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Vi K. Chiu

Assistant Professor, Division of Hematology/Oncology
School of Medicine

Fellowship — Hematology/Oncology, Memorial Sloan-Kettering Cancer Center, 2009

Residency — Internal Medicine, UT Southwestern, Dallas, 2005

M.D., Ph.D. — Internal Medicine & Cell Biology, New York University, 2002

B.S. — Biochemistry; Chemistry and Material Sciences, UCLA, 1994

Phone: (949) 824-9432
Fax: (949) 824-2557
Email: vkchiu@uci.edu

University of California, Irvine
839 Health Sciences Road
Sprague Hall, Room 116
Irvine, CA 92697

picture of Vi K. Chiu

Tumorigenic Adult Stem Cells, Colon Cancer, Small Cell Lung Cancer, Pancreatic Cancer, and Tumor Microenvironment
ASCO Young Investigator Award (2008)
Pasteur Foundation Fellowship (2005)
UCLA President’s Undergraduate Fellowship (1994)
UT Southwestern (Dallas) SURFellowship (1994)
UCLA Ramsey Award in Physical Chemistry (1993)
As a physician scientist, I prioritize translational research to develop effective oncologic therapies for human colon, pancreatic and small cell lung cancers. My laboratory focuses on oncogenic Ras, Wnt and chemokine signaling pathways. These pathways drive the development and progression of human tumors from aberrant adult stem cells and their activated stromal microenvironment. Therapeutic targeting of Wnt and chemokine signaling may lead to improvement in patient survival.
Publications Peer review:

Kobayashi, H., Butler, J.M., O’Donnell, R., Kobayashi, M., Ding, BS, Bonner, B., Chiu, V.K., Nolan, D.J., Shido, K., Benjamin, L., and Rafii, S. Angiocrine factors derived from Akt-activated endothelium balance self-renewal and differentiation of hematopoietic stem cells. Nature Cell Biology. 2010 Nov 4; 12 (11): 1046-56.

Michaelson, D., Ali W., Chiu, V.K., Bergo, M., Silletti, J., Wright, L., Young, S.G., and Philips, M.R. Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases. Mol Biol Cell. 2005 Apr; 16(4): 1606-16.

Chiu, V.K., Silletti, J., Dinsell, V., Wiener, H., Loukeris, K., Ou, G., Philips, M.R., and Pillinger, M.H. Carboxyl methlylation of Ras regulates membrane targeting and effector engagement. J Biol Chem. 2004 Feb 20;279(8): 7346-52.

Bivona, T.G., Weiner, H., Silletti, J., Chiu, V.K., and Philips, M.R. Rap1 upregulation and activation on plasma membrane regulates T cell adhesion. J Cell Biol. 2004 Feb 2;164(3): 461-70.

Bivona, T.G., de Castro, I.P., Ahearn, I.M., Grana, T.M Chiu, V.K., Lockyer, P.J., Cullen, P.J., Pellicer, A., Cox, A.D., and Philips, M.R. Phospholipase C activates Ras on the Golgi apparatus by means of RasGRP1. Nature. 2003 Aug 7;424: 694-698.

Chiu, V.K., Bivona, T., Hach, A., Sajous, B.J., Silletti, J., Weiner, H., Johnson-II, R.L., Cox, A.D., and Philips, M.R. Ras signalling on the endoplasmic reticulum and the Golgi. Nature Cell Biology. 2002 May;4(5): 343-50.

Choy, E., Chiu, V.K., Silletti, J., Feoktistov, M., Morimoto, T., Michaelson, D., Ivanov, I.E., and Philips, M.R. Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi. Cell. 1999 Jul 9;98(1): 69-80.

Dai, Q., Choy, E., Chiu, V., Romano, J., Slivka, S.R., Steitz, S.A., Michaelis, S., and Philips, M.R. Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. J Biol Chem. 1998 Jun 12;273(24): 15030-4.

Chiu, V.K., Walsh, C.M., Liu, C.C., Reed, J.C., and Clark, W.R. Bcl-2 blocks degranulation but not fas based cell-mediated cytotoxicity. J Immunol. 1995 Mar 1;154(5): 2023-32.

Walsh, C.M., Glass, A.A., Chiu, V., and Clark, W.R. The role of the Fas lytic pathway in a perforin-less CTL hybridoma. J Immunol. 1994 Sep 15;153(6): 2506-14.

Book Chapters:

Chiu, V. “Myelodysplastic and Myeloproliferative Disorders.” Parkland Manual of in-patient medicine: an evidence based approach. Philadelphia: F.A. Davis Company, 2006. 847-855.
American Society for Clinical Oncology
American Association for Cancer Research
Research Centers Chao Family Comprehensive Cancer Center
Cancer Research Institute
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=5882
Last updated 06/13/2013