| Ellena M. Peterson | |
Positions: |
Professor, Pathology School of Medicine Associate Dean, Admissions and Outreach School of Medicine 
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Degree: |
Ph.D., Georgetown University, 1978, Microbiology and Immunology |
Research |
Chlamydia Vaccine Development and the Rapid Detection of Infectious Agents |
Abstract: |
Research interests in the clinical/applied area are the development of rapid procedures for the detection of clinically relevant pathogenic bacteria, viruses and fungi with particular interest in sexually transmitted pathogens. In the basic research area, attempts are being made to define the key structural elements of the pathogen Chlamydia at the molecular level that are important in eliciting a protective host immunological response. These include exploring components of the outer membrane of this pathogen and more recently, the type three secretion system. |
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Last Five Years of Publications Slepenkin, A., L. M. de la Maza. and E. M. Peterson. Interaction between Components of the Type III Secretion System of Chlamydiaceae. J. Bacteriology, 187: 473-479, 2005. Tan, G. L. and E. M. Peterson. CHROMagar™ Candida for the Direct Susceptibility Testing of Yeast from Blood Cultures. J. Clin. Microbiol., 43:1727-1731, 2005. Naiki, Y., K. S. Michelsen, N. W. J. Schroder, R. Alsabeh, A. Slepenkin, W. Zhang, S. Chen, B. Wei, E. M. Peterson and M. Arditi. MyD88 is pivotal for the early inflammatory response and subsequent bacterial clearance and survival in a mouse model of Chlamydia pneumoniae pneumonia. J. Biol. Chem., 280: 2924-2929,2005. Pal, S., E. M. Peterson and L. M. de la Maza. Vaccination of newborn mice induces a strong protective immune response against respiratory and genital challenges with Chlamydia trachomatis. Vaccine, 23: 5351-5358, 2005. Pal, S., E. M. Peterson and L. M. de la Maza. Vaccination with the Chlamydia trachomatis major outer membrane protein can elicit an immune response as protective as that resulting from inoculation with live bacteria. Infect. Immun. 73: 8153-8160, 2005. Pal, S., A. P. Schmidt, E. M. Peterson, C. L. Wilson and L. M. de la Maza, Role of metalloproteinase-7 in the modulation of a Chlamdyia trachomatis infection. Immunol. 117: 213-219, 2005. Pal, S., E, M. Peterson, R. Rappuoli, G. Ratti and L. M. de la Maza. Immunization with the Chlamydia trachomatis major outer membrane protein, using adjuvants developed for human vaccines, can induce partial protection in a mouse model against a genital challenge. Vaccine, 24:766-775, 2006. Slepenkin A., P.-A Enquist., U. Hägglund., L. M. de la Maza, M. Elofsson and E. M. Peterson. Reversal of the Anti-Chlamydial Activity of Putative Type Three Secretion Inhibitors by Iron. Infect. Immun., 75: 3478-3489, 2007. Sun, G., S. Pal, A. K. Sarcon, S. Kim, E. Sugawara, H. Nikaido, M. Cocco, E. M. Peterson and L.M. de la Maza. Structural and functional analyses of the major outer membrane protein of Chlamydia trachomatis. J. Bacteriol, 189: 6222-6235, 2007. Schro¨der, NWJ, T. R. Crother, Y. Naiki, S. Chen, M. H. Wong, A. Yilmaz, A Slepenkin, D. Schulte, Randa Alsabeh, T. M. Doherty, E. Peterson, A. E. Nel, and M. Arditi. Innate Immune responses during respiratory infection with a bacterial pathogen induce allergic airway sensitization. J Allergy Clin Immunol, 122:595-602, 2008. Naiki Y, Sorrentino R, Wong MH, Michelsen KS, Shimada K, Chen S, Yilmaz A, Slepenkin A, Schröder NW, Crother TR, Bulut Y, Doherty TM, Bradley M, Shaposhnik Z, Peterson EM, Tontonoz P, Shah PK, Arditi M. TLR/MyD88 and LXRalpha Signaling Pathways Reciprocally Control Chlamydia Pneumoniae-Induced Acceleration of Atherosclerosis. J. Immunol, 181:7176-7185, 2008. Pal, S, J. Bravo, E.M. Peterson and L. M. de la Maza. Protection of wild-type and severe combined immunodeficiency mice against an intranasal challenge by passive immunization with monoclonal antibodies to the Chlamydia trachomatis mouse pneumonitis major outer membrane protein. Infect. Immun. 76: 5581-5587, 2008. Shimada K, Chen S, Dempsey PW, Sorrentino R, Alsabeh R, Slepenkin AV, Peterson E, Doherty TM, Underhill D, Crother TR, Arditi M. The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection. PLoS Pathog. 2009 Apr;5(4):e1000379. Epub 2009 Apr 10. Erratum in: PLoS Pathog. 2009 Apr;5(4). doi: 10.1371/annotation/f3aa682e-3bc2-4a05-ac7f-05c6cfe1bbd7. PLoS Pathog. 2009 Apr;5(4). Kari Laszlo, William M. Whitmire, Deborah D. Crane, Nathalie Reveneau, John H. Carlson, Morgan M. Goheen, Ellena M. Peterson, Sukumar Pal, Luis M. de la Maza, and Harlan D. Caldwell. Chlamydia trachomatis Native Major Outer Membrane Protein Induces Partial Protection in Non-Human Primates: Implication for a Trachoma Transmission Blocking Vaccine. J. Immunology 182: 8063-8070, 2009. Sun, G., S. Pal, J. Weiland, E. M. Peterson and L.M. de la Maza. Protection against an intranasal challenge by vaccines formulated with native and recombinant preparations of the Chlamydia trachomatis major outer membrane protein. Vaccine, 27:5020-5025, 2009. Di Russo Case, E. E. M. Peterson and M. Tan. Promoters for Chlamydia Type III Secretion Genes Show a Differential Response to DNA Supercoiling that Correlates with Temporal Expression Pattern. J. Bacteriol., 192:2569-74, 2010. Chu, Hencelyn, Anatoly Slepenkin, Mikael Elofsson, Pia Keyser, Luis M. de la Maza and Ellena M. Peterson. Candidate vaginal microbicides with activity against Chlamydia trachomatis and Neisseria gonorrhoeae. International J. of Antimicrobial Agents 36:145-150, 2010. Courtney Reynolds, Victor Quan; Diane Kim, Ellena Peterson, Julie Dunn, Matthew Whealon, Leah Terpstra, Hildy Meyers, Michele Cheung; Bruce Lee, Susan S. Huang. Methicillin-Resistant Staphylococcus aureus (MRSA) Carriage in 10 Nursing Homes in Orange County, California. Infection Control and Hospital Epidemiology, in press 2010. Liss MA, Alexandra Chang ,Rosanne Santos, Amy Nakama-Peeples , Ellena M. Peterson, Kathryn Osann , John Billimek, Richard J. Szabo and Atreya Dash. Prevalence and Significance of Fluoroquinolone-Resistant Escherichia Coli in Patients Undergoing Transrectal Ultrasound Guided Prostate Needle Biopsy. The Journal of Urology, in press April 2011 |
Professional
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American Society for Microbiology |
| American Venereal Disease Association | |
| Fellow: American Academy of Microbiology | |
Address |
University of California D440 Medical Sciences I Mail Code: 4800 Irvine, CA 92697-480 |
Phone: | (949) 824-4169, 7450 |
Fax: | (949) 824-2160 |
Email: | epeterso@uci.edu |
| www.ucihs.uci.edu/com/pathology/faculty/epeterson.html |
| Updated | 12/15/2010 |
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