Wengui Yu
Professor of Clinical Neurology and Vice Chair for Hospital Affairs, Neurology
School of Medicine
School of Medicine
Director, UCI Stroke Center
School of Medicine
School of Medicine
M.D., Jiangxi Medical College, 1983
Ph.D., McGill University, 1997, Experimental Medicine
Ph.D., McGill University, 1997, Experimental Medicine
University of California, Irvine
200 S. Manchester Ave. #206E Orange, CA
Mail Code: 4280
Irvine, CA 92697
200 S. Manchester Ave. #206E Orange, CA
Mail Code: 4280
Irvine, CA 92697
Research Interests
Acute basilar artery occlusion, intracerebral hemorrhage, intracranial stenosis and stenting, resistant hypertension, arterial dissection, and coma
Publications
1. Xu L, Yu W, and Tian J. Effects of sodium ferulate on 14C-arachidonic acid metabolism by rabbit platelets. Journal of Integrated Traditional Chinese Medicine and Western Medicine. 1988; 8:614-618.
2. Yu W and Xu L. Highlights of the thromboxane synthetase inhibitor research. Advances in Physiological Science. 1990; 21:216-220.
3. Xu L, Yu W, Tian J, and Liu Q. Effect of sodium ferulate on arachidonic acid metabolism. Acta Pharmaceutica Sinica. 1990; 25:412-416.
4. Wang T, Yu W, and Powell WS. Formation of monohydroxy derivatives of arachidonic acid, linoleic acid, and oleic acid during oxidation of low-density lipoprotein by copper ions and endothelial cells. Journal of lipid Research. 1992; 33:525-537.
5. Yu W and Xu L. Effect of acetylsalvianolic acid A on platelet function. Acta Pharmaceutica Sinica. 1994; 29:412-416.
6. Yu W and Powell WS. Analysis of leukotrienes, lipoxins, and monooxygenated metabolites of arachidonic acid by reversed-phase high-pressure liquid chromatography. Analytical Biochemistry. 1995; 226:241-251.
7. Yu W, Xu L, Martin JG, and Powell WS. Eicosanoid synthesis and cellular infiltration in Brown Norway rat lung after allergen challenge. American Journal of Respiratory Cell and Molecular Biology. 1995; 13:477-486.
8. Yu W and Xu L. Acetylsalvianolic acid A—a new thromboxane synthetase inhibitor. Acta Pharmaceutica Sinica. 1997; 32:467-469.
9. Bozza PT, Yu W, Penrose JF, Morgan ES, Dvorak AM & Weller PF. Eosinophil lipid bodies: specific, inducible intracellular sites for enhanced eicosanoid formation. Journal of Experimental Medicine. 1997; 186:909-920.
10. Bozza PT, Yu W, and Weller PF. Mechanisms of formation and function of eosinophil lipid bodies: inducible intracellular sites involved in arachidonic acid metabolism. Memorias do Instituto Oswaldo Cruz. 1997;92 Supplement 2:135-40.
11. Weller PF, Bozza PT, Yu W & Dvorak AM. Cytoplasmic lipid bodies in eosinophils: central roles in eicosanoid generation. Allergology International. 1997; 46:141-153.23.
12. Yu W and Xu L. Effect of acetylsalvianolic acid A on arachidonic acid metabolism in platelets. Acta Pharmaceutica Sinica. 1998; 33:62-63.
13. Stamatiou P, Hamid Q, Yu W, Rokach IJ, Khanapure SP, and Powell WS. 5-oxo-ETE induces pulmonary eosinophilia in an integrin-dependent manner in Brown Norway rat. Journal of Clinical Investigation. 1998; 102:2165-2172.
14. Yu W, Bozza PT, Tzizik D, Dvorak AM & Weller PF. Co-compartmentalization of MAP kinases and cytosolic phospholipase A2 at cytoplasmic lipid bodies. American Journal of Pathology. 1998; 152:759-769.
15. Bozza PT, Yu W, Casara J & Weller PF. Pathways for eosinophil lipid body induction: differing signal transduction in cells from normal and hypereosinophilic subjects. Journal of Leukocyte Biology. 1998; 64:563-569.
16. Weller PF, Bozza PT, Yu W & Dvorak AM. Cytoplasmic lipid bodies in eosinophils: central roles in eicosanoid generation. Int Arch Allergy Immunol. 1999; 118:450-452.
17. Yu W, Cassara J, and Weller PF. Localization of phosphotidylinositol-3-kinase (PI3K) to cytoplasmic lipid bodies of leukocytes. Blood. 2000;95: 1078-1085.
18. Yu W and Horowitz SH. Familial hemiplegic migraine and its abortive therapy with intravenous verapamil. Neurology. 2001; 57(9):1732-1733. doi: 10.1212/wnl.57.9.1732. PMID: 11706128.
19. Bozza PT, Pacheco P, Yu W, and Weller PF. NS-398: cyclooxygenase-2 independent inhibition of leukocyte priming for lipid body formation and enhanced leukotriene generation. Prostaglandins Leukot Essent Fatty Acids. 2002; 67:237-44.
20. Yu W and Horowitz SH. Treatment of sporadic hemiplegic migraine with calcium channel blocker verapamil. Neurology. 2003; 60(1):120-121. doi: 10.1212/01.wnl.0000042051.16284.70. PMID: 12525732.
21. Yu W, Binder D, Foster-Barber A, Malek R, Smith WS and Higashida RT. Endovascular embolectomy of acute basilar artery occlusion. Neurology. 2003; 61:1421-1423. doi: 10.1212/wnl.61.10.1421. PMID: 14638968.
22. Yu W and Horowitz SH. Treatment of sporadic hemiplegic migraine with verapamil, a calcium channel blocker. Review Series: Neurology. 2003; 3:22-23.
23. Yu W and Smith WS. Anticoagulation in acute stroke management: beyond anecdotal experience. Stroke Rounds 2004;2(4).
24. Horowitz SH, Spollen LE, and Yu W. Hereditary neuropathy with liability to pressure palsy: fulminant development with axonal loss during military training. Journal of Neurology, Neurosurgery and Psychiatry. 2004;75(11):1629-1631. doi:10.1136/jnnp.2003.029314. PMID: 15489403.
25. Yu W, Smith WS, Singh S, Ko N, Cullen SP, Dowd C, Halback V, Higashida RT. Long-term outcome of endovascular stenting for symptomatic basilar artery stenosis. Neurology. 2005; 64:1055-1057. (Highlighted on page 937).
26. McIntosh A, Hungs M, Kostanian V, and Yu W. Carotid artery dissection and MCA stroke following methamphetamine use. Neurology. 2006; 67:2259-2260. (American Academy of Neurology Press Release. December 26, 2006).
27. Stradling D, Yu W, Langdorf M, Tsai F, Kostanian V, Hasso AN, Welbourne SJ, Schooley Y, Fisher MJ, Cramer SC. Stroke care delivery before vs. after JCAHO stroke center. Neurology. 2007; 68:469-470.1012.
28. Yu W, Kostanian V, and Fisher MJ. Endovascular recanalization of basilar artery occlusion 80 days after symptom onset. Stroke. 2007; 38(4):1387-9. doi: 10.1161/01.STR.0000260186.93667.a2. PMID: 17322092.
29. Kostanian V, Mathews MS, Westhout FD, Yu W. Facial steal syndrome: identification and endovascular management. The Neuroradiology Journal 2007;20(1):85-88.
30. Yu W. Overview of Neurocritical Care in the United States. Chinese Journal of Stroke. 2008; 3(4): 242-245.
31. Raychaudhuri R, Yu W, Hatanpaa K, Cavuoti D, Pride GL, White J. Basilar Artery Dissection Treated by Neuroform Stenting: Fungal Stent Infection. Surgical Neurology. 2009;71(4):477-80.
32. Yu W, Rives J, Welch B, White J, Stehel E, and Samson D. Hypoplasia or occlusion of the ipsilateral cranial venous drainage is associated with early fatal edema of middle cerebral artery infarction. Stroke. 2009; 40(12):3736-3739. doi: 10.1161/STROKEAHA.109.563080. PMID: 19762692.
33. Beshay JE, Morgan H, Madden, Yu W, and Sarode R. Emergency reversal of anticoagulation and antiplatelet therapies in neurosurgical patients. Journal of Neurosurgery. 2010;112(2):307-18.
34. Jiang WJ, Yu W, Du B, Wong EHC, and Gao F. Wingspan experience at Beijing Tiantan Hospital: new insights into the mechanisms of procedural complication from viewing intraoperative transient ischemic attacks during awake stenting for vertebrobasilar stenosis. J NeuroIntervent Surg. 2010; 2:99-103.
35. Yu W. Stroke Patient’s Nutrition Support: Should Not Be Forgotten. Chinese Journal of Stroke. 2011; 6(09):680-683.
36. Yu W. Nutrition Support for ischemic stroke. Chinese Journal of Stroke. 2011;6 (09):717-717.
37. Jiang WJ, Yu W, Du B, Gao F, and Cui LY. Outcome of patients with ? 70% symptomatic intracranial stenosis after Wingspan stenting. Stroke. 2011; 42(2):1971-1975. doi: 10.1161/STROKEAHA.110.595926. PMID: 21636814.
38. Jiang WJ, Yu W, Ma N, Du B, Lou X, and Rasmussen PA. High resolution MRI guided endovascular intervention of basilar artery disease. J NeuroIntervent Surg. 2011; 3:375-378.
39. Jiang WJ and Yu W. Stenting for intracranial arterial stenosis. N Engl J Med. 2011; 365:2140-2141.
40. Yu W, Rickert K, Flores B, and Samson D. Infectious Mid Basilar Artery Aneurysm from Pseudomona Meningitis. J NeuroIntervent Surg. 2012;4(3): e10.
41. Chaudry P, Friedman D, and Yu W. Unilateral pupillary mydriasis from nebulized ipratropium bromide: A false sign of brain herniation in the intensive care unit. India Journal of Critical Care Medicine. 2014;18 (3):176-177.
42. Kostanian and Yu W. Successful Recanalization of Chronic Basilar Artery Occlusion. Neurological Cases. 2014; 1:1-3.
43. Yu W, Lee A and Welch B. Herpes Simplex Encephalitis Presents as large Temporal Lobe Hemorrhage. Neurological Cases. 2014; 1:12-15.
44. Kavi T, Moheet A, and Yu W. (2016). Empirical Treatment of West Nile Neuroinvasive Disease with IVIG. Neurological Cases. 2016; 1:12-15.
45. Lai TT, Lavian M, Al-Khoury L, Suzuki S, and Yu W. Case Report of Endovascular Therapy of Acute Basilar Artery Occlusion: Beyond the Restricted Time Window. Neurological Cases 2016; 3(2):1-4.
46. Dastur CK, Yu W. Current management of spontaneous intracerebral haemorrhage. Stroke Vasc Neurol. 2017; 2(1):21-29.00. PMID: 28959487.
47. Hong D, Stradling D, Dastur CD, Akbari Y, Groysman L, Al-Khoury L, Chen J, Small SL and Yu W. Resistant Hypertension after Hypertensive Intracerebral Hemorrhage Is Associated with More Medical Interventions and Longer Hospital Stays without Affecting Outcome. Front. Neurol. 8:184. doi: 10.3389/fneur.2017.00184. PMID 28515710.
48. Yu W, Kavi T, Majic TJ, Alva K, Moheet A, Lyden P, Schievink W, Lekovic G, Alexander MJ. Treatment modality and benchmarks of aneurysmal subarachnoid hemorrhage at a Comprehensive Stroke Center. Front. Neurol. 2018. https://doi.org/10.3389/fneur.2018.00152. PMID: 29599745.
49. Yu W, Jiang W. Stenting for intracranial stenosis: potential future for the prevention of disabling or fatal stroke. Stroke Vasc Neurol. 2018; svn-2018-000158. doi:10.1136/svn-2018-000158. PMID: 30294469.
50. Raychev RI, Stradling D, Patel N, Gee JR, Lombardi DL, Moon JL, Brown DM, Pathak P, Yu W, Stratton SJ, Cramer SC. Evolution of a U.S. County System for Acute Comprehensive Stroke Care. Stroke. 2018; 49:1217-1222. doi: 10.1161/STROKEAHA.118.020620. PMID: 29626136.
51. Chang PD, E. Kuoy, J. Grinband, B.D. Weinberg, M. Thompson, R. Homo, J. Chen, H. Abcede, M. Shafie, L. Sugrue, C.G. Filippi, M.-Y. Su, W. Yu, C. Hess and D. Chow. Hybrid 3D/2D Convolutional Neural Network for Hemorrhage Evaluation on Head CT. American Journal of Neuroradiology. July 2018, DOI: https://doi.org/10.3174/ajnr.A5742. PMID: 30049723.
52. Jiang WJ, Liu AF, Yu W, et al. Outcomes of Multimodality In situ Recanalization in Hybrid Operating Room (MIRHOR) for symptomatic chronic internal carotid artery occlusions. J Neurointerv Surg. 2019;11(8):825-832. doi:10.1136/neurintsurg-2018-014384. PMID: 30610071.
53. Bower MM, Sweidan AJ, Shafie M, Atallah S, Groysman LI, Yu W. Contemporary Reversal of Oral Anticoagulation in Intracerebral Hemorrhage. Stroke. 2019;50(2):529-536. doi:10.1161/STROKEAHA.118.023840. PMID: 30636573.
54. Alexander M, Zauner A, Chaloupka J, Baxter B, Callison R, Gupta R, Song S, and Yu W. WEAVE Trial Final Results in 152 On-Label Patients. Stroke. 2019; 50(4):889-894. doi: 10.1161/STROKEAHA.118.023996. PMID: 31125298.
55. Yu W, Jiang W. A Simple Imaging Guide for Endovascular Thrombectomy in Acute Ischemic Stroke: From Time Window to Perfusion Mismatch and Beyond. Front Neurol. 2019; 10:502. doi: 10.3389/fneur.2019.00502. PMID: 31178813.
56. Shreve L, Kaur A, Vo C, Wu J, Cassidy JM, Nguyen A, Zhou R, Tran TB, Yang DZ, Medizade AI, Chakravarthy B, Hoonpongsimanont W, Barton E, Yu W, Srinivasan R, and Cramer SC. Electroencephalography Measures are Useful for Identifying Large Acute Ischemic Stroke in the Emergency Department. J Stroke Cerebrovasc Dis. 2019. pii: S1052-3057(19)30252-6. doi: 10.1016/j.jstrokecerebrovasdis.2019.05.019. PMID: 31174955
57. Sweidan AJ, Bower MM, Paullus J, Sterpi M, Stern-Nezer S, Dastur C, Yu W, Groysman LI. Refractory Central Neurogenic Hyperventilation: A Novel Approach Utilizing Mechanical Dead Space. Front Neurol. 2019 Sept 4; 10:937. doi:10.3389/fneur.2019.00937. PMID: 31551906
58. Bower MM, Sweidan AJ, Xu JC, Stern-Nezer S, Yu W, Groysman LI. Quantitative Pupillometry in the Intensive Care Unit. J Intensive Care Med. 2019 Oct 10:885066619881124. doi: 10.1177/0885066619881124. PMID: 31601157.
59. Tran D, Zhu Z, Shafie M, Abcede H, Stradling D, Yu W. Three easily implementable changes reduce median door-to-needle time for intravenous thrombolysis by 23?minutes. BMC Neurol. 2019 Nov 26;19(1):300. doi: 10.1186/s12883-019-1527-8. PMID: 31771530
60. Sweidan AJ, Singh NK, Conovaloff JL, Bower M, Groysman L, Shafie M, Yu W. Coagulopathy reversal in intracerebral haemorrhage. Stroke Vasc Neurol. 2020 Feb 20; 5(1): 29–33. doi: 10.1136/svn-2019-000274. PMID: 32411405
61. Zhu Z, Yu W. Update in the treatment of extracranial atherosclerotic disease for stroke prevention. Stroke Vasc Neurol. 2020 Mar; 5(1): 65–70. doi: 10.1136/svn-2019-000261. PMID: 32411410
62. Liu A, Li C, Yu W, Lin LM, Qiu HC, Zhang YQ, Lv XL, Wang K, Liu C, Jiang WJ.
Dissection-related carotid-cavernous fistula (CCF) following surgical revascularization of chronic internal carotid artery occlusion: a new subtype of CCF and proposed management. Chin Neurosurg JI. 6, 2 (2020). https://doi.org/10.1186/s41016-019-0180-9.
63. Liu L, Yu W. Editorial: Multimodality Monitoring or Evaluation of Neuro-Function in Modern NICU. Front Neurol. 2020; 10:1423. doi: 10.3389/fneur.2019.01423. eCollection 2019. PMID: 32116994.
64. Liu S, Zheng H, Yu W, Ramakrishnan V, Shah S, Gonzalez LF, Singh I, Graffagnino C, Feng W. Investigation of S-Nitrosoglutathione in stroke: A systematic review and meta-analysis of literature in pre-clinical and clinical research. Exp Neurol. 2020; 328:113262. doi: 10.1016/j.expneurol. 202; 113262. PMID: 32119935
65. Sweidan AJ and Yu W (2020) Asymptomatic Chronic Ischemic Penumbra from Middle Cerebral Artery Occlusion: A Case Report and Literature Review. Ann Case Report. 2020 March;14: 337. DOI: 10.29011/2574-7754/100337.
66. Zhu Z, Osman S, Stradling D, Shafie M, Yu W. Clinical characteristics and outcomes of methamphetamine associated versus non methamphetamine intracerebral hemorrhage. Sci Rep. 2020 Apr 14;10(1):6375. doi: 10.1038/s41598-020-63480-z. PMID: 32286468.
67. Osman S, Golshani K, Yu W. Thrombosis of The Anterior Third of the Superior Sagittal Sinus Causing Unilateral Infarct in A Patient with Thrombocytosis and Thalassemia. Ann Case Report. 2020 March;14: 327. DOI: 10.29011/2574-7754/100327.
68. Zhu Z, Bower M, Stern-Nezer S, Atallah S, Stradling D, Groysman L, MD; Dastur CK, Akbari Y, and Yu W. Early initiation of oral antihypertensives reduces ICU stay and hospital cost in patients with intracerebral hemorrhage. Neurocrit Care. 2020 Apr 6. doi: 10.1007/s12028-020-00951-1. PMID: 32119935.
69. Alexander MJ, Zauner A, Gupta R, Alshekhlee A, Fraser JF, Toth G, Given C, Mackenzie L, Kott B, Hassan AE, Shownkeen H, Baxter BW, Callison RC, Yu W. The WOVEN trial: Wingspan One-year Vascular Events and Neurologic Outcomes. J Neurointerv Surg. 2020 Apr;13(4):307-310. doi: 10.1136/neurintsurg-2020-016208. PMID: 32561658.
70. Nagamine M, Chow DS, Chang PD, Boden-Albala B, Yu W and Soun JE. Impact of COVID-19 on Acute Stroke Presentation at a Comprehensive Stroke Center. Front. Neurol. 2020 Aug 14; 11:850. doi: 10.3389/fneur.2020.00850. PMID: 32922355
71. Anderson N, Janarious A, Liu S, Flanagan L, Stradling D, and Yu W. Language disparity is not a significant barrier for time-sensitive care of acute ischemic stroke. BMC Neurol. 2020 Oct 2; 20(1): 363. PMID: 33008325.
72. Osman S, Zhu Z, Farag M, Groysman M, Dastur CK, Akbari Y, Stern-Nezer SRJ, Stradling D, Yu W. Intracerebral hemorrhage: who gets tested for methamphetamines and why might it matter? BMC Neurol 2020 Oct 27;20: 392. https://doi.org/10.1186/s12883-020-01967-y. PMID: 33109106
73. Erani F, Zolotova N, Vanderschelden, Khoshab N, Sarian H, Nazarzai L, Wu J, Chakravarthy B, Hoonpongsimanont W, Yu W, Shahbaba B, Srinivasan R, Cramer SC. Electroencephalography Might Improve Diagnosis of Acute Stroke and Large Vessel Occlusion. Stroke. 2020 Nov; 51:00–00. DOI: 10.1161/STROKEAHA.120.030150. PMID: 32942967.
74. Soun JE, Chow DS, Nagamine M, Takhtawala RS, Filippi CG, Yu W, Chang PD. Artificial Intelligence and Acute Stroke Imaging. AJNR Am J Neuroradiol. 2020 Nov 26. doi: 10.3174/ajnr.A6883. Epub ahead of print. PMID: 33243898.
75. Shafie M and Yu W. Recanalization Therapy for Acute Ischemic Stroke with Large Vessel Occlusion: Where We Are and What Comes Next? Translational Stroke Research. 2021 Jan 6. doi: 10.1007/s12975-020-00879-w. Epub ahead of print. PMID: 33409732.
76. Gao B, Gu H, Yu W, Liu S, Zhou Q, Kang K, Zhang J, Li Z, Zhao X, Wang Y. Admission Dehydration Is Associated With Significantly Lower In-Hospital Mortality After Intracerebral Hemorrhage. Front Neurol. 2021 Mar 8;12:637001. doi: 10.3389/fneur.2021.637001. PMID: 33763017; PMCID: 7982572.
77. Liu S, Liu Y, Zhang J, Yu W, Zhao S. Recurrent Hemorrhagic Transformation of Cardioembolic Stroke in an Elderly Patient: A Case Report and Literature Review. J. Neuroscience and Neurological Surgery. 2021 May 10; 8(5); DOI:10.31579/2578-8868/183.
78. Shimeng Liu, Zhu Zhu, Mohammad Shafie, Hermelinda Abcede, Jay Shah, Shuichi Suzuki, Li-Mei Lin, Kiarash Golshani, Dana Stradling, Wengui Yu. Ongoing Improvement in Acute Ischemic Stroke Therapy Per Concurrent Guidelines and Easily Implementable Quality Improvement Protocol. J. Neuroscience and Neurological Surgery. 2021 May 27. 9(1); DOI:10.31579/2578-8868/184.
79. Sophia Angelides, Amit Chaudhari, Wengui Yu. Common Carotid Artery Thrombus in the Setting of COVID-19 Vasculopathy. J. Neuroscience and Neurological Surgery. 2021 June 7. DOI: https://doi.org/10.31579/2578-8868/190.
80. Li Q, Wang C, Li W, Zhang Z, Wang S, Wupuer A, Hu X, Wumaier K, Zhu Y, Li H, Yu W. A Novel Mutation in COL4A1 Gene in a Chinese Family with Pontine Autosomal Dominant Microangiopathy and Leukoencephalopathy. Transl Stroke Res. 2021 Aug 20. doi: 10.1007/s12975-021-00926-0. Epub ahead of print. PMID: 34415564.
81. Hosseini Farahabadi M, Milani-Nejad S, Liu S, Yu W and Shafie M (2021) Left Atrial Dilatation and Reduced Left Ventricular Ejection Fraction Are Associated With Cardioembolic Stroke. Front. Neurol. 2021 September 13. 12:680651. doi: 10.3389/fneur.2021.680651.
82. Jia B, Zhang X, Ma N, Mo D, Gao F, Sun X, Song L, Liu L, Deng Y, Xu X, Zhang Y, Liu Z, Guan S, Zhang F, Li B, Zheng H, Liu X, Liu Y, Chen K, Shuai J, Wan J, Wang J, Shi X, Li T, Chang B, Liebeskind DS, Yu W*, Miao Z;* NOVA Trial Investigators. Comparison of Drug-Eluting Stent With Bare-Metal Stent in Patients With Symptomatic High-grade Intracranial Atherosclerotic Stenosis: A Randomized Clinical Trial. JAMA Neurol. 2022 Jan 4:e214804. doi: 10.1001/jamaneurol.2021.4804. Epub ahead of print. PMID: 34982098; PMCID: PMC8728659.
83. Bower MM, Suzuki S, Golshani K, Lin LM, Shafie M, Abcede HG, Shah J, Stradling D, Yu W. Comparative Studies of Cerebral Reperfusion Injury in the Posterior and Anterior Circulations After Mechanical Thrombectomy. Transl Stroke Res. 2022 Jan 10. doi: 10.1007/s12975-021-00977-3. Epub ahead of print. PMID: 35006533.
84. Yu W, Higashida RT. Endovascular Thrombectomy for Acute Basilar Artery Occlusion: Latest Findings and Critical Thinking on Future Study Design. Transl Stroke Res. 2022 Mar 29. doi: 10.1007/s12975-022-01008-5. Epub ahead of print. PMID: 35349051.
85. Shah J, Liu S, Yu W. Contemporary antiplatelet therapy for secondary stroke prevention: a narrative review of current literature and guidelines. Stroke & Vascular Neurology 2022; April 3. doi:10.1136/svn-2021001166.
86. Angelides S, Chaudhari A, Khachatryan T, Yu W. Recurrent Ischemic Strokes in the Territory of Recurrent Artery of Heubner: Presenting in Relation to Facial Swelling and Weakness. J. Neuroscience and Neurological Surgery. 2022; April 11. DOI:10.31579/2578-8868/241.
87. Falcone JA, Lopez A, Stradling D, Yu W, Chen JW. Blood Pressure and Spot Sign in Spontaneous Supratentorial Subcortical Intracerebral Hemorrhage. Neurocrit Care. 2022 Aug;37(1):246-254. doi: 10.1007/s12028-022-01485-4. Epub 2022 Apr 20. PMID: 35445934; PMCID: PMC9283165.
88. Yu W. Vasospasm and Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage: Recent Advances and Future Directions in Translational Research. Transl Stroke Res. 2023 Apr;14(2):119-120. doi: 10.1007/s12975-022-01028-1. Epub 2022 May 2. PMID: 35501554.
89. Kuoy E, Glavis-Bloom J, Hovis G, Yep B, Biswas A, Masudathaya LA, Norrick LA, Limfueco J, Soun JE, Chang PD, Chu E, Akbari Y, Yaghmai V, Fox JC, Yu W, Chow DS. Point-of-Care Brain MRI: Preliminary Results from a Single-Center Retrospective Study. Radiology. 2022 Aug 2:211721. doi: 10.1148/radiol.211721. Epub ahead of print. PMID: 35916678.
90. Fote GM, Raefsky S, Mock K, Chaudhari A, Shafie M and Yu W. Intracranial Arterial Calcifications: Potential Biomarkers of Stroke Risk and Outcome. Front. Neurol. 2022 Sept 1, 13:900579. doi: 10.3389/fneur.2022.900579. PMID: 36119671; PMCID: PMC9475140.
91. Schlossman J, Ro D, Salehi S, Chow D, Yu W, Chang PD, Soun JE. Head-to-head comparison of commercial artificial intelligence solutions for detection of large vessel occlusion at a comprehensive stroke center. Front Neurol. 2022 Oct 10;13:1026609. doi: 10.3389/fneur.2022.1026609. PMID: 36299266; PMCID: PMC9588973.
92. Alexander MJ, Yu W; WEAVE Trial Investigators. Stenting Plus Medical Therapy and Risk of Stroke and Death in Patients With Symptomatic Intracranial Stenosis. JAMA. 2022 Dec 27;328(24):2456-2457. doi: 10.1001/jama.2022.18918. PMID: 36573984.
93. Dhar R, Yu W, Yenari M, Lee JM. Collateral Flow: Prolonging the Ischemic Penumbra. Transl Stroke Res. 2023 Feb;14(1):1-2. doi: 10.1007/s12975-023-01126-8. Epub 2023 Jan 10. PMID: 36626110.
94. Sun X, Yang M, Sun D, Peng G, Deng Y, Zhao X, Liu L, Ma N, Gao F, Mo D, Yu W, Wang Y, Wang Y, Miao Z. Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis (BASIS): protocol of a prospective, multicentre, randomised, controlled trial. Stroke Vasc Neurol. 2023 May 18:svn-2022-002288. doi: 10.1136/svn-2022-002288.
95. Soun JE, Zolyan A, McLouth J, Elstrott S, Nagamine M, Liang C, Dehkordi-Vakil FH, Chu E, Floriolli D, Kuoy E, Joseph J, Abi-Jaoudeh N, Chang PD, Yu W and Chow DS (2023) Impact of an automated large vessel occlusion detection tool on clinical workflow and patient outcomes. Front. Neurol. 2023 May 25;14:1179250. doi: 10.3389/fneur.2023.1179250. PMID: 37305764; PMCID: PMC10248058.
96. Zhu Z, Vanderschelden B, Lee SJ, Blackwill H, Shafie M, Soun JE, Chow D, Chang P, Stradling D, Qian T, Yu W. Methamphetamine use increases the risk of cerebral small vessel disease in young patients with acute ischemic stroke. Sci Rep. 2023 May 25;13(1):8494. doi: 10.1038/s41598-023-35788-z. PMID: 37231082.
97. Alexander MJ, Yu W. Intracranial atherosclerosis update for neurointerventionalists. Journal of NeuroInterventional Surgery. 2023 Jun 9:jnis-2022-019628. doi: 10.1136/jnis-2022-019628. Epub ahead of print. PMID: 37295944.
98. Khachatryan T, Shafie M, Abcede H, Shah J, Nagamine M, Granstein J, Yuki I, Golshani K, Suzuki S and Yu W Rescue therapy after thrombectomy for large vessel occlusion due to underlying atherosclerosis: review of literature. Front. Neurol. 2023 June 16; 14:1181295. doi: 10.3389/fneur.2023.1181295.
2. Yu W and Xu L. Highlights of the thromboxane synthetase inhibitor research. Advances in Physiological Science. 1990; 21:216-220.
3. Xu L, Yu W, Tian J, and Liu Q. Effect of sodium ferulate on arachidonic acid metabolism. Acta Pharmaceutica Sinica. 1990; 25:412-416.
4. Wang T, Yu W, and Powell WS. Formation of monohydroxy derivatives of arachidonic acid, linoleic acid, and oleic acid during oxidation of low-density lipoprotein by copper ions and endothelial cells. Journal of lipid Research. 1992; 33:525-537.
5. Yu W and Xu L. Effect of acetylsalvianolic acid A on platelet function. Acta Pharmaceutica Sinica. 1994; 29:412-416.
6. Yu W and Powell WS. Analysis of leukotrienes, lipoxins, and monooxygenated metabolites of arachidonic acid by reversed-phase high-pressure liquid chromatography. Analytical Biochemistry. 1995; 226:241-251.
7. Yu W, Xu L, Martin JG, and Powell WS. Eicosanoid synthesis and cellular infiltration in Brown Norway rat lung after allergen challenge. American Journal of Respiratory Cell and Molecular Biology. 1995; 13:477-486.
8. Yu W and Xu L. Acetylsalvianolic acid A—a new thromboxane synthetase inhibitor. Acta Pharmaceutica Sinica. 1997; 32:467-469.
9. Bozza PT, Yu W, Penrose JF, Morgan ES, Dvorak AM & Weller PF. Eosinophil lipid bodies: specific, inducible intracellular sites for enhanced eicosanoid formation. Journal of Experimental Medicine. 1997; 186:909-920.
10. Bozza PT, Yu W, and Weller PF. Mechanisms of formation and function of eosinophil lipid bodies: inducible intracellular sites involved in arachidonic acid metabolism. Memorias do Instituto Oswaldo Cruz. 1997;92 Supplement 2:135-40.
11. Weller PF, Bozza PT, Yu W & Dvorak AM. Cytoplasmic lipid bodies in eosinophils: central roles in eicosanoid generation. Allergology International. 1997; 46:141-153.23.
12. Yu W and Xu L. Effect of acetylsalvianolic acid A on arachidonic acid metabolism in platelets. Acta Pharmaceutica Sinica. 1998; 33:62-63.
13. Stamatiou P, Hamid Q, Yu W, Rokach IJ, Khanapure SP, and Powell WS. 5-oxo-ETE induces pulmonary eosinophilia in an integrin-dependent manner in Brown Norway rat. Journal of Clinical Investigation. 1998; 102:2165-2172.
14. Yu W, Bozza PT, Tzizik D, Dvorak AM & Weller PF. Co-compartmentalization of MAP kinases and cytosolic phospholipase A2 at cytoplasmic lipid bodies. American Journal of Pathology. 1998; 152:759-769.
15. Bozza PT, Yu W, Casara J & Weller PF. Pathways for eosinophil lipid body induction: differing signal transduction in cells from normal and hypereosinophilic subjects. Journal of Leukocyte Biology. 1998; 64:563-569.
16. Weller PF, Bozza PT, Yu W & Dvorak AM. Cytoplasmic lipid bodies in eosinophils: central roles in eicosanoid generation. Int Arch Allergy Immunol. 1999; 118:450-452.
17. Yu W, Cassara J, and Weller PF. Localization of phosphotidylinositol-3-kinase (PI3K) to cytoplasmic lipid bodies of leukocytes. Blood. 2000;95: 1078-1085.
18. Yu W and Horowitz SH. Familial hemiplegic migraine and its abortive therapy with intravenous verapamil. Neurology. 2001; 57(9):1732-1733. doi: 10.1212/wnl.57.9.1732. PMID: 11706128.
19. Bozza PT, Pacheco P, Yu W, and Weller PF. NS-398: cyclooxygenase-2 independent inhibition of leukocyte priming for lipid body formation and enhanced leukotriene generation. Prostaglandins Leukot Essent Fatty Acids. 2002; 67:237-44.
20. Yu W and Horowitz SH. Treatment of sporadic hemiplegic migraine with calcium channel blocker verapamil. Neurology. 2003; 60(1):120-121. doi: 10.1212/01.wnl.0000042051.16284.70. PMID: 12525732.
21. Yu W, Binder D, Foster-Barber A, Malek R, Smith WS and Higashida RT. Endovascular embolectomy of acute basilar artery occlusion. Neurology. 2003; 61:1421-1423. doi: 10.1212/wnl.61.10.1421. PMID: 14638968.
22. Yu W and Horowitz SH. Treatment of sporadic hemiplegic migraine with verapamil, a calcium channel blocker. Review Series: Neurology. 2003; 3:22-23.
23. Yu W and Smith WS. Anticoagulation in acute stroke management: beyond anecdotal experience. Stroke Rounds 2004;2(4).
24. Horowitz SH, Spollen LE, and Yu W. Hereditary neuropathy with liability to pressure palsy: fulminant development with axonal loss during military training. Journal of Neurology, Neurosurgery and Psychiatry. 2004;75(11):1629-1631. doi:10.1136/jnnp.2003.029314. PMID: 15489403.
25. Yu W, Smith WS, Singh S, Ko N, Cullen SP, Dowd C, Halback V, Higashida RT. Long-term outcome of endovascular stenting for symptomatic basilar artery stenosis. Neurology. 2005; 64:1055-1057. (Highlighted on page 937).
26. McIntosh A, Hungs M, Kostanian V, and Yu W. Carotid artery dissection and MCA stroke following methamphetamine use. Neurology. 2006; 67:2259-2260. (American Academy of Neurology Press Release. December 26, 2006).
27. Stradling D, Yu W, Langdorf M, Tsai F, Kostanian V, Hasso AN, Welbourne SJ, Schooley Y, Fisher MJ, Cramer SC. Stroke care delivery before vs. after JCAHO stroke center. Neurology. 2007; 68:469-470.1012.
28. Yu W, Kostanian V, and Fisher MJ. Endovascular recanalization of basilar artery occlusion 80 days after symptom onset. Stroke. 2007; 38(4):1387-9. doi: 10.1161/01.STR.0000260186.93667.a2. PMID: 17322092.
29. Kostanian V, Mathews MS, Westhout FD, Yu W. Facial steal syndrome: identification and endovascular management. The Neuroradiology Journal 2007;20(1):85-88.
30. Yu W. Overview of Neurocritical Care in the United States. Chinese Journal of Stroke. 2008; 3(4): 242-245.
31. Raychaudhuri R, Yu W, Hatanpaa K, Cavuoti D, Pride GL, White J. Basilar Artery Dissection Treated by Neuroform Stenting: Fungal Stent Infection. Surgical Neurology. 2009;71(4):477-80.
32. Yu W, Rives J, Welch B, White J, Stehel E, and Samson D. Hypoplasia or occlusion of the ipsilateral cranial venous drainage is associated with early fatal edema of middle cerebral artery infarction. Stroke. 2009; 40(12):3736-3739. doi: 10.1161/STROKEAHA.109.563080. PMID: 19762692.
33. Beshay JE, Morgan H, Madden, Yu W, and Sarode R. Emergency reversal of anticoagulation and antiplatelet therapies in neurosurgical patients. Journal of Neurosurgery. 2010;112(2):307-18.
34. Jiang WJ, Yu W, Du B, Wong EHC, and Gao F. Wingspan experience at Beijing Tiantan Hospital: new insights into the mechanisms of procedural complication from viewing intraoperative transient ischemic attacks during awake stenting for vertebrobasilar stenosis. J NeuroIntervent Surg. 2010; 2:99-103.
35. Yu W. Stroke Patient’s Nutrition Support: Should Not Be Forgotten. Chinese Journal of Stroke. 2011; 6(09):680-683.
36. Yu W. Nutrition Support for ischemic stroke. Chinese Journal of Stroke. 2011;6 (09):717-717.
37. Jiang WJ, Yu W, Du B, Gao F, and Cui LY. Outcome of patients with ? 70% symptomatic intracranial stenosis after Wingspan stenting. Stroke. 2011; 42(2):1971-1975. doi: 10.1161/STROKEAHA.110.595926. PMID: 21636814.
38. Jiang WJ, Yu W, Ma N, Du B, Lou X, and Rasmussen PA. High resolution MRI guided endovascular intervention of basilar artery disease. J NeuroIntervent Surg. 2011; 3:375-378.
39. Jiang WJ and Yu W. Stenting for intracranial arterial stenosis. N Engl J Med. 2011; 365:2140-2141.
40. Yu W, Rickert K, Flores B, and Samson D. Infectious Mid Basilar Artery Aneurysm from Pseudomona Meningitis. J NeuroIntervent Surg. 2012;4(3): e10.
41. Chaudry P, Friedman D, and Yu W. Unilateral pupillary mydriasis from nebulized ipratropium bromide: A false sign of brain herniation in the intensive care unit. India Journal of Critical Care Medicine. 2014;18 (3):176-177.
42. Kostanian and Yu W. Successful Recanalization of Chronic Basilar Artery Occlusion. Neurological Cases. 2014; 1:1-3.
43. Yu W, Lee A and Welch B. Herpes Simplex Encephalitis Presents as large Temporal Lobe Hemorrhage. Neurological Cases. 2014; 1:12-15.
44. Kavi T, Moheet A, and Yu W. (2016). Empirical Treatment of West Nile Neuroinvasive Disease with IVIG. Neurological Cases. 2016; 1:12-15.
45. Lai TT, Lavian M, Al-Khoury L, Suzuki S, and Yu W. Case Report of Endovascular Therapy of Acute Basilar Artery Occlusion: Beyond the Restricted Time Window. Neurological Cases 2016; 3(2):1-4.
46. Dastur CK, Yu W. Current management of spontaneous intracerebral haemorrhage. Stroke Vasc Neurol. 2017; 2(1):21-29.00. PMID: 28959487.
47. Hong D, Stradling D, Dastur CD, Akbari Y, Groysman L, Al-Khoury L, Chen J, Small SL and Yu W. Resistant Hypertension after Hypertensive Intracerebral Hemorrhage Is Associated with More Medical Interventions and Longer Hospital Stays without Affecting Outcome. Front. Neurol. 8:184. doi: 10.3389/fneur.2017.00184. PMID 28515710.
48. Yu W, Kavi T, Majic TJ, Alva K, Moheet A, Lyden P, Schievink W, Lekovic G, Alexander MJ. Treatment modality and benchmarks of aneurysmal subarachnoid hemorrhage at a Comprehensive Stroke Center. Front. Neurol. 2018. https://doi.org/10.3389/fneur.2018.00152. PMID: 29599745.
49. Yu W, Jiang W. Stenting for intracranial stenosis: potential future for the prevention of disabling or fatal stroke. Stroke Vasc Neurol. 2018; svn-2018-000158. doi:10.1136/svn-2018-000158. PMID: 30294469.
50. Raychev RI, Stradling D, Patel N, Gee JR, Lombardi DL, Moon JL, Brown DM, Pathak P, Yu W, Stratton SJ, Cramer SC. Evolution of a U.S. County System for Acute Comprehensive Stroke Care. Stroke. 2018; 49:1217-1222. doi: 10.1161/STROKEAHA.118.020620. PMID: 29626136.
51. Chang PD, E. Kuoy, J. Grinband, B.D. Weinberg, M. Thompson, R. Homo, J. Chen, H. Abcede, M. Shafie, L. Sugrue, C.G. Filippi, M.-Y. Su, W. Yu, C. Hess and D. Chow. Hybrid 3D/2D Convolutional Neural Network for Hemorrhage Evaluation on Head CT. American Journal of Neuroradiology. July 2018, DOI: https://doi.org/10.3174/ajnr.A5742. PMID: 30049723.
52. Jiang WJ, Liu AF, Yu W, et al. Outcomes of Multimodality In situ Recanalization in Hybrid Operating Room (MIRHOR) for symptomatic chronic internal carotid artery occlusions. J Neurointerv Surg. 2019;11(8):825-832. doi:10.1136/neurintsurg-2018-014384. PMID: 30610071.
53. Bower MM, Sweidan AJ, Shafie M, Atallah S, Groysman LI, Yu W. Contemporary Reversal of Oral Anticoagulation in Intracerebral Hemorrhage. Stroke. 2019;50(2):529-536. doi:10.1161/STROKEAHA.118.023840. PMID: 30636573.
54. Alexander M, Zauner A, Chaloupka J, Baxter B, Callison R, Gupta R, Song S, and Yu W. WEAVE Trial Final Results in 152 On-Label Patients. Stroke. 2019; 50(4):889-894. doi: 10.1161/STROKEAHA.118.023996. PMID: 31125298.
55. Yu W, Jiang W. A Simple Imaging Guide for Endovascular Thrombectomy in Acute Ischemic Stroke: From Time Window to Perfusion Mismatch and Beyond. Front Neurol. 2019; 10:502. doi: 10.3389/fneur.2019.00502. PMID: 31178813.
56. Shreve L, Kaur A, Vo C, Wu J, Cassidy JM, Nguyen A, Zhou R, Tran TB, Yang DZ, Medizade AI, Chakravarthy B, Hoonpongsimanont W, Barton E, Yu W, Srinivasan R, and Cramer SC. Electroencephalography Measures are Useful for Identifying Large Acute Ischemic Stroke in the Emergency Department. J Stroke Cerebrovasc Dis. 2019. pii: S1052-3057(19)30252-6. doi: 10.1016/j.jstrokecerebrovasdis.2019.05.019. PMID: 31174955
57. Sweidan AJ, Bower MM, Paullus J, Sterpi M, Stern-Nezer S, Dastur C, Yu W, Groysman LI. Refractory Central Neurogenic Hyperventilation: A Novel Approach Utilizing Mechanical Dead Space. Front Neurol. 2019 Sept 4; 10:937. doi:10.3389/fneur.2019.00937. PMID: 31551906
58. Bower MM, Sweidan AJ, Xu JC, Stern-Nezer S, Yu W, Groysman LI. Quantitative Pupillometry in the Intensive Care Unit. J Intensive Care Med. 2019 Oct 10:885066619881124. doi: 10.1177/0885066619881124. PMID: 31601157.
59. Tran D, Zhu Z, Shafie M, Abcede H, Stradling D, Yu W. Three easily implementable changes reduce median door-to-needle time for intravenous thrombolysis by 23?minutes. BMC Neurol. 2019 Nov 26;19(1):300. doi: 10.1186/s12883-019-1527-8. PMID: 31771530
60. Sweidan AJ, Singh NK, Conovaloff JL, Bower M, Groysman L, Shafie M, Yu W. Coagulopathy reversal in intracerebral haemorrhage. Stroke Vasc Neurol. 2020 Feb 20; 5(1): 29–33. doi: 10.1136/svn-2019-000274. PMID: 32411405
61. Zhu Z, Yu W. Update in the treatment of extracranial atherosclerotic disease for stroke prevention. Stroke Vasc Neurol. 2020 Mar; 5(1): 65–70. doi: 10.1136/svn-2019-000261. PMID: 32411410
62. Liu A, Li C, Yu W, Lin LM, Qiu HC, Zhang YQ, Lv XL, Wang K, Liu C, Jiang WJ.
Dissection-related carotid-cavernous fistula (CCF) following surgical revascularization of chronic internal carotid artery occlusion: a new subtype of CCF and proposed management. Chin Neurosurg JI. 6, 2 (2020). https://doi.org/10.1186/s41016-019-0180-9.
63. Liu L, Yu W. Editorial: Multimodality Monitoring or Evaluation of Neuro-Function in Modern NICU. Front Neurol. 2020; 10:1423. doi: 10.3389/fneur.2019.01423. eCollection 2019. PMID: 32116994.
64. Liu S, Zheng H, Yu W, Ramakrishnan V, Shah S, Gonzalez LF, Singh I, Graffagnino C, Feng W. Investigation of S-Nitrosoglutathione in stroke: A systematic review and meta-analysis of literature in pre-clinical and clinical research. Exp Neurol. 2020; 328:113262. doi: 10.1016/j.expneurol. 202; 113262. PMID: 32119935
65. Sweidan AJ and Yu W (2020) Asymptomatic Chronic Ischemic Penumbra from Middle Cerebral Artery Occlusion: A Case Report and Literature Review. Ann Case Report. 2020 March;14: 337. DOI: 10.29011/2574-7754/100337.
66. Zhu Z, Osman S, Stradling D, Shafie M, Yu W. Clinical characteristics and outcomes of methamphetamine associated versus non methamphetamine intracerebral hemorrhage. Sci Rep. 2020 Apr 14;10(1):6375. doi: 10.1038/s41598-020-63480-z. PMID: 32286468.
67. Osman S, Golshani K, Yu W. Thrombosis of The Anterior Third of the Superior Sagittal Sinus Causing Unilateral Infarct in A Patient with Thrombocytosis and Thalassemia. Ann Case Report. 2020 March;14: 327. DOI: 10.29011/2574-7754/100327.
68. Zhu Z, Bower M, Stern-Nezer S, Atallah S, Stradling D, Groysman L, MD; Dastur CK, Akbari Y, and Yu W. Early initiation of oral antihypertensives reduces ICU stay and hospital cost in patients with intracerebral hemorrhage. Neurocrit Care. 2020 Apr 6. doi: 10.1007/s12028-020-00951-1. PMID: 32119935.
69. Alexander MJ, Zauner A, Gupta R, Alshekhlee A, Fraser JF, Toth G, Given C, Mackenzie L, Kott B, Hassan AE, Shownkeen H, Baxter BW, Callison RC, Yu W. The WOVEN trial: Wingspan One-year Vascular Events and Neurologic Outcomes. J Neurointerv Surg. 2020 Apr;13(4):307-310. doi: 10.1136/neurintsurg-2020-016208. PMID: 32561658.
70. Nagamine M, Chow DS, Chang PD, Boden-Albala B, Yu W and Soun JE. Impact of COVID-19 on Acute Stroke Presentation at a Comprehensive Stroke Center. Front. Neurol. 2020 Aug 14; 11:850. doi: 10.3389/fneur.2020.00850. PMID: 32922355
71. Anderson N, Janarious A, Liu S, Flanagan L, Stradling D, and Yu W. Language disparity is not a significant barrier for time-sensitive care of acute ischemic stroke. BMC Neurol. 2020 Oct 2; 20(1): 363. PMID: 33008325.
72. Osman S, Zhu Z, Farag M, Groysman M, Dastur CK, Akbari Y, Stern-Nezer SRJ, Stradling D, Yu W. Intracerebral hemorrhage: who gets tested for methamphetamines and why might it matter? BMC Neurol 2020 Oct 27;20: 392. https://doi.org/10.1186/s12883-020-01967-y. PMID: 33109106
73. Erani F, Zolotova N, Vanderschelden, Khoshab N, Sarian H, Nazarzai L, Wu J, Chakravarthy B, Hoonpongsimanont W, Yu W, Shahbaba B, Srinivasan R, Cramer SC. Electroencephalography Might Improve Diagnosis of Acute Stroke and Large Vessel Occlusion. Stroke. 2020 Nov; 51:00–00. DOI: 10.1161/STROKEAHA.120.030150. PMID: 32942967.
74. Soun JE, Chow DS, Nagamine M, Takhtawala RS, Filippi CG, Yu W, Chang PD. Artificial Intelligence and Acute Stroke Imaging. AJNR Am J Neuroradiol. 2020 Nov 26. doi: 10.3174/ajnr.A6883. Epub ahead of print. PMID: 33243898.
75. Shafie M and Yu W. Recanalization Therapy for Acute Ischemic Stroke with Large Vessel Occlusion: Where We Are and What Comes Next? Translational Stroke Research. 2021 Jan 6. doi: 10.1007/s12975-020-00879-w. Epub ahead of print. PMID: 33409732.
76. Gao B, Gu H, Yu W, Liu S, Zhou Q, Kang K, Zhang J, Li Z, Zhao X, Wang Y. Admission Dehydration Is Associated With Significantly Lower In-Hospital Mortality After Intracerebral Hemorrhage. Front Neurol. 2021 Mar 8;12:637001. doi: 10.3389/fneur.2021.637001. PMID: 33763017; PMCID: 7982572.
77. Liu S, Liu Y, Zhang J, Yu W, Zhao S. Recurrent Hemorrhagic Transformation of Cardioembolic Stroke in an Elderly Patient: A Case Report and Literature Review. J. Neuroscience and Neurological Surgery. 2021 May 10; 8(5); DOI:10.31579/2578-8868/183.
78. Shimeng Liu, Zhu Zhu, Mohammad Shafie, Hermelinda Abcede, Jay Shah, Shuichi Suzuki, Li-Mei Lin, Kiarash Golshani, Dana Stradling, Wengui Yu. Ongoing Improvement in Acute Ischemic Stroke Therapy Per Concurrent Guidelines and Easily Implementable Quality Improvement Protocol. J. Neuroscience and Neurological Surgery. 2021 May 27. 9(1); DOI:10.31579/2578-8868/184.
79. Sophia Angelides, Amit Chaudhari, Wengui Yu. Common Carotid Artery Thrombus in the Setting of COVID-19 Vasculopathy. J. Neuroscience and Neurological Surgery. 2021 June 7. DOI: https://doi.org/10.31579/2578-8868/190.
80. Li Q, Wang C, Li W, Zhang Z, Wang S, Wupuer A, Hu X, Wumaier K, Zhu Y, Li H, Yu W. A Novel Mutation in COL4A1 Gene in a Chinese Family with Pontine Autosomal Dominant Microangiopathy and Leukoencephalopathy. Transl Stroke Res. 2021 Aug 20. doi: 10.1007/s12975-021-00926-0. Epub ahead of print. PMID: 34415564.
81. Hosseini Farahabadi M, Milani-Nejad S, Liu S, Yu W and Shafie M (2021) Left Atrial Dilatation and Reduced Left Ventricular Ejection Fraction Are Associated With Cardioembolic Stroke. Front. Neurol. 2021 September 13. 12:680651. doi: 10.3389/fneur.2021.680651.
82. Jia B, Zhang X, Ma N, Mo D, Gao F, Sun X, Song L, Liu L, Deng Y, Xu X, Zhang Y, Liu Z, Guan S, Zhang F, Li B, Zheng H, Liu X, Liu Y, Chen K, Shuai J, Wan J, Wang J, Shi X, Li T, Chang B, Liebeskind DS, Yu W*, Miao Z;* NOVA Trial Investigators. Comparison of Drug-Eluting Stent With Bare-Metal Stent in Patients With Symptomatic High-grade Intracranial Atherosclerotic Stenosis: A Randomized Clinical Trial. JAMA Neurol. 2022 Jan 4:e214804. doi: 10.1001/jamaneurol.2021.4804. Epub ahead of print. PMID: 34982098; PMCID: PMC8728659.
83. Bower MM, Suzuki S, Golshani K, Lin LM, Shafie M, Abcede HG, Shah J, Stradling D, Yu W. Comparative Studies of Cerebral Reperfusion Injury in the Posterior and Anterior Circulations After Mechanical Thrombectomy. Transl Stroke Res. 2022 Jan 10. doi: 10.1007/s12975-021-00977-3. Epub ahead of print. PMID: 35006533.
84. Yu W, Higashida RT. Endovascular Thrombectomy for Acute Basilar Artery Occlusion: Latest Findings and Critical Thinking on Future Study Design. Transl Stroke Res. 2022 Mar 29. doi: 10.1007/s12975-022-01008-5. Epub ahead of print. PMID: 35349051.
85. Shah J, Liu S, Yu W. Contemporary antiplatelet therapy for secondary stroke prevention: a narrative review of current literature and guidelines. Stroke & Vascular Neurology 2022; April 3. doi:10.1136/svn-2021001166.
86. Angelides S, Chaudhari A, Khachatryan T, Yu W. Recurrent Ischemic Strokes in the Territory of Recurrent Artery of Heubner: Presenting in Relation to Facial Swelling and Weakness. J. Neuroscience and Neurological Surgery. 2022; April 11. DOI:10.31579/2578-8868/241.
87. Falcone JA, Lopez A, Stradling D, Yu W, Chen JW. Blood Pressure and Spot Sign in Spontaneous Supratentorial Subcortical Intracerebral Hemorrhage. Neurocrit Care. 2022 Aug;37(1):246-254. doi: 10.1007/s12028-022-01485-4. Epub 2022 Apr 20. PMID: 35445934; PMCID: PMC9283165.
88. Yu W. Vasospasm and Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage: Recent Advances and Future Directions in Translational Research. Transl Stroke Res. 2023 Apr;14(2):119-120. doi: 10.1007/s12975-022-01028-1. Epub 2022 May 2. PMID: 35501554.
89. Kuoy E, Glavis-Bloom J, Hovis G, Yep B, Biswas A, Masudathaya LA, Norrick LA, Limfueco J, Soun JE, Chang PD, Chu E, Akbari Y, Yaghmai V, Fox JC, Yu W, Chow DS. Point-of-Care Brain MRI: Preliminary Results from a Single-Center Retrospective Study. Radiology. 2022 Aug 2:211721. doi: 10.1148/radiol.211721. Epub ahead of print. PMID: 35916678.
90. Fote GM, Raefsky S, Mock K, Chaudhari A, Shafie M and Yu W. Intracranial Arterial Calcifications: Potential Biomarkers of Stroke Risk and Outcome. Front. Neurol. 2022 Sept 1, 13:900579. doi: 10.3389/fneur.2022.900579. PMID: 36119671; PMCID: PMC9475140.
91. Schlossman J, Ro D, Salehi S, Chow D, Yu W, Chang PD, Soun JE. Head-to-head comparison of commercial artificial intelligence solutions for detection of large vessel occlusion at a comprehensive stroke center. Front Neurol. 2022 Oct 10;13:1026609. doi: 10.3389/fneur.2022.1026609. PMID: 36299266; PMCID: PMC9588973.
92. Alexander MJ, Yu W; WEAVE Trial Investigators. Stenting Plus Medical Therapy and Risk of Stroke and Death in Patients With Symptomatic Intracranial Stenosis. JAMA. 2022 Dec 27;328(24):2456-2457. doi: 10.1001/jama.2022.18918. PMID: 36573984.
93. Dhar R, Yu W, Yenari M, Lee JM. Collateral Flow: Prolonging the Ischemic Penumbra. Transl Stroke Res. 2023 Feb;14(1):1-2. doi: 10.1007/s12975-023-01126-8. Epub 2023 Jan 10. PMID: 36626110.
94. Sun X, Yang M, Sun D, Peng G, Deng Y, Zhao X, Liu L, Ma N, Gao F, Mo D, Yu W, Wang Y, Wang Y, Miao Z. Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis (BASIS): protocol of a prospective, multicentre, randomised, controlled trial. Stroke Vasc Neurol. 2023 May 18:svn-2022-002288. doi: 10.1136/svn-2022-002288.
95. Soun JE, Zolyan A, McLouth J, Elstrott S, Nagamine M, Liang C, Dehkordi-Vakil FH, Chu E, Floriolli D, Kuoy E, Joseph J, Abi-Jaoudeh N, Chang PD, Yu W and Chow DS (2023) Impact of an automated large vessel occlusion detection tool on clinical workflow and patient outcomes. Front. Neurol. 2023 May 25;14:1179250. doi: 10.3389/fneur.2023.1179250. PMID: 37305764; PMCID: PMC10248058.
96. Zhu Z, Vanderschelden B, Lee SJ, Blackwill H, Shafie M, Soun JE, Chow D, Chang P, Stradling D, Qian T, Yu W. Methamphetamine use increases the risk of cerebral small vessel disease in young patients with acute ischemic stroke. Sci Rep. 2023 May 25;13(1):8494. doi: 10.1038/s41598-023-35788-z. PMID: 37231082.
97. Alexander MJ, Yu W. Intracranial atherosclerosis update for neurointerventionalists. Journal of NeuroInterventional Surgery. 2023 Jun 9:jnis-2022-019628. doi: 10.1136/jnis-2022-019628. Epub ahead of print. PMID: 37295944.
98. Khachatryan T, Shafie M, Abcede H, Shah J, Nagamine M, Granstein J, Yuki I, Golshani K, Suzuki S and Yu W Rescue therapy after thrombectomy for large vessel occlusion due to underlying atherosclerosis: review of literature. Front. Neurol. 2023 June 16; 14:1181295. doi: 10.3389/fneur.2023.1181295.
Professional Societies
American Academy of Neurology
Neurocritical Care Society
American Heart Association and American Stroke Association
American Neurological Association
Other Experience
Postdoctoral Fellowship
Harvard University 1994—1998
Harvard University 1994—1998
Neurology Residency
University of Missouri, Columbia 1998—2002
University of Missouri, Columbia 1998—2002
Neurocritical care Fellowship
UC San Francisco 2002—2004
UC San Francisco 2002—2004
Division Chief, Neurological Critical Care
University of Texas Southwestern Medical Center 2006—2012
University of Texas Southwestern Medical Center 2006—2012
Director, Neuroscience Intensive Care Unit
Cedars-Sinai Medical Center 2012—2014
Cedars-Sinai Medical Center 2012—2014
Link to this profile
https://faculty.uci.edu/profile/?facultyId=6127
https://faculty.uci.edu/profile/?facultyId=6127
Last updated
06/17/2023
06/17/2023