propane, an HIV-1 Protease Inhibitor and GST Substrate. Biochem. Biophys. Res. Comm., 261: 844-847, 1999.
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Said, B., Ross, M.K., Hamade, A.K., Matsumoto, D.C., and Shank, R.C., DNA-damaging effects of genotoxins in mixture: Non-additive effects of aflatoxin B1 and N-acetylamino-fluorene on their mutagenicity in Salmonella typhimurium. Toxicol. Sci., 52: 226-231 (1999)
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Ross, M.K., Said, B. and Shank, R.C., DNA-damaging effects of genotoxins in mixture: 2. Modulation of covalent binding to DNA. Toxicol. Sci., 53: 224-236 (2000).
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Professional
Societies
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Society of Toxicology
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American Chemical Society
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Address |
University of California
FRF 100, North Campus
Mail Code: 1825
Irvine, CA 92697
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Phone: | (949) 824-5186, 5436 |
Fax: | (949) 824-2070 |
Email: | rcshank@uci.edu |
| Updated |
09/17/2002
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Copyright (c) Regents of the University of California, 1997. All rights reserved.
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