Hannah Lui Park

Assistant Professor, Epidemiology
School of Medicine

Program Manager, UCI Athena Breast Health Network

Ph.D., Stanford University, 2003, Biological Sciences

M.S., University of Southern California Keck School of Medicine, 1999, Cell and Neurobiology

B.A., University of California, Berkeley, 1997, Molecular and Cell Biology

Phone: (949) 824-2651
Email: hlpark@uci.edu

University of California, Irvine
839 Health Sciences Road
218 Sprague Hall
Irvine, CA 92617

Cancer epigenetics, DNA methylation, cancer biology, cancer biomarkers, genetic epidemiology, epigenetic epidemiology
URLs Athena at UCI
Athena Breast Health Network
Publications Kim MS, Louwagie J, Carvalho B, Terhaar Sive Droste JS, Park HL, Chae YK, Yamashita K, Liu J, Ostrow KL, Ling S, Guerrero-Preston R, Demokan S, Yalniz Z, Dalay N, Meijer GA, Van Criekinge W, Sidransky D. Promoter DNA methylation of oncostatin m receptor-beta as a novel diagnostic and therapeutic marker in colon cancer. PLoS One. (2009) 4:e6555.

Ostrow KL, Park HL, Hoque MO, Kim MS, Liu J, Argani P, Westra W, Van Criekinge W, Sidransky D. Pharmacologic unmasking of epigenetically silenced genes in breast cancer. Clin Cancer Res. (2009) 15:1184-91.

Tokumaru Y, Yamashita K, Kim MS, Park HL, Osada M, Mori M, Sidransky D. The role of PGP9.5 as a tumor suppressor gene in human cancer. Int J Cancer. (2008) 123:753-9.

Hoque MO, Kim MS, Ostrow KL, Liu J, Wisman GB, Park HL, Poeta ML, Jeronimo C, Henrique R, Lendvai A, Schuuring E, Begum S, Rosenbaum E, Ongenaert M, Yamashita K, Califano J, Westra W, van der Zee AG, Van Criekinge W, Sidransky D. Genome-wide promoter analysis uncovers portions of the cancer methylome. Cancer Res. (2008) 68:2661-70.

Park HL, Kim MS, Yamashita K, Westra W, Carvalho AL, Lee J, Jiang WW, Baek J, Liu J, Osada M, Moon CS, Califano JA, Mori M, Sidransky D. DCC promoter hypermethylation in esophageal squamous cell carcinoma. Int J of Cancer. (2008) 122:2498-02.

Yamashita K, Kim MS, Park HL, Tokumaru Y, Osada M, Inoue H, Mori M, Sidransky D. HOP/OB1/NECC1 promoter DNA is frequently hypermethylated and involved in tumorigenic ability in esophageal squamous cell carcinoma. Mol Cancer Res. (2008) 1:31-41.

Jiang WW, Zahurak M, Zhou ZT, Park HL, Guo ZM, Wu GJ, Sidransky D, Trink B, Califano JA. Alterations of GPI transamidase subunits in head and neck squamous carcinoma. Mol Cancer. (2007) 6:74.

Kim MS, Yamashita K, Chae YK, Tokumaru Y, Chang X, Zahurak M, Osada M, Park HL, Chuang A, Califano JA, Sidransky D. A promoter methylation pattern in the N-methyl-D-aspartate receptor 2B gene predicts poor prognosis in esophageal squamous cell carcinoma. Clin Cancer Res. (2007) 13:6658-65.

Liu JW, Kim MS, Nagpal J, Yamashita K, Poeta L, Chang X, Lee J, Park HL, Jeronimo C, Westra WH, Mori M, Moon C, Trink B, Sidransky D. Quantitative hypermethylation of NMDAR2B in human gastric cancer. Int J Cancer. (2007) 121:1994-2000.

Osada M, Park HL, Park MJ, Liu JW, Wu G, Trink B, Sidransky D. A p53-type response element in the GDF15 promoter confers high specificity for p53 activation. Biochem Biophys Res Commun. (2007) 354:913-8.

Carvalho AL, Chuang A, Jiang WW, Lee J, Begum S, Poeta L, Zhao M, Jerónimo C, Henrique R, Nayak CS, Park HL, Brait MR, Liu C, Zhou S, Koch W, Fazio VM, Ratovitski E, Trink B, Westra W, Sidransky D, Moon CS, Califano JA. Deleted in colorectal cancer is a putative conditional tumor-suppressor gene inactivated by promoter hypermethylation in head and neck squamous cell carcinoma. Cancer Res. (2006) 66:9401-7.

Jiang WW, Zahurak M, Goldenberg D, Milman Y, Park HL, Westra WH, Koch W, Sidransky D, Califano J. Increased plasma DNA integrity index in head and neck cancer patients. Int J Cancer. (2006) 119:2673-6.

Yamashita K, Park HL, Kim MS, Osada M, Tokumaru Y, Inoue H, Mori M, Sidransky D. PGP9.5 methylation in diffuse-type gastric cancer. Cancer Res. (2006) 66:3921-7.

Kim MS, Yamashita K, Baek JH, Park HL, Carvalho AL, Osada M, Hoque MO, Upadhyay S, Mori M, Moon C, Sidransky D. N-methyl-D-aspartate receptor type 2B is epigenetically inactivated and exhibits tumor-suppressive activity in human esophageal cancer. Cancer Res. (2006) 66:3409-18.

Osada M, Park HL, Nagakawa Y, Begum S, Yamashita K, Wu G, Kim MS, Trink B, Sidransky D. A novel response element confers p63- and p73-specific activation of the WNT4 promoter. Biophys Biochem Res Comm. (2006) 339: 1120-1128.

Osada M, Park HL, Nagakawa Y, Yamashita K, Fomenkov A, Kim MS, Wu G, Nomoto S, Trink B, Sidransky D. Differential recognition of response elements determines target gene specificity for p53 and p63. Mol Cell Biol. (2005) 25:6077-89.

Osada M, Nagakawa Y, Park HL, Yamashita K, Wu G, Kim MS, Fomenkov A, Trink B, Sidransky D. p63-specific activation of the BPAG-1e promoter. J Invest Derm. (2005) 125:52-60.

Mandelker DL, Yamashita K, Tokumaru Y, Mimori K, Howard DL, Tanaka Y, Carvalho AL, Jiang WW, Park HL, Kim MS, Osada M, Mori M, Sidransky D. PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma. Cancer Res. (2005) 65:4963-8.

Huang YP, Wu G, Guo Z, Osada M, Fomenkov T, Park HL, Trink B, Sidransky D, Fomenkov A, Ratovitski EA. Altered sumoylation of p63alpha contributes to the split-hand/foot malformation phenotype. Cell Cycle (2004) 3:1587-96.

Lui HM, Chen J, Wang L, Naumovski L. ARMER (Apoptotic Regulator in the Membrane of the Endoplasmic Reticulum), a novel inhibitor of apoptosis. Mol Cancer Res. (2003) 1: 508-518.

Chen YG, Lui HM, Lin SL, Lee JM, Ying S-Y. Regulation of cell proliferation, apoptosis, and carcinogenesis by activin. Exp Biol Med. (2002) 227: 75-87.

Ying S-Y, Lui HM, Lin S-L, Chuong C-M. Generation of full-length cDNA library from single human prostate cancer cells. BioTechniques (1999) 27:410-414.

Chou YC, Guzman RC, Swanson Sm, Yang J, Lui HM, Wu V, Nandi S. Induction of mammary carcinomas by N-methyl-N- nitrosourea in ovariectomized rats treated with epidermal growth factor. Carcinogenesis (1999) 20: 677-84.
Other Experience Postdoctoral Fellow
Johns Hopkins University School of Medicine 2003—2005

Department of Biological Sciences, UC Irvine 2007—2009

Assistant Project Scientist
Department of Epidemiology, UC Irvine 2010—2011

Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=5825
Last updated 01/04/2012