Bryce Anthony Mander
Associate Professor, Psychiatry & Human Behavior
School of Medicine
School of Medicine
Affiliated faculty, Cognitive Sciences
School of Social Sciences
School of Social Sciences
Affiliated faculty, Pathology
School of Medicine
School of Medicine
Ph.D., Northwestern University, 2008, Neuroscience
University of California, Irvine
5154 California Ave., Room 238
Irvine, CA 92617
5154 California Ave., Room 238
Irvine, CA 92617
Research Interests
Sleep, Sleep Deprivation, Sleep Disorders, Cognitive Aging, Alzheimer’s Disease, Memory, Neurodegeneration
Research Abstract
Dr. Mander’s recent published work utilized a multimodal neuroimaging approach to quantitatively triangulate relationships between sleep quality, brain structure and function, Alzheimer’s disease neuropathology, and episodic and procedural memory in healthy older adults. Specifically, he has conducted targeted research that revealed that age-related decrements in quantitative measures of non-rapid-eye-movement (NREM) sleep oscillations, including slow waves and sleep spindles, contribute to memory decline in older age. These relationships are statistically mediated by the influence of these sleep oscillations on the functioning of the hippocampus in support of facilitating novel encoding and the long-term retention of episodic experiences and procedural skills.
Another critical focus of Dr. Mander’s work is to elucidate the mechanisms explaining why some older adults show more disrupted sleep than others. Using magnetic resonance imaging (MRI) techniques, he has shown that regionally-specific degeneration of white and grey matter in the brain predicts the topographically-specific disruption of NREM slow waves and sleep spindles in cognitively normal older adults. Using positron emission tomography (PET) imaging, he has further shown that, in cognitively normal older adults at risk for Alzheimer’s disease, the degree of accumulated Alzheimer’s disease pathology (e.g. ß-amyloid and tau pathology) disrupts quantitative properties of NREM sleep oscillations in a manner that appears distinct from that observed in normal aging. This is particularly important, because identifying preclinical biomarkers of increased Alzheimer’s disease risk will support targeted early interventions to prevent the emergence of Alzheimer’s disease. Moreover, all of this work supports the emerging hypothesis that sleep disruption mechanistically contributes to the initial pathophysiology of Alzheimer’s disease and to the cognitive impairment associated with its progression.
Dr. Mander also has a programmatic focus on relationships between sleep physiology, cognition, mood, health, and brain development across childhood. Recent work in the lab shows that fitness is associated with local expression of brain oscillations during sleep, cognitive function, and mood in developing adolescents. Current studies are examining mechanistic links between these variables, and the impact of exercise on local sleep expression and cognitive and mental health outcomes.
Dr. Mander is currently involved in multiple collaborative projects both at University of California, Irvine and at other academic institutions around the world. These collaborations include longitudinal studies, in multiple distinct populations at increased risk for Alzheimer’s disease, tracking relationships between changes in quantitative sleep measures, brain structure and function, cortical ß-amyloid and tau burden, cardiovascular health, and memory in healthy older adults. He is also involved in studies aimed at characterizing the clinical biomarker potential of quantitative sleep measures, as well as the efficacy of sleep interventions to boost cognition in older adults with Alzheimer's disease pathology. The ultimate goal of his research program is to characterize how and when sleep interacts with neurodegenerative pathology and medical disorders to impact dementia risk, and to determine if sleep interventions can effectively promote healthy cognitive aging in older adults with or at risk for neurodegenerative dementias.
Another critical focus of Dr. Mander’s work is to elucidate the mechanisms explaining why some older adults show more disrupted sleep than others. Using magnetic resonance imaging (MRI) techniques, he has shown that regionally-specific degeneration of white and grey matter in the brain predicts the topographically-specific disruption of NREM slow waves and sleep spindles in cognitively normal older adults. Using positron emission tomography (PET) imaging, he has further shown that, in cognitively normal older adults at risk for Alzheimer’s disease, the degree of accumulated Alzheimer’s disease pathology (e.g. ß-amyloid and tau pathology) disrupts quantitative properties of NREM sleep oscillations in a manner that appears distinct from that observed in normal aging. This is particularly important, because identifying preclinical biomarkers of increased Alzheimer’s disease risk will support targeted early interventions to prevent the emergence of Alzheimer’s disease. Moreover, all of this work supports the emerging hypothesis that sleep disruption mechanistically contributes to the initial pathophysiology of Alzheimer’s disease and to the cognitive impairment associated with its progression.
Dr. Mander also has a programmatic focus on relationships between sleep physiology, cognition, mood, health, and brain development across childhood. Recent work in the lab shows that fitness is associated with local expression of brain oscillations during sleep, cognitive function, and mood in developing adolescents. Current studies are examining mechanistic links between these variables, and the impact of exercise on local sleep expression and cognitive and mental health outcomes.
Dr. Mander is currently involved in multiple collaborative projects both at University of California, Irvine and at other academic institutions around the world. These collaborations include longitudinal studies, in multiple distinct populations at increased risk for Alzheimer’s disease, tracking relationships between changes in quantitative sleep measures, brain structure and function, cortical ß-amyloid and tau burden, cardiovascular health, and memory in healthy older adults. He is also involved in studies aimed at characterizing the clinical biomarker potential of quantitative sleep measures, as well as the efficacy of sleep interventions to boost cognition in older adults with Alzheimer's disease pathology. The ultimate goal of his research program is to characterize how and when sleep interacts with neurodegenerative pathology and medical disorders to impact dementia risk, and to determine if sleep interventions can effectively promote healthy cognitive aging in older adults with or at risk for neurodegenerative dementias.
Awards and Honors
Dr. Mander has received the Wayne A. Hening Sleep Medicine Investigator Award from the American Academy of Neurology, which emphasizes work revealing critical novel links between neurology and sleep medicine. He also received an award for Excellence in Research on Alzheimer’s and Related Disorders from the Northern California and Northern Nevada chapter of the Alzheimer’s Association.
Short Biography
Dr. Mander received his PhD in Neuroscience at Northwestern University, and completed his postdoctoral fellowship in the Department of Psychology at University of California, Berkeley. His research is concerned with characterizing the role of sleep in cognitive function and overall brain health across the human lifespan in both healthy populations and populations at risk for neurodegenerative disease.
Publications
Melikyan ZA, Kawas CH, Paganini-Hill A, Jiang L, Mander BA, Corrada MM. Self-reported sleep in relation to risk of dementia a quarter of a century later at age 90+: The 90+ Study. Behav Sleep Med. 2023 Sep 3;21(5):620-632. doi: 10.1080/15402002.2022.2148668. Epub 2022 Nov 23. PMID: 37540023; PMCID: PMC10403699.
Zavecz Z, Shah VD, Murillo OG, Vallat R, Mander BA, Winer JR, Jagust WJ, Walker MP. NREM sleep as a novel protective cognitive reserve factor in the face of Alzheimer's disease pathology. BMC Med. 2023 May 3;21(1):156. doi: 10.1186/s12916-023-02811-z. PMID: 37138290; PMCID: PMC10155344.
Mander BA, Dave A, Lui KK, Sprecher KE, Berisha D, Chappel-Farley MG, Chen IY, Riedner BA, Heston M, Suridjan I, Kollmorgen G, Zetterberg H, Blennow K, Carlsson CM, Okonkwo OC, Asthana S, Johnson SC, Bendlin BB, Benca RM. Inflammation, tau pathology, and synaptic integrity associated with sleep spindles and memory prior to ß-amyloid positivity. Sleep. 2022 Sep 8;45(9):zsac135. doi: 10.1093/sleep/zsac135. PMID: 35670275; PMCID: PMC9758508.
Chappel-Farley, M.G., Mander, B.A., Nan, B., Grill, J.D., Yassa, M.A., Benca, R.M. Symptoms of obstructive sleep apnea are associated with less frequent exercise and worse subjective cognitive function across adulthood. Sleep 2021 Oct 4:zsab240. doi: 10.1093/sleep/zsab240. PMID: 34604910
Skelin, I., Zhang, H., Zheng, J., Ma, S., Mander B.A., Knight, R.T., McNaughton, B.L., Lin, J.J. Coupling between slow-waves and sharp-wave ripples engages distributed neural activity during sleep in humans. Proc Natl Acad Sci USA 2021 118(21) e2012075118; doi: 10.1073/pnas.2012075118. PMID: 34001599
Neikrug, A.B., Mander, B.A., Radom-Aizik, S., Chen, I.Y., Stehli, A., Lui, K.K., Chappel-Farley, M.G., Dave, A., Benca, R.M. Aerobic fitness and the sleeping brain of adolescents—a pilot study. Sleep Advances 2021, 2(1) zpab005; doi: https://doi.org/10.1093/sleepadvances/zpab005. PMID: 33981996
Dudysova, D., Janku, K., Smotek, M., Saifutdinova, E., Koprivova, J., Buskova, J., Mander, B.A., Brunovsky, M., Zach, P., Korcak, J., Andrashko, V., Viktorinova, M., Tyls, F., Bravermanova, A., Froese, T., Palenicek, T., Horacek, J. The effects of daytime psilocybin administration on sleep: implications for antidepressant action. Front Pharmacol 2020 11:602590; doi: 10.3389/fphar.2020.602590. PMID: 33343372
Mander, B.A. Local Sleep and Alzheimer’s disease pathophysiology. Front Neurosci 2020 14:525970; doi: 10.3389/fnins.2020.525970. PMID: 33071726.
Winer, J.R., Mander, B.A., Kumar, S., Reed, M., Baker, S.L., Jagust, W.J., Walker, M.P. Sleep disturbance forecasts prospective ß-amyloid accumulation across subsequent years. Curr Biol 2020 30(21):4291-4298.e3; doi: 10.1016/j.cub.2020.08.017. PMID: 32888482.
Lendner, J.D., Helfrich, R.F., Mander, B.A., Romundstad, L., Lin, J.J., Walker, M.P., Larsson, P.G., Knight, R.T. An electrophysiological marker of arousal live in humans. eLife 2020 9:e55092; doi: 10.7554/eLife.55092.
Skelin, I., Zhang, H., Zheng, J., Ma, S., Mander B.A., Knight, R.T., McNaughton, B.L., Lin, J.J. Coupling between slow-waves and sharp-wave ripples engages distributed neural activity during sleep in humans. Proc Natl Acad Sci USA 2021 118(21) e2012075118; doi: 10.1073/pnas.2012075118. PMID: 34001599
Neikrug, A.B., Mander, B.A., Radom-Aizik, S., Chen, I.Y., Stehli, A., Lui, K.K., Chappel-Farley, M.G., Dave, A., Benca, R.M. Aerobic fitness and the sleeping brain of adolescents—a pilot study. Sleep Advances 2021, 2(1) zpab005; doi: https://doi.org/10.1093/sleepadvances/zpab005. PMID: 33981996
Dudysova, D., Janku, K., Smotek, M., Saifutdinova, E., Koprivova, J., Buskova, J., Mander, B.A., Brunovsky, M., Zach, P., Korcak, J., Andrashko, V., Viktorinova, M., Tyls, F., Bravermanova, A., Froese, T., Palenicek, T., Horacek, J. The effects of daytime psilocybin administration on sleep: implications for antidepressant action. Front Pharmacol 2020 11:602590; doi: 10.3389/fphar.2020.602590. PMID: 33343372
Mander, B.A. Local Sleep and Alzheimer’s disease pathophysiology. Front Neurosci 2020 14:525970; doi: 10.3389/fnins.2020.525970. PMID: 33071726.
Winer, J.R., Mander, B.A., Kumar, S., Reed, M., Baker, S.L., Jagust, W.J., Walker, M.P. Sleep disturbance forecasts prospective ß-amyloid accumulation across subsequent years. Curr Biol 2020 30(21):4291-4298.e3; doi: 10.1016/j.cub.2020.08.017. PMID: 32888482.
Lendner, J.D., Helfrich, R.F., Mander, B.A., Romundstad, L., Lin, J.J., Walker, M.P., Larsson, P.G., Knight, R.T. An electrophysiological marker of arousal live in humans. eLife 2020 9:e55092; doi: 10.7554/eLife.55092.
Grants
Relationships between local and global mechanisms of sleep apnea, Alzheimer's disease biomarkers, and memory impairment in cognitively asymptomatic older adults
National Institute on Aging (Baltimore)2020-08-01 to 2025-04-30|Grant
GRANT_NUMBER: K01AG068353
URL: https://app.dimensions.ai/details/grant/grant.9329401
Circuit-specific tau burden and mechanisms of sleep-dependent memory processing in older adults at risk for Alzheimer’s disease National Institute on Aging (Baltimore)2022-08-01 to 2024-07-30|Grant GRANT_NUMBER: R21AG079552 URL: https://reporter.nih.gov/project-details/10539903#details
Interacting mechanisms of sleep and aerobic fitness: Implications for health in the growing child National Heart, Lung, and Blood Institute (Baltimore)2021-04-01 to 2025-03-31|Grant GRANT_NUMBER: R01HL153807 (PI: Neikrug, Co-I: Mander) URL: https://reporter.nih.gov/project-details/10226656#details
Professional Societies
Sleep Research Society
International Society to Advance Alzheimer's Research and Treatment
World Sleep Society
Research Centers
Center for Sleep and Circadian Neuroscience
Fellow of the Center for the Neurobiology of Learning and Memory
Faculty Member of the UCI Institute for Memory Impairments and Neurological Disorders
Link to this profile
https://faculty.uci.edu/profile/?facultyId=6367
https://faculty.uci.edu/profile/?facultyId=6367
Last updated
08/11/2023
08/11/2023