Vi K. Chiu
Assistant Professor, Division of Hematology/Oncology
School of Medicine
School of Medicine
Fellowship — Hematology/Oncology, Memorial Sloan-Kettering Cancer Center, 2009
Residency — Internal Medicine, UT Southwestern, Dallas, 2005
M.D., Ph.D. — Internal Medicine & Cell Biology, New York University, 2002
B.S. — Biochemistry; Chemistry and Material Sciences, UCLA, 1994
Residency — Internal Medicine, UT Southwestern, Dallas, 2005
M.D., Ph.D. — Internal Medicine & Cell Biology, New York University, 2002
B.S. — Biochemistry; Chemistry and Material Sciences, UCLA, 1994
University of California, Irvine
839 Health Sciences Road
Sprague Hall, Room 116
Irvine, CA 92697
839 Health Sciences Road
Sprague Hall, Room 116
Irvine, CA 92697
Research Interests
Stem Cell Aberrancy in Cancer, Colorectal Cancer, Pancreatic Cancer, Small Cell Lung Cancer and Tumor Microenvironment
Academic Distinctions
ASCO Young Investigator Award (2008)
Pasteur Foundation Fellowship (2005)
UCLA President’s Undergraduate Fellowship (1994)
UT Southwestern (Dallas) SURFellowship (1994)
UCLA Ramsey Award in Physical Chemistry (1993)
Pasteur Foundation Fellowship (2005)
UCLA President’s Undergraduate Fellowship (1994)
UT Southwestern (Dallas) SURFellowship (1994)
UCLA Ramsey Award in Physical Chemistry (1993)
Research Abstract
As a physician scientist, I prioritize translational research to develop effective oncologic therapies for human colon, pancreatic and small cell lung cancers. My laboratory focuses on oncogenic Ras, Wnt and chemokine signaling pathways in the human tumor microenvironment. These pathways drive the development and progression of human tumors from aberrant adult stem cells and their activated stromal microenvironment. Therapeutic targeting of stem cell aberrancies and chemokine signaling may lead to improvement in patient survival.
Publications
Peer review:
Le Rolle, AF, Chiu, TK, Zeng, Z, Shia, J, Weiser, MR, Paty, PB, Chiu, VK. Oncogenic KRAS activates the embryonic stem cell-like program in human colon cancer initiation. Oncotarget. 2016 Jan 19; 7(3):2159-74. PMID 26744320
Le Rolle, A., Chiu, T.K., Fara, M., Zeng, Z., Shia, J., Weiser, M.R., Paty, P.B., Chiu, V.K. The prognostic significance of CXCL1 hypersecretion by human colorectal epithelia and myofibroblasts. Journal of Translational Medicine. 2015 June 24. PMID 26104296
Le Rolle, A., Klempner, S.J., Christopher, G.R., Serry, T., Sanford, E.M., Balasubramanian, S., Ross, J.S., Stephens, P.J., Miller, V.A., Ali, S.M., and Chiu, V.K. Identification and characterization of RET fusions in advanced colorectal cancer. Oncotarget. 2015 May 30. PMID 26078337
Mirpuri, R.G., Brammeier, J., Chen, H., Hsu, F., Chiu, V.K., and Chang, E.Y. Spinal Cord Stimulation for Treatment of the Pain Associated with Hereditary Multiple Osteochondromas. Journal Of Pain Research. 2015 Aug 8; 8: 557-560.
Kobayashi, H., Butler, J.M., O’Donnell, R., Kobayashi, M., Ding, BS, Bonner, B., Chiu, V.K., Nolan, D.J., Shido, K., Benjamin, L., and Rafii, S. Angiocrine factors derived from Akt-activated endothelium balance self-renewal and differentiation of hematopoietic stem cells. Nature Cell Biology. 2010 Nov 4; 12 (11): 1046-56. PMID 20972423
Michaelson, D., Ali W., Chiu, V.K., Bergo, M., Silletti, J., Wright, L., Young, S.G., and Philips, M.R. Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases. Mol Biol Cell. 2005 Apr; 16(4): 1606-16. PMID 15659645
Chiu, V.K., Silletti, J., Dinsell, V., Wiener, H., Loukeris, K., Ou, G., Philips, M.R., and Pillinger, M.H. Carboxyl methlylation of Ras regulates membrane targeting and effector engagement. J Biol Chem. 2004 Feb 20;279(8): 7346-52. PMID 14660603
Bivona, T.G., Weiner, H., Silletti, J., Chiu, V.K., and Philips, M.R. Rap1 upregulation and activation on plasma membrane regulates T cell adhesion. J Cell Biol. 2004 Feb 2;164(3): 461-70. PMID 11988737
Bivona, T.G., de Castro, I.P., Ahearn, I.M., Grana, T.M Chiu, V.K., Lockyer, P.J., Cullen, P.J., Pellicer, A., Cox, A.D., and Philips, M.R. Phospholipase C activates Ras on the Golgi apparatus by means of RasGRP1. Nature. 2003 Aug 7;424: 694-698. PMID 14757755
Chiu, V.K., Bivona, T., Hach, A., Sajous, B.J., Silletti, J., Weiner, H., Johnson-II, R.L., Cox, A.D., and Philips, M.R. Ras signalling on the endoplasmic reticulum and the Golgi. Nature Cell Biology. 2002 May;4(5): 343-50. PMID 12845332
Choy, E., Chiu, V.K., Silletti, J., Feoktistov, M., Morimoto, T., Michaelson, D., Ivanov, I.E., and Philips, M.R. Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi. Cell. 1999 Jul 9;98(1): 69-80. PMID 10412982
Dai, Q., Choy, E., Chiu, V., Romano, J., Slivka, S.R., Steitz, S.A., Michaelis, S., and Philips, M.R. Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. J Biol Chem. 1998 Jun 12;273(24): 15030-4. PMID 9614111
Chiu, V.K., Walsh, C.M., Liu, C.C., Reed, J.C., and Clark, W.R. Bcl-2 blocks degranulation but not fas based cell-mediated cytotoxicity. J Immunol. 1995 Mar 1;154(5): 2023-32. PMID 7532659
Walsh, C.M., Glass, A.A., Chiu, V., and Clark, W.R. The role of the Fas lytic pathway in a perforin-less CTL hybridoma. J Immunol. 1994 Sep 15;153(6): 2506-14. PMID 7521365
Editorials, Chapters
Chiu, VK and Le Rolle, AF. Cancer comes of age embryonically. Aging. 2016. May 12. PMID 27191151
Chiu, VK. “Myelodysplastic and Myeloproliferative Disorders.” Parkland Manual of in-patient medicine: an evidence based approach. Philadelphia: F.A. Davis Company, 2006.
Le Rolle, AF, Chiu, TK, Zeng, Z, Shia, J, Weiser, MR, Paty, PB, Chiu, VK. Oncogenic KRAS activates the embryonic stem cell-like program in human colon cancer initiation. Oncotarget. 2016 Jan 19; 7(3):2159-74. PMID 26744320
Le Rolle, A., Chiu, T.K., Fara, M., Zeng, Z., Shia, J., Weiser, M.R., Paty, P.B., Chiu, V.K. The prognostic significance of CXCL1 hypersecretion by human colorectal epithelia and myofibroblasts. Journal of Translational Medicine. 2015 June 24. PMID 26104296
Le Rolle, A., Klempner, S.J., Christopher, G.R., Serry, T., Sanford, E.M., Balasubramanian, S., Ross, J.S., Stephens, P.J., Miller, V.A., Ali, S.M., and Chiu, V.K. Identification and characterization of RET fusions in advanced colorectal cancer. Oncotarget. 2015 May 30. PMID 26078337
Mirpuri, R.G., Brammeier, J., Chen, H., Hsu, F., Chiu, V.K., and Chang, E.Y. Spinal Cord Stimulation for Treatment of the Pain Associated with Hereditary Multiple Osteochondromas. Journal Of Pain Research. 2015 Aug 8; 8: 557-560.
Kobayashi, H., Butler, J.M., O’Donnell, R., Kobayashi, M., Ding, BS, Bonner, B., Chiu, V.K., Nolan, D.J., Shido, K., Benjamin, L., and Rafii, S. Angiocrine factors derived from Akt-activated endothelium balance self-renewal and differentiation of hematopoietic stem cells. Nature Cell Biology. 2010 Nov 4; 12 (11): 1046-56. PMID 20972423
Michaelson, D., Ali W., Chiu, V.K., Bergo, M., Silletti, J., Wright, L., Young, S.G., and Philips, M.R. Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases. Mol Biol Cell. 2005 Apr; 16(4): 1606-16. PMID 15659645
Chiu, V.K., Silletti, J., Dinsell, V., Wiener, H., Loukeris, K., Ou, G., Philips, M.R., and Pillinger, M.H. Carboxyl methlylation of Ras regulates membrane targeting and effector engagement. J Biol Chem. 2004 Feb 20;279(8): 7346-52. PMID 14660603
Bivona, T.G., Weiner, H., Silletti, J., Chiu, V.K., and Philips, M.R. Rap1 upregulation and activation on plasma membrane regulates T cell adhesion. J Cell Biol. 2004 Feb 2;164(3): 461-70. PMID 11988737
Bivona, T.G., de Castro, I.P., Ahearn, I.M., Grana, T.M Chiu, V.K., Lockyer, P.J., Cullen, P.J., Pellicer, A., Cox, A.D., and Philips, M.R. Phospholipase C activates Ras on the Golgi apparatus by means of RasGRP1. Nature. 2003 Aug 7;424: 694-698. PMID 14757755
Chiu, V.K., Bivona, T., Hach, A., Sajous, B.J., Silletti, J., Weiner, H., Johnson-II, R.L., Cox, A.D., and Philips, M.R. Ras signalling on the endoplasmic reticulum and the Golgi. Nature Cell Biology. 2002 May;4(5): 343-50. PMID 12845332
Choy, E., Chiu, V.K., Silletti, J., Feoktistov, M., Morimoto, T., Michaelson, D., Ivanov, I.E., and Philips, M.R. Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi. Cell. 1999 Jul 9;98(1): 69-80. PMID 10412982
Dai, Q., Choy, E., Chiu, V., Romano, J., Slivka, S.R., Steitz, S.A., Michaelis, S., and Philips, M.R. Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. J Biol Chem. 1998 Jun 12;273(24): 15030-4. PMID 9614111
Chiu, V.K., Walsh, C.M., Liu, C.C., Reed, J.C., and Clark, W.R. Bcl-2 blocks degranulation but not fas based cell-mediated cytotoxicity. J Immunol. 1995 Mar 1;154(5): 2023-32. PMID 7532659
Walsh, C.M., Glass, A.A., Chiu, V., and Clark, W.R. The role of the Fas lytic pathway in a perforin-less CTL hybridoma. J Immunol. 1994 Sep 15;153(6): 2506-14. PMID 7521365
Editorials, Chapters
Chiu, VK and Le Rolle, AF. Cancer comes of age embryonically. Aging. 2016. May 12. PMID 27191151
Chiu, VK. “Myelodysplastic and Myeloproliferative Disorders.” Parkland Manual of in-patient medicine: an evidence based approach. Philadelphia: F.A. Davis Company, 2006.
Professional Societies
American Society for Clinical Oncology
American Association for Cancer Research
SWOG
Research Centers
Chao Family Comprehensive Cancer Center
Cancer Research Institute
Link to this profile
https://faculty.uci.edu/profile/?facultyId=5882
https://faculty.uci.edu/profile/?facultyId=5882
Last updated
08/02/2016
08/02/2016