Home | For Faculty | Help | About | Webmaster

Olga V Razorenova

Assistant Professor, Molecular Biology and Biochemistry
School of Biological Sciences

Ph.D., Engelhardt Institute of Molecular Biology (Moscow, Russia), 2006, Molecular Biology


M.S., Lomonosov Moscow State University (Moscow, Russia), 2000, Molecular Genetics

Phone: (949) 824-8156
Email: olgar@uci.edu

University of California, Irvine
845 Health Sciences Road
Gross Hall - Room 3010
Mail Code: 3900
Irvine, CA 92697

picture of Olga V Razorenova

Research
Interests
Tumor Microenvironment, Hypoxia, Tumor Progression, Metastasis, Therapeutic Target, Drug Screening, siRNA Screening
   
URLs Personal website
   
Lab website
   
Appointments Ph.D. Student, Laboratory of Peter Chumakov, Engelhardt Institute of Molecular Biology
Research Scholar, Laboratories of Peter Chumakov and Tatiana Byzova, Lerner Research Institute, Cleveland Clinic
Postdoctoral Scholar, Laboratory of Amato Giaccia, Stanford University
   
Research
Abstract
My research interests include molecular, cellular and genetic basis of cancer. Dissection of mechanisms of tumor initiation and progression based on mouse models of ovarian and breast cancers. Primary focus is on the role of hypoxia and tumor micro-environment in the progression and metastatic spread of epithelial tumors. Additional area of expertise includes small molecule chemical library screens to identify anti-cancer drugs in multiple cell reporter based assays and the use of synthetic lethality concept.
   
Publications Razorenova O.V.*, Castellini L.*, Colavitti R.*, Edgington L.E., Nicolau M., Huang X., Bedogni B., Mills E.M., Bogyo M., Giaccia A.J. The Apoptosis Repressor with a CARD Domain (ARC) is a Direct HIF1 Target Gene and Promotes Survival and Proliferation of VHL Deficient Renal Cancer Cells. Mol Cell Biol. 2013; [Epub ahead of print]
* - equal contribution
   
  Razorenova O.V.* Brain and Muscle ARNT-Like protein BMAL1 regulates ROS homeostasis and senescence: a possible link to Hypoxia Inducible Factor mediated pathway. Cell Cycle. 2012; 11(2):213-214. Invited News and Views.
* - corresponding author
   
  Razorenova O.V., Finger E., Colavitti R., Chernikova S.B., Boiko A.D., Chan C., Krieg A.J., Bedogni B., LaGory E., Weissman I.L., Broome-Powell M., Giaccia A.J. VHL loss in renal cell carcinoma leads to HIF-dependent upregulation of CUB domain-containing protein 1 to stimulate PKCdelta-driven migration. Proc Natl Acad Sci USA. 2011; 108(5):1931-1936.
   
  Razorenova O.V. and Giaccia A.J. Hypoxia, Gene Expression, and Metastasis. Chapter 3 in "The Tumor Microenvironment" Book, ed. Bagley RG. 2010; pp 43-58.
   
  Razorenova O.V., Ivanov A.V., Budanov A.V., Chumakov P.M. Development of virus-based reporter systems for monitoring transcriptional activity of hypoxia-inducible factor 1. Gene. 2005; 350(1):89-98.
   
  Razorenova O.V., Agapova L.S., Chumakov P.M. p53 gene expression and activation of p53-dependent transcription in melanoma cell lines. Mol Biol (Mosk). 2005; 39(3):445-456. Russian.
   
  Razorenova O.V., Agapova L.S., Budanov A.V., Ivanov A.V., Strunina S.M., Chumakov P.M. Retroviral reporter systems for the assessment of activity of stress-induced signal transduction pathways controlled by p53, HIF-1 and HSF-1 transcription factors. Mol Biol (Mosk). 2005; 39(2):286-293. Russian.
   
  Razorenova O.V., Karpova N.N., Smirnova Iu.B., Kusulidu L.K., Reneva N.K., Subocheva E.A., Kim A.I., Liubomirskaia N.V., Il'in Iu.V. Interlineage distribution and characteristics of the structure of two subfamilies of Drosophila melanogaster MDG4 (gypsy) retrotransposon. Genetika. 2001; 37(2):175-182. Russian.
   
  Boiko A.D., Razorenova O.V., van de Rijn M., Swetter S.M., Johnson D.L., Ly D.P., Butler P.D., Yang G.P., Joshua B., Kaplan M.J., Longaker M.T., Weissman I.L. Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271. Nature. 2010; 466:133-137.
   
  Chernikova S.B., Razorenova O.V., Higgins J., Sishc B.J., Nicolau M., Dorth J.A., Chernikova D.A., Kwok S., Brooks J.D., Bailey S.M., Game J.C., Brown J.M. Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability. Cancer Research. 2012; 72(8):2111-9.
   
  Chernikova S.B., Dorth J.A., Razorenova O.V., Game J.C., Brown J.M. Deficiency in Bre1 Impairs Homologous Recombination Repair and Cell Cycle Checkpoint Response to Radiation Damage in Mammalian Cells. Radiat Res. 2010; 174(5):558-65.
   
  Krieg A.J., Rankin E.B., Chan D., Razorenova O., Fernandez S., Giaccia A.J. Regulation of the Histone Demethylase JMJD1A by HIF-1? Enhances Hypoxic Gene Expression and Tumor Growth. Mol Cell Biol. 2009; 30(1):344-353.
   
  Malinin N.L., Zhang L., Choi J., Ciocea A., Razorenova O., Ma Y.Q., Podrez E.A., Tosi M., Lennon D.P., Caplan A.I., Shurin S.B., Plow E.F., Byzova T.V. A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans. Nature Medicine. 2009; 15(3):313-318.
   
  Mahabeleshwar G.H., Chen J., Feng W., Somanath P.R., Razorenova O.V., Byzova T.V. Integrin affinity modulation in angiogenesis. Cell Cycle. 2008; 7(3):335-347.
   
  Somanath P.R.*, Razorenova O.V.*, Chen J., Byzova T.V. Role for Akt1 kinase in angiogenesis and endothelial cell biology. Cell Cycle. 2006; 5(5):512-518. Review.
* - equal contribution
   
  Boiko A.D., Porteous S., Razorenova O.V., Krivokrysenko V.I., Williams B., Gudkov A.V. A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation. Genes and Development. 2006; 20(2):236-252.
   
  Chen J.*, Somanath P.R.*, Razorenova O., Chen W.S., Hay N., Bornstein P., Byzova T.V. Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. Nature Medicine. 2005; 11(11):1188-1196.
* - equal contribution.
   
  De S., Razorenova O., McCabe N.P., O’Toole T.E., Qin J., Byzova T.V. VEGF–integrin interplay controls tumor growth and vascularization. Proc Natl Acad Sci USA. 2005; 102(21):7589-7594.
   
  Narizhneva N.V., Razorenova O.V., Podrez E.A., Chen J., Chandraesekharan U., DiCorleto P.E., Plow E.F., Topol E.J., Byzova T.V. Thrombospondin-1 upregulates expression of cell adhesion molecules and promotes monocyte binding to endothelium. FASEB J. 2005; 19(9):1158-1160.
   
  Gurova K.V., Hill J.E., Razorenova O.V., Chumakov P.M., Gudkov A.V. p53 pathway in renal cell carcinoma is repressed by a dominant mechanism. Cancer Res. 2004; 64(6):1951-1958.
   
  Lyubomirskaya N.V., Smirnova J.B., Razorenova O.V., Karpova N.N., Surkov S.A., Avedisov S.N., Kim A.I., Ilyin Y.V. Two variants of the Drosophila melanogaster retrotransposon gypsy (MDG4): structural and functional differences, and distribution in fly stocks. Mol Genet Genomics. 2001; 265(2):367-374.
   
  Kusulidu L.K., Karpova N.N., Razorenova O.V., Glukhov I.A., Kim A.I., Liubomirskaia N.V., Il'in Iu.V. Mobile genetic element MDG4 (gypsy) in Drosophila melanogaster. Features of structure and regulation of transposition. Genetika. 2001; 37(12):1589-1597. Russian.
   
  Kusulidu L.K., Karpova N.N., Razorenova O.V., Glukhov I.A., Kim A.I., Lyubomirskaya N.V., Ilyin Y.V. Structural polymorphism of the transposable element MDG4 (gypsy) in Drosophila melanogaster strains. Doklady Akademii Nauk. 2001; 376(1):133-138. Russian.
   
  Kim A.I., Pasiukova E.G., Karpova N.N., Razorenova O.V. Genomic factors regulating the transposition of Drosophila mobile elements. Genetika. 1999; 35(11):1511-1521. Review. Russian.
   
Professional
Society
American Association for Cancer Research - AACR
   
Other Experience
Graduate Programs Cancer Biology

Cell Biology

Cellular and Molecular Biosciences

Developmental Biology and Genetics

Mechanisms of Gene Expression

   
Research Center Chao Family Comprehensive Cancer Center
   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=5948
   
Last updated 01/05/2014