Jogeshwar Mukherjee

Professor and Director, Preclinical Imaging, Radiological Sciences
School of Medicine

2015 Distinguished Investigator, ARR, Radiological Sciences


Ph.D., University of Jodhpur (INDIA), 1980, Chemistry

Phone: (949) 824-2018
Email: j.mukherjee@uci.edu

University of California, Irvine
Med Sci I, B140
Preclinical Imaging
Radiological Sciences
Mail Code: 5000
Irvine, CA 92697

picture of Jogeshwar  Mukherjee

Research
Interests
Radiopharmaceutical Design & Development; PET Imaging and Quantitation; Neuroscience
   
URL Preclinical Imaging
   
Academic
Distinctions
2015 Distinguished Investigator Award, Academy Radiology Research (http://www.acadrad.org/2015-distinguished-investigators-award/)
   
Appointments Chemist, Federal Service Grade Scientist-11 Biological Magnetic Resonance Laboratory, Veteran's Administration Medical Center, Kansas City, MO

Assistant Professor, Department of Radiology, The University of Chicago; Director, Radiopharmaceutical Laboratories and Cyclotron Facility, Department of Radiology, The University of Chicago, Chicago, IL.

Associate Professor, Department of Internal Medicine, Wright State University; Chief Radiochemist, Department of Nuclear Medicine and PET, Kettering Medical Center, Dayton, OH.

Professor, Department of Radiological Sciences, University of California-Irvine.
   
Research
Abstract
The mission of preclinical imaging (PCI) is to promote the development and use of non-invasive imaging technology by supporting research, teaching and service. These imaging modalities include positron emission tomography (PET), computer assisted tomography (CT), optical imaging methods and other emerging technologies. Radiopharmaceuticals for PET play a key role in the advancement of this technology. Using state of the art methods and appropriate quality control measures, PCI designs, develops and produces novel radiopharmaceuticals that are suitable for animal and human use research. Advancements in imaging are carried out at with an emphasis in the following five major areas of research: 1. Probe Development; 2. Radiopharmaceutical Production; 3. In Vitro Testing; 4. In Vivo Imaging; 5. Quantitative Image Analysis; and 6. Translational Research. Current research areas include development of new radiopharmaceutical and imaging methods for: 1. Neuroscience (Alzheimer’s & Parkinson’s disease, substance abuse, schizophrenia, memory&cognition, mood disorders, others); 2. Diabetes and Obesity; 3. Cardiovascular studies; and 4. Oncology.
   
Publications SELECTED PUBLICATIONS (2012 - Present):

Bieszczcad, K., Kant, R., Constantinescu, C., Pandey, S., Kawai, H.D., Metherate, R., Weinberger, N.M., Mukherjee, J.: Nicotinic acetylcholine receptors in the rat forebrain that bind 18F-Nifene; relating PET imaging, autoradiography and behavior. Synapse, 66: 418-434, 2012.

Reist, C., Wu, J., Lilja, Y., Mukherjee, J., Gripeos, D., Constantinescu, C., Raggi, M.A., Mercolini, L., Ozdemir, V.: Ketoconazole-associated preferential increase in dopamine D2 receptor occupancy in striatum compared to pituitary in vivo. J. Clin. Psychopharm., 32: 110-113, 2012.

Wooten, D.W., Hillmer, A.T., Moraino, J.D., Ahlers, E.O., Slesarev, M., Barnhart, T., Mukherjee, J., Schneider, M.L., and Christian, B.T. Measurement of 5-HT1A receptor density and in vivo binding parameters of 18F-Mefway in the nonhuman primate. J. Cereb. Blood Flow Metab., 32: 1546-1558, 2012.

Nalbandian, A., Liewellyn, K.J., Kitazawa M., Yin, H.Z., Badadani, M., Edwards R., Nguyen, C., Mukherjee, J., Mozaffer, T., Weiss, J.H. and Kimonis, V. The homozygous VCPR155H/R155H mouse exhibits accelerated VCP disease-associated pathology. PLOS One, 7(9), e46308, 2012 (published online September 2012).

Pandey, S.K., Pan, S., Kant, R., Pan, M.L., Kuruvilla, S.A. and Mukherjee, J.: Synthesis and evaluation of 123I-Niodene as potential imaging agent for nicotinic a4b2 receptors. Bioorg. Med. Chem. Lett., 22: 7610-7614, 2012.

Reist, C., Mukherjee, J., Wu, J; Modulating blood-brain barrier permeability and treatment-resistant psychiatric illness: Is pituitary neuroimaging a new frontier? Curr. Pharmacogenomics Personalized Med., 10, 182-184, 2012.

Hillmer, A.T., Wooten, D.W., Slesarev, M.S., Ahlers, E.O., Barnhart, T.E., Murali, D., Schneider, M.L., Mukherjee, J., Christian, B.T.: PET imaging of ?4?2 nicotinic acetylcholine receptors: Quantitative analysis of 18F-Nifene kinetics in the nonhuman primate. J. Nucl. Med., 53:1471-1480, 2012.

Pichika, R., Kuruvilla, S.A., Patel, N., Vu, K., Sinha, S., Easwaramoorthy, B., Shi, B., Narayanan, T.K., Christian, B. and Mukherjee, J.: Nicotine ?4?2 receptor imaging agents. Part IV. Synthesis and evaluation of 18F-Nifrolene in rodents and non-human primate by PET imaging. Nucl. Med Biol., 40: 117-125, 2013 (published online November 2012).

Galitovskiy, V., Kuruvilla, S.A., Sevrioukov, E., Corches, A., Pan, M.L., Kalantri-Dehaghi, M., Mukherjee, J., Grando, S. Development of novel approach to diagnostic imaging of lung cancer with 18F-nifene PET/CT using A/J mice treated with NNK. J. Cancer Res & Therapy, 1: 128-137, 2013.

Mirbolooki, M.R., Constantinescu, C., Pan, M.L., Mukherjee, J.; Targeting presynaptic norepinephrine transporter in brown adipose tissue: A novel imaging approach and potential treatment for diabetes and obesity. Synapse, 67: 79-93, 2013 (published online October 2012).

Saigal, N., Bajwa, A.K., Faheem, S. S., Coleman, R., Pandey, S.K., Constantinescu, C.C., Fong, V., Mukherjee, J; Evaluation of serotonin 5HT1A receptors in rodent models using 18F- mefway PET. Synapse, 67: 596-608, 2013 [Cover image in the issue is from the paper] (published online March 2013).

Nalbandian, A., Liewellyn, K.J., Badadani, M., Yin, H.Z., Nguyen, C., Katheria V., Watts, G., Mukherjee, J., Vesa, J., Caiozzo, V., Mozaffer, T., Weiss, J.H. and Kimonis, V.; A progressive translational mouse model of VCP disease: The VCPR155H/+ mouse. Muscle & Nerve, 47: 260-270, 2013 (published online August 2012).

Constantinescu, C., Sevrioukov, E., Pan, M.L., Garcia, A., Mukherjee, J.; Evaluation of [18F]Mefway radiation dosimetry based on whole-body MicroPET/CT imaging of mice. Mol. Imag. Biol., 15: 222-229, 2013 (published online August 2012).

Constantinescu, C., Garcia, A., Mirbolooki, M.R., Sevrioukov, E., Pan, M.L., Mukherjee, J.; Evaluation of [18F]Nifene radiation dosimetry based on whole-body MicroPET/CT imaging of mice. Nucl. Med. Biol., 40: 289-294, 2013 (published online December 2012).

Upadhyay, S.K., Eckel-Mahan, K., Mirbolooki, MR., Tjong, I., Griffey, SF., Schmunk, G., Jones, J., Halbout, B., Iadonato, S., Borreli, E., Wang, PH., Mukherjee, J., Sassone-Corsi, P., Chandy, KG. Voltage-gated Kv1.3 channels: Target for brown adipose tissue activation and treatment of metabolic syndrome. PNAS, 110: E2239-2248, 2013 (published online May 2013).

Hillmer, A.T., Wooten, D.W., Farhoud, M., Barnhart, T.E., Mukherjee, J., Christian, B.: The effects of lobeline on a4b2 nicotinic acetylcholine receptor binding and uptake of 18F-nifene in rats. J. Neurosci. Methods, 214: 163-169, 2013 (published online Feb 2013).

Pithia, N., Gulati, N., Pandey, S., Coleman, R., Kant, R. Mukherjee, J. Synthesis and Biological Evaluation of 18F-Norfallypride in the rodent brain using PET imaging. Nucl. Med. Biol., 40: 697-704, 2013 (published on line, April 2013).

Wooten, D.W., Hillmer, A.T., Moirano, J.M., Tudorascu, D.L., Ahlers, E.O., Slesarev, M.S., Barnhart, T.E., Mukherjee, J., Schneider, M.L., Christian, B.T.: 5-HT1A sex based differences in Bmax, in vivo KD, and BPND in the nonhuman primate. Neuroimage, 77: 125-132, 2013 (published online, March 2013).

Hillmer, A., Wooten, W.D., Slesarev, M.S., Ahlers, E.O., Barnhart, T.E., Schneider, M.L., Mukherjee, J., Christian, B.T. Measuring ?4?2 nicotinic acetylcholine receptor density in vivo 18F-nifene PET in the nonhuman primate. . J. Cereb. Blood Flow Metab., 33: 1806-1814, 2013 (published on line August 2013).

Potkin, S.G., Keator, D.B., Kesler-West, M.L., Nguyen, D.D., van Erp, T.G.M., Mukherjee, J., Shah, N., Preda, A. D2 receptor occupancy following lurasidone treatment in patients with schizophrenia or schizophrenia disorder. CNS Spectrums, doi:10.1017/S109285291300059X, 2013 (published on line October 2013).

Hillmer, A., Wooten, D., Farhoud, M., Higgins, A., Lao, P., Barnhart, T., Mukherjee, J., Christian, B. PET imaging of acetylcholinesterase inhibitor induced effects on ?4?2 nicotinic acetylcholine receptor binding. Synapse, 67: 882-886, 2013 (published on line August 2013).

Mirbolooki, M.R., Upadhyay, S.K., Constantinescu, C., Pan, M.L., Mukherjee, J. Adrenergic pathway activation enhances brown adipose tissue metabolism: A 18F-FDG PET/CT study in mice. Nucl Med Biol., 41(1):10-16, 2014 (published on line October 2013).

Baranwal, A., Patel, H.H., Mukherjee, J. 18F-Fluorodeoxyglycosylamines: Maillard reaction of 18F-FDG with biological amines. J. Label. Compds. Radiopharm., 57(2): 86-91, 2014 (published online, earlyview, December 2013).

Tahara, N., Mukherjee, J., de Haas, H.J., Petrov, A.D., Tawakol, A., Haider, N., Tahara, A., Constantinescu, C.C., Zhou J., Boersma, H.H., Imaizumi, T., Nakano, M., Finn, A., Fayad, Z., Virmani, R. Fuster, F., Bosca, L. and Narula, J.: 2-Deoxy-[2-18F]fluoro-D-mannose positron emission tomography imaging in atherosclerosis. Nature Medicine, 20(2): 215-219, 2014 (online, January 12, 2014).

Pandey, S.K., Venugopal, A., Kant, R., Coleman, R.A., Mukherjee, J. 124I-Epidepride: A high affinity and selective PET radiotracer with potential for extended imaging of dopamine D2/D3 receptors. Nucl. Med. Biol.,41(5): 426-431, 2014 (published online January 2014).

Pandey, S.K., Kaur, J., Easwaramoorthy, B., Shah A., Coleman, R.A., Mukherjee, J. Multimodality imaging probe for PET and fluorescence imaging. Molecular Imaging, 13(3): 1-7, 2014 (published online March 2014).

Tang, W., Kuruvilla, S.A., Galitovskiy, V., Pan, M-L., Grando, S.A., Mukherjee, J.: Targeting histone deacetylase in lung cancer for early diagnosis: 18F-FAHA PET/CT imaging of NNK-treated A/J mice model. Amer. J. Nucl. Med. Mol. Imaging, 4(4): 324-332, 2014.

Garcia, A., Venugopal, A., Pan, M-L., Mukherjee, J. Imaging pancreas in healthy and diabetic rodent model using 18F-fallypride PET/CT. Diabetes Technology. & Therapeutics Development., 16(10): 640-643, 2014 (published online May 2014).

Kuruvilla, S.A., Hillmer, A., Wooten, D.W., Patel, A., Christian, B.T., Mukherjee, J. Synthesis and evaluation of 2-18F-fluoro-5-iodo-3-[2-(S)-3,4-dehydropyrrolinylmethoxy]pyridine (18F-niofene) as a potential imaging agent for nicotinic a4b2 receptors. Amer. J. Nucl. Med. Mol. Imaging, 4(4): 354-364, 2014.

Kaur, J., Khararjian, A., Coleman, R.A., Constantinescu, C.C., Pan, M-L., Mukherjee, J. Spinal cord dopamine D2/D3 receptors: In vivo and ex vivo imaging in the rat using 18F/11C-Fallypride. Nucl. Med. Biol., 41: 841-847, 2014 (published online August 2014).

Wooten, D., Hillmer, A., Murali, D., Barnhart, T., Bonab, A., Normandin, M., Schneider, M.L., Thio, J.P., Bajwa, A.K., Mukherjee, J., Christian, B.T. An in vivo comparison of 3- and 4-trans-[18F]Mefway in the nonhuman primate. Amer. J. Nucl. Med. Mol. Imag., 4(5): 483-489, 2014. [Cover image online in the issue is from the paper]

Hillmer, A.T, Wooten, D.W., Bajwa, A.K., Higgins, A.T., Lao, P.J., Bettehauser, T.J., Barnhart, T.E., Rowley, H.A., Stone, C.K., Sterling, J.C., Mukherjee, J., Christian, B.T. First in Human Evaluation of [18F]Mefway, a PET Radioligand Specific to Serotonin-1A Receptors. J. Nucl. Med., 55(12): 1973-1979, 2014. [Cover image in the issue is from the paper]

Mirbolooki, M.R., Schade, K.N., Constantinescu, C.C., Pan, M-L., Mukherjee, J. Enhancement of 18F-fluorodeoxyglucose metabolism in rat brain frontal cortex using a ?beta3 adrenoceptor agonist. Synapse, 69 (2): 96-98, 2015 (published online November 2014).

Thio, J.P., Liang, C., Bajwa, A.K., Wooten, D.W., Christian, B.T., Mukherjee, J. Synthesis and evaluation of mefway analogs as ligands for serotonin 5HT1A receptors. Med. Chem. Res., 24(4): 1480-1486, 2015 (published online September 2014).

Schade, K.N., Baranwal, A., Liang, C., Mirbolooki, M.R., Mukherjee, J. Preliminary Evaluation of ?3-Adrenoceptor Agonist-Induced 18F-FDG Metabolic Activity in Brown Adipose Tissue of Obese Zucker Rat. Nuclear Medicine & Biology, 42(8):691-694, 2015 (published online April 2015).

Baranwal, A., Mukherjee, J. 18F-Fluorodeoxyglucamines: Reductive amination of hydrophilic 18F-fluoro-2-deoxyglucose with lipophilic amines for the development of potential PET imaging agents. Bioorganic Medicinal Chemistry Letter, 25 (15): 2902-2906, 2015 (published online May 2015).
   
  Mukherjee, J., Constantinescu, C.C., Hoang, A.T., Jerjian, T., Majji D., Pan, M-L.: Evaluation of 18F-fallypride binding to dopamine D3 receptor subtype using in vitro and in vivo imaging in the rodent brain. Synapse, 69 (12): 577-591, 2015 [Cover image in the issue is from the paper].

Baranwal, A., Mirbolooki, M.R., Mukherjee, J.: Initial assessment of ß3-adrenoceptor activated brown adipose tissue in streptozotocin-induced diabetic rodent model using 18F-FDG PET/CT Molecular Imaging, 14: 561-566, 2015.

Mukherjee, J., Bajwa, A.K., Wooten, D.W., Hillmer, A.T., Pan, M-L., Pandey, S.K., Saigal, N., Christian, B.T.: Comparative assessment of 18F-Mefway as a serotonin 5-HT1A receptor PET imaging agent across species-rodents, nonhuman primates and humans. J. Comparative Neurology, 524(7): 1457-1471, 2016.

Pan, M.L., Mukherjee, M.T., Patel, H.H., Patel, B., Constantinescu, C.C., Mirbolooki, M.R., Liang, C., Mukherjee, J.: Evaluation of [11C]TAZA for amyloid A? plaque imaging in postmortem Alzheimer’s disease brain region and whole body distribution in rodent PET/CT. Synapse, 70: 163-176, 2016 (Editor’s Choice Paper).

Pithia, N.K., Liang, C., Pan, X-Z., Pan, M-L., Mukherjee, J.: Synthesis and evaluation of (S)-[18F]Fesetron in the rat brain as a potential PET imaging agent for serotonin 5-HT3 receptors. Bioorg. Med. Chem. Lett., 26 (8): 1919-1924, 2016.

Mukherjee, J., Baranwal, A., Schade, K.N.: Classification of therapeutic and experimental drugs for brown adipose tissue activation: Potential treatment strategies for diabetes and obesity. Current Diabetes Reviews, 12: 414-428, 2016.
   
Grants National Institute of Health, R01: “PET imaging agents for a4b2 nicotinic receptors”, Principal Investigator: J. Mukherjee
   
National Institute of Health, R21: "Fluorine-18 labeled functional dopamine receptor imaging agents”, Principal Investigator: J. Mukherjee
   
Professional
Societies
1983 - Present: American Chemical Society
1989 - Present: Society of Nuclear Medicine
1995 - Present: Society of Neuroscience
2004 – Present: Society of Radiopharmaceutical Science
Life Member: Indo-American Society of Nuclear Medicine
   
Graduate Programs Cellular and Molecular Biosciences

   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=5942
   
Last updated 11/20/2016