picture of Thomas J. Carew

Thomas J. Carew

Donald Bren Professor and Chair, Neurobiology and Behavior
School of Biological Sciences
Center for Neurobiology of Learning and Memory
Degree
  Ph.D., University of Califronia, Riverside, 1970
   
Graduate Programs
  Neurobiology and Behavior
 
Web Site
  http://neurobiology.uci.edu
 
Interests
  Cellular and molecular mechanisms of memory
 
Abstract
  Memories can last from a few seconds to a lifetime. In my laboratory we study the neuronal basis of these diverse forms of memory. We use a relatively simple animal, Aplysia, because its nervous system affords significant advantages for identifying synaptic, biophysical, and molecular changes underlying different stages of memory. The fundamental goal of our experiments is to achieve an understanding of the mechanisms by which the nervous system acquires, stores, and retrieves information.
 
Academic Distinctions
  2001 Elected Fellow of AAAS 2003 Chancellor's Award for Excellence in Fostering Undergraduate Research 2004 Elected Fellow, American Academy of Arts and Sciences 2005 Elected Chair of Neuroscience Section, AAAS 2005 Elected Councilor, International Society for Neuroethology 2006 Elected Member, Dana Alliance 2008 Elected President, Society for Neuroscience
 
Publications
  Shobe, J., Zhao, Y., Ye, X., Stough,, S., Martin, K. and Carew, T.J. (2009) A novel signaling cascade mediates activity-dependent synaptic facilitation and memory formation in Aplysia. Neuron 61:113-125.
 
 
  Ye, X., Shobe, J.L., Sharma, S.K., Marina, A., and Carew, T.J. (2008) Small G proteins exhibit pattern sensitivity in MAPK activation during the induction of memory and synaptic facilitation in Aplysia. PNAS ,U S A. 2008 Dec 23;105 51):20511-6
 
 
  Philips, G.T., Tzvetkova, E I., and Carew, T.J. (2007) Transient mitogen-activated protein kinase activation is confined to a narrow temporal window required for the induction of two-trial long-term memory in Aplysia. J. Neuroscience: 27(50) 13701-13705.
 
 
  Marinesco S, Wickremasinghe, N and Carew, T.J. (2006) Regulation of behavioral and synaptic plasticity by serotonin release within local modulatory fields in Aplysia J. Neuroscience.
 
 
  Sharma, SK, Sherff, CM, Stough,S, Hsuan, V and Carew,TJ (2006) A tropomyosin-related kinase B ligand is required for ERK activation, long-term synaptic facilitation, and long-term memory in Aplysia. Proc Natl Acad Sci, 103:14206-14210.
 
 
  Reissner, K. Shobe, J, and Carew, TJ (2006) Molecular nodes in memory processing: insights from Aplysia. Cell Mol Life Sci. 63(9):963-74.
 
 
  Philips, G. T., Tzvetkova, E I., Marinesco, S. and Carew, J. (2006) Latent Memory for Sensitization in Aplysia Learning & Memory, Learning&Memory, 13:224-229.
 
 
  Sherff, CM and Carew, TJ (2004) Parallel somatic and synaptic processing in the induction of intermediate-term and long-term synaptic facilitation in Aplysia. PNAS 101:7463-7468
 
 
  Sutton, M.A., Bagnall, MW, Sharma, SK, Shobe, J., and Carew, TJ (2004) Intermediate-term memory for site-specific sensitization in Aplysia is maintained by persistent activation of protein kinse C. J. Neuroscience 24: 3600-3609
 
 
  Sharma, SK and Carew, TJ (2004) The Roles of MAPK Cascades in Synaptic Plasticity and Memory in Aplysia: Facilitatory Effects and Inhibitory Constraints. Learning&Memory 11: 373-378.
 
 
  Marinesco, S, Kolkman, KE and Carew, TJ (2004) Serotonergic modulation in Aplysia : I. A distributed serotonergic network activated by sensitizing stimuli. J Neurophysiol: 92: 2468-2486
 
 
  Marinesco, S, Wickremasinghe, N, Kolkman, KE, and Carew, TJ (2004) Serotonergic modulation in Aplysia : II. Cellular and behavioral consequences of increased serotonergic tone. J Neurophysiol:92: 2487- 2497
 
Phone
  (949) 824-6114
 
Fax
  (949) 824-2447
 
Email
  tcarew@uci.edu
 
Address
  University of California, Irvine
2205 McGaugh Hall
  301 Qureshey Research Lab
  Mail Code: 4550
  Irvine, CA 92697
   
Position
  President
Company
  Society for Neuroscience
Start Year
  2009
End Year