Alessio Pigazzi

Associate Clinical Professor, Surgery
School of Medicine

A.B., Boston University, 1991, Biology

M.D., Boston University School of Medicine, 1998, Medicine

Ph.D., Boston University School of Medicine, 1998, Biochemistry

M.D., Universita' degli Studi di Roma "La Sapienza", Medicine

Phone: (714) 456-8511

University of California, Irvine
333 City Blvd West
Suite 850
Orange, CA 92868

picture of Alessio  Pigazzi

Top Doctors, Pasadena Magazine, 2012
Resident Achievement Award, SAGES 2002
Alpha Omega Alpha, Honor Medical Society, 1998
Savenor Prize for Student Excellence in Surgery, Boston University, 1998
American Heart Association Student Research Fellowship, 1992-1993
Karen Grunebaum Research Award, Boston University, 1993
Betty Lea Stone, American Cancer Society Student Research Award, 1992
Publications BOOK CHAPTERS

1. Pigazzi A, Ravalli S. Crigler-Najjar Syndrome, in E-Medicine, online medical textbook, 2001.

2. Ewing DE, Pigazzi A, Ballantyne, G. Robotic Colorectal Surgery. In Ballantyne GH Robotic Surgery: Theory and Operative Technique, Lippincott Williams and Wilkins, in press

3. Ewing DE, Pigazzi A, Ballantyne, G. Telerobotic Laparoscopic Colorectal Surgery. In: Ballantyne GH. Primer of Robotic and Telerobotic Surgery. Lippincott Williams and Wilkins. Philadelphia. 2004.

4. Pigazzi A, Ewing, DE, Ballantyne G. Credentialing in Telerobotic Surgery. In: Ballantyne GH. Primer of Robotic and Telerobotic Surgery. Lippincott Williams and Wilkins. Philadelphia. 2004.

5. Pigazzi A, Wagman LD. Robotic insertion of hepatic artery infusion pump In: International Principles of Laparoscopic Surgery. Edited by Eldo E. Frezza, MD. Cine-Med, Inc., Woodbury 2006

6. Oxner CR, Pigazzi, A. Laparoscopic Low Anterior Resection. In: Nguyen, NT, Scott-Conner C. The SAGES Manual. Springer. New York, 2012

7. Pigazzi A. Robotic-Assisted Total Mesorectal Excision. In: Corman, ML.
Corman’s Colon and Rectal Surgery. Lippincott Williams and Wilkins. Philadelphia, 2012.

8. Halabi WJ, Jafari MD, Pigazzi A “Rectal Surgery” In “Robotic Surgery for the General Surgeon” Editor: Dimitry Oleynikov MD. Nova Publishing. In progress.

9. Jafari MD, Pigazzi A. Operative Techniques in Surgery. Low Anterior Rectal Resection: Robotic-Assisted Laparoscopic Technique. Philadelphia: Lippincott Williams & Wilkins.
10. Jafari MD, Pigazzi A. Minimally Invasive Approaches to Colon and Rectal Disease: Techniques and Best Practices. Robotic Surgery. New York City: Springer.
11. Lee KH, Jafari MD, Pigazzi A. Robotics in General Surgery. Robotic-Assisted Extralevator abdomineoperineal resection.

1. Upchurch GR JR, Welch GN, Fabian AJ, Pigazzi A, Keaney JF Jr, Loscalzo J. Stimulation of endothelial nitric oxide production by homocyst(e)ine. Atherosclerosis. 1997; 132(2):177

2. Upchurch GR JR, Welch GN, Freedman JE, Fabian AJ, Pigazzi A, Scribner AM, Alpert CS, Keaney JF Jr, Loscalzo J. High-dose heparin decreases nitric oxide production by cultured bovine endothelial cells. Circulation. 1997;95(8):2115

3. Manfredi PL, Herskovitz S, Folli F, Pigazzi A, Swerdlow ML. Spinal edidural abscess: treatment options. Eur Neurol. 1998; 40(1):58

4. Welch GN, Upchurch, GR Jr, Farivar RS, Pigazzi A Vu K, Brecher P, Keaney JF Jr, Loscalzo J. Homocysteine-induced nitric oxide production in vascular smooth muscle cells by NF-kappa B-dependent transcriptional activation of Nos2. Proc Assoc Am Physicians. 1998;110(1):22

5. Manfredi PL, Chandler S, Pigazzi A, Payne R. Outcome of cancer pain consultations. Cancer. 2000; 89(4):920

6. Pigazzi A, Manfredi PL. Case presentation: Undertreatment of pain: a risk associated with neuromuscular blockade in the intensive care unit. J Pain Symptom Manage. 2000; 19(2):154

7. Pigazzi A, Heydrick S, Folli F, Benoit S, Michelson A, Loscalzo J. Nitric oxide inhibits thrombin receptor-activating peptide-induced phosphoinositide 3-kinase activity in human platelets. J Biol Chem. 1999; 274(20):14368

8. Ewing DE, Pigazzi A, Wang Y, Ballantyne G. Robots in the operating room-the history. Sem Laparosc Surg. 2004; 11(2):63-71

9. Stipa F, Burza A, Lucandri G, Ferri M, Pigazzi A, Ziparo V, Casula G, Stipa S Outcomes for early rectal cancer managed with transanal endoscopic microsurgery: a 5-year follow-up study. Surg Endosc. 2006; 20(4):541-5

10. Ballantyne GH, Ewing D, Pigazzi A, Wasielewski A. Telerobotic-assisted Laparoscopic Right Hemicolectomy: Lateral to Medial or Medial to Lateral Dissection? Surg Lapar Endosc & Perc Techn 2006; 16 (6): 406-410

11. Pigazzi, A, Ellenhorn JDI, Ballantyne GH, Paz IB, Robotic-assisted laparoscopic low anterior resection with total mesorectal excision for rectal cancer. Surg Endosc 2006; 20:1521-1525

12. Anderson C, Ellenhorn JD, Hellan M, Pigazzi A. Pilot series of robotic assisted laparoscopic subtotal gastrectomy with extended lymphadectomy for gastric cancer. 2007; 21(9):1662-6

13. Pigazzi A, Hellan M, Ewing DR, Paz IB, Ballantyne GH Laparoscopic Medial-to-Lateral Colon Dissection: How and Why. Journal of Gastrointestinal Surgery 2007; 11:778-782.

14. Anderson C, Hellan M, Trisal V, Kernstine K, Pigazzi A. Robotic Surgery for gastrointestinal malignancies. Int J Med Robot. 2007; 3(4):297-300

15. Anderson C, Hellan M, Pigazzi A. Robotic–assisted laparoscopic gastrectomy for distal gastric cancer. E publication July 2007 WEBSURG

16. Hellan M, Pigazzi A. Robotic-assisted placement of hepatic artery infusion catheter for regional chemotherapy. Surg Endosc. 2008; 22(2):548-51

17. Pigazzi A, Anderson C, Mojica-Manosa P, Smith D, Hernandez K, Paz IB, Ellenhorn JDI. Impact of a full time preceptor on the institutional outcome of laparoscopic colectomy. Surg Endosc. 2008; 22(3):635-9

18. Hellan M, Anderson C, Paz IB, Pigazzi A. Short-term outcomes after robotic-assisted surgery for rectal cancer. Ann Surg Oncol. 2007; 14(11):3168-73

19. Stipa F, Pigazzi A, Bascone B,Cimitan A,Villotti G, Burza V, Vitale A. Management of obstructive colorectal cancer with endoscopic stenting followed by single stage surgery: open or laparoscopic resection? Surg Endosc. 2008; 22(6):1477-81

20. Anderson C, Uman G, Pigazzi A. Oncologic outcomes of laparoscopic surgery for rectal cancer: A systematic review and meta-analysis of the literature. Eur J Surg Oncol. 2008 Oct;34(10):1135-42

21. Hellan M, Stein H, Pigazzi A. Totally robotic low anterior resection with total mesorectal excision and splenic flexure mobilization. Surg Endosc. 2009 Feb;23(2):447-51. Epub 2008 Dec 5.

22. Guzman EA, Dagis A, Bening L, Pigazzi A. Laparoscopic gastrojejunostomy in patients with obstruction of the gastric outlet secondary to advanced malignancies. Am Surg. 2009 Feb;75(2):129-32

23. Kim J, Sun CL, Mailey B, Prendergast C, Artinyan A, Bhatia S, Pigazzi A, Ellenhorn JD. Race and ethnicity correlate with survival in patients with gastric adenocarcinoma. Ann Oncol. 2009 Jul 21.

24. Guzman EA, Pigazzi A, Lee B, Soriano PA, Nelson RA, Benjamin Paz I, Trisal V, Kim J, Ellenhorn JD. Totally laparoscopic gastric resection with extended lymphadenectomy for gastric adenocarcinoma. Ann Surg Oncol. 2009 Aug;16(8):2218-23

25. Hellan M, Anderson C, Pigazzi A. Extracorporeal versus intracorporeal anastomosis for laparoscopic right hemicolectomy. JSLS. 2009 Jul-Sep;13(3):312-7.

26. Guzman EA, Nelson RA, Kim J, Pigazzi A, Trisal V, Paz B, Di Ellenhorn J. Increased incidence of pancreatic fistulas after the introduction of a bioabsorbable staple line reinforcement in distal pancreatic resections. Am Surg. 2009 Oct; 75(10):954-7.

27. Baek JH, McKenzie S, Garcia-Aguilar J, Pigazzi A. Oncologic outcomes of robotic-assisted total mesorectal excision for the treatment of rectal cancer.Ann Surg. 2010 May; 251(5):882-6.

28. Pigazzi A, Luca F, Patriti A, Valvo M, Ceccarelli G, Casciola L, Biffi R, Garcia-Aguilar J, Baek JH. Multicentric Study on Robotic Tumor-Specific Mesorectal Excision for the Treatment of Rectal Cancer. Ann Surg Oncol. 2010 Jun;17(6):1614-20

29. Pigazzi A, Garcia-Aguilar J. Robotic colorectal surgery: for whom and for what? Dis Colon Rectum. 2010 Jul; 53 (7):969-70

30. McKenzie S, Baek JH, Wakabayashi M, Garcia-Aguilar J, Pigazzi A. Totally laparoscopic right colectomy with transvaginal specimen extraction: the authors' initial institutional experience. Surg Endosc. 2010 Aug; 24(8):2048-52.

31. McKenzie S, Lee W, Artinyan A, Mailey B, Pigazzi A, Ellenhorn J, Kim J. Surgical resection and multidisciplinary care for primary and metastatic pancreatic islet cell carcinomas.J Gastrointest Surg. 2010 Nov;14(11):1796-803

32. Kachikwu EL, Trisal V, Kim J, Pigazzi A, Ellenhorn JD. Minimally invasive total gastrectomy for gastric cancer: a pilot series. J Gastrointest Surg. 2011 Jan; 15(1):81-6

33. Baek JH, Pastor C, Pigazzi A. Robotic and laparoscopic total mesorectal excision for rectal cancer: a case-matched study. Surg Endosc. 2011 Feb; 25(2):521-5

34. Kim J, Artinyan A, Mailey B, Christopher S, Lee W, McKenzie S, Chen SL, Bhatia S, Pigazzi A, Garcia-Aguilar J. An interaction of race and ethnicity with socioeconomic status in rectal cancer outcomes. Ann Surg. 2011 Apr;253(4):647-54

35. Akmal Y, Bailey C, Baek JH, Metchikian M, Pigazzi A. Oncological outcomes of laparoscopic colon resection for cancer after implementation of a full-time preceptorship. Surg Endosc. 2011 Apr 13. [Epub ahead of print]

36. Chen Z, Liu Z, Li W, Qu K, Deng X, Varma MG, Fichera A, Pigazzi A, Garcia-Aguilar J. Chromosomal copy number alterations are associated with tumor response to chemoradiation in locally advanced rectal cancer. Genes Chromosomes Cancer. 2011 May 16

37. Garcia-Aguilar J, Shi Q, Thomas CR Jr, Chan E, Cataldo P, Marcet J, Medich D, Pigazzi A, Oommen S, Posner MC. Neoadjuvant Chemoradiation and Local Excision for T2N0 Rectal Cancer: Preliminary Results of the ACOSOG Z6041 Trial. Ann Surg Oncol. 2012 Feb;19(2):384-91.

38. Ho J, Pigazzi A. Laparoscopic repair of extraction site ventral hernia after robotic prostatectomy: institutional experience with 42 consecutive cases. Hernia. 2011 Jun 21. [Epub ahead of print]

39. Collinson FJ, Jayne DG, Pigazzi A, Tsang C, Barrie JM, Edlin R, Garbett C, Guillou P, Holloway I, Howard H, Marshall H, McCabe C, Pavitt S, Quirke P, Rivers CS, Brown JM. An international, multicentre, prospective, randomised, controlled, unblinded, parallel-group trial of robotic-assisted versus standard laparoscopic surgery for the curative treatment of rectal cancer. Int J Colorectal Dis. 2012 Feb;27(2):233-41

40. Allison N, Tieu K, Snyder B, Pigazzi A, Wilson E. Technical feasibility of robot-assisted Ventral hernia repair. World J Surg. 2012 Feb;36(2):447-52

41. Akmal Y, Baek JH, McKenzie S, Garcia-Aguilar J, Pigazzi A. Robot-assisted total mesorectal excision: is there a learning curve? Surg Endosc. 2012 Sep;26(9):2471-6. Epub 2012 Mar 22.

42. Masoomi H, Kang CY, Chaudhry O, Pigazzi A, Mills S, Carmichael JC, Stamos MJ. Predictive factors of early bowel obstruction in colon and rectal surgery: data from the Nationwide Inpatient Sample, 2006-2008. J Am Coll Surg. 2012 May;214(5):831-7. PMID: 22464661 Epub 2012 Mar 28

43. Kang CY, Halabi WJ, Luo R, Pigazzi A, Nguyen NT, Stamos MJ. Laparoscopic Colorectal Surgery: A Better Look Into the Latest Trends. Arch Surg. 2012 Apr 16. PMID:22508667 [Epub ahead of print]

44. Baek JH, Alrubaie A, Guzman EA, Choi SK, Anderson C, Mills S, Carmichael J, Dagis A, Qian D, Kim J, Garcia-Aguilar J, Stamos MJ, Bening L, Pigazzi A. The association of hospital volume with rectal cancer surgery outcomes. Int J Colorectal Dis. 2012 Jul 29. PMID:22842664 [Epub ahead of print]

45. Kang CY, Halabi WJ, Chaudhry OO, Nguyen V, Pigazzi A, Carmichael JC, Mills S, Stamos MJ. Risk Factors for Anastomotic Leakage after Anterior Resection for Rectal Cancer. Arch Surg. 2012 Sep 17:1-7. doi: 10.1001/2013.jamasurg.2. PMID: 22508667 [Epub ahead of print]

46. Kang CY, Carmichael JC, Friesen J, Stamos MJ, Mills S, Pigazzi A. Robotic-assisted extralevator abdominoperineal resection in the lithotomy position: technique and early outcomes. Am Surg. 2012 Oct;78(10):1033-7. PMID: 23025934

47. Jimenez Rodriguez RM, Lee MR, Pigazzi A. Trocar guided laparoscopic feeding jejunostomy: a simple new technique. Surg Laparosc Endosc Percutan Tech. 2012 Oct;22(5):e250-3. doi: 10.1097/SLE.0b013e31826366ff. PMID:23047399

48. Kang CY, Chaudhry OO, Halabi WJ, Carmichael JC, Stamos MJ, Mills S. “Outcomes of Laparoscopic Colorectal Surgery: data from the Nationwide Inpatient Sample 2009”. American Journal of Surgery. 2012 Oct. PMID: 23122910

49. Lee KH, Lee MR, Pigazzi A. Robotic-assisted laparoscopic segmental resection with rectoanal anastomosis: a new approach for the management of complicated rectourethral fistula. Tech Coloproctol. 2012 Oct 31. [Epub ahead of print]

50. Kang CY, Halabi WJ, Chaudhry OO, Nguyen VQ, Carmichael JC, Pigazzi A, Stamos MJ, Mills S. “A Nationwide Analysis of Laparoscopy in High-Risk Colorectal Surgery Patients”. Journal of Gastrointestinal Surgery. 2012 Dec 1. PMID:23212528

51. Lee KH, Ho J, Akmal Y, Nelson R, Pigazzi A. Short- and long-term outcomes of intracorporeal versus extracorporeal ileocolic anastomosis in laparoscopic right hemicolectomy for colon cancer. Surg Endosc. 2013 Jan 9. [Epub ahead of print]

52. Jafari MD, Lee K, Halabi WJ, Carmichael JC, Mills S, Pigazzi A, Stamos MJ. “The Use of Indocyanine Green Fluorescence Dye to Assess Anastomotic Tissue Perfusion during Robotic-Assisted Laparoscopic Low Anterior Resection: A Single Institution Pilot Study”. Surgical Endoscopy. 2013 Feb 13. PMID: 23404152

53. Halabi WJ, Jafari MD, Nguyen VQ, Kang CY, Carmichael JC, Mills S, Pigazzi A, Stamos MJ. “Colonic Volvulus in the United States: Trends, Outcomes and Predictors of Mortality”. Annals of Surgery. 2013 Mar 18. PMID: 23511842

54. Halabi WJ, Pigazzi A. “Ask the Experts: The Current Status of Robotic Surgery for Colorectal Cancer” Colorectal Cancer. April 2013, Vol. 2, No. 2, 113-116

55. Halabi WJ, Kang CY, Jafari MD, Nguyen VQ, Carmichael JC, Mills S, Stamos MJ, Pigazzi A. "Robotic-Assisted Colorectal Surgery in the United States: A Nationwide Analysis of Trends and Outcomes". World Journal of Surgery. 2013 Apr 6. PMID: 23564216

56. Halabi WJ, Jafari MD, Mills S, Carmichael JC, Stamos MJ, Pigazzi A. “Epidural Analgesia in Open Colorectal Surgery: A Nationwide Analysis of Trends and Outcomes” Journal of Gastrointestinal Surgery- 2013 Apr 18. PMID: 223595885

57. Jafari MD, Halabi WJ, Nguyen VQ, Stamos MJ, Carmichael JC, Mills S, Pigazzi A. “Associated 30-Day Morbidity of Diverting Ileostomy for Rectal Cancer: Analysis of the ACS-NSQIP” American Surgeon. In press

58. Halabi WJ, Jafari MD, Nguyen VQ, Carmichael JC, Mills S, Pigazzi A, Stamos MJ, Foster CE. “Colorectal Surgery in Kidney Transplant Recipients: A Decade of Trends and Outcomes in the United States" American Surgeon- In press

59. Halabi WJ, Kang CY, Nguyen VQ, Carmichael JC, Mills S, Stamos MJ, Pigazzi A “The Use of Epidural Analgesia in Laparoscopic Colorectal Surgery: A Nationwide Analysis of Trends and Outcomes”. JAMA Surgery- In press

60. Jafari DM, Halabi WJ, Nguyen VQ, Carmichael JC, Mills S, Stamos MJ, Pigazzi A. “Surgical Outcomes of Hyperthermic Intraperitoneal Chemotherapy: Analysis of the American College of Surgeons National Surgical Quality Improvement Program” JAMA Surgery- In press

61. Halabi WJ, Nguyen VQ, Carmichael JC, Pigazzi A, Stamos MJ, Mills S. “Total Colectomy for C Difficile. Predictors of Mortality. Halabi WJ, Nguyen VQ, Carmichael JC, Pigazzi A, Stamos MJ, Mills S. Journal of the American College of Surgeons- In Press.

62. Halabi WJ, Jafari MD, Carmichael JC, Nguyen VQ, Phelan M, Mills S, Stamos MJ, Pigazzi A. "Laparoscopic versus open parastomal hernia repair: an ACS-NSQIP analysis of short-term outcomes" Surgical Endoscopy- In Press.

63. “Ureteral Injuries in Colorectal Surgery: an Analysis of Trends, Outcomes and Risk Factors over a 10-year period in the United States” Halabi WJ, Jafari MD, Nguyen VQ, Carmichael JC, Mills S, Pigazzi A, Stamos MJ. Dis Colon Rectum (Accepted August 2013)

64. Jafari MD, Jafari F, Halabi WJ, Phelan M , Carmichael JC, Mills SD, Pigazzi A, Stamos MJ: Colorectal Cancer Resections in the Aging Population of the United States: A Trend Towards Decreasing Rates and Improved Outcomes. JAMA Surg (Accepted August 2013)

65. Wissam J. Halabi, Mehraneh D. Jafari, Vinh Q. Nguyen, Joseph C. Carmichael, Steven Mills, Alessio Pigazzi, Michael J. Stamos, Blood transfusions in colorectal cancer surgery: incidence, outcomes, and predictive factors: an American College of Surgeons National Surgical Quality Improvement Program analysis, The American Journal of Surgery, Volume 206, Issue 6, December 2013, Pages 1024-1033

66. Jafari MD, Jafari F, Halabi WJ, et al. Colorectal Cancer Resections in the Aging US Population: A Trend Toward Decreasing Rates and Improved Outcomes. JAMA Surg. Published online April 09, 2014. doi:10.1001/jamasurg.2013.4930.

67. Jafari MD, Pigazzi A. Techniques For Laparoscopic Repair of Major Intraoperative Vascular Injury: Case Reports and Review of Literature. Surgical Endoscopy. 2013 Aug; 27(8): 3021-7. PubMed PMID: 23407911.

68. Jafari MD, Pigazzi A. Laparoscopic Total Colectomy with Trans-anal Extraction. Society of the American Gastrointestinal Endoscopic Surgeons TV Library. April 2013.

69. Jafari, M.D., Stamos M.J., and Pigazzi A. Robotic Assisted Laparoscopic Total Proctocolectomy with Ileal Pouch Anal Anastomosis. Gastroenterology 144, no. 5; Supplement 1 (May 2013): S-1052.

70. Halabi WJ, Jafari MD, Chen A, Nguyen VQ, Carmichael JC, Mills S, Stamos MJ, Pigazzi A. The First Validated Nomogram to Predict 30-Day Mortality Following Surgery for Small Bowel Obstruction. Gastroenterology 144, Issue 5, no. 5, Supplement 1 (May 2013): S-1084.

71. Halabi WJ, Jafari MD, Perez E, Nguyen VQ, Carmichael JC, Mills S, Stamos MJ, Pigazzi A. Anastomotic Leak Following Anterior Resection for Rectal Cancer: Does the Presence of a Defunctioning Stoma Reduce the Burden of a Leak ? Gastroenterology 144, no. 5, Supplement 1 (May 2013): S-1071.
Fellow, American College of Surgeons
Fellow, Society of Surgical Oncology
Member, American Society of Colon and Rectal Surgeons
Member, Society for Surgery of the Alimentary Tract
Member, Pacific Coast Surgical Association
Member, American College of Surgeon Oncology Group
Member, Minimally Invasive Robotic Association
Member, Society of American Gastrointestinal Surgeons
Member, American Society for Metabolic and Bariatric Surgery
Member, American Society of Clinical Oncology
Founding Member, Clinical Robotic Surgery Association
Member, Associazione Italiana di Studi Nord-Americani
Member, Orange County Medical Association
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Last updated 07/11/2014