Michael A Yassa
Professor and James L. McGaugh Chair in the Neurobiology of Learning and Memory, Neurobiology and Behavior
School of Biological Sciences
School of Biological Sciences
Professor, Psychiatry & Human Behavior
School of Medicine
School of Medicine
Professor, Neurology
School of Medicine
School of Medicine
Professor, Psychological Science
School of Social Ecology
School of Social Ecology
Director, Center for the Neurobiology of Learning and Memory
Associate Dean of Diversity, Equity and Inclusion
School of Biological Sciences
School of Biological Sciences
Ph.D., University of California, Irvine, 2010, Neurobiology
B.A., Johns Hopkins University, 2002, Neuroscience
M.A., Johns Hopkins University, 2007, Psychological and Brain Sciences
B.A., Johns Hopkins University, 2002, Neuroscience
M.A., Johns Hopkins University, 2007, Psychological and Brain Sciences
University of California, Irvine
320 Qureshey Research Lab
Mail Code: 3800
Irvine, CA 92697
320 Qureshey Research Lab
Mail Code: 3800
Irvine, CA 92697
Research Interests
learning, memory, aging, alzheimer's disease, neuroimaging, depression, anxiety, hippocampus
Websites
Research Abstract
We strive to understand how brains can store and retrieve information and in using this knowledge to improve the human condition. We use cutting-edge human neuroscience tools to understand learning and memory in healthy and diseased brains. In particular, we are discovering ways in which our memory abilities change throughout the lifespan from childhood to older adulthood. We are developing approaches to diagnose and treat memory disorders in patients with progressive diseases like Alzheimer’s disease or mood disorders like depression. We also explore the impact of lifestyle factors like sleep, diet, and exercise on memory and cognition. Our toolkit is dynamic and diverse. It includes cross-species brain imaging as well as direct electrophysiological recordings from the brains of epilepsy patients before they undergo neurological surgery. We develop and refine cognitive assessment tools, with the goal of designing improved diagnostic and prognostic tests that can be used in community mental health settings. We are building new tools for high-resolution imaging and to explore the brain’s structure and function at fine levels of detail. We collaborate vigorously and widely with investigators across the globe and provide support to the community with open-source development and open data to facilitate team discovery science. Finally, we foster an inclusive research and training environment where our differences are valued, and our identities are embraced. We work together to dismantle all forms of systemic racism, bias, and discrimination on our campus and beyond.
Awards and Honors
2001 - Member, National Honor Society for Neuroscience (Nu Rho Psi)
2001 - Member, National Honor Society in Biology (Beta Beta Beta)
2001 - Member, National Honor Society in Psychology (Psi Chi)
2006 Graduate Research Fellowship Honorable Mention, National Science Foundation
2007 - 2010 Graduate Research Fellowship, National Science Foundation
2010 Fine Science Tools Travel Award in Neuroscience, University of California, Irvine
2010 Roger W. Russell Scholar’s Award in the Neurobiology of Learning & Memory
2010 Carl Cotman Scholar’s Award in the Neurobiology of Neurological Disorders
2011 Ossoff Scholars Award in Cognitive Disorders Research
2012 Distinguished Lectureship in Neuroscience and Aging, National Institute on Aging
2014 Eugene Williams Endowed Lectureship, St. Luke’s Hospital, Chesterfield, MO
2015 Excellence in Teaching Award, National Society for Leadership and Success
2015 Departmental Service Award, UCI Department of Neurobiology and Behavior
2016 Robert Newcomb Interdisciplinary Team Science Award – 90+ Study (Co-I)
2017 Frank Logan ‘Quad-L’ Early Career Award in Learning, Memory, and Cognition
2017 - 2020 Chancellor’s Fellow, University of California, Irvine
2018 Young Investigator Award, Cognitive Neuroscience Society
2018 Allen Edwards Endowed Lectureship, University of Washington
2018 Robert Newcomb Interdisciplinary Team Science Award – Conte Center (Co-I)
2018 Great Minds Series Inaugural Speaker, Board of Trustees, UC Irvine Foundation
2018 Eliot Stellar Endowed Lectureship in Neuroscience, University of Pennsylvania
2019 Robert Newcomb Interdisciplinary Team Science Award – BEACoN Group (PI)
2020 Service in Social Justice Award, UCI Department of Neurobiology and Behavior
2020 Inclusive Excellence Spirit Award, Office of Inclusive Excellence, UC Irvine
2001 - Member, National Honor Society in Biology (Beta Beta Beta)
2001 - Member, National Honor Society in Psychology (Psi Chi)
2006 Graduate Research Fellowship Honorable Mention, National Science Foundation
2007 - 2010 Graduate Research Fellowship, National Science Foundation
2010 Fine Science Tools Travel Award in Neuroscience, University of California, Irvine
2010 Roger W. Russell Scholar’s Award in the Neurobiology of Learning & Memory
2010 Carl Cotman Scholar’s Award in the Neurobiology of Neurological Disorders
2011 Ossoff Scholars Award in Cognitive Disorders Research
2012 Distinguished Lectureship in Neuroscience and Aging, National Institute on Aging
2014 Eugene Williams Endowed Lectureship, St. Luke’s Hospital, Chesterfield, MO
2015 Excellence in Teaching Award, National Society for Leadership and Success
2015 Departmental Service Award, UCI Department of Neurobiology and Behavior
2016 Robert Newcomb Interdisciplinary Team Science Award – 90+ Study (Co-I)
2017 Frank Logan ‘Quad-L’ Early Career Award in Learning, Memory, and Cognition
2017 - 2020 Chancellor’s Fellow, University of California, Irvine
2018 Young Investigator Award, Cognitive Neuroscience Society
2018 Allen Edwards Endowed Lectureship, University of Washington
2018 Robert Newcomb Interdisciplinary Team Science Award – Conte Center (Co-I)
2018 Great Minds Series Inaugural Speaker, Board of Trustees, UC Irvine Foundation
2018 Eliot Stellar Endowed Lectureship in Neuroscience, University of Pennsylvania
2019 Robert Newcomb Interdisciplinary Team Science Award – BEACoN Group (PI)
2020 Service in Social Justice Award, UCI Department of Neurobiology and Behavior
2020 Inclusive Excellence Spirit Award, Office of Inclusive Excellence, UC Irvine
Short Biography
Dr. Michael Yassa is a professor in the departments of Neurobiology and Behavior, Neurology, Psychiatry and Human Behavior, and Psychological Science at UCI. He currently serves as the Associate Dean of Diversity, Equity, and Inclusion in the School of Biological Sciences and has been the director of the world-renowned Center for the Neurobiology of Learning and Memory since 2016. His research focuses on how our brains encode and store information into memories and how memories are used to guide everyday decisions. His work particularly addresses how memories are disrupted in neurological and neuropsychiatric disease. Dr. Yassa received his bachelor’s and master’s degrees from the Johns Hopkins University and his PhD from the University of California, Irvine. He began his career as an assistant professor in the Department of Psychological and Brain Sciences at the Johns Hopkins University in 2010 and moved to the University of California Irvine in 2014. He has been awarded numerous research grants including from the National Science Foundation, National Institute on Aging, National Institute for Mental Health, and private foundations. He has authored over 100 research articles and his work is published in top tier journals. He has appeared on BBC World News, ABC News, CNN Health, NBC News and the PBS Newshour, and has been featured in numerous radio interviews and podcasts. Finally, Dr. Yassa has received multiple awards for research and teaching excellence and is a highly celebrated mentor. His lab fosters an inclusive research and training environment where different cultural identities are valued and embraced.
Publications
Assaf, M., Rivkin, P., Kuzu, C., Calhoun, V., Kraut, M., Groth, K., Yassa, M.A., Hart, J., Pearlson, G. (2005) Abnormal object-recall and anterior cingulate over-activation correlate with formal thought disorder in schizophrenia. Biological Psychiatry 59: 452-459.
Bassett, S., Kusevic, I., Cristinzio, C., Yassa, M.A., Avramopoulos, D., Yousem, D., Fallin, M. (2005) Brain activation in offspring of AD cases corresponds to 10q linkage. Annals of Neurology 58: 142-146.
Reading, S., Yassa, M.A., Dziorny, A., Gourley, L., Yallapragada, V., Rosenblatt, A., Margolis, R., Aylward, E., Brandt, J., Mori, S., van Zijl, P., Bassett, S., Ross, C. (2005) Regional white matter change in pre-symptomatic Huntington’s disease: a diffusion tensor imaging study. Psychiatry Research: Neuroimaging 140(1): 55-62.
Bassett, S., Yousem, D., Cristinzio, C., Kusevic, I., Yassa, M.A., Caffo, B., Zeger, S. (2006) Familial risk for Alzheimer’s disease alters fMRI activation patterns. Brain 129: 1229-1239.
Bazin, P.L., Cuzzocreo, J.L., Yassa, M.A., Gandler, W., McAuliffe, M.J., Bassett, S.S., Pham, D.L. (2007) Volumetric neuroimage analysis extensions for the MIPAV software package. Journal of Neuroscience Methods 165(1):111-21.
Yassa, M.A., Verduzco, G., Cristinzio C., Bassett, S. (2008) Altered fMRI activation during mental rotation in those at genetic risk for Alzheimer’s disease. Neurology 70(20):1898-904.
Yassa, M.A., Stark, C.E.L. (2008) Multiple Recognition-related signals in the medial temporal lobe. Hippocampus 18(9): 945-954.
Yassa, M.A., Stark, C.E.L. (2009) A quantitative evaluation of cross-participant alignment techniques for MRI studies of the medial temporal lobe. NeuroImage 44(2):319-327.
Cuzzocreo, J., Yassa, M.A., Verduzco, G., Honeycutt, N., Scott, D., Bassett, S. (2009) Effect of handedness on a verbal auditory memory fMRI task. Human Brain Mapping 30(4):1271-1278.
Yousem, D.M., Yassa, M.A., Cristinzio, C., Kusevic, I., Mohamed, M., Caffo, B.S., Bassett, S.S. (2009) Intelligence and medial temporal lobe function in older adults: A Functional MR Imaging-based investigation. American Journal of Neuroradiology 30(8):1477-81.
Bonekamp, D., Yassa, M.A., Munro, C. Geckle, R., Yousem, D., Barker, P.B., Schretlen, D.J., Brandt, J., Horska, (2009) A. Gray Matter in Amnestic Mild Cognitive Impairment: Voxel-based Morphometry. NeuroReport 21(4):259-63.
Gallagher, M., Bakker, A., Yassa, M.A., Stark, C.E.L. (2010) Bridging neurocognitive aging and disease modification: targeting functional mechanisms of impairment. Current Alzheimer’s Research 7, 197-199.
Yassa, M.A., Stark, S.M., Bakker, A., Albert, M.S., Gallagher, M., Stark, C.E.L. (2010) High-resolution functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic mild cognitive impairment. NeuroImage 51:1242-1252.
Yassa, M.A., Lacy, J.W., Stark, S.M., Albert, M.S., Gallagher, M., Stark, C.E.L. (2010-11) Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults. Hippocampus 21:968-979.
Stark, S.M., Yassa, M.A., Stark, C.E.L. (2010) Individual differences in spatial pattern separation performance associated with healthy aging in humans. Learning and Memory 17(6):284-8.
Yassa, M.A., Muftuler, L.T., Stark, C.E.L. (2010) Ultrahigh-resolution microstructural diffusion tensor imaging (msDTI) elucidates perforant path degradation in aged humans in vivo. Proceedings of the National Academy of Sciences U S A 107(28): 12687-91.
Lacy, J.W., Yassa, M.A., Stark, S.M., Stark, C.E.L. (2011) Distinct pattern separation related transfer functions in human CA3/dentate and CA1 revealed using high-resolution fMRI and variable mnemonic similarity. Learning and Memory 18(1):15-18.
Yassa, M.A., Mattfeld A.T., Stark, S.M., Stark, C.E.L. (2011) Age-related memory deficits linked to circuit-specific disruptions in the hippocampus. Proceedings of the National Academy of Sciences U S A 108(21):8873-8.
Yassa, M.A. (2011) Searching for novel biomarkers using high resolution diffusion tensor imaging. Journal of Alzheimer’s Disease 26:297-305.
Yassa, M.A., Stark, C.E.L. (2011) Pattern separation and the hippocampus. Trends in Neuroscience 34(10):515-525.
Segal, S., Stark, S.M., Kattan, D., Stark, C.E., Yassa, M.A. (2012) Norepineprhine-mediated emotional arousal facilitates subsequent pattern separation. Neurobiology of Learning and Memory 97(4): 465-469.
Bakker, A., Krauss, G., Albert, M.A., Speck, C.L., Jones, L.R., Stark, C.E., Yassa, M.A., Bassett, S.S., Shelton, A.L., Gallagher, M. (2012) Reducing hippocampal hyperactivity improves cognition in mild cognitive impairment. Neuron 74, 467-474.
Yassa, M.A., Hazlett, R.L., Stark, C.E., Hoehn-Saric, R. (2012) Functional MRI of the amygdala and bed nucleus of the stria terminalis during conditions of uncertainty in generalized anxiety disorder. Journal of Psychiatric Research 46(8):1045-1052.
Stark, S.M., Yassa, M.A., Lacy, J.W., Stark, C.E. (2013) A task to assess behavioral pattern separation (BPS) in humans: data from healthy aging and mild cognitive impairment. Neuropsychologia 51(12):2442-9.
Kim, J., Yassa, M.A. (2013) Assessing recollection and familiarity of similar lures in a behavioral pattern separation task. Hippocampus 23(4): 287–294.
Leal, S., Yassa, M.A. (2013) Perturbations of Neural Circuitry in Aging, Mild Cognitive Impairment, and Alzheimer’s Disease. Ageing Research Reviews 12(3):823-31.
Ly, M., Murray, E., Yassa, M.A. (2013) Perceptual versus conceptual interference and pattern separation of verbal stimuli in young and older adults. Hippocampus 23:425-430.
Schwab, E., Cetingul, E., Afsari, B., Yassa, M.A., Vidal, R. (2013) Rotation invariant features for HARDI. Information Processing in Medical Imaging - Lecture Notes in Computer Science 7917: 705-717. [peer-reviewed full-length conference paper]
Schurgin, M.W., Reagh, Z.M., Yassa, M.A., Flombaum, J.I. (2013) Spatiotemporal continuity alters long-term memory representations. Visual Cognition 21:6, 715-718.
Reagh, Z.M., Roberts, J.M., Ly, M., DiProspero, N., Murray, E., Yassa, M.A. (2013) Spatial discrimination deficits as a function of mnemonic interference in aged adults with and without memory impairment. Hippocampus 24(3):303–314.
Yassa, M.A., Reagh, Z.M. (2013) Competitive Trace Theory (CTT): A role for the hippocampus in contextual interference during retrieval. Frontiers in Behavioral Neuroscience 7:107.
Borota, D., Murray, E., Watabe, J., Keceli, G., Toscano, J. Yassa, M.A. (2014) Post-study caffeine administration enhances memory consolidation in humans. Nature Neuroscience 17:201–203.
Leal, S., Tighe, S., Yassa, M.A. (2014) Asymmetric effects of emotion on mnemonic interference. Neurobiology of Learning and Memory 111:41-48.
Reagh, Z.M., Yassa, M.A. (2014) Repetition strengthens target recognition but impairs similar lure discrimination: Evidence for trace competition. Learning and Memory 21: 342-346.
Leal, S.L., Tighe, S.K., Jones, C.J., Yassa, M.A. (2014) Pattern separation of emotional information in hippocampal dentate and CA3. Hippocampus 24(9): 1146-1155.
Roberts, J.M., Ly, M., Murray, E., Yassa, M.A. (2014) Temporal discrimination deficits as a function of lag interference in older adults. Hippocampus 24(10):1189-96.
Anderson, B.A., Leal, S.L., Hall, M.G., Yassa, M.A., Yantis, S. (2014) The attribution of value-based attentional priority in individuals with depressive symptoms. Cognitive, Affective, and Behavioral Neuroscience 14(4):1221-7.
Leal, S.L., Yassa, M.A. (2014) Effect of aging on mnemonic discrimination of emotional information. Behavioral Neuroscience 128(5):539-547.
Reagh, Z.M., Yassa, M.A. (2014) Object and spatial mnemonic interference differentially engage lateral and medial entorhinal cortex in humans. Proc Natl Acad Sci U S A 111(40):E4264-73.
Reagh, Z.M., Watabe, J., Ly, M., Murray, E., Yassa, M.A. (2014) Dissociated signals in human dentate gyrus and CA3 predict different facets of recognition memory. Journal of Neuroscience 34(40):13301-13.
Yushkevich, P.A., Amaral, R.S.C., Augustinack, J.C., Bender, A.R., Bernstein, J.D., Boccardi, M., Bocchetta, M., Burggren, A.C., Carr, V.A., Chakravarty, M.M., Chetelat, G., Daugherty, A., Davachi, L., Ding, S.L., Ekstrom, A., Geerlings, M.I., Hassan, A., Huang, YU., Iglesias, E., La Joie, R., Kerchner, G.A., LaRoque, K., Van Leemput, K., Libby, L.A., Malykhin, N., Mueller, S.G., Olsen, R.K., Palombo, D.J., Parekh, M., Pluta, J., Preston, A.R., Pruessner, J.C., Ranganath, C., Raz, N., Schlichting, M.L., Shoemaker, D., Singh, S., Stark, C.E.L., Suthana, N., Tompary A., Turowskiah, M.M., Wagner, A.D., Wang, L., Winterburn, J.L., Wisse, L.E.M., Yassa, M.A., Zeineh, M.M. for the Hippocampal Subfield Group (HSG) (2015). Quantitative comparison of 21 protocols for labeling hippocampal subfields and parahippocampal cortical subregions in in vivo MRI: initial steps towards a harmonized segmentation protocol. Neuroimage 111:526-41.
Chang, A., Murray, E. A., Yassa, M.A. (2015) Expertise and pattern separation: A potential mechanism for the “other race” effect. Behavioral Neuroscience 129(5):666-672.
Schwab, E., Yassa, M.A., Weiner, M., Vidal, R. (2015) HARDI feature selection, registration, and atlas building applied to Abeta pathology characterization. Medical Image Computing and Computer-Assisted Interventions (MICCAI). Mathematics and Visualization Series: Computational and Diffusion MRI 207-218.
Cunningham, C., Yassa, M.A., Egeth, H.E. (2015) Massive memory revisited: Limitations on storage capacity for object details in visual long-term memory. Learning and Memory. 22(11):563-6.
Leal, S.L., Yassa, M.A. (2015) Neurocognitive aging and the hippocampus across species. Trends in Neurosciences 38(12): 800–812.
Reagh, Z.M., Do, H., Noche, J., Murray, E.A., Leal, S.L., Chun, A., Yassa, M.A. (2016) Greater loss of object than spatial mnemonic discrimination in aged adults. Hippocampus 26(4):417-22.
Leal, S.L., Noche, J., Murray, E.A., Yassa, M.A. (2016) Positivity effect specific to older adults with subclinical memory impairment. Learning and Memory. 2016 Jul 15;23(8):415-21.
Leal, S.L., Noche, J.A., Murray, E.A., Yassa, M.A. (2016) Age-related individual variability in memory performance is associated with amygdala-hippocampal circuit function and emotional pattern separation. Neurobiology of Aging. 49:9-19.
Reagh, Z.M., Murray, E.A., Yassa, M.A. (2016) Repetition reveals ups and downs of hippocampal, thalamic, and neocortical engagement during mnemonic decisions. Hippocampus. 27(2):169-183.
Wisse, L.E.M., Daugherty A., Olsen, R.K., Berron, D., Carr, V., Stark, C.E.L., Amaral, R., Amunts, K., Augustinack,J.C., Bender, A.R., Bernstein, J.D., Boccardi,M., Bocchetta, M., Burggren, A., Chakravarty, M.M., Chupin, M., Ekstrom, A., de Flores, R., Insausti,R., Kanel, P., Kedo, O., Kennedy,K., Kerchner, G.A., LaRocque, K., Liu, X., Maass, A., Malykhin, M., Mueller, S., Ofen, N., Palombo, D.J., Parekh, M., Pluta, J.B., Pruessner, J., Raz, N., Rodrigue, K., Schoemaker, D., Shafer, A.T., Steve, T., Suthana, N., Wang, L., Winterburn, J.L., Yassa, M.A., Yushkevich, P., la Joie, R., for the Hippocampal Subfield Group (HSG) (2016) A harmonized segmentation protocol for hippocampal and parahippocampal subregions: why do we need one and what are the key goals? Hippocampus. 27(1)3-11.
Suwabe, K., Hyodo, K., Byun, K.H., Ochi, G., Yassa, M.A., Soya, H. (2017) Acute moderate exercise improves mnemonic discrimination in young adults. Hippocampus. 27(3):229-234.
Zheng, J., Anderson, K.L., Leal, S.L., Shestyuk, A., Gulsen, G., Mnatsakanyan, L., Vadera, S., Yassa, M.A., Hsu, F.P., Knight, R.T., Lin, J.J. (2017) Amygdala-hippocampal dynamics during salient information processing. Nature Communications. 8:14413.
Snigdha, S., Yassa, M.A., Rivera C., Milgram, N.W., Cotman, C.W. Pattern separation and goal directed behavior in the aged canine. Learning and Memory. In press.
Leal, S.L., Noche, J.A., Murray, E.A., Yassa, M.A. (2017) Disruption of amygdala-entorhinal-hippocampal network in late-life depression. Hippocampus. 27(4):464-476
Suwabe, K., Hyodo, K., Byun, K.H., Ochi, G., Fukui, T., Shimizu, T., Kato, M., Yassa, M.A., Soya, H. (2017) Aerobic fitness associates with mnemonic discrimination as a mediator of physical activity effects: Evidence for memory flexibility in young adults. Scientific Reports. 7:5140.
Stark, S., Reagh, Z.M., Yassa, M.A.*, Stark, C.E.* (2017-2018) What’s in a Context? Cautions, limitations, and potential paths forward. Neuroscience Letters 680:77-87. *Co-corresponding authors.
Kraguljac, N., Carle, M., Frölich, M., Tran, S., Yassa, M.A., White, D.M., Reddy, A., Lahti, A.C. (2017) Mnemonic Discrimination Deficits in First-Episode Psychosis and a Ketamine Model Suggests Dentate Gyrus Pathology Linked to N-Methyl-D-Aspartate Receptor Hypofunction. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 3(3):231-238.
Reagh, Z.M., Yassa, M.A. (2017) Selective vulnerabilities and biomarkers in neurocognitive aging. F1000 Reviews 6:491.
Leal, S.L., Yassa, M.A. (2018) Integrating new findings and examining clinical applications of pattern separation. Nature Neuroscience 21(2):163-173.
Reagh, Z.M., Noche, J.A., Tustison, N., Delisle, D., Murray, E.A., Yassa, M.A. (2018) Functional Imbalance of Anterolateral Entorhinal Cortex and Hippocampal Dentate/CA3 Underlies Age-Related Object Pattern Separation Deficits. Neuron 97, 1187-1198.
Yassa, M.A. (2018) Brain rhythms: Higher frequency theta oscillations make sense in moving humans. Current Biology 28, R70-72.
Risbrough VB, Glynn LM, Davis EP, Sandman CA, Obenaus A, Stern HS, Keator DB, Yassa MA, Baram TZ, Baker DG (2018). Does Anhedonia Presage Increased Risk of Posttraumatic Stress Disorder? Adolescent Anhedonia and Posttraumatic Disorders. Curr Top Behav Neurosci 38:249-265.
Sinha, N., Berg, C., Tustison, N., Shaw, A., Hill, D., Yassa, M.A., Gluck, M.A. (2018) APOE e4 Status in Healthy Older African Americans is Associated with Deficits in Pattern Separation and Hippocampal Hyperactivation. Neurobiology of Aging 69, 221-229.
Stevenson, R., Zheng, J., Mnatsakanyan, L., Vadera, S., Knight, R., Lin, J.J.*, Yassa, M.A.* (2018) Hippocampal CA1 gamma power predicts the precision of spatial memory judgments. Proceedings of the National Academy of Science U S A 115(40):10148-10153. *Co-corresponding authors.
Sinha N, Reagh ZM, Tustison NJ, Berg CN, Shaw A, Myers CE, Hill D, Yassa MA, Gluck MA (2018). ABCA7 Risk Variant in Healthy Older African Americans is Associated with a Functionally Isolated Entorhinal Cortex Mediating Deficient Generalization of Prior Discrimination Training. Hippocampus 29(6):527-538.
Suwabe, K., Byun, K.H., Hyodo, K., Reagh, Z.M., Roberts, J.M., Matsushita, A., Soatome, K., Ochi, G., Fukuiem T., Suzuki, K., Sankai, Y., Yassa, M.A.*, Soya, H.* (2018) Rapid stimulation of human dentate gyrus function with acute mild exercise. Proceedings of the National Academy of Science U S A 115(41):10487-10492. *Co-corresponding authors.
Cunningham, T.J., Leal, S.L., Yassa, M.A., Payne, J.D. (2018) Post-encoding stress enhances mnemonic discrimination of negative stimuli. Learning and Memory 25(12):611-619.
Suwabe, K., Byun, K.H., Hyodo, K., Reagh, Z.M., Roberts, J.M., Matsushita, A., Soatome, K., Ochi, G., Fukuiem T., Suzuki, K., Sankai, Y., Yassa, M.A.*, Soya, H.* (2018) Reply to Gronwald et al: Exercise intensity does indeed matter! VO2max is the gold standard indicator. Proceedings of the National Academy of Science U S A 115(51):E11892-E11893. *Co-corresponding authors.
Montchal, M., Reagh, Z.M., Yassa, M.A. (2019) Temporal memory is supported by the anterolateral entorhinal cortex in humans. Nature Neuroscience 22(2):284-288.
Brown, E.S., Sayed, N., Choi, C., Tustison, N., Roberts, J., Yassa, M.A., Van Enkevort, E., Nakamura, A., Ivleva, E.I., Sunderajan, P., Khan, D.A., Vazquez, M., McEwen, B., Kulikova, A., Frol, A.B., Holmes, T. (2019) A randomized, double-blind, placebo-controlled trial of lamotrigine for prescription corticosteroid effects on the human hippocampus. European Journal of Neuropsychopharmacology 29(3):376-383.
Zheng, J., Stevenson, R.F., Mander, B.A., Mnatsakanyan, L., Hsu, F.P.K., Vadera, S., Knight, R.T., Yassa M.A.*, Lin, J.J.* (2019) Multiplexing of Theta and Alpha Rhythms in the Amygdala-Hippocampal Circuit Supports Pattern Separation of Emotional Information. Neuron 102(4):887-898.e5. *Co-corresponding authors.
Márquez, F., Yassa, M.A. (2019) Neuroimaging biomarkers for Alzheimer’s disease. Molecular Neurodegeneration 14(1):21.
Tustison, N.J., Holbrook, A.J., Avants, B.B., Roberts, J.M., Cook, P.A., Reagh, Z.M., Stone, J.R., Gillen, D.L., Yassa, M.A. (2019) Longitudinal mapping of cortical thickness measurements: an ADNI-based evaluation study. Journal of Alzheimer’s Disease 71(1):165-183.
Brown, E.S., Kulikova, A., Enkevort, E.V., Nakamura A., Ivleva, E.I., Tustison N.J., Roberts, J., Yassa, M.A., Choi, C., Frol A., Khan D.A., Vazquez M., Holmes, T., Malone K. (2019) A randomized trial of an NMDA receptor antagonist for reversing corticosteroid effects on the human hippocampus. Neuropsychopharmacology 44(13):2263-2267.
Yassa, M.O., Yassa, M.A. (2019) Special Issue on the International Conference on Learning and Memory. Learning and Memory 26(7):i.
Stevenson, R., Reagh, Z., Yassa, M.A. (2019) Pattern separation and source memory engage distinct hippocampal and neocortical regions during retrieval. Journal of Neuroscience 40(4):843-851.
Brown, E.S., Nguyen D., Yassa, M.A., Tustison, N., Roberts, J., Kulikova, A., Nakamura, A., Ivleva, E., Van Enkevort, Kulikova, A., Enkevort, E.V. (2019) The relationship between cumulative exogenous corticosteroid exposure and volumes of hippocampal subfields and surrounding structures. Journal of Clinical Psychopharmacology 39(6):653-657.
Yaros, J., Salama, D., Delisle, D., Larson, M., Miranda, B., Yassa, M.A. (2019) A Memory Computational Basis for the Other-Race Effect. Scientific Reports 18;9(1):19399.
Riphagen, J.M., Schmiedek, L., Gronenschild, E.H.B.M., Yassa, M.A., Priovoulos N., Sack, A.T., Verhey, F.R.J., Jacobs, H.I.L. (2020) Associations between pattern separation and hippocampal subfield structure and function vary along the lifespan: A 7 T imaging study. Scientific Reports 10(1), 1-13.
Holbrook, A., Tustison, N., Márquez, F., Roberts, J., Reagh, Z., Stone, J., Yassa, M.A. Gillen, D. (2020) Anterolateral Entorhinal Cortex Thickness as a Biomarker for Early Detection of Alzheimer’s Disease. Alzheimer’s and Dementia 12(1):e12068. doi: 10.1002/dad2.12068.
Rosas, H.D., Hsu, E., Mercaldo, N., Lai, F., Pulsifer, M., Keator, D.B., Brickman, A.M., Price, J., Yassa, M.A., Hom, C., Krinsky-McHale, S.J., Silverman, W., Lott, I., Schupf, N. (2020) Alzheimer-related altered white matter microstructural integrity in Down syndrome: A model for sporadic AD? Alzheimer’s and Dementia 7;12(1):e12040.
Lao, P.J., Gutierrez, J., Keator, D.B., Banerjee, A., Igwe, K.C., Liang, K.L., Rizvi, B., Sathishkumar, M., Moni, F., Andrews, H., Krinsky-McHale, Head, E., Lee, J., Lai, L., Yassa, M.A., Rosas, H.D., Silverman, W., Lott, I.T., Schupf, N., Brickman, A. (2020) Alzheimer-Related Cerebrovascular Disease in Down Syndrome. Annals of Neurology 88(6):1165-1177.
Keator, D., Doran, E., Taylor, L., Phelan, M., Hom, C., Tseung, K., van Erp, T, Potkin, S., Brickman, A.M., Rosas, D.H., Yassa, M.A., Silverman, W., Lott, I. (2020) Brain amyloid and the transition to dementia in Down syndrome. Alzheimer’s and Dementia 12(1):e12126.
Sinha, N., Berg, C.N., Yassa, M.A., Gluck, M.A. (2020) Increased Dynamic Reconfiguration in Medial Temporal Lobe Network Following Exercise Intervention Mediates Flexible Generalization of Learning. Neurobiology of Learning and Memory 177:107340.
Granger, S.J., Glynn, L.M., Sandman, C.A., Small, S.L., Keator, D.B., Baram, T.Z., Stern, H., Yassa, M.A.*, Davis, E.P.* (2020) Accelerated Maturation of the Uncinate Fasciculus after Early-Life Unpredictable Patterns of Maternal Signals. *Co-corresponding. J Neurosci 41(6):1242-1250.
Granger, S.J., Leal, S.L., Janecek, J., McMillan, L., Stern, H., Yassa, M.A. (2020) Integrity of the Uncinate Fasciculus Predicts Emotional Pattern Separation-Related fMRI Signals in the Hippocampal Dentate and CA3. Neurobiology of Learning and Memory 177:107359.
Papp, K., Rentz. D.M., Maruff, P., Sun, C.K., Raman, R., Donohue, M., Schembri, A., Stark, C.E., Yassa, M.A., Wessels, A., Yaari, R., Holdridge, K., Aisen, P., Sperling, R. (2021) The computerized cognitive composite (C3) in an Alzheimer’s disease secondary prevention trial. The Journal of Prevention of Alzheimer’s Disease 80(1):59-67.
Suthana, N., Ekstrom, A., Yassa, M.A., Stark, C.E. (2021) Pattern separation in the human hippocampus: Response to Quiroga (2020). Trends in Cognitive Sciences. In press.
Pagen, L., Smeets, T., Muller-Ehrenberg, L., Yassa, M.A., Verhey, F., Jacobs, H. (2021) Pilot Study: Elevated noradrenaline levels are related to diminished practice effects in memory. Journal of Alzheimer’s Disease. 80(4): 1675-1685.
Memel, M., Saffaroni, A., Cobigo, Y., Casaletto, K., Bettcher, B., Yassa, M.A., Elahi, F., Wolf, A., Rosen, H., Kramer, J. (2021) APOE moderates the effect of hippocampal blood flow on memory pattern separation in clinically normal older adults. Hippocampus. In Press. 10.1002/hipo.23327.
Tustison, N.J., Cook, P.A., Holbrook, A.J., Johnson, H.J., Muschelli, J., Devanyi, G.A., Duda, J.T., Das, S., Cullen, N.C., Gillen, D.L., Yassa, M.A., Stone, J.R., Gee, J.C., Avants, B.B. for the Alzheimer’s Disease Neuroimaging Initiative. (2021) ANTsX: A dynamic ecosystem for quantitative biological and medical imaging. Scientific Reports 11: 9068.
Kark, S.M., Birnie, M.T., Baram, T.Z., Yassa, M.A. (2021) Functional connectivity of the human paraventricular thalamic nucleus: insights from high field functional MRI. Frontiers in Integrative Neuroscience. 10.3389/fnint.2021.662293
Chappel-Farley, M., Mander, B.A., Nan, B., Grill, J., Yassa, M.A.*, Benca, R.* Sleep mediates the effects of exercise frequency on subjective cognitive complaints in cognitively healthy adults with heightened Alzheimer’s disease risk. * Co-Corresponding Authors. Sleep. Accepted.
Damrongthai, C., Kuwamizu, R., Suwabe, K., Ochi, G., Yamazaki, Y., Fukuie, T., Adachi, K., Yassa, M.A., Churdchomjan, W., Soya, H. Running boosts mood and executive function coinciding with bilateral prefrontal activation: An fNIRS study. Scientific Reports. Accepted.
DiProspero, N.D., Phelan, M., Janecek, J., Keator, D.B., van Erp, T.G.M., Doran, E., Lott, I., Yassa, M.A. Reduced long-range default mode connectivity predicts conversion to Alzheimer's disease in older individuals with Down syndrome. Journal of Alzheimer’s Disease. Accepted.
Wendel, K.M., Short, A.K., Noarbe, B., Haddad, E., Palma, A., Yassa, M.A., Baram, T.Z., Obenaus, A. Early Life Adversity in Male Mice Sculpts Reward Circuits. Neurobiology of Stress. Accepted.
Jutten, R.J., Rentz, D.M., Fu, J.F., Mayblyum, D.V., Amariglio, R.E., Buckley, R.F., Properzi, M.J., Maruff, P.T., Stark, C.E., Yassa, M.A., Johnson, K.A., Sperling, R.A., Papp, K.V. Monthly at-home computerized cognitive testing to detect diminished practice effects in preclinical Alzheimer’s disease. Frontiers in Aging Neuroscience. Accepted.
Granger, S.J., Adams, J.G., Kark, S.M., Sathishkumar, M., Chen, I.Y., McMillan, L., Janecek, J., Benca, R.M., Yassa, M.A. Latent Anxiety in Clinical Depression is Related to Impaired Target Recognition of Negative Items in an Emotional Pattern Separation Task. Journal of Affective Disorders. Accepted.
Bassett, S., Kusevic, I., Cristinzio, C., Yassa, M.A., Avramopoulos, D., Yousem, D., Fallin, M. (2005) Brain activation in offspring of AD cases corresponds to 10q linkage. Annals of Neurology 58: 142-146.
Reading, S., Yassa, M.A., Dziorny, A., Gourley, L., Yallapragada, V., Rosenblatt, A., Margolis, R., Aylward, E., Brandt, J., Mori, S., van Zijl, P., Bassett, S., Ross, C. (2005) Regional white matter change in pre-symptomatic Huntington’s disease: a diffusion tensor imaging study. Psychiatry Research: Neuroimaging 140(1): 55-62.
Bassett, S., Yousem, D., Cristinzio, C., Kusevic, I., Yassa, M.A., Caffo, B., Zeger, S. (2006) Familial risk for Alzheimer’s disease alters fMRI activation patterns. Brain 129: 1229-1239.
Bazin, P.L., Cuzzocreo, J.L., Yassa, M.A., Gandler, W., McAuliffe, M.J., Bassett, S.S., Pham, D.L. (2007) Volumetric neuroimage analysis extensions for the MIPAV software package. Journal of Neuroscience Methods 165(1):111-21.
Yassa, M.A., Verduzco, G., Cristinzio C., Bassett, S. (2008) Altered fMRI activation during mental rotation in those at genetic risk for Alzheimer’s disease. Neurology 70(20):1898-904.
Yassa, M.A., Stark, C.E.L. (2008) Multiple Recognition-related signals in the medial temporal lobe. Hippocampus 18(9): 945-954.
Yassa, M.A., Stark, C.E.L. (2009) A quantitative evaluation of cross-participant alignment techniques for MRI studies of the medial temporal lobe. NeuroImage 44(2):319-327.
Cuzzocreo, J., Yassa, M.A., Verduzco, G., Honeycutt, N., Scott, D., Bassett, S. (2009) Effect of handedness on a verbal auditory memory fMRI task. Human Brain Mapping 30(4):1271-1278.
Yousem, D.M., Yassa, M.A., Cristinzio, C., Kusevic, I., Mohamed, M., Caffo, B.S., Bassett, S.S. (2009) Intelligence and medial temporal lobe function in older adults: A Functional MR Imaging-based investigation. American Journal of Neuroradiology 30(8):1477-81.
Bonekamp, D., Yassa, M.A., Munro, C. Geckle, R., Yousem, D., Barker, P.B., Schretlen, D.J., Brandt, J., Horska, (2009) A. Gray Matter in Amnestic Mild Cognitive Impairment: Voxel-based Morphometry. NeuroReport 21(4):259-63.
Gallagher, M., Bakker, A., Yassa, M.A., Stark, C.E.L. (2010) Bridging neurocognitive aging and disease modification: targeting functional mechanisms of impairment. Current Alzheimer’s Research 7, 197-199.
Yassa, M.A., Stark, S.M., Bakker, A., Albert, M.S., Gallagher, M., Stark, C.E.L. (2010) High-resolution functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic mild cognitive impairment. NeuroImage 51:1242-1252.
Yassa, M.A., Lacy, J.W., Stark, S.M., Albert, M.S., Gallagher, M., Stark, C.E.L. (2010-11) Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults. Hippocampus 21:968-979.
Stark, S.M., Yassa, M.A., Stark, C.E.L. (2010) Individual differences in spatial pattern separation performance associated with healthy aging in humans. Learning and Memory 17(6):284-8.
Yassa, M.A., Muftuler, L.T., Stark, C.E.L. (2010) Ultrahigh-resolution microstructural diffusion tensor imaging (msDTI) elucidates perforant path degradation in aged humans in vivo. Proceedings of the National Academy of Sciences U S A 107(28): 12687-91.
Lacy, J.W., Yassa, M.A., Stark, S.M., Stark, C.E.L. (2011) Distinct pattern separation related transfer functions in human CA3/dentate and CA1 revealed using high-resolution fMRI and variable mnemonic similarity. Learning and Memory 18(1):15-18.
Yassa, M.A., Mattfeld A.T., Stark, S.M., Stark, C.E.L. (2011) Age-related memory deficits linked to circuit-specific disruptions in the hippocampus. Proceedings of the National Academy of Sciences U S A 108(21):8873-8.
Yassa, M.A. (2011) Searching for novel biomarkers using high resolution diffusion tensor imaging. Journal of Alzheimer’s Disease 26:297-305.
Yassa, M.A., Stark, C.E.L. (2011) Pattern separation and the hippocampus. Trends in Neuroscience 34(10):515-525.
Segal, S., Stark, S.M., Kattan, D., Stark, C.E., Yassa, M.A. (2012) Norepineprhine-mediated emotional arousal facilitates subsequent pattern separation. Neurobiology of Learning and Memory 97(4): 465-469.
Bakker, A., Krauss, G., Albert, M.A., Speck, C.L., Jones, L.R., Stark, C.E., Yassa, M.A., Bassett, S.S., Shelton, A.L., Gallagher, M. (2012) Reducing hippocampal hyperactivity improves cognition in mild cognitive impairment. Neuron 74, 467-474.
Yassa, M.A., Hazlett, R.L., Stark, C.E., Hoehn-Saric, R. (2012) Functional MRI of the amygdala and bed nucleus of the stria terminalis during conditions of uncertainty in generalized anxiety disorder. Journal of Psychiatric Research 46(8):1045-1052.
Stark, S.M., Yassa, M.A., Lacy, J.W., Stark, C.E. (2013) A task to assess behavioral pattern separation (BPS) in humans: data from healthy aging and mild cognitive impairment. Neuropsychologia 51(12):2442-9.
Kim, J., Yassa, M.A. (2013) Assessing recollection and familiarity of similar lures in a behavioral pattern separation task. Hippocampus 23(4): 287–294.
Leal, S., Yassa, M.A. (2013) Perturbations of Neural Circuitry in Aging, Mild Cognitive Impairment, and Alzheimer’s Disease. Ageing Research Reviews 12(3):823-31.
Ly, M., Murray, E., Yassa, M.A. (2013) Perceptual versus conceptual interference and pattern separation of verbal stimuli in young and older adults. Hippocampus 23:425-430.
Schwab, E., Cetingul, E., Afsari, B., Yassa, M.A., Vidal, R. (2013) Rotation invariant features for HARDI. Information Processing in Medical Imaging - Lecture Notes in Computer Science 7917: 705-717. [peer-reviewed full-length conference paper]
Schurgin, M.W., Reagh, Z.M., Yassa, M.A., Flombaum, J.I. (2013) Spatiotemporal continuity alters long-term memory representations. Visual Cognition 21:6, 715-718.
Reagh, Z.M., Roberts, J.M., Ly, M., DiProspero, N., Murray, E., Yassa, M.A. (2013) Spatial discrimination deficits as a function of mnemonic interference in aged adults with and without memory impairment. Hippocampus 24(3):303–314.
Yassa, M.A., Reagh, Z.M. (2013) Competitive Trace Theory (CTT): A role for the hippocampus in contextual interference during retrieval. Frontiers in Behavioral Neuroscience 7:107.
Borota, D., Murray, E., Watabe, J., Keceli, G., Toscano, J. Yassa, M.A. (2014) Post-study caffeine administration enhances memory consolidation in humans. Nature Neuroscience 17:201–203.
Leal, S., Tighe, S., Yassa, M.A. (2014) Asymmetric effects of emotion on mnemonic interference. Neurobiology of Learning and Memory 111:41-48.
Reagh, Z.M., Yassa, M.A. (2014) Repetition strengthens target recognition but impairs similar lure discrimination: Evidence for trace competition. Learning and Memory 21: 342-346.
Leal, S.L., Tighe, S.K., Jones, C.J., Yassa, M.A. (2014) Pattern separation of emotional information in hippocampal dentate and CA3. Hippocampus 24(9): 1146-1155.
Roberts, J.M., Ly, M., Murray, E., Yassa, M.A. (2014) Temporal discrimination deficits as a function of lag interference in older adults. Hippocampus 24(10):1189-96.
Anderson, B.A., Leal, S.L., Hall, M.G., Yassa, M.A., Yantis, S. (2014) The attribution of value-based attentional priority in individuals with depressive symptoms. Cognitive, Affective, and Behavioral Neuroscience 14(4):1221-7.
Leal, S.L., Yassa, M.A. (2014) Effect of aging on mnemonic discrimination of emotional information. Behavioral Neuroscience 128(5):539-547.
Reagh, Z.M., Yassa, M.A. (2014) Object and spatial mnemonic interference differentially engage lateral and medial entorhinal cortex in humans. Proc Natl Acad Sci U S A 111(40):E4264-73.
Reagh, Z.M., Watabe, J., Ly, M., Murray, E., Yassa, M.A. (2014) Dissociated signals in human dentate gyrus and CA3 predict different facets of recognition memory. Journal of Neuroscience 34(40):13301-13.
Yushkevich, P.A., Amaral, R.S.C., Augustinack, J.C., Bender, A.R., Bernstein, J.D., Boccardi, M., Bocchetta, M., Burggren, A.C., Carr, V.A., Chakravarty, M.M., Chetelat, G., Daugherty, A., Davachi, L., Ding, S.L., Ekstrom, A., Geerlings, M.I., Hassan, A., Huang, YU., Iglesias, E., La Joie, R., Kerchner, G.A., LaRoque, K., Van Leemput, K., Libby, L.A., Malykhin, N., Mueller, S.G., Olsen, R.K., Palombo, D.J., Parekh, M., Pluta, J., Preston, A.R., Pruessner, J.C., Ranganath, C., Raz, N., Schlichting, M.L., Shoemaker, D., Singh, S., Stark, C.E.L., Suthana, N., Tompary A., Turowskiah, M.M., Wagner, A.D., Wang, L., Winterburn, J.L., Wisse, L.E.M., Yassa, M.A., Zeineh, M.M. for the Hippocampal Subfield Group (HSG) (2015). Quantitative comparison of 21 protocols for labeling hippocampal subfields and parahippocampal cortical subregions in in vivo MRI: initial steps towards a harmonized segmentation protocol. Neuroimage 111:526-41.
Chang, A., Murray, E. A., Yassa, M.A. (2015) Expertise and pattern separation: A potential mechanism for the “other race” effect. Behavioral Neuroscience 129(5):666-672.
Schwab, E., Yassa, M.A., Weiner, M., Vidal, R. (2015) HARDI feature selection, registration, and atlas building applied to Abeta pathology characterization. Medical Image Computing and Computer-Assisted Interventions (MICCAI). Mathematics and Visualization Series: Computational and Diffusion MRI 207-218.
Cunningham, C., Yassa, M.A., Egeth, H.E. (2015) Massive memory revisited: Limitations on storage capacity for object details in visual long-term memory. Learning and Memory. 22(11):563-6.
Leal, S.L., Yassa, M.A. (2015) Neurocognitive aging and the hippocampus across species. Trends in Neurosciences 38(12): 800–812.
Reagh, Z.M., Do, H., Noche, J., Murray, E.A., Leal, S.L., Chun, A., Yassa, M.A. (2016) Greater loss of object than spatial mnemonic discrimination in aged adults. Hippocampus 26(4):417-22.
Leal, S.L., Noche, J., Murray, E.A., Yassa, M.A. (2016) Positivity effect specific to older adults with subclinical memory impairment. Learning and Memory. 2016 Jul 15;23(8):415-21.
Leal, S.L., Noche, J.A., Murray, E.A., Yassa, M.A. (2016) Age-related individual variability in memory performance is associated with amygdala-hippocampal circuit function and emotional pattern separation. Neurobiology of Aging. 49:9-19.
Reagh, Z.M., Murray, E.A., Yassa, M.A. (2016) Repetition reveals ups and downs of hippocampal, thalamic, and neocortical engagement during mnemonic decisions. Hippocampus. 27(2):169-183.
Wisse, L.E.M., Daugherty A., Olsen, R.K., Berron, D., Carr, V., Stark, C.E.L., Amaral, R., Amunts, K., Augustinack,J.C., Bender, A.R., Bernstein, J.D., Boccardi,M., Bocchetta, M., Burggren, A., Chakravarty, M.M., Chupin, M., Ekstrom, A., de Flores, R., Insausti,R., Kanel, P., Kedo, O., Kennedy,K., Kerchner, G.A., LaRocque, K., Liu, X., Maass, A., Malykhin, M., Mueller, S., Ofen, N., Palombo, D.J., Parekh, M., Pluta, J.B., Pruessner, J., Raz, N., Rodrigue, K., Schoemaker, D., Shafer, A.T., Steve, T., Suthana, N., Wang, L., Winterburn, J.L., Yassa, M.A., Yushkevich, P., la Joie, R., for the Hippocampal Subfield Group (HSG) (2016) A harmonized segmentation protocol for hippocampal and parahippocampal subregions: why do we need one and what are the key goals? Hippocampus. 27(1)3-11.
Suwabe, K., Hyodo, K., Byun, K.H., Ochi, G., Yassa, M.A., Soya, H. (2017) Acute moderate exercise improves mnemonic discrimination in young adults. Hippocampus. 27(3):229-234.
Zheng, J., Anderson, K.L., Leal, S.L., Shestyuk, A., Gulsen, G., Mnatsakanyan, L., Vadera, S., Yassa, M.A., Hsu, F.P., Knight, R.T., Lin, J.J. (2017) Amygdala-hippocampal dynamics during salient information processing. Nature Communications. 8:14413.
Snigdha, S., Yassa, M.A., Rivera C., Milgram, N.W., Cotman, C.W. Pattern separation and goal directed behavior in the aged canine. Learning and Memory. In press.
Leal, S.L., Noche, J.A., Murray, E.A., Yassa, M.A. (2017) Disruption of amygdala-entorhinal-hippocampal network in late-life depression. Hippocampus. 27(4):464-476
Suwabe, K., Hyodo, K., Byun, K.H., Ochi, G., Fukui, T., Shimizu, T., Kato, M., Yassa, M.A., Soya, H. (2017) Aerobic fitness associates with mnemonic discrimination as a mediator of physical activity effects: Evidence for memory flexibility in young adults. Scientific Reports. 7:5140.
Stark, S., Reagh, Z.M., Yassa, M.A.*, Stark, C.E.* (2017-2018) What’s in a Context? Cautions, limitations, and potential paths forward. Neuroscience Letters 680:77-87. *Co-corresponding authors.
Kraguljac, N., Carle, M., Frölich, M., Tran, S., Yassa, M.A., White, D.M., Reddy, A., Lahti, A.C. (2017) Mnemonic Discrimination Deficits in First-Episode Psychosis and a Ketamine Model Suggests Dentate Gyrus Pathology Linked to N-Methyl-D-Aspartate Receptor Hypofunction. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 3(3):231-238.
Reagh, Z.M., Yassa, M.A. (2017) Selective vulnerabilities and biomarkers in neurocognitive aging. F1000 Reviews 6:491.
Leal, S.L., Yassa, M.A. (2018) Integrating new findings and examining clinical applications of pattern separation. Nature Neuroscience 21(2):163-173.
Reagh, Z.M., Noche, J.A., Tustison, N., Delisle, D., Murray, E.A., Yassa, M.A. (2018) Functional Imbalance of Anterolateral Entorhinal Cortex and Hippocampal Dentate/CA3 Underlies Age-Related Object Pattern Separation Deficits. Neuron 97, 1187-1198.
Yassa, M.A. (2018) Brain rhythms: Higher frequency theta oscillations make sense in moving humans. Current Biology 28, R70-72.
Risbrough VB, Glynn LM, Davis EP, Sandman CA, Obenaus A, Stern HS, Keator DB, Yassa MA, Baram TZ, Baker DG (2018). Does Anhedonia Presage Increased Risk of Posttraumatic Stress Disorder? Adolescent Anhedonia and Posttraumatic Disorders. Curr Top Behav Neurosci 38:249-265.
Sinha, N., Berg, C., Tustison, N., Shaw, A., Hill, D., Yassa, M.A., Gluck, M.A. (2018) APOE e4 Status in Healthy Older African Americans is Associated with Deficits in Pattern Separation and Hippocampal Hyperactivation. Neurobiology of Aging 69, 221-229.
Stevenson, R., Zheng, J., Mnatsakanyan, L., Vadera, S., Knight, R., Lin, J.J.*, Yassa, M.A.* (2018) Hippocampal CA1 gamma power predicts the precision of spatial memory judgments. Proceedings of the National Academy of Science U S A 115(40):10148-10153. *Co-corresponding authors.
Sinha N, Reagh ZM, Tustison NJ, Berg CN, Shaw A, Myers CE, Hill D, Yassa MA, Gluck MA (2018). ABCA7 Risk Variant in Healthy Older African Americans is Associated with a Functionally Isolated Entorhinal Cortex Mediating Deficient Generalization of Prior Discrimination Training. Hippocampus 29(6):527-538.
Suwabe, K., Byun, K.H., Hyodo, K., Reagh, Z.M., Roberts, J.M., Matsushita, A., Soatome, K., Ochi, G., Fukuiem T., Suzuki, K., Sankai, Y., Yassa, M.A.*, Soya, H.* (2018) Rapid stimulation of human dentate gyrus function with acute mild exercise. Proceedings of the National Academy of Science U S A 115(41):10487-10492. *Co-corresponding authors.
Cunningham, T.J., Leal, S.L., Yassa, M.A., Payne, J.D. (2018) Post-encoding stress enhances mnemonic discrimination of negative stimuli. Learning and Memory 25(12):611-619.
Suwabe, K., Byun, K.H., Hyodo, K., Reagh, Z.M., Roberts, J.M., Matsushita, A., Soatome, K., Ochi, G., Fukuiem T., Suzuki, K., Sankai, Y., Yassa, M.A.*, Soya, H.* (2018) Reply to Gronwald et al: Exercise intensity does indeed matter! VO2max is the gold standard indicator. Proceedings of the National Academy of Science U S A 115(51):E11892-E11893. *Co-corresponding authors.
Montchal, M., Reagh, Z.M., Yassa, M.A. (2019) Temporal memory is supported by the anterolateral entorhinal cortex in humans. Nature Neuroscience 22(2):284-288.
Brown, E.S., Sayed, N., Choi, C., Tustison, N., Roberts, J., Yassa, M.A., Van Enkevort, E., Nakamura, A., Ivleva, E.I., Sunderajan, P., Khan, D.A., Vazquez, M., McEwen, B., Kulikova, A., Frol, A.B., Holmes, T. (2019) A randomized, double-blind, placebo-controlled trial of lamotrigine for prescription corticosteroid effects on the human hippocampus. European Journal of Neuropsychopharmacology 29(3):376-383.
Zheng, J., Stevenson, R.F., Mander, B.A., Mnatsakanyan, L., Hsu, F.P.K., Vadera, S., Knight, R.T., Yassa M.A.*, Lin, J.J.* (2019) Multiplexing of Theta and Alpha Rhythms in the Amygdala-Hippocampal Circuit Supports Pattern Separation of Emotional Information. Neuron 102(4):887-898.e5. *Co-corresponding authors.
Márquez, F., Yassa, M.A. (2019) Neuroimaging biomarkers for Alzheimer’s disease. Molecular Neurodegeneration 14(1):21.
Tustison, N.J., Holbrook, A.J., Avants, B.B., Roberts, J.M., Cook, P.A., Reagh, Z.M., Stone, J.R., Gillen, D.L., Yassa, M.A. (2019) Longitudinal mapping of cortical thickness measurements: an ADNI-based evaluation study. Journal of Alzheimer’s Disease 71(1):165-183.
Brown, E.S., Kulikova, A., Enkevort, E.V., Nakamura A., Ivleva, E.I., Tustison N.J., Roberts, J., Yassa, M.A., Choi, C., Frol A., Khan D.A., Vazquez M., Holmes, T., Malone K. (2019) A randomized trial of an NMDA receptor antagonist for reversing corticosteroid effects on the human hippocampus. Neuropsychopharmacology 44(13):2263-2267.
Yassa, M.O., Yassa, M.A. (2019) Special Issue on the International Conference on Learning and Memory. Learning and Memory 26(7):i.
Stevenson, R., Reagh, Z., Yassa, M.A. (2019) Pattern separation and source memory engage distinct hippocampal and neocortical regions during retrieval. Journal of Neuroscience 40(4):843-851.
Brown, E.S., Nguyen D., Yassa, M.A., Tustison, N., Roberts, J., Kulikova, A., Nakamura, A., Ivleva, E., Van Enkevort, Kulikova, A., Enkevort, E.V. (2019) The relationship between cumulative exogenous corticosteroid exposure and volumes of hippocampal subfields and surrounding structures. Journal of Clinical Psychopharmacology 39(6):653-657.
Yaros, J., Salama, D., Delisle, D., Larson, M., Miranda, B., Yassa, M.A. (2019) A Memory Computational Basis for the Other-Race Effect. Scientific Reports 18;9(1):19399.
Riphagen, J.M., Schmiedek, L., Gronenschild, E.H.B.M., Yassa, M.A., Priovoulos N., Sack, A.T., Verhey, F.R.J., Jacobs, H.I.L. (2020) Associations between pattern separation and hippocampal subfield structure and function vary along the lifespan: A 7 T imaging study. Scientific Reports 10(1), 1-13.
Holbrook, A., Tustison, N., Márquez, F., Roberts, J., Reagh, Z., Stone, J., Yassa, M.A. Gillen, D. (2020) Anterolateral Entorhinal Cortex Thickness as a Biomarker for Early Detection of Alzheimer’s Disease. Alzheimer’s and Dementia 12(1):e12068. doi: 10.1002/dad2.12068.
Rosas, H.D., Hsu, E., Mercaldo, N., Lai, F., Pulsifer, M., Keator, D.B., Brickman, A.M., Price, J., Yassa, M.A., Hom, C., Krinsky-McHale, S.J., Silverman, W., Lott, I., Schupf, N. (2020) Alzheimer-related altered white matter microstructural integrity in Down syndrome: A model for sporadic AD? Alzheimer’s and Dementia 7;12(1):e12040.
Lao, P.J., Gutierrez, J., Keator, D.B., Banerjee, A., Igwe, K.C., Liang, K.L., Rizvi, B., Sathishkumar, M., Moni, F., Andrews, H., Krinsky-McHale, Head, E., Lee, J., Lai, L., Yassa, M.A., Rosas, H.D., Silverman, W., Lott, I.T., Schupf, N., Brickman, A. (2020) Alzheimer-Related Cerebrovascular Disease in Down Syndrome. Annals of Neurology 88(6):1165-1177.
Keator, D., Doran, E., Taylor, L., Phelan, M., Hom, C., Tseung, K., van Erp, T, Potkin, S., Brickman, A.M., Rosas, D.H., Yassa, M.A., Silverman, W., Lott, I. (2020) Brain amyloid and the transition to dementia in Down syndrome. Alzheimer’s and Dementia 12(1):e12126.
Sinha, N., Berg, C.N., Yassa, M.A., Gluck, M.A. (2020) Increased Dynamic Reconfiguration in Medial Temporal Lobe Network Following Exercise Intervention Mediates Flexible Generalization of Learning. Neurobiology of Learning and Memory 177:107340.
Granger, S.J., Glynn, L.M., Sandman, C.A., Small, S.L., Keator, D.B., Baram, T.Z., Stern, H., Yassa, M.A.*, Davis, E.P.* (2020) Accelerated Maturation of the Uncinate Fasciculus after Early-Life Unpredictable Patterns of Maternal Signals. *Co-corresponding. J Neurosci 41(6):1242-1250.
Granger, S.J., Leal, S.L., Janecek, J., McMillan, L., Stern, H., Yassa, M.A. (2020) Integrity of the Uncinate Fasciculus Predicts Emotional Pattern Separation-Related fMRI Signals in the Hippocampal Dentate and CA3. Neurobiology of Learning and Memory 177:107359.
Papp, K., Rentz. D.M., Maruff, P., Sun, C.K., Raman, R., Donohue, M., Schembri, A., Stark, C.E., Yassa, M.A., Wessels, A., Yaari, R., Holdridge, K., Aisen, P., Sperling, R. (2021) The computerized cognitive composite (C3) in an Alzheimer’s disease secondary prevention trial. The Journal of Prevention of Alzheimer’s Disease 80(1):59-67.
Suthana, N., Ekstrom, A., Yassa, M.A., Stark, C.E. (2021) Pattern separation in the human hippocampus: Response to Quiroga (2020). Trends in Cognitive Sciences. In press.
Pagen, L., Smeets, T., Muller-Ehrenberg, L., Yassa, M.A., Verhey, F., Jacobs, H. (2021) Pilot Study: Elevated noradrenaline levels are related to diminished practice effects in memory. Journal of Alzheimer’s Disease. 80(4): 1675-1685.
Memel, M., Saffaroni, A., Cobigo, Y., Casaletto, K., Bettcher, B., Yassa, M.A., Elahi, F., Wolf, A., Rosen, H., Kramer, J. (2021) APOE moderates the effect of hippocampal blood flow on memory pattern separation in clinically normal older adults. Hippocampus. In Press. 10.1002/hipo.23327.
Tustison, N.J., Cook, P.A., Holbrook, A.J., Johnson, H.J., Muschelli, J., Devanyi, G.A., Duda, J.T., Das, S., Cullen, N.C., Gillen, D.L., Yassa, M.A., Stone, J.R., Gee, J.C., Avants, B.B. for the Alzheimer’s Disease Neuroimaging Initiative. (2021) ANTsX: A dynamic ecosystem for quantitative biological and medical imaging. Scientific Reports 11: 9068.
Kark, S.M., Birnie, M.T., Baram, T.Z., Yassa, M.A. (2021) Functional connectivity of the human paraventricular thalamic nucleus: insights from high field functional MRI. Frontiers in Integrative Neuroscience. 10.3389/fnint.2021.662293
Chappel-Farley, M., Mander, B.A., Nan, B., Grill, J., Yassa, M.A.*, Benca, R.* Sleep mediates the effects of exercise frequency on subjective cognitive complaints in cognitively healthy adults with heightened Alzheimer’s disease risk. * Co-Corresponding Authors. Sleep. Accepted.
Damrongthai, C., Kuwamizu, R., Suwabe, K., Ochi, G., Yamazaki, Y., Fukuie, T., Adachi, K., Yassa, M.A., Churdchomjan, W., Soya, H. Running boosts mood and executive function coinciding with bilateral prefrontal activation: An fNIRS study. Scientific Reports. Accepted.
DiProspero, N.D., Phelan, M., Janecek, J., Keator, D.B., van Erp, T.G.M., Doran, E., Lott, I., Yassa, M.A. Reduced long-range default mode connectivity predicts conversion to Alzheimer's disease in older individuals with Down syndrome. Journal of Alzheimer’s Disease. Accepted.
Wendel, K.M., Short, A.K., Noarbe, B., Haddad, E., Palma, A., Yassa, M.A., Baram, T.Z., Obenaus, A. Early Life Adversity in Male Mice Sculpts Reward Circuits. Neurobiology of Stress. Accepted.
Jutten, R.J., Rentz, D.M., Fu, J.F., Mayblyum, D.V., Amariglio, R.E., Buckley, R.F., Properzi, M.J., Maruff, P.T., Stark, C.E., Yassa, M.A., Johnson, K.A., Sperling, R.A., Papp, K.V. Monthly at-home computerized cognitive testing to detect diminished practice effects in preclinical Alzheimer’s disease. Frontiers in Aging Neuroscience. Accepted.
Granger, S.J., Adams, J.G., Kark, S.M., Sathishkumar, M., Chen, I.Y., McMillan, L., Janecek, J., Benca, R.M., Yassa, M.A. Latent Anxiety in Clinical Depression is Related to Impaired Target Recognition of Negative Items in an Emotional Pattern Separation Task. Journal of Affective Disorders. Accepted.
Grants
NIA R01 AG034613 - High-resolution structural and functional brain imaging of the medial temporal lobe in neurocognitive aging
NIMH R01 MH102392 - Neural mechanisms of emotional memory modulation in major depressive disorder
NIH/NIA R21 AG049220 - Selective Age-Related Vulnerability In Human Perirhinal And Lateral Entorhinal Cortices
NIH/NIA U01 AG051412 - Biomarkers for Alzheimer’s Disease in Adults with Down Syndrome
NIA P50 AG16573 (UCI ADRC) High-Resolution Neuroimaging Biomarkers of Preclinical Alzheimer’s Disease
NIA R01AG053555 - Neuroimaging Biomarkers for Cognitive Decline in Elderly with Amyloid Pathology
NIMH P50MH096889 (Silvio O. Conte Center) Fragmented Early Life Environmental And Emotional/Cognitive Vulnerabilities | Imaging Core
NINDS R13NS106922 - International Conference on Learning and Memory (#LEARNMEM2018)
Professional Societies
Society for Neuroscience
Cognitive Neuroscience Society
Memory Disorders Research Society
Faculty for Undergraduate Neuroscience
American Psychological Association
Faculty of 1000
American Association for the Advancement of Science
Graduate Programs
Interdepartmental Neuroscience Program
Mathematical and Computational Biology
Medical Scientist Training Program
Neurobiology and Behavior
Research Centers
Center for the Neurobiology of Learning and Memory
Alzheimer's Disease Research Center
Conte Center on Adolescent Vulnerabilities
Sleep and Circadian Neuroscience Center
Link to this profile
https://faculty.uci.edu/profile/?facultyId=6078
https://faculty.uci.edu/profile/?facultyId=6078
Last updated
02/15/2022
02/15/2022