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Kim Green

Assistant Professor, Neurobiology and Behavior
School of Biological Sciences

Ph.D., University of Leeds, 2002, Cellular Physiology

Phone: (949) 824-3859
Email: kim.green@uci.edu

University of California, Irvine
3422 Biological Sciences III
Mail Code: 4545
Irvine, CA 92697

picture of Kim  Green

Alzheimer's disease, therapeutics, glucocorticoid, APP processing
Publications 1. Taylor SC, Green KN, Carpenter E, Peers C. Protein kinase C evokes quantal catecholamine release from PC12 cells via activation of L-type Ca2+ channels. Journal of Biological Chemistry. 2000 Sep 1;275(35):26786-91.

2. Green KN, Taylor SC, Smith IF, Peers C. Differential coupling of voltage-gated Ca(2+) channels to catecholamine secretion from separate PC12 cell batches. Neuroscience Letters. 2001 Mar 23;301(1):13-6.

3. Green KN, Peers C. Amyloid beta peptides mediate hypoxic augmentation of Ca(2+) channels. Journal of Neurochemistry. 2001 May;77(3):953-6.

4. Taylor SC, Green KN, Smith IF, Peers C. Prion protein fragment 106-126 potentiates catecholamine secretion from PC-12 cells. Am J Physiol Cell Physiol. 2001 Dec;281(6):C1850-7.

5. Green KN, Peers C. Divergent pathways account for two distinct effects of amyloid beta peptides on exocytosis and Ca(2+) currents: involvement of ROS and NF-kappaB. Journal of Neurochemistry. 2002 Jun;81(5):1043-51.

6. Green KN, Boyle JP, Peers C. Hypoxia potentiates exocytosis and Ca2+ channels in PC12 cells via increased amyloid beta peptide formation and reactive oxygen species generation. Journal of Physiology. 2002 Jun 15;541(Pt 3):1013-23.

7. Giles GI, Tasker KM, Johnson RJ, Jacob C, Peers C, Green KN. Electrochemistry of chalcogen compounds: prediction of antioxidant activity. Chem Commun. 2001 Dec 7;(23):2490-1.

8. Webster NJ, Green KN, Peers C, Vaughan PF. Altered processing of amyloid precursor protein in the human neuroblastoma SH-SY5Y by chronic hypoxia. Journal of Neurochemistry. 2002 Dec;83(6):1262-71.

9. Giles GI, Fry FH, Tasker KM, Holme AL, Peers C, Green KN, Klotz LO, Sies H, Jacob C. Evaluation of sulfur, selenium and tellurium catalysts with antioxidant potential. Org Biomol Chem. 2003 Dec 7;1(23):4317-22. 2003 Nov 04.

10. Peers C, Green KN, Boyle JP. Amyloid peptide-mediated hypoxic regulation of Ca2+ channels in PC12 cells. Adv Exp Med Biol. 2003; 536:187-92.

11. Smith IF, Boyle JP, Green KN, Pearson HA, Peers C. Hypoxic remodelling of Ca2+ mobilization in type I cortical astrocytes: involvement of ROS and pro-amyloidogenic APP processing. Journal of Neurochemistry. 2004 Feb;88(4):869-77.

12. Akbari Y, Hitt BD, Murphy MP, Dagher NN, Tseng BP, Green KN, Golde TE, LaFerla FM. Presenilin regulates capacitative calcium entry dependently and independently of gamma-secretase activity. Biochem Biophys Res Commun. 2004 Oct 1;322(4):1145-52.

13. Webster NJ, Green KN, Settle VJ, Peers C, Vaughan PF. Altered processing of the amyloid precursor protein and decreased expression of ADAM 10 by chronic hypoxia in SH-SY5Y: no role for the stress-activated JNK and p38 signalling pathways. Brain Res Mol Brain Res. 2004 Nov 4;130(1-2):161-9.

14. Oddo S, Caccamo A, Green KN, Liang K, Tran L, Chen Y, Leslie FM, LaFerla FM. Chronic Nicotine Administration Exacerbates Tau Pathology in a Transgenic Model of Alzheimer's Disease. Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):3046-51.

15. Billings LM, Oddo S, Green KN, McGaugh JL, LaFerla FM. Intraneuronal Aß causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron 2005, Vol 45, 675-688

16. Smith IF, Hitt BD, Green KN, Oddo S, LaFerla FM. Enhanced Ca2+-induced Ca2+ release in a 3xTg-AD model of Alzheimer’s disease. Journal of Neurochemistry. 2005 Sep;94(6):1711-8.

17. Smith IF, Green KN & LaFerla FM. Ca2+ dysregulation and Alzheimer’s disease: Recent advances gained from genetically modified animals. Cell Calcium. 2005 Sep-Oct;38(3-4):427-37.

18. Peers C, Scragg JL, Boyle JP, Fearon IM, Taylor SC, Green KN, Webster NJ, Ramsden M, Pearson HA. A central role for ROS in the functional remodelling of L-type Ca2+ channels by hypoxia. Philos Trans R Soc Lond B Biol Sci. 2005 Dec 29;360(1464):2247-54.

19. Oddo S, Caccamo A, Smith IF, Green KN & LaFerla FM. A dynamic relationship between intracellular and extracellular pools of A?. American Journal of Pathology. 2006 Jan;168(1):184-94.

20. Kitazawa M, Oddo S, Yamasaki TR, Green KN, LaFerla FM. LPS-induced inflammation exacerbates tau pathology by a cdk5-mediated pathway in a transgenic model of Alzheimer`s disease. Journal of Neuroscience. Sept 21, 2005 25(38) 8843-53.

21. Caccamo A, Oddo S, Billings LM, Green KN, Martinez-Coria H, Fisher A, Laferla FM. M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice. Neuron. 2006 Mar 2;49(5):671-82.

22. Kitazawa M, Green KN, Caccamo A, LaFerla FM. Genetically Augmenting A{beta}42 Levels in Skeletal Muscle Exacerbates Inclusion Body Myositis-Like Pathology and Motor Deficits in Transgenic Mice. American Journal of Pathology. 2006 Jun;168(6):1986-97.

23. Green KN, Billings LM, Roozendaal B, McGaugh JL, LaFerla FM. Glucocorticoids increase A? and tau pathology in a mouse model of Alzheimer’s disease. Journal of Neuroscience. 2006 Aug 30;26(35):9047-56.

24. Billings LM*, Green KN*, McGaugh JL, LaFerla FM. Learning decreases A?*56, tau pathology, and ameliorates behavioral decline in 3xTg-AD mice. Journal of Neuroscience. 2007 Jan 24;27(4):751-61. * equal contribution

25. Tseng BP, Green KN, Chan JL, Blurton-Jones M, LaFerla FM. A? Mediated Ubiquitin-Proteasome System Impairments Exacerbate Pathogenic Amyloid and Tau Accumulation in Alzheimer Disease. Neurobiology of Aging. 2007 May 31

26. Green KN, Martinez-Coria H, Hall EB, Yurko-Mauro KA, Ellis L, LaFerla FM. Dietary DHA and DPAn-6 Ameliorate Amyloid-ß and Tau Pathology via a Mechanism Involving Presenilin 1 Levels. Journal of Neuroscience. 2007 April 18

27. LaFerla FM, Green KN, Oddo S. Intracellular A? in Alzheimer Disease. Nature Reviews Neuroscience. 2007 Jul;8(7):499-509.

28. Clinton LK, Billings LM, Green KN, Caccamo A, Ngo J, Oddo S, McGaugh JL, LaFerla FM. Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice. Neurobiology of Disease. 2007 Jun 23;

29. Green KN, Smith IF, LaFerla FM. Role of calcium in the pathogenesis of Alzheimer’s disease and transgenic models. Calcium signaling and disease 507-521. 2007

30. Koike MA, Myczek K, Green KN, LaFerla FM. Impact of A? and tau on cognition in mouse models of Alzheimer’s disease. Animal Models of Human Cognitive Aging (2008).

31. Green KN, Demuro A, Hitt BD, Smith IF, Parker I, LaFerla FM. Presenilin as a physiological regulator of SERCA pump activity. Journal of Cell Biology 2008 Jun 30;181(7):1107-16.

32. Green KN* and LaFerla FM*. Linking Calcium to A? and Alzheimer’s disease. Neuron 2008 July 31; * corresponding author

33. Morrissette DA, Parachikova A, Green KN, Laferla FM. Relevance of transgenic mouse models to human Alzheimer disease. J Biol Chem. 2008 Oct 22.

34. Green KN, Steffan JS, Martinez-Coria H, Thompson LM, Schreiber SS, LaFerla FM. Nicotinamide restores cognition in AD transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau. Journal of Neuroscience. 2008 Nov 5;28(45):11500-10

35. Blurton-Jones M, Kitazawa M, Martinez-Coria H, Castello NA, Müller FJ, Loring JF, Yamasaki TR, Poon WW, Green KN, Laferla FM. Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proc Natl Acad Sci U S A. 2009 Jul 24.

36. Aiken CT, Steffan JS, Guerrero CM, Khashwji H, Lukacsovich T, Simmons D, Purcell JM, Menhaji K, Zhu YZ, Green K, Laferla F, Huang L, Thompson LM, Marsh JL. Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity. J Biol Chem. 2009 Oct 23;284(43):29427-36.

37. Green KN. Calcium in the initiation, progression and as an effector of Alzheimer's disease pathology. J Cell Mol Med. 2009 Jul 24. Invited Review.

38. Thompson LM, Aiken CT, Kaltenbach LS, Agrawal N, Illes K, Khoshnan A, Martinez-Vincente M, Arrasate M, O'Rourke JG, Khashwji H, Lukacsovich T, Zhu YZ, Lau AL, Massey A, Hayden MR, Zeitlin SO, Finkbeiner S, Green KN, LaFerla FM, Bates G, Huang L, Patterson PH, Lo DC, Cuervo AM, Marsh JL, Steffan JS. IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. J Cell Biol. 2009 Dec 28;187(7):1083-99.

39. Martinez-Coria H, Green KN, Billings Luhrs L, Kitazawa M, Albrecht M, Rammes G, Parsons C, Gupta S, Banerjee P, LaFerla FM. Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice. Am J Pathol. 2009 Dec 30.

40. Koike MA*, Green KN*, Blurton-Jones M, LaFerla F. Oligemic hypoperfusion differentially affects tau and amyloid-? pathology. Am J Pathol. 2010 May 14 * = equal contribution

41. Parachikova A, Visilevko V, Cribbs D, LaFerla FM, Green KN. Minocycline, an anti-inflammatory agent, restores cognition and reduces pathology in a transgenic mouse model of Alzheimer’s disease. Journal of Alzheimer’s Disease. 2010 Jan 1;21(2):527-42.

42. Green KN and Schreiber SS. Advances in Our Understanding of the Patholophysiology of Alzheimer’s Disease. US Neurology. 2010 Aug

43. Parachikova A, Green KN, Hendrix C and LaFerla FM. Formulation of a medical food cocktail for Alzheimer’s disease: beneficial effects on cognition and neuropathology in a mouse model of the disease. PLoS ONE. 2010 Nov 5(11): e14015.

44. Lin AJ, Koike MA, Green KN, Kim JG, Mazhar A, Rice TB, Laferla FM, Tromberg BJ. Spatial Frequency Domain Imaging of Intrinsic Optical Property Contrast in a Mouse Model of Alzheimer's Disease. Ann Biomed Eng. 2011 Feb 19.

45. Neely K, Green KN*, LaFerla FM*. Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a ?-secretase independent manner. Journal of Neuroscience. 2011 Feb 23;31(8):2781-91. * corresponding author

46. Green KN*, Khashwji H, Estrada T, and LaFerla FM*. ST101 induces a novel 17-kDa APP cleavage that precludes Aß generation in vivo. Annals of Neurology. 2011 Mar 17 * corresponding author

47. Koike MA, Garcia FG, Kitazawa, M, Green KN*, LaFerla FM*. Transient cerebral ischemia induces long-term alterations in phosphorylated APP and tau aggregates. Neurosci Lett. 2011 Mar 22. * corresponding author

48. Neely KM and Green KN. Presenilins mediate efficient proteolysis via the autophagosome-lysosome system. Autophagy. Autophagy. 2011 Jun 1;7(6).

49. Green KN and LaFerla FM. Animal models of Alzheimer’s disease. The Biology of Alzheimer Disease. In Press
Research Center Institute for Memory Impairments and Neurological Disorders (UCI MIND)
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Last updated 09/23/2011