Xiangmin Xu

Associate Professor, Anatomy & Neurobiology
School of Medicine

Ph.D., Vanderbilt University, 2004, Psychology / Neuroscience

Phone: (949) 824-0040
Email: xiangmin.xu@uci.edu

University of California, Irvine
362 Med Surge II
Anatomy and Neurobiology
Mail Code: 1275
Irvine, CA 92697

picture of Xiangmin  Xu

Research
Interests
Neural circuits, Cell-type specific, Electrophysiology, Imaging, Optical stimulation, Molecular genetics
   
URL Dr. Xu's lab website
   
Academic
Distinctions
10/2013 Recipient of the 2014 C. J. Herrick Award in Neuroanatomy of the American Association of Anatomists
09/2013 Recipient of the 2013 Krieg Cortical Explorer Award, the Cajal Club Foundation
04/2013 2013 Randolph Blake Early Career Award, Vanderbilt University
08/2012 2012 NARSAD Young Investigator Award, Brain & Behavior Research Foundation
2010-2011 The Best 1st Year Course Award from the Association of Students, UCI School of Medicine [Histology, teaching faculty]
12/2006 NIH Pathway to Independence Award (K99/R00), National Institute on Drug Abuse / NIH
11/2004 Kreig Cortical Kudos Award (Cortical Scholar Award), the Cajal Club / Society for Neuroscience
09/1999 - 02/2004 Teaching/Research Assistantship, Vanderbilt University
09/1999 - 02/2004 University Tuition Scholarship, Vanderbilt University
09/1998 - 06/1999 University Scholarship & Fellowship, Vanderbilt University
   
Research
Abstract
Dr. Xu's interests are in neural circuitry, which applies to understanding the neurobiology of sensory perception, learning and memory, and epilepsy. Understanding how neural circuits give rise to perception, cognition, and behavior is central to understanding how the brain works. This is also key to understanding the mechanistic basis of neurological disorders. Our research is focused on understanding cell-type specific cortical circuit organization and function, using combined approaches of electrophysiology, optical stimulation and imaging, molecular genetics and viral tracing. Our research program is funded by NIH grants and private foundation funds.
   
Publications Xu, X.*, Olivas, N.D., Levi, R., Ikrar, T., Nenadic, Z. (2010) High resolution and fast functional mapping of cortical circuitry through a novel combination of voltage sensitive dye imaging and laser scanning photostimulation. Journal of Neurophysiology 103, 2301 – 2312. * Senior and corresponding author


Shi, Y., Nenadic, Z., Xu, X. (2010) Novel use of matched filtering for synaptic event detection and extraction. PLoS ONE 5(11): e15517. doi:10.1371/journal.pone.0015517.

Xu, X. (2011) High precision and fast functional mapping of brain circuitry through laser scanning photostimulation and fast dye imaging. In: Laser scanning, theory and applications (Wang C-C, ed), pp 113-132. Rijeka, Croatia: InTech.

Ikrar, T., Olivas, N., Shi, Y., Xu, X. (2011) Mapping inhibitory neuronal circuits by laser scanning photostimulation. Journal of Visualized Experiments (56), e3109, DOI : 10.3791/3109. [PMID:22006064]

Ikrar, T., Shi, Y., Velasquez, T, Goulding, M. and Xu, X.(2012) Cell-type specific regulation of cortical excitability through the allatostatin receptor system. Frontiers in Neural Circuits 6:2. doi:10.3389/fncir.2012.00002 [PMCID: PMC3262160]

Li Y, Aimone, J.B., Xu, X., Callaway, E.M., Gage, F.H. (2012) Development of GABAergic inputs controls the contribution of maturing neurons to the adult hippocampal network.Proceedings of National Academy of Sciences USA, 109: 4290-4295.

Olivas, N.D., Quintanar-Zilinskas, V., Nenadic, Z., Xu, X. (2012) Laminar circuit organization and response modulation in mouse visual cortex. Frontiers in Neural Circuits 6:70. doi: 10.3389/fncir.2012.00070 [PMCID: PMC3464489]

Clement, J.P., Aceti, M., Creson, T.K., Ozkan, E.D., Shi, Y., Reish, N.J., Almonte, A.G., Miller, B.H., Wiltgen, B.J., Miller, C.A., Xu, X., Rumbaugh, G. (2012) Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses. Cell 151:709-723. [PMID: 23141534]

Ahrar, S., Nguyen, T.V., Shi, Y., Thomas, P.V., Ikrar, T., Xu, X.*, Hui, E.E.* (2013) Optical stimulation and imaging of functional brain circuitry in a laminar flow chamber. Lab Chip 13:536-41. [PMID: 23044655] * Co-corresponding Authors

Haettig, J.#, Sun, Y.#, Wood, M.A.*, Xu, X*. (2013) Cell-type specific inactivation of hippocampal CA1 disrupts location-dependent object recognition in the mouse. Learning & Memory 20:139-146. [PMID: 23418393] #Co-first authors; * Co-corresponding Authors

Kuhlman, S.J. #, Olivas, N.D. #, Tring, E., Ikrar, T., Xu, X.*, Trachtenberg, J.T.* (2013) A disinhibitory microcircuit initiates critical period plasticity in visual cortex. Nature (Advanced Online Publication): August 2013. DOI: 10.1038/nature12485. #Co-first authors; * Co-corresponding Authors

San Antonio, A., Liban, K., Ikrar, T., Tsyganovskiy, E., Xu, X. (2013). Distinct physiological and developmental properties of hippocampal CA2 subfield revealed using anti-Purkinje cell protein 4 (PCP4) immunostaining. Journal of Comparative Neurology. 2013 Oct 25. doi: 10.1002/cne.23486. [Epub ahead of print].

Ikrar, T., Guo, N., He, K., Besnard, A., Levinson, S., Hill, A., Lee, H., Hen, R., Xu, X.*, Sahay, A. * Adult neurogenesis modifies excitability of the dentate gyrus. Frontiers in Neural Circuits, 26 December 2013 | doi: 10.3389/fncir.2013.00204. * Co-corresponding Authors

Kuhlman, S.J. #, Olivas, N.D. #, Tring, E., Ikrar, T., Xu, X.*, Trachtenberg, J.T.* (2013) A disinhibitory microcircuit initiates critical period plasticity in visual cortex. Nature 501, 543-546. [PMCID: PMC3962838] # Co-first authors; * Co-corresponding authors

Andrew, S., Liban, K., Ikrar, T., Tsyganovskiy, E., Xu, X. (2013). Distinct physiological and developmental properties of hippocampal CA2 subfield revealed using anti-Purkinje cell protein 4 (PCP4) immunostaining. Journal of Comparative Neurology (2013 doi: 10.1002/cne.23486). [Epub ahead of print] [PMCID: PMC4001794]

Ikrar, T., Guo, N., He, K., Besnard, A., Levinson, S., Hill, A., Lee, H., Hen, R., Xu, X.*, Sahay, A.* (2013) Adult neurogenesis modifies excitability of the dentate gyrus. Frontiers in Neural Circuits (2013 doi: 10.3389/fncir.2013.00204). [PMCID: PMC3872742] * Co-corresponding authors

Shi, Y., Ikrar, T., Olivas, N.D., Xu, X. (2013) Bi-directional global spontaneous network activity immediately precedes the canonical unidirectional circuit organization in the developing hippocampus. Journal of Comparative Neurology (2013 doi: 10.1002/cne.23528). [Epub ahead of print] [PMID: 24357090]

Parks, G. #, Olivas, N.D. #, Ikrar, T. #, Sanathara, N., Wang, L., Wang, Z., Civelli, O. *, Xu, X. * (2014) Histamine inhibits the melanin-concentrating hormone system: Implications for sleep and arousal. Journal of Physiology (http://jp.physoc.org/content/early/2014/03/17/jphysiol.2013.268771.long) [Epub ahead of print] [PMID: 24639485] # Co-first authors; * Co-corresponding authors

Sun, Y., Nguyen, A., Nguyen, J., Le, L., Saur, D., Choi, J., Callaway, E.M., Xu, X. (2014) Cell-type specific circuit connectivity of hippocampal CA1 revealed through Cre-dependent rabies tracing. Cell Reports 7: 269–280. http://dx.doi.org/10.1016/j.celrep.2014.02.030. [PMCID: PMC3998524]
   
  Nguyen AQ, Dela Cruz JA, Sun Y, Holmes TC, Xu X. Genetic cell targeting uncovers specific neuronal types and distinct subregions in the bed nucleus of the stria terminalis. J Comp Neurol. 2015 Dec 30; PubMed PMID: 26718312.

Xu X, Olivas ND, Ikrar T, Peng T, Holmes TC, Nie Q, Shi Y. Primary visual cortex shows laminar-specific and balanced circuit organization of excitatory and inhibitory synaptic connectivity. J Physiol. 2016 Apr 1;594 (7):1891-910. PubMed PMID: 26844927.

Xu X, Ikrar T, Sun Y, Santos R, Holmes, TC, Francesconi W, Berton, F. High-resolution and cell-type-specific photostimulation mapping shows weak excitatory versus strong inhibitory inputs in the bed nucleus of the stria terminalis. J Neurophysiol. 2016, 115:3204-16. [PMID: 27052587]

Xu X, Sun Y, Holmes, TC, López A. Non-canonical connections between the subiculum and hippocampal CA1. J Comp Neurol. 2016, 524:3666-3673 [PMID: 27150503]

Baohan, A., Ikrar, T., Tring, E., Xu, X.*, Trachtenberg, T.* Pten and EphB4 regulate the establishment of perisomatic inhibition in mouse visual cortex. Nature Communications 2016 7:12829 doi: 10.1038/ncomms12829 * Co-corresponding Authors

Sun, Y., Ikrar, T., Davis, M.F., Gong, N., Zheng, X., Luo, Z.D., Lai, C., Mei, L., Holmes, T.C., Gandhi, S.P., Xu, X.* Neuregulin-1 / ErbB4 signaling regulates visual cortical plasticity. Neuron 92:160-173. http://dx.doi.org/10.1016/j.neuron.2016.08.033 [PMID: 27641496] * Corresponding Author

Stephany, C., Ikrar, T., Nguyen, C., Xu, X.*, McGee, A.W.* Nogo receptor 1 confines a dishinhibitory microcircuit to the critical period in visual cortex. J Neurosci. 2016, 36:11006-11012. * Co-corresponding Authors

Garcia-Junco-Clemente, P., Ikrar, T., Tring, E., Xu, X., Ringach, D.L. & Trachtenberg, J.T. An inhibitory pull-push circuit in frontal cortex Nature Neuroscience 2017, 20:389-392. doi: 10.1038/nn.4483. [PMID: 28114295]

Yanjun Sun, Steven Grieco, Todd Holmes, and Xiangmin Xu. Local and long-range circuit connections to hilar mossy cells in the dentate gyrus. eNuro 2017 ENEURO.0097-17.2017. doi: 10.1523/ENEURO.0097-17.2017.
   
   
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Last updated 05/20/2017