Trina M. Norden-Krichmar

Assistant Professor, Epidemiology
School of Medicine

Ph.D., University of California, San Diego, Scripps Institution of Oceanography, Marine Biology

M.S., George Washington University, Washington, DC, Computer Science

B.S., University of Maryland, College Park, Maryland, Biochemistry

Phone: (949) 824-8802

University of California, Irvine
216 Irvine Hall
Mail Code: 7550
Irvine, CA 92697

picture of Trina M. Norden-Krichmar

Bioinformatics; genetic factors in human diseases; gene expression analysis; non-coding RNA; metagenomics; environmental and marine genomics
My research involves computational methods to analyze, integrate, and interpret the various sources of biological data for the study of medical, marine, and environmental applications of genomics. I have been involved in a wide range of projects using next generation sequencing, de novo assembly, read mapping, functional annotation, and differential gene expression analysis. Recently, my research involves common and rare variant association studies for the investigation of genetic variation and gene regulation mechanisms as they relate to human disease.
Publications Norden-Krichmar, T.M., Gizer, I.R., Wilhelmsen, K.C., Schork, N.J., and Ehlers, C.L. (2015) “Variants near CCK receptors are associated with electrophysiological responses to pre-pulse startle stimuli in a Mexican American cohort”, Twin Research and Human Genetics, doi:10.1017/thg.2015.77.
  Ishii, S., Suzuki, S., Tenney, A., Norden-Krichmar, T.M., Nealson, K.H., and Bretschger, O. (2015) “Microbial metabolic networks in complex electrogenic biofilm recovered from a stimulus-induced metatranscriptomics approach”, Scientific Reports, 5:14840, doi: 10.1038/srep14840.
  Norden-Krichmar, T.M., Gizer, I.R., Wilhelmsen, K.C., Schork, N.J., and Ehlers, C.L. (2014) “Protective variant associated with alcohol dependence in a Mexican American cohort”, BMC Medical Genetics, 15:136, doi:10.1186/s12881-014-0136-z.

Norden-Krichmar, T.M., Gizer, I.R., Libiger, O., Wilhelmsen, K.C., Ehlers, C.L., and Schork, N.J. (2014) “Correlation analysis of genetic admixture and social identification with body mass index in a Native American community”, American Journal of Human Biology, doi:10.1002/ajhb.22521.

Ishii, S., Suzuki, S., Norden-Krichmar, T.M., Phan, T., Wanger, G., Nealson, K.H., Sekiguchi, Y., Gorby, Y.A., and Bretschger, O. (2013) “Microbial population and functional dynamics associated with surface potential and carbon metabolism”, International Society of Microbial Ecology (ISME) Journal, doi:10.1038/ismej.2013.217.

Ishii, S., Suzuki, S., Norden-Krichmar, T.M., Wu, A., Yamanaka, Y., Nealson, K.H., and Bretschger, O. (2013) “Identifying the microbial communities and operational conditions for optimized wastewater treatment in microbial fuel cells”, Water Research Journal, 47:7120-7130, doi:10.1016/j.watres.2013.07.048.

Ishii, S., Suzuki, S., Norden-Krichmar, T.M., Tenney, A., Chain P.S.G., Scholz, M., Nealson, K.H., and Bretschger, O. (2013) “A novel metatranscriptomic approach to identify gene expression dynamics during extracellular electron transfer”, Nature Communications 4:1601, doi:10.1038/ncomms2615.

Shrestha, R.P., Tesson, B., Norden-Krichmar, T.M., Federowicz, S., Hildebrand, M. and Allen, A.E. (2012) ”Whole transcriptome analysis of the silicon response of the diatom Thalassiosira pseudonana” BMC Genomics, 13:499, doi:10.1186/1471-2164-13-499.

Bertrand, E.M., Allen, A.E., Dupont, C.L., Norden-Krichmar, T.M., Bai, J., Valas, R.E. and Saito, M.A. (2012) "Influence of cobalamin scarcity on diatom molecular physiology and identification of a cobalamin acquisition protein" PNAS, doi:10.1073/pnas.1201731109.

Ishii, S., Suzuki, S., Norden-Krichmar, T.M., Nealson, K.H., Sekiguchi, Y., Gorby, Y.A., Bretschger, O. (2012) “Functionally stable and phylogenetically diverse microbial enrichments from microbial fuel cells during wastewater treatment” PLoS ONE 7(2): e30495, doi:10.1371/journal.pone.0030495.

Norden-Krichmar, T.M., Allen, A.E., Gaasterland, T., and Hildebrand, M. (2011) “Characterization of the small RNA transcriptome of the diatom, Thalassiosira pseudonana” PLoS ONE 6(8): e22870, doi:10.1371/journal.pone.0022870.

Norden-Krichmar, T.M., Holtz, J., Pasquinelli, A.E., and Gaasterland, T. (2007) “Computational prediction and experimental validation of Ciona intestinalis microRNA genes” BMC Genomics, 8: 445.
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Last updated 12/14/2015