Hirohito Ichii
Professor of Clinical Surgery, Surgery
School of Medicine
School of Medicine
M.D., Kobe University school of Medicine
Ph.D., Kobe university graduate school of Medicine
Ph.D., Kobe university graduate school of Medicine
University of California, Irvine
City Tower, Suite 1205, Rt. 19
Irvine, CA 92868
City Tower, Suite 1205, Rt. 19
Irvine, CA 92868
Research Interests
Islet, Pancreas, kidney transplantation, islet isolation, Type I diabetes, Memory T cell, Immunosuppression
Appointments
Postdoctoral associate Diabetes Research Institute, University of Miami scholl of Medicine
Transplant fellow, Miami Transplant institute, University of Miami scholl of Medicine
Research Assistant Professor, Diabetes Research Institute, University of Miami scholl of Medicine
Transplant fellow, Miami Transplant institute, University of Miami scholl of Medicine
Research Assistant Professor, Diabetes Research Institute, University of Miami scholl of Medicine
Publications
1. Ohta H, Ichii H, Arimoto A, Ukikusa M, Awane H. Tc-99m sestamibi uptake in tuberculosis of the breast. Clincal Nucl Medicine. 1998 ;23(2):106-8
2. Ichii H, Sakamoto A, Hatano M, Okada S, Toyama H, Taki S, Arima M, Kuroda Y, Tokuhisa T. Role for Bcl-6 in the generation and maintenance of memory CD8+ T cells. Nature Immunology. 2002 ;3(6):558-63.
3. Toyama H, Okada S, Hatano M, Takahashi Y, Takeda N, Ichii H, Takemori T, Kuroda Y, Tokuhisa T. Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells. Immunity. 2002 ;17(3):329-39.
4. Arima M, Toyama H, Ichii H, Kojima S, Okada S, Hatano M, Cheng G, Kubo M, Fukuda T, Tokuhisa T. A putative silencer element in the IL-5 gene recognized by Bcl6. Journal of Immunology. 2002 ;169(2):829-36.
5. Ichii H, Takada M, Kashiwagi R, Sakane M, Tabata F, Ku Y, Fujimori T, Kuroda Y. Three-dimensional reconstruction of biliary tract using spiral computed tomography for laparoscopic cholecystectomy. World Journal of Surgery. 2002 May ;26(5):608-11.
6. Ichii H, Sakamoto A, Tokuhisa T. Role for Bcl6 in T cell differentiation. Annual Review Immunology. 187-193, 2002.
7. Ichii H, Sakamoto A, Tokuhisa T. Bcl6 and memory CD8 T cell. Molecular Medicine vol.39, II. 2003.
8. Ichii H, Sakamoto A, Kuroda Y, Tokuhisa T. Bcl6 acts as an amplifier for the generation and proliferative capacity of central memory CD8+ T cells. Journal of Immunology. 2004 ;173(2):883-91.
9. Ichii H, Pileggi A, Molano RD, Baidal DA, Khan A, Kuroda Y, Inverardi L, Goss JA, Alejandro R, Ricordi C. Rescue purification maximizes the use of human islet preparations for transplantation. American Journal of Transplantation. 2005 Jan;5(1):21-30.
10. Klein D, Barbe-Tuana F, Pugliese A, Ichii H, Garza D, Gonzalez M, Molano RD, Ricordi C, Pastori RL. A functional CD40 receptor is expressed in pancreatic beta cells. Diabetologia. 2005 Feb; 48(2):268-76.
11. Mendoza V, Klein D, Ichii H, Ribeiro MM, Ricordi C, Hankeln T, Burmester T, Pastori RL. Protection of islets in culture by delivery of oxygen binding neuroglobin via protein transduction. Transplantation Proceedings. 2005; 37(1):237-40.
12. Pileggi A, Molano RD, Berney T, Ichii H, San Jose S, Zahr E, Poggioli R, Linetsky E, Ricordi C, Inverardi L. Prolonged allogeneic islet graft survival by protoporphyrins. Cell Transplantation. 2005; 14(2-3):85-96.
13. Ichii H, Inverardi L, Pileggi A, Molano RD, Cabrera O, Caicedo A, Messinger S, Kuroda Y, Berggren PO, Ricordi C. A novel method for the assessment of cellular composition and beta-cell viability in human islet preparations. American Journal of Transplantation. 2005; 5(7):1635-45
14. Ichii H. Islet Transplantation in U.S.A. Transplantation Now. 2005, 8(4):394-400.
15. Froud T, Ricordi C, Baidal DA, Hafiz MM, Ponte G, Cure P, Pileggi A, Poggioli R, Ichii H, Khan A, Ferreira JV, Pugliese A, Esquenazi VV, Kenyon NS, Alejandro R. Islet transplantation in type 1 diabetes mellitus using cultured islets and steroid-free immunosuppression: Miami experience. American Journal of Transplantation. 2005 Aug;5(8):2037-46.
16. Ichii H, Wang X, Messinger S, Alvarez A, Fraker C, Khan A, Kuroda Y, Inverardi L, Goss JA, Alejandro R, Ricordi C. Improved Human Islet Isolation Using Nicotinamide. American Journal of Transplantation. 2006; 6(9): 2060-68.
17. Barbé-Tuana FM, Klein D, Ichii H, Berman-Weinberg D, Coffey L, Kenyon NS, Ricordi C, Pastori RL. CD40-CD40 ligand interaction in pancreatic islets activates pro-inflammatory pathways. Diabetes. 2006; 55(9):2437-45.
18. Fraker C, Timmins MR, Guarino RD, Haaland PD, Ichii H, Molano D, Pileggi A, Poggioli R, Presnell SC, Inverardi L, Zehtab M, Ricordi C. The Use of the BD Oxygen Biosensor System to Assess Isolated Islets of Langerhans: Oxygen Consumption as a Potential Measure of Islet Potency. Cell Transplantation. 2006;15(8-9):745-58.
19. Fornoni A, Cobianchi L, Sanabria N, Antonello P, Molano DR, Ichii H, Inverardi L, Ricordi C, Pastori R. The L isoform but not any D modification of c-jun N-terminal kinase (JNK) inhibitory peptide improves beta cell mass and function. Biochem Biophys Res Commun. Mar 2;354(1):227-33. 2007
20. Ichii H, Sakamoto A, Arima M, Hatano M, Kuroda Y, Tokuhisa T. Bcl6 is essential for the generation of long-term memory CD4+ T cells. International Immunology. 2007 Apr;19(4):427-33
21. Ichii H, Sakuma Y, Pileggi A, Fraker C, Alvarez A, Montelongo J, Szust J, Khan A, Inverardi L, Naziruddin B, Levy MF, Klintmalm GB, Goss JA, Alejandro R, Ricordi C. Shipment of Human Islets for Transplantation. American Journal of Transplantation. 2007 April 7(4):1010-20.
22. Ponte GM, Pileggi A, Messinger S, Alejandro A, Ichii H, Baidal DA, Khan A, Ricordi C, Goss JA, Alejandro R. Toward maximizing the success rates of human islet isolation: Influence of donor and isolation factors. Cell Transplantation. 2007;16(6):595-607.
23. Yamamoto T., Ricordi C, Messinger S, Sakuma Y, Miki A., Rodriguez R,. Haertter R, Khan A, Alejandro R, Ichii H. Deterioration and Variability of Highly Purified Collagenase Blends used in Clinical Islet Isolation. Transplantation 2007 Oct 27;84(8):997-1002.
24. Fornoni A, Pileggi A, Molano DR, Sanabria N, Tejada T, Gonzalez-Quintana J, Ichii H, Inverardi L, Ricordi C, Pastori R. Inhibition of c-jun N terminal kinase (JNK) improves functional ?-cell mass in human pancreatic islets and leads to AKT and GSK-3 phosphorylation. Diabetologia. 2008 Feb;51(2):298-308.
25. Zahr E, R. Molano RD, Pileggi A, Ichii H, Jose SS, Bocca N, An W, Gonzalez-Quintana J, Faker C, Ricordi C Inverardi L. Rapamycin impairs the proliferation of islet beta-cells. Transplantation 2007 Dec 27;84(12):1576-83.
26. Miki A. Ricordi C. Yamamoto T. Mita A. Barker S. Khan A. Alejandro R. Ichii H. Effect of Human Islet Rescue Gradient Purification on Islet yield and Fractional Beta cell Viability. Transplantation Proceedings. 2008 Mar;40(2):360-1. PMC2614214
27. Yamamoto T, Ricordi C, Miki A, Sakuma Y, Mita A, Barker S, Molano RS, Fornoni A, Pileggi A, Inverardi L, Ichii H. Beta-cell Specific Cytoprotection by Prolactin on Human Islet. Transplantation Proceedings. 2008 Mar;40(2):382-3. PMC2614218
28. Sakuma Y, Ricordi C, Miki A, Yamamoto T, Pileggi A, Khan A, Alejandro R , Inverardi L, Ichii H. Factors Affecting Human Islet Isolation. Transplantation Proceedings. 2008 Mar;40(2):343-5. PMC2614209
29. Zahr E, R. Molano RD, Pileggi A, Ichii H, Jose SS, Bocca N, An W, Gonzalez-Quintana J, Faker C, Ricordi C Inverardi L. Rapamycin Impairs beta-Cell Proliferation In Vivo. Transplantation Proceedings. 2008 Mar;40(2):436-7.
30. Mita A, Ricordi C, Miki A, Barker S, Haertter R, Hashikura Y , Miyagawa S , Burke GW , Inverardi L, Ichii H. Anti-Pro-Inflammatory Effects of Sirolimus on Human Islet Preparations. Transplantation. 2008 Jul 15;86(1):46-53. PMC2650480
31. Klein D, Timoneri F, Ichii H, Ricordi C, Pastori RL. CD40-CD40L interaction in human islets induces mostly proinflammatory genes. Diabetologia. 2008 Oct;51(10):1853-61.
32. Ichii H, Miki A, Yamamoto T, Baker S, Mita A, Rodriguez-Diaz R, Molano DR, Klein D, Pastori RL, Alejandro R, Inverardi L, Pileggi A, Ricordi C. Characterization of Pancreatic Ductal Cell in Human Islet Preparations. Laboratory Investigation. 2008 Nov;88(11):1167-77. PMC3793849
33. Varona-Santos JL, Pileggi A, Molano RD, Sanabria N, Ijaz A, Ichii H, Pastori RL, Inverardi L, Ricordi C, Fornoni A. Lack of JNK1 but not JNK2 facilitates pancreatic islet function, viability and graft survival after transplantation. Diabetologia. 2008 Dec;51(12):2271-80. Epub 2008 Oct 14.
34. Fenjves ES, Ochoa MS, Cechin S, Gay-Rabinstein C, Pérez-Alvarez I, Ichii H, Mendez A, Ricordi C, Curran MA. Protection of Human Pancreatic Islets Using a Lentiviral Vector Expressing two Genes; cFLIP and GFP. Cell Transplantation. 2008;17(7):793-802.
35. Ichii H, Ricordi C. Current Status of Islet Cell Transplantation. J Hepatobiliary Pancreat Surgery. 2009;16(2):101-12. doi: 10.1007/s00534-008-0021-2. Epub 2008 Dec 26. PMC3777531
36. Mita A, Ricordi C, Miki A, Barker S, Khan A, Alvarez A, Hashikura Y, Miyagawa S, Ichii H. The purification method using iodixanol based density gradient significantly reduces cytokine/chemokine production from human islet preparations, leading to prolong beta-cell survival during pre-transplant culture. Transplantation Proceedings. 2009, Jan-Feb;41(1):314-5. PMC3780973
37. Takahashi H, Ruiz P, Ricordi C, Miki A, Mita A, Barker S, Tzakis A, Ichii H. In situ quantitative immunoprofiling of regulatory cells using Laser Scanning Cytometry. Transplantation Proceedings. 2009 Jan-Feb;41(1):238-9. PMC3777540
38. Sakuma Y, Ricordi C, Miki A, Yamamoto T, Mita A, Barker S, Molano DR, Pileggi A, Yasuda Y, Yada T, Ichii H. The Effect of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Islet Transplantation. Transplantation Proceedings. 2009, Jan-Feb;41(1):343-5. PMC3777528
39. Yamamoto T, Horiguchi A, ItoM, Nagata H, Ichii H, Miyakawa S. Quality control for clinical islet transplantation: Organ procurement and preservation, Islet processing facility and Islet potency test. J Hepatobiliary Pancreat Surg. 2009 Feb 26. Epub ahead of print.
40. Burgess MD, Moore KD, Carter GM, Alli AA, Granda CS, Ichii H, Ricordi C, Gower, Jr. W.R. C-Type Natriuretic Peptide Receptor (NPR-C) Expression in Pancreatic Alpha Cells. Histochem Cell Biol. 2009 Apr 8. [Epub ahead of print]
41. Pileggi A, Ribeiro MM, Hogan AR, Molano RD, Cobianchi L, Ichii H, Embury J, Inverardi L, Fornoni A, Ricordi C, Pastori RL. Impact of Pancreatic Cold Preservation on Islet Recovery and Function. Transplantation. 2009, May 27; 87(10): 1442-1450.
42. Miki A. Ricordi C, Messinger S, Yamamoto T, Mita A, Barker S, Khan A, Alejandro R, Ichii H Toward Improving Human Islet Isolation from Younger Donors; Rescue Purification is More Efficient for Trapped Islets. Cell Transplantation. 2009, 18(1), 13-22. PMC3777447
43. Pileggi A, Ribeiro MM, Hogan AR, Molano RD, Embury JE, Ichii H, Cobianchi L, Fornoni A, Ricordi C, Pastori RL. Effects of pancreas cold ischemia on islet function and quality Transplantation Proceedings. 2009 Jun;41(5):1808-9.
44. Vendrame F, Pileggi A, Laughlin E, Martin-Pagola A, Molano RD, Allende G, Diamantopoulos S, Standifer N, Ichii H, Takahashi H, Mendez A, Geubtner K, Reijonen H, Ruiz P, Sageshima J, Ciancio G, Ricordi C, Nepom GT, Burke GW, Pugliese A. Type 1 diabetes recurrence after simultaneous pancreas-kidney transplantation despite immunosuppression. Diabetes 2010 Apr; 59(4):947-57. PMC2844842
45. Yamamoto T, Mita A, Ricordi C , Miki A, Sakuma Y, Timoneri F, Barker S, Fornoni A, MolanoRD, Inverardi L, Pileggi A, Ichii H. PRL Supplementation to Culture Medium Improves Beta-Cell Survival. Transplantation 2010 Jun 15;89(11):1328-35. PMC3780980
46. Mita A, Ricordi C, Messinger M, Miki A, Misawa R, Barker S, Molano RD, Haertter R, Khan A, Miyagawa S, Pileggi A, Inverardi L, Alejandro R, Hering BJ, Ichii H. Anti-proinflammatory Effects of Iodixanol (OptiPrep)-Based Density Gradient Purification on Human Islet Preparations. Cell transplantation 2010;19(12):1537-46. PMC3777530
47. Ohtsuka H, Sakamoto A, Pan J, Inage S, Horigome S, Ichii H, Arima M, Hatano M, Okada S, Tokuhisa T. Bcl6 is required for the development of mouse CD4+ and CD8alpha+ dendritic cells. Journal of Immunology 2011 Jan 1;186(1):255-63.
48. Lamb M, Storrs R, Li S, Liang O, Laugenour K, Dorian R, Chapman D, Ichii H, Imagawa D, Foster C 3rd, King S, Lakey JR. Function and viability of human islets encapsulated in alginate sheets: in vitro and in vivo culture. Transplantation Proceedings. 2011 Nov;43(9):3265-6.
49. Foster CE 3rd, Weng RR, Piper M, Laugenour K, Ichii H, Lakey J, Malinoski D. Induction therapy by anti-thymocyte globulin (rabbit) versus basiliximab in deceased donor renal transplants and the effect on delayed graft function and outcomes. Transplantation Proceedings. 2012 Jan;44(1):164-6.
50. Misawa R, Ricordi C, Miki A, Barker S, Molano RD, Khan A, Miyagawa S, Inverardi L, Alejandro R, Pileggi A, Ichii H. Evaluation of Viable ß-cell Mass is Useful for Selecting Collagenase for Human Islet Isolation: Comparison of Collagenase NB1 and Liberase HI. Cell Transplantation 2012; 21(1):39-47. PMC3777446
51. Takahashi H, Ruiz P, Ricordi C, Miki A, Mita A, Misawa R, Barker S, Burke GW, Tzakis AG, Ichii H. Quantitative In Situ Analysis of FoxP3+ T Regulatory Cells on Transplant Tissue Using Laser Scanning Cytometry. Cell Transplantation 2012; 21(1):113-25. PMC3777543
52. Iglesias I, Valiente L, Shiang KD, Ichii H, Kandeel F, Al-Abdullah IH. The Effects of Digestion Enzymes on Islet Viability and Cellular Composition. Cell Transplantation 2012;21(4):649-55.
53. Ichii H, Masuda Y, Hassanzadeh T, Saffarian M, Gollapudi S, Nosratola D, Vaziri ND. Iron Sucrose Impairs Phagocytic Function and Promotes Apoptosis in Polymorphonuclear Leukocytes. American Journal of Nephrology 2012 36(1):50-57. PMC3986045
54. Klein D, Bravo-Egana V, Misawa R, Vargas N, Rosero S, Ichii H, Umland O, Zhijie J, Tsinoremas N, Ricordi C, Inverardi L, Domínguez-Bendala J, Pastroi RL. MicroRNA expression in alpha and beta cells of human pancreatic islets. Plos One 2013;8(1): e55064. doi: 10.1371/journal.pone.0055064. PMC3558471
55. Vaziri ND, Yuan J, Khazaeli M, Masuada Y, Ichii H, Liu S. Oral activated charcoal adsorbent (AST-120) ameliorates CKD-induced intestinal epithelial barrier disruption. American Journal of Nephrology 2013;37(6):518-25. doi: 10.1159/000351171. PMC3777856
56. Robles L, Vaziri ND, Ichii H. Role of oxidative stress in the pathogenesis of pancreatitis: Effect of antioxidant therapy. Pancreatic disorders & Therapy 2013. 3: 112. doi:10.4172/2165-7092.1000112. PMC4009983
57. Molnar MZ, Ichii H, Lineen J, Foster CE, Mathe Z, Schiff J, Kim J, Pahl MV, Amin AN, Kalantar-Zadeh K, Kovesdy CP. Timing of Return to Dialysis in Patients with Failing Kidney Transplants. Semin Dial. 2013 Nov-Dec;26(6):667-74.
58. Robles L, Ichii H. Total Pancreatectomy and Islet Auto Transplantation for Chronic Pancreatitis. Pancreatic disorders & Therapy 2013 Nov 29, 3:3 http://dx.doi.org/10.4172/2165-7092.1000e129
59. Masuda Y, Ichii H, Vaziri N.D., At pharmacologically relevant concentrations intravenous iron preparations cause pancreatic beta cell death. American Journal of Translational Research. 2013 Dec 1;6(1):64-70. PMC3853425
60. Masuda Y, Vaziri ND, Takasu C, Li S, Robles L, Pham C, Le A, Vo K, Farzaneh SH, Stamos MJ, Ichii H. Salutary effect of pre-treatment with an Nrf2 inducer on ischemia reperfusion injury in the rat liver. Gastroenterol Hepatol (Que). 2014;1(1):1-7. PMC4280567
61. Miki A. Ricordi C, Yamamoto T, Sakuma Y, Misawa R, Mita A, Inverardi L, Alejandro R, Ichii H. Improved human islet preparations using Glucocorticoid and Exendin-4. Pancreas 2014 Jul 16. [Epub ahead of print].
62. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Purified Human Pancreatic Islets (PHPI) Master Production Batch Record– A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2014; 2 (2): e891
63. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Functional assessment of purified human pancreatic islets: glucose stimulated insulin release by ELISA –– A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2014; 2 (2): e900
64. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Purified Human Pancreatic Islets, CIT Culture Media – A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2014; 2 (3): e981
65. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Purified Human Pancreatic Islets, CIT Digestion Solution– A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2014; 2 (3): e985
66. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Purified Human Pancreatic Islets, CIT Transplant Wash Media – A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2014; 2 (3): e987
67. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Purified Human Pancreatic Islets, CIT Wash Solution– A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2014; 2 (3): e989
68. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Purified Human Pancreatic Islets, CIT Purification Density Gradients – A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2014; 2 (3): e991
69. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Purified Human Pancreatic Islets, CIT Purification Solution– A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2014; 2 (3): e993
70. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Purified Human Pancreatic Islets, Supplementary Purification, Biocoll Procedure & Record– A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2014; 2 (3): e995
71. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Purified Human Pancreatic Islets, Supplementary Purification, Discontinuous Polysucrose Procedure & Record– A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2014; 2 (3): e997
72. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Purified Human Pancreatic Islets, Supplementary Purification, OptiPrep Procedure and Record– A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2014; 2 (3): e999
73. Ichii H. Pileggi A, Molano RD, Linetsky E, Alejandro R, Inverardi L, Ricordi C. Cellular Composition and Fractional ß-Cell Viability Assay Protocol at the Diabetes Research Institute – University of Miami. CellR4 2014; 2 (4): e1121.
74. Robles L, Vaziri ND, Li S, Masuda Y, Takasu C, Takasu M, Vo K, Farzaneh SH, Stamos MJ, Ichii H. Dimethyl Fumarate protects pacreatic islet cells and non-endocrine tissue in L-Arginine induced Chronic Pancreatitis. PloS one 2014 Sep 8;9 (9): e107111. PMC4157838
75. Li S, Vaziri ND, Masuda Y, Hajighasemi-Ossareh MH, Robles L, Le A, Vo K, Chan JY, Foster CE, Stamos MJ, Ichii H. The activation of Nrf2-keap1 pathway in islets increases islet isolation. Cell Transplantation 2015; 24 (11):2273-83. doi: 10.3727/096368915X686210.
76. Takasu C Vaziri ND, Li S, Robles L, Vo K, Takasu M, Pham C, Farzaneh SH, Foster CE, Stamos MJ, Ichii H. Treatment with Dimethyl Fumarate ameliorates calcineurin inhibitor-induced Nephrotoxicity. Transplantation 2015 Jun;99(6):1144-50. doi: 10.1097/TP.0000000000000647.
77. Robles L, Vaziri ND, Li S, Takasu C, Masuda Y, Vo K, Farzaneh SH, Stamos MJ, Ichii H. Treatment with the Nrf2 activator, Dimethyl Fumarate, ameliorates acute pancreatitis in a rodent model. Pancreas 2015 Apr;44(3):441-7. doi: 10.1097/MPA.0000000000000275. PMC4357568
78. Masuda Y, Vaziri ND, Li S, Le A, Hajighasemi-Ossareh MH, Robles L, Foster CE, Stamos MJ, Al-Abodullah I, Ricordi C, Ichii H. The effect of Nrf2 pathway activation on human pancreatic islet cells. Plos one 2015 Jun 25;10(6): e0131012. doi: 10.1371/journal.pone.0131012. eCollection 2015
79. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Purified Human Pancreatic Islets CIT Enzyme Solution: Serva Enzymes Proportional Units Collagenase & Neutral Protease – A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2015; 3 (1): e1342
80. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Purified Human Pancreatic Islets: CIT Enzyme Solution Vitacyte Enzymes and Vitacyte/Serva Enzymes Combination – A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2015; 3 (1): e1350
81. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Purified Human Pancreatic Islets CIT Enzyme Solution Roche Enzymes– A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2015; 3 (1): e1360
82. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Purified Human Pancreatic Islet: Qualitative and Quantitative Assessment of Islets Using Dithizone (DTZ)– A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2015; 3 (1): e1369
83. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Purified Human Pancreatic Islet: Viability Estimation of Islet Using Fluorescent Dyes, Attachment I, Preparation of Fluorescein Diacetate and Propidium Iodine Solutions –Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2015; 3 (1): e1374
84. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Purified Human Pancreatic Islet: Viability Estimation of Islet Using Fluorescent Dyes, Attachment I, Preparation of Fluorescein Diacetate and Propidium Iodine Solutions– A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2015; 3 (1): e1376
85. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Purified Human Pancreatic Islet – Viability Estimation of Islet Using Fluorescent Dyes (FDA/PI)– A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2015; 3 (1): e1378
86. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Purified Human Pancreatic Islets, Specification (Product Codes PHPI-A-01, PHPI-L-01, PHPI-E-01)– A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2015; 3 (1): e1437
87. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Purified Human Pancreatic Islets, In Vivo Islets Function– A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2015; 3 (1): e1444
88. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Purified Human Pancreatic Islets, Interim Certificate of Analysis (Product Code PHPI-A-01)– A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2015; 3 (1): e1446
89. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Purified Human Pancreatic Islets, Certificate of Analysis (Product Code PHPI-A-01) – A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2015; 3 (1): e1448
90. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Purified Human Pancreatic Islets, CIT Transplant Media– A Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2015; 3 (1): e1523
91. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Purified Human Pancreatic Islets, Deceased Donor Pancreas Qualification – Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium CellR4 2016; 4 (2): e1822
92. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Purified Human Pancreatic Islets, CIT Enzyme Solution-SERVA Enzymes Proportional Units Collagenase & Neutral Protease – Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium CellR4 2016; 4 (2): e1831
93. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Raw Material Specification, CMRL 1066, Supplemented, CIT Modifications – Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2016; 4 (3): e1895
94. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Raw Material Specification, CMRL 1066 Transplant Media, Contains Hepes and Without Sodium Bicarbonate – Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2016; 4 (3): e1897
95. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Raw Material Specification, Hanks’ Balanced Salt Solution, Sterile – Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2016; 4 (3): e1904
96. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Raw Material Specification, Heparin Sodium Injection, USP – Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2016; 4 (3): e1906
97. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Raw Material Specification, Hepes Buffer, 1 M Solution, Sterile – Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2016; 4 (3): e1908
98. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Raw Material Specification, Gradient Stock Solution – Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2016; 4 (3): e1910
99. Aliva J, Begley B, Ichii H … et al. (93 out of 141 authors). Raw Material Specification, Phase I Solution – Standard Operating Procedure of the NIH Clinical Islet Transplantation Consortium. CellR4 2016; 4 (3): e1912
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130. Moghadamyeghaneh Z, Hanna MH, Alizadeh RF, Obi Y, Foster CE, Stamos MJ, Ichii H. A Nationwide Analysis of Kidney Auto-Transplantation. The American Surgeon. 2017 Feb 1;83(2):162-169.
131. Robles L, Vaziri ND, Li S, Masuda Y, Takasu C, Takasu M, Vo K, Farzaneh SH, Stamos MJ, Ichii H. Synthetic Triterpenoid RTA dh404 (CDDO-dhTFEA) Ameliorates Acute Pancreatitis. Pancreas 2016 May-Jun;45(5):720-9. doi: 10.1097/MPA.0000000000000518.
132. Tran MH, Foster CE, Kalantar-Zadeh K, Ichii H. Kidney Transplantation for obese patients. World J Transplant. 2016 Mar 24;6(1):135-43. doi: 10.5500/wjt. v6. i1.135. PMC4801789
133. FazlAlizadeh R, Moghadamyeghaneh Z, Demirjian AN, Imagawa DK, Foster CE, Lakey JR, Stamos MJ, Ichii H. Total Pancreatectomy and Islet Autotransplantation; A Decade Nationwide Analysis. World J Transplant. 2016 Mar 24;6(1):233-8. doi: 10.5500/wjt.v6.i1.233. PMC4801800
134. Tran MH, Ichii H, Pasch W, Carpenter P, Foster CE. Treatment of Focal Segmental Glomerulosclerosis Recurrence in the Renal Allograft: A Report of Two Cases. Case Reports in Nephrology and Dialysis. 2016 Mar 30, 2016 ;6:53–60 DOI: 10.1159/000445428. PMC4836136
135. Gahagan JV, Whealon MD, Reddy U, Foster CE, Ichii H. Hand-assisted laparoscopic donor nephrectomy in complete situs inversus. Journal of Endourology case report. 2016 May 1;2(1):108-10. doi: 10.1089/cren.2016.0045. eCollection 2016. PMC4996604
136. Mowlds DS, Foster CE, Ichii H. Invasive Squamous Cell Bladder Cancer of the ureterovesical junction in a Renal Transplant Patient: A Case Report. Journal of Surgical Case report. 2017 May 2;2017(5): rjx066. doi: 10.1093/jscr/rjx066. eCollection 2017 Feb. PMC 5411735
137. Dosch AR, Pahl M, Reddy U, Foster CE, Ichii H. Post-transplantation nephroptosis causing recurrent episodes of acute renal failure and hypertension secondary to intermittent vascular torsion of intraperitoneal renal allograft. Journal of Surgical Case report. 2017 May 2;2017(5):rjx033. doi: 10.1093/jscr/rjx033. eCollection 2017 May. PMC 5441242
138. Suematsu Y, Obi Y, Shimomura A, Fazlaliazdeh R, Moti L. Kashyap ML, Vaziri ND, Ichii H. The Risk of Postoperative Venous Thromboembolism among Pregnant Women. American Journal of Cardiology. Aug 1;120(3):479-483. doi: 10.1016/j.amjcard.2017.04.053.
139. Takasu C, Vaziri ND, Li S, Robles L, Vo K, Takasu M, Pham C, Farzaneh SH, Shimada M, Stamos MJ, Ichii H. Treatment with Dimethyl Fumarate ameliorates Liver Ischemia/Reperfusion Injury. World Journal of Gastroenterology. 2017 Jul 7;23(25):4508-4516. doi: 10.3748/wjg.v23.i25.4508.
140. Shimomura A, Obi Y, FazlAliazdeh R, Li S, Nguyen NT, Stamos, MJ, Kalantar-Zadeh, K, Ichii H. Impact of pre-operative estimated GFR on post-operative pulmonary complications in laparoscopic surgeries. Scientific reports. 2017 Jul 26;7(1):6504. doi: 10.1038/s41598-017-06842-4.
141. Miki A, Ricordi C, Yamamoto T, Misawa R, Mita A, Molano RD, Vaziri ND, Pileggi A, Ichii H. Divergent antioxidant capacity of human islet cell subsets: A potential cause of beta-cell vulnerability in diabetes and islet transplantation. PLoS One. 2018 May 3;13(5):e0196570. doi: 10.1371/journal.pone.0196570. eCollection 2018.
142. Ui T, Obi Y, Shimomura A, Lefor AK, Fazl Alizadeh R, Said H, Nguyen NT, Stamos MJ, Kalantar-Zadeh K, Sata N, Ichii H. High and low estimated glomerular filtration rates are associated with adverse outcomes in patients undergoing surgery for gastrointestinal malignancies. Nephrology Dialysis Transplantation. 2019 May 1;34(5):810-818. doi: 10.1093/ndt/gfy108.
143. Tantisattamo E, Dafoe DC, Reddy UG, Ichii H, Rhee CM, Streja E, Landman J, Kalantar-Zadeh K. Current Management of Patients with Acquired Solitary Kidney. Review article. Kidney Int Rep. 2019 Jul 11;4(9):1205-1218. doi: 10.1016/j.ekir.2019.07.001.
144. Hasjim B, Fujitani RM, Chen SL, Donayre C, Kuo IJ, Raza A, Reddy U, Ichii H, Kabutey NK. Utilization of Carbon Dioxide Angiography and Percutaneous Balloon Angioplasty for Treatment of Transplant Renal Artery Stenosis. Annals of Vascular Surgery 2019 Nov 8. pii: S0890-5096(19)30967-7. doi: 10.1016/j.avsg.
145. Kojayan GG, Fazl Alizadeh R, Li S, Ichii H. Reducing pancreatic fibrosis using antioxidant therapy targeting nrf2 antioxidant pathway: a possible treatment for chronic pancreatitis. Review article: Pancreas. 2019 Nov/Dec;48(10):1259-1262. doi: 10.1097/MPA.0000000000001433
146. Tantisattamo E, Hanna RM, Reddy UG, Ichii H, Dafoe DC, Danovitch GM, Kalantar-Zadeh K. Novel options for failing allograft in kidney transplanted patients to avoid or defer dialysis therapy. Curr Opin Nephrol Hypertens. 2020 Jan;29(1):80-91. doi:
147. Rowland R, Ponticorvo A, Lopez AJ, Ichii H, Durkin AJ. Monitoring kidney optical properties during cold storage preservation with spatial frequency domain imaging. J Biomed Opt. 2019 Nov;24(11):1-7. doi: 10.1117/1.JBO.24.11.116003.
148. Lau H, Khosrawipour V, Kocbach P, Mikolajczk A, Ichii H, Schubert J, Bania J, Khosrawipour T. Internationally lost COVID-19 cases. J Microbiol Immunol 2020. https://doi.org/10.1016/j.jmii.2020.03.013. [Epub ahead of print]
149. Lau H, Khosrawipour V, Kocbach P, Mikolajczyk A, Ichii H, Zacharksi M, Bania J, Khosrawipour T. The association between international and domestic air traffic and the coronavirus (COVID-19) outbreak. J Microbiol Immunol 2020 Mar 28. pii: S1684-1182(20)30086-4. doi: 10.1016/j.jmii.2020.03.026. [Epub ahead of print]
150. Lau H, Khosrawipour V, Kocbach P, Mikolajczyk A, Ichii H, Zacharksi M, Bania J, Khosrawipour T. Failure in initial stage containment of global COVID-19 epicenters. Journal of Medical Virology. 2020 Apr 16. doi: 10.1002/jmv.25883. [Epub ahead of print]
151. Lopez AJ, Lau H, Li S, Ichii H. Potential Utilization of Nrf2/Keap1 Pathway in Pancreatic Islet Cell Transplantation. Antioxidants (Basel). 2020 Apr 16;9(4). pii: E321. doi: 10.3390/antiox9040321. Review.
152. Li S, Takasu C, Lau H, Robles L, Vo K, Farzaneh SH, Vaziri N. Stamos MJ, Ichii H. Preventive effect of dimethyl fumarate against DSS induced colitis via activation of the Nrf2 antioxidant and anti-inflammatory pathway. Antioxidants (Basel). 2020 Apr 24;9(4). pii: E354. doi: 10.3390/antiox9040354.
153. Tantisattamo E, Molnar MZ, Bing T. Ho BT, Reddy UG, Dafoe DC, Ichii H, Ferrey AJ, Hanna RM, Kalantar-Zadeh K, Amin A. Approach and Management for Hypertension after Kidney Transplantation. Frontiers in Medicine 2020 Jun 16;7:229. doi: 10.3389/fmed.2020.00229.
154. Tantisattamo E, Reddy UG, Duong DK, Ferrey AJ, Ichii H, Dafoe DC, Kalantar-Zadeh K. Hyponatremia: A Possible Immuno-Neuroendocrine Interface with COVID-19 in a Kidney Transplant Recipient. Transplant Infectious Disease 2020 Jun 8:e13355. doi: 10.1111/tid.13355.
155. Tantisattamo E, Ferrey AJ, Reddy UG, Ichii H, Dafoe DC, Kalantar-Zadeh K. Haddon Matrix for Kidney Transplantation during COVID-19 Pandemic: A Problem Solving Framework for Present and Future. Transplant Infectious Disease. 2020 Jun 20:e13373. doi: 10.1111/tid.13373. Online ahead of print.
156. Lau H, Khosrawipour V, Kocbach P, Mikolajczyk A, Ichii H, Zacharksi M, Bania J, Khosrawipour T. Evaluating the massive underreporting and undertesting of COVID-19 cases in multiple global epicenters. Pulmonology. 2020 Jun 6:S2531-0437(20)30129-X. doi: 10.1016/j.pulmoe.2020.05.015.
157. Okuda Y, Streja E, Rhee CM, Tantisattamo E, Reddy U, Laster M, Tang Y, Ben-Ezer D, Rajpoot D, Molnar MZ, Ichii H, Dafoe D, Obi Y, Kalantar-Zadeh K. Association of Age with Risk of First and Subsequent Allograft Failure and Mortality among Young Kidney Transplant Recipients in the USA. Transplant International. 2020 Aug 11. doi: 10.1111/tri.13717.
158. Li S, Eguchi N, Lau H, Ichii H. The role of the Nrf2 signaling in Obesity and Insulin Resistance. International Journal of Molecular Sciences. 2020 Sep 22;21(18):6973. doi: 10.3390/ijms21186973
159. Eguchi N, Vaziri ND, Dafoe DC, Ichii H. The role of oxidative stress in pancreatic ß cell dysfunction in Diabetes. International Journal of Molecular Sciences. 2021 Feb 3;22(4):1509. doi: 10.3390/ijms22041509. PMID: 33546200
160. Li S, Vaziri ND, Swentek L, Takasu C, Vo K, Stamos MJ, Ricordi C, Ichii H. Prevention of Autoimmune Diabetes In NOD Mice By Dimethyl Fumarate. Antioxidants (Basel). 2021 Jan 29;10(2):193. doi: 10.3390/antiox10020193. PMID: 33572792
161. Klangjareonchai T, Eguchi N, Tantisattamo E, Ferrey AJ, Reddy U, Dafoe DC, Ichii H. Current Pharmacological Intervention and Medical Management for Diabetic Kidney Transplant Recipients. Pharmaceutics. 2021 Mar 19;13(3):413. doi: 10.3390/pharmaceutics13030413. PMID: 33808901
162. Swentek L, Chung D, Ichii H. Antioxidant Therapy of Pancreatitis. Antioxidants (Basel). 2021 Apr 23;10(5):657. doi: 10.3390/antiox10050657.
163. Xie L, O’Leary M, Jefferson FA, Karani R, Limfueco L, Parkhomenko E, Sung JM, Patel RM, Ichii H, Dafoe D, Clayman RV, Landman J. Interactive Virtual Reality Renal Models as an Educational and Preoperative Planning Tool for Laparoscopic Donor Nephrectomy. Urology. 2021 Jul;153:192-198. doi: 10.1016/j.urology.2020.12.046. PMID: 33556447
164. Tantisattamo E, Dafoe DC, Ferrey AJ, Ichii H, Lee RA, Zuckerman JE, MD, Sisk AE, Ted Farzaneh T, Guccione J, Kabutey NK, Kalantar-Zadeh K, Reddy UG. Kidney Allograft Infarction Associated with Transplant Renal Artery Stenosis in A COVID-19 Kidney Transplant Recipient. Clin Nephrol Case Stud. 2021 Jul 26;9:93-104. doi: 10.5414/CNCS110462. eCollection 2021.
165. Lau H, Lopez AJ, Eguchi N, Shimomura A, Ferrey A, Tantisattamo E, Reddy UG, Dafoe D, Ichii H. Intraoperative near-infrared spectroscopy monitoring of renal allograft reperfusion in kidney transplant recipients: A feasibility and proof-of-concept study. J Clin Med. 2021 Sep 22;10(19):4292. doi: 10.3390/jcm10194292.PMID: 34640317
166. Tantisattamo E, Reddy UG, Ichii H, Ferrey AJ, Dafoe DC, Ioannou, Pitman TR, Kalantar-Zadeh K. Is It Time to Utilize Genetic Testing for Living Kidney Donor Evaluation? Nephron. 2021 Dec 9:1-7. doi: 10.1159/000520150. Online ahead of print.
167. Eguchi N, Toribio AJ, Alexander M, Xu I, Whaley DL, Hernandez LF, Dafoe D, Ichii H. Dysregulation of ß-cells Proliferation in Diabetes: Possibilities of combination therapy in the development of a comprehensive treatment. Biomedicine. 2022 Feb 17;10(2):472. doi: 10.3390/biomedicines10020472.
168. Hernandez LF, Eguchi N, Whaley D, Alexander M, Tantisattamo E, Ichii H. Anti-Oxidative Therapy in Diabetic Nephropathy. Frontiers in Bioscience-Scholar. 2022 May 9;Volume 12:Issue 2. Doi:10.31083/j.fbs1402014.
169. Eguchi N, Damyar K, Alexander M, Dafoe D, Lakey JRT, Ichii H. Anti-oxidative Therapy in Islet Cell Transplantation. Antioxidants. 2022 May 24;11(6):1038. doi: 10.3390/antiox11061038.
170. Rickels MR, Eggerman TL, Bayman L, Qidwai JC, Alejandro R, Bridges ND, Hering BJ, Markmann JF, Senior PA, Hunsicker LG; Clinical Islet Transplantation Consortium. Long-term Outcomes With Islet-Alone and Islet-After-Kidney Transplantation for Type 1 Diabetes in the Clinical Islet Transplantation Consortium: Aliva J, Begley B, .. Ichii H … et al. The CIT-08 Study. Diabetes Care. 2022 Oct 17:dc212688. doi: 10.2337/dc21-2688. Online ahead of print. PMID: 36250905
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29. Zahr E, R. Molano RD, Pileggi A, Ichii H, Jose SS, Bocca N, An W, Gonzalez-Quintana J, Faker C, Ricordi C Inverardi L. Rapamycin Impairs beta-Cell Proliferation In Vivo. Transplantation Proceedings. 2008 Mar;40(2):436-7.
30. Mita A, Ricordi C, Miki A, Barker S, Haertter R, Hashikura Y , Miyagawa S , Burke GW , Inverardi L, Ichii H. Anti-Pro-Inflammatory Effects of Sirolimus on Human Islet Preparations. Transplantation. 2008 Jul 15;86(1):46-53. PMC2650480
31. Klein D, Timoneri F, Ichii H, Ricordi C, Pastori RL. CD40-CD40L interaction in human islets induces mostly proinflammatory genes. Diabetologia. 2008 Oct;51(10):1853-61.
32. Ichii H, Miki A, Yamamoto T, Baker S, Mita A, Rodriguez-Diaz R, Molano DR, Klein D, Pastori RL, Alejandro R, Inverardi L, Pileggi A, Ricordi C. Characterization of Pancreatic Ductal Cell in Human Islet Preparations. Laboratory Investigation. 2008 Nov;88(11):1167-77. PMC3793849
33. Varona-Santos JL, Pileggi A, Molano RD, Sanabria N, Ijaz A, Ichii H, Pastori RL, Inverardi L, Ricordi C, Fornoni A. Lack of JNK1 but not JNK2 facilitates pancreatic islet function, viability and graft survival after transplantation. Diabetologia. 2008 Dec;51(12):2271-80. Epub 2008 Oct 14.
34. Fenjves ES, Ochoa MS, Cechin S, Gay-Rabinstein C, Pérez-Alvarez I, Ichii H, Mendez A, Ricordi C, Curran MA. Protection of Human Pancreatic Islets Using a Lentiviral Vector Expressing two Genes; cFLIP and GFP. Cell Transplantation. 2008;17(7):793-802.
35. Ichii H, Ricordi C. Current Status of Islet Cell Transplantation. J Hepatobiliary Pancreat Surgery. 2009;16(2):101-12. doi: 10.1007/s00534-008-0021-2. Epub 2008 Dec 26. PMC3777531
36. Mita A, Ricordi C, Miki A, Barker S, Khan A, Alvarez A, Hashikura Y, Miyagawa S, Ichii H. The purification method using iodixanol based density gradient significantly reduces cytokine/chemokine production from human islet preparations, leading to prolong beta-cell survival during pre-transplant culture. Transplantation Proceedings. 2009, Jan-Feb;41(1):314-5. PMC3780973
37. Takahashi H, Ruiz P, Ricordi C, Miki A, Mita A, Barker S, Tzakis A, Ichii H. In situ quantitative immunoprofiling of regulatory cells using Laser Scanning Cytometry. Transplantation Proceedings. 2009 Jan-Feb;41(1):238-9. PMC3777540
38. Sakuma Y, Ricordi C, Miki A, Yamamoto T, Mita A, Barker S, Molano DR, Pileggi A, Yasuda Y, Yada T, Ichii H. The Effect of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Islet Transplantation. Transplantation Proceedings. 2009, Jan-Feb;41(1):343-5. PMC3777528
39. Yamamoto T, Horiguchi A, ItoM, Nagata H, Ichii H, Miyakawa S. Quality control for clinical islet transplantation: Organ procurement and preservation, Islet processing facility and Islet potency test. J Hepatobiliary Pancreat Surg. 2009 Feb 26. Epub ahead of print.
40. Burgess MD, Moore KD, Carter GM, Alli AA, Granda CS, Ichii H, Ricordi C, Gower, Jr. W.R. C-Type Natriuretic Peptide Receptor (NPR-C) Expression in Pancreatic Alpha Cells. Histochem Cell Biol. 2009 Apr 8. [Epub ahead of print]
41. Pileggi A, Ribeiro MM, Hogan AR, Molano RD, Cobianchi L, Ichii H, Embury J, Inverardi L, Fornoni A, Ricordi C, Pastori RL. Impact of Pancreatic Cold Preservation on Islet Recovery and Function. Transplantation. 2009, May 27; 87(10): 1442-1450.
42. Miki A. Ricordi C, Messinger S, Yamamoto T, Mita A, Barker S, Khan A, Alejandro R, Ichii H Toward Improving Human Islet Isolation from Younger Donors; Rescue Purification is More Efficient for Trapped Islets. Cell Transplantation. 2009, 18(1), 13-22. PMC3777447
43. Pileggi A, Ribeiro MM, Hogan AR, Molano RD, Embury JE, Ichii H, Cobianchi L, Fornoni A, Ricordi C, Pastori RL. Effects of pancreas cold ischemia on islet function and quality Transplantation Proceedings. 2009 Jun;41(5):1808-9.
44. Vendrame F, Pileggi A, Laughlin E, Martin-Pagola A, Molano RD, Allende G, Diamantopoulos S, Standifer N, Ichii H, Takahashi H, Mendez A, Geubtner K, Reijonen H, Ruiz P, Sageshima J, Ciancio G, Ricordi C, Nepom GT, Burke GW, Pugliese A. Type 1 diabetes recurrence after simultaneous pancreas-kidney transplantation despite immunosuppression. Diabetes 2010 Apr; 59(4):947-57. PMC2844842
45. Yamamoto T, Mita A, Ricordi C , Miki A, Sakuma Y, Timoneri F, Barker S, Fornoni A, MolanoRD, Inverardi L, Pileggi A, Ichii H. PRL Supplementation to Culture Medium Improves Beta-Cell Survival. Transplantation 2010 Jun 15;89(11):1328-35. PMC3780980
46. Mita A, Ricordi C, Messinger M, Miki A, Misawa R, Barker S, Molano RD, Haertter R, Khan A, Miyagawa S, Pileggi A, Inverardi L, Alejandro R, Hering BJ, Ichii H. Anti-proinflammatory Effects of Iodixanol (OptiPrep)-Based Density Gradient Purification on Human Islet Preparations. Cell transplantation 2010;19(12):1537-46. PMC3777530
47. Ohtsuka H, Sakamoto A, Pan J, Inage S, Horigome S, Ichii H, Arima M, Hatano M, Okada S, Tokuhisa T. Bcl6 is required for the development of mouse CD4+ and CD8alpha+ dendritic cells. Journal of Immunology 2011 Jan 1;186(1):255-63.
48. Lamb M, Storrs R, Li S, Liang O, Laugenour K, Dorian R, Chapman D, Ichii H, Imagawa D, Foster C 3rd, King S, Lakey JR. Function and viability of human islets encapsulated in alginate sheets: in vitro and in vivo culture. Transplantation Proceedings. 2011 Nov;43(9):3265-6.
49. Foster CE 3rd, Weng RR, Piper M, Laugenour K, Ichii H, Lakey J, Malinoski D. Induction therapy by anti-thymocyte globulin (rabbit) versus basiliximab in deceased donor renal transplants and the effect on delayed graft function and outcomes. Transplantation Proceedings. 2012 Jan;44(1):164-6.
50. Misawa R, Ricordi C, Miki A, Barker S, Molano RD, Khan A, Miyagawa S, Inverardi L, Alejandro R, Pileggi A, Ichii H. Evaluation of Viable ß-cell Mass is Useful for Selecting Collagenase for Human Islet Isolation: Comparison of Collagenase NB1 and Liberase HI. Cell Transplantation 2012; 21(1):39-47. PMC3777446
51. Takahashi H, Ruiz P, Ricordi C, Miki A, Mita A, Misawa R, Barker S, Burke GW, Tzakis AG, Ichii H. Quantitative In Situ Analysis of FoxP3+ T Regulatory Cells on Transplant Tissue Using Laser Scanning Cytometry. Cell Transplantation 2012; 21(1):113-25. PMC3777543
52. Iglesias I, Valiente L, Shiang KD, Ichii H, Kandeel F, Al-Abdullah IH. The Effects of Digestion Enzymes on Islet Viability and Cellular Composition. Cell Transplantation 2012;21(4):649-55.
53. Ichii H, Masuda Y, Hassanzadeh T, Saffarian M, Gollapudi S, Nosratola D, Vaziri ND. Iron Sucrose Impairs Phagocytic Function and Promotes Apoptosis in Polymorphonuclear Leukocytes. American Journal of Nephrology 2012 36(1):50-57. PMC3986045
54. Klein D, Bravo-Egana V, Misawa R, Vargas N, Rosero S, Ichii H, Umland O, Zhijie J, Tsinoremas N, Ricordi C, Inverardi L, Domínguez-Bendala J, Pastroi RL. MicroRNA expression in alpha and beta cells of human pancreatic islets. Plos One 2013;8(1): e55064. doi: 10.1371/journal.pone.0055064. PMC3558471
55. Vaziri ND, Yuan J, Khazaeli M, Masuada Y, Ichii H, Liu S. Oral activated charcoal adsorbent (AST-120) ameliorates CKD-induced intestinal epithelial barrier disruption. American Journal of Nephrology 2013;37(6):518-25. doi: 10.1159/000351171. PMC3777856
56. Robles L, Vaziri ND, Ichii H. Role of oxidative stress in the pathogenesis of pancreatitis: Effect of antioxidant therapy. Pancreatic disorders & Therapy 2013. 3: 112. doi:10.4172/2165-7092.1000112. PMC4009983
57. Molnar MZ, Ichii H, Lineen J, Foster CE, Mathe Z, Schiff J, Kim J, Pahl MV, Amin AN, Kalantar-Zadeh K, Kovesdy CP. Timing of Return to Dialysis in Patients with Failing Kidney Transplants. Semin Dial. 2013 Nov-Dec;26(6):667-74.
58. Robles L, Ichii H. Total Pancreatectomy and Islet Auto Transplantation for Chronic Pancreatitis. Pancreatic disorders & Therapy 2013 Nov 29, 3:3 http://dx.doi.org/10.4172/2165-7092.1000e129
59. Masuda Y, Ichii H, Vaziri N.D., At pharmacologically relevant concentrations intravenous iron preparations cause pancreatic beta cell death. American Journal of Translational Research. 2013 Dec 1;6(1):64-70. PMC3853425
60. Masuda Y, Vaziri ND, Takasu C, Li S, Robles L, Pham C, Le A, Vo K, Farzaneh SH, Stamos MJ, Ichii H. Salutary effect of pre-treatment with an Nrf2 inducer on ischemia reperfusion injury in the rat liver. Gastroenterol Hepatol (Que). 2014;1(1):1-7. PMC4280567
61. Miki A. Ricordi C, Yamamoto T, Sakuma Y, Misawa R, Mita A, Inverardi L, Alejandro R, Ichii H. Improved human islet preparations using Glucocorticoid and Exendin-4. Pancreas 2014 Jul 16. [Epub ahead of print].
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73. Ichii H. Pileggi A, Molano RD, Linetsky E, Alejandro R, Inverardi L, Ricordi C. Cellular Composition and Fractional ß-Cell Viability Assay Protocol at the Diabetes Research Institute – University of Miami. CellR4 2014; 2 (4): e1121.
74. Robles L, Vaziri ND, Li S, Masuda Y, Takasu C, Takasu M, Vo K, Farzaneh SH, Stamos MJ, Ichii H. Dimethyl Fumarate protects pacreatic islet cells and non-endocrine tissue in L-Arginine induced Chronic Pancreatitis. PloS one 2014 Sep 8;9 (9): e107111. PMC4157838
75. Li S, Vaziri ND, Masuda Y, Hajighasemi-Ossareh MH, Robles L, Le A, Vo K, Chan JY, Foster CE, Stamos MJ, Ichii H. The activation of Nrf2-keap1 pathway in islets increases islet isolation. Cell Transplantation 2015; 24 (11):2273-83. doi: 10.3727/096368915X686210.
76. Takasu C Vaziri ND, Li S, Robles L, Vo K, Takasu M, Pham C, Farzaneh SH, Foster CE, Stamos MJ, Ichii H. Treatment with Dimethyl Fumarate ameliorates calcineurin inhibitor-induced Nephrotoxicity. Transplantation 2015 Jun;99(6):1144-50. doi: 10.1097/TP.0000000000000647.
77. Robles L, Vaziri ND, Li S, Takasu C, Masuda Y, Vo K, Farzaneh SH, Stamos MJ, Ichii H. Treatment with the Nrf2 activator, Dimethyl Fumarate, ameliorates acute pancreatitis in a rodent model. Pancreas 2015 Apr;44(3):441-7. doi: 10.1097/MPA.0000000000000275. PMC4357568
78. Masuda Y, Vaziri ND, Li S, Le A, Hajighasemi-Ossareh MH, Robles L, Foster CE, Stamos MJ, Al-Abodullah I, Ricordi C, Ichii H. The effect of Nrf2 pathway activation on human pancreatic islet cells. Plos one 2015 Jun 25;10(6): e0131012. doi: 10.1371/journal.pone.0131012. eCollection 2015
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130. Moghadamyeghaneh Z, Hanna MH, Alizadeh RF, Obi Y, Foster CE, Stamos MJ, Ichii H. A Nationwide Analysis of Kidney Auto-Transplantation. The American Surgeon. 2017 Feb 1;83(2):162-169.
131. Robles L, Vaziri ND, Li S, Masuda Y, Takasu C, Takasu M, Vo K, Farzaneh SH, Stamos MJ, Ichii H. Synthetic Triterpenoid RTA dh404 (CDDO-dhTFEA) Ameliorates Acute Pancreatitis. Pancreas 2016 May-Jun;45(5):720-9. doi: 10.1097/MPA.0000000000000518.
132. Tran MH, Foster CE, Kalantar-Zadeh K, Ichii H. Kidney Transplantation for obese patients. World J Transplant. 2016 Mar 24;6(1):135-43. doi: 10.5500/wjt. v6. i1.135. PMC4801789
133. FazlAlizadeh R, Moghadamyeghaneh Z, Demirjian AN, Imagawa DK, Foster CE, Lakey JR, Stamos MJ, Ichii H. Total Pancreatectomy and Islet Autotransplantation; A Decade Nationwide Analysis. World J Transplant. 2016 Mar 24;6(1):233-8. doi: 10.5500/wjt.v6.i1.233. PMC4801800
134. Tran MH, Ichii H, Pasch W, Carpenter P, Foster CE. Treatment of Focal Segmental Glomerulosclerosis Recurrence in the Renal Allograft: A Report of Two Cases. Case Reports in Nephrology and Dialysis. 2016 Mar 30, 2016 ;6:53–60 DOI: 10.1159/000445428. PMC4836136
135. Gahagan JV, Whealon MD, Reddy U, Foster CE, Ichii H. Hand-assisted laparoscopic donor nephrectomy in complete situs inversus. Journal of Endourology case report. 2016 May 1;2(1):108-10. doi: 10.1089/cren.2016.0045. eCollection 2016. PMC4996604
136. Mowlds DS, Foster CE, Ichii H. Invasive Squamous Cell Bladder Cancer of the ureterovesical junction in a Renal Transplant Patient: A Case Report. Journal of Surgical Case report. 2017 May 2;2017(5): rjx066. doi: 10.1093/jscr/rjx066. eCollection 2017 Feb. PMC 5411735
137. Dosch AR, Pahl M, Reddy U, Foster CE, Ichii H. Post-transplantation nephroptosis causing recurrent episodes of acute renal failure and hypertension secondary to intermittent vascular torsion of intraperitoneal renal allograft. Journal of Surgical Case report. 2017 May 2;2017(5):rjx033. doi: 10.1093/jscr/rjx033. eCollection 2017 May. PMC 5441242
138. Suematsu Y, Obi Y, Shimomura A, Fazlaliazdeh R, Moti L. Kashyap ML, Vaziri ND, Ichii H. The Risk of Postoperative Venous Thromboembolism among Pregnant Women. American Journal of Cardiology. Aug 1;120(3):479-483. doi: 10.1016/j.amjcard.2017.04.053.
139. Takasu C, Vaziri ND, Li S, Robles L, Vo K, Takasu M, Pham C, Farzaneh SH, Shimada M, Stamos MJ, Ichii H. Treatment with Dimethyl Fumarate ameliorates Liver Ischemia/Reperfusion Injury. World Journal of Gastroenterology. 2017 Jul 7;23(25):4508-4516. doi: 10.3748/wjg.v23.i25.4508.
140. Shimomura A, Obi Y, FazlAliazdeh R, Li S, Nguyen NT, Stamos, MJ, Kalantar-Zadeh, K, Ichii H. Impact of pre-operative estimated GFR on post-operative pulmonary complications in laparoscopic surgeries. Scientific reports. 2017 Jul 26;7(1):6504. doi: 10.1038/s41598-017-06842-4.
141. Miki A, Ricordi C, Yamamoto T, Misawa R, Mita A, Molano RD, Vaziri ND, Pileggi A, Ichii H. Divergent antioxidant capacity of human islet cell subsets: A potential cause of beta-cell vulnerability in diabetes and islet transplantation. PLoS One. 2018 May 3;13(5):e0196570. doi: 10.1371/journal.pone.0196570. eCollection 2018.
142. Ui T, Obi Y, Shimomura A, Lefor AK, Fazl Alizadeh R, Said H, Nguyen NT, Stamos MJ, Kalantar-Zadeh K, Sata N, Ichii H. High and low estimated glomerular filtration rates are associated with adverse outcomes in patients undergoing surgery for gastrointestinal malignancies. Nephrology Dialysis Transplantation. 2019 May 1;34(5):810-818. doi: 10.1093/ndt/gfy108.
143. Tantisattamo E, Dafoe DC, Reddy UG, Ichii H, Rhee CM, Streja E, Landman J, Kalantar-Zadeh K. Current Management of Patients with Acquired Solitary Kidney. Review article. Kidney Int Rep. 2019 Jul 11;4(9):1205-1218. doi: 10.1016/j.ekir.2019.07.001.
144. Hasjim B, Fujitani RM, Chen SL, Donayre C, Kuo IJ, Raza A, Reddy U, Ichii H, Kabutey NK. Utilization of Carbon Dioxide Angiography and Percutaneous Balloon Angioplasty for Treatment of Transplant Renal Artery Stenosis. Annals of Vascular Surgery 2019 Nov 8. pii: S0890-5096(19)30967-7. doi: 10.1016/j.avsg.
145. Kojayan GG, Fazl Alizadeh R, Li S, Ichii H. Reducing pancreatic fibrosis using antioxidant therapy targeting nrf2 antioxidant pathway: a possible treatment for chronic pancreatitis. Review article: Pancreas. 2019 Nov/Dec;48(10):1259-1262. doi: 10.1097/MPA.0000000000001433
146. Tantisattamo E, Hanna RM, Reddy UG, Ichii H, Dafoe DC, Danovitch GM, Kalantar-Zadeh K. Novel options for failing allograft in kidney transplanted patients to avoid or defer dialysis therapy. Curr Opin Nephrol Hypertens. 2020 Jan;29(1):80-91. doi:
147. Rowland R, Ponticorvo A, Lopez AJ, Ichii H, Durkin AJ. Monitoring kidney optical properties during cold storage preservation with spatial frequency domain imaging. J Biomed Opt. 2019 Nov;24(11):1-7. doi: 10.1117/1.JBO.24.11.116003.
148. Lau H, Khosrawipour V, Kocbach P, Mikolajczk A, Ichii H, Schubert J, Bania J, Khosrawipour T. Internationally lost COVID-19 cases. J Microbiol Immunol 2020. https://doi.org/10.1016/j.jmii.2020.03.013. [Epub ahead of print]
149. Lau H, Khosrawipour V, Kocbach P, Mikolajczyk A, Ichii H, Zacharksi M, Bania J, Khosrawipour T. The association between international and domestic air traffic and the coronavirus (COVID-19) outbreak. J Microbiol Immunol 2020 Mar 28. pii: S1684-1182(20)30086-4. doi: 10.1016/j.jmii.2020.03.026. [Epub ahead of print]
150. Lau H, Khosrawipour V, Kocbach P, Mikolajczyk A, Ichii H, Zacharksi M, Bania J, Khosrawipour T. Failure in initial stage containment of global COVID-19 epicenters. Journal of Medical Virology. 2020 Apr 16. doi: 10.1002/jmv.25883. [Epub ahead of print]
151. Lopez AJ, Lau H, Li S, Ichii H. Potential Utilization of Nrf2/Keap1 Pathway in Pancreatic Islet Cell Transplantation. Antioxidants (Basel). 2020 Apr 16;9(4). pii: E321. doi: 10.3390/antiox9040321. Review.
152. Li S, Takasu C, Lau H, Robles L, Vo K, Farzaneh SH, Vaziri N. Stamos MJ, Ichii H. Preventive effect of dimethyl fumarate against DSS induced colitis via activation of the Nrf2 antioxidant and anti-inflammatory pathway. Antioxidants (Basel). 2020 Apr 24;9(4). pii: E354. doi: 10.3390/antiox9040354.
153. Tantisattamo E, Molnar MZ, Bing T. Ho BT, Reddy UG, Dafoe DC, Ichii H, Ferrey AJ, Hanna RM, Kalantar-Zadeh K, Amin A. Approach and Management for Hypertension after Kidney Transplantation. Frontiers in Medicine 2020 Jun 16;7:229. doi: 10.3389/fmed.2020.00229.
154. Tantisattamo E, Reddy UG, Duong DK, Ferrey AJ, Ichii H, Dafoe DC, Kalantar-Zadeh K. Hyponatremia: A Possible Immuno-Neuroendocrine Interface with COVID-19 in a Kidney Transplant Recipient. Transplant Infectious Disease 2020 Jun 8:e13355. doi: 10.1111/tid.13355.
155. Tantisattamo E, Ferrey AJ, Reddy UG, Ichii H, Dafoe DC, Kalantar-Zadeh K. Haddon Matrix for Kidney Transplantation during COVID-19 Pandemic: A Problem Solving Framework for Present and Future. Transplant Infectious Disease. 2020 Jun 20:e13373. doi: 10.1111/tid.13373. Online ahead of print.
156. Lau H, Khosrawipour V, Kocbach P, Mikolajczyk A, Ichii H, Zacharksi M, Bania J, Khosrawipour T. Evaluating the massive underreporting and undertesting of COVID-19 cases in multiple global epicenters. Pulmonology. 2020 Jun 6:S2531-0437(20)30129-X. doi: 10.1016/j.pulmoe.2020.05.015.
157. Okuda Y, Streja E, Rhee CM, Tantisattamo E, Reddy U, Laster M, Tang Y, Ben-Ezer D, Rajpoot D, Molnar MZ, Ichii H, Dafoe D, Obi Y, Kalantar-Zadeh K. Association of Age with Risk of First and Subsequent Allograft Failure and Mortality among Young Kidney Transplant Recipients in the USA. Transplant International. 2020 Aug 11. doi: 10.1111/tri.13717.
158. Li S, Eguchi N, Lau H, Ichii H. The role of the Nrf2 signaling in Obesity and Insulin Resistance. International Journal of Molecular Sciences. 2020 Sep 22;21(18):6973. doi: 10.3390/ijms21186973
159. Eguchi N, Vaziri ND, Dafoe DC, Ichii H. The role of oxidative stress in pancreatic ß cell dysfunction in Diabetes. International Journal of Molecular Sciences. 2021 Feb 3;22(4):1509. doi: 10.3390/ijms22041509. PMID: 33546200
160. Li S, Vaziri ND, Swentek L, Takasu C, Vo K, Stamos MJ, Ricordi C, Ichii H. Prevention of Autoimmune Diabetes In NOD Mice By Dimethyl Fumarate. Antioxidants (Basel). 2021 Jan 29;10(2):193. doi: 10.3390/antiox10020193. PMID: 33572792
161. Klangjareonchai T, Eguchi N, Tantisattamo E, Ferrey AJ, Reddy U, Dafoe DC, Ichii H. Current Pharmacological Intervention and Medical Management for Diabetic Kidney Transplant Recipients. Pharmaceutics. 2021 Mar 19;13(3):413. doi: 10.3390/pharmaceutics13030413. PMID: 33808901
162. Swentek L, Chung D, Ichii H. Antioxidant Therapy of Pancreatitis. Antioxidants (Basel). 2021 Apr 23;10(5):657. doi: 10.3390/antiox10050657.
163. Xie L, O’Leary M, Jefferson FA, Karani R, Limfueco L, Parkhomenko E, Sung JM, Patel RM, Ichii H, Dafoe D, Clayman RV, Landman J. Interactive Virtual Reality Renal Models as an Educational and Preoperative Planning Tool for Laparoscopic Donor Nephrectomy. Urology. 2021 Jul;153:192-198. doi: 10.1016/j.urology.2020.12.046. PMID: 33556447
164. Tantisattamo E, Dafoe DC, Ferrey AJ, Ichii H, Lee RA, Zuckerman JE, MD, Sisk AE, Ted Farzaneh T, Guccione J, Kabutey NK, Kalantar-Zadeh K, Reddy UG. Kidney Allograft Infarction Associated with Transplant Renal Artery Stenosis in A COVID-19 Kidney Transplant Recipient. Clin Nephrol Case Stud. 2021 Jul 26;9:93-104. doi: 10.5414/CNCS110462. eCollection 2021.
165. Lau H, Lopez AJ, Eguchi N, Shimomura A, Ferrey A, Tantisattamo E, Reddy UG, Dafoe D, Ichii H. Intraoperative near-infrared spectroscopy monitoring of renal allograft reperfusion in kidney transplant recipients: A feasibility and proof-of-concept study. J Clin Med. 2021 Sep 22;10(19):4292. doi: 10.3390/jcm10194292.PMID: 34640317
166. Tantisattamo E, Reddy UG, Ichii H, Ferrey AJ, Dafoe DC, Ioannou, Pitman TR, Kalantar-Zadeh K. Is It Time to Utilize Genetic Testing for Living Kidney Donor Evaluation? Nephron. 2021 Dec 9:1-7. doi: 10.1159/000520150. Online ahead of print.
167. Eguchi N, Toribio AJ, Alexander M, Xu I, Whaley DL, Hernandez LF, Dafoe D, Ichii H. Dysregulation of ß-cells Proliferation in Diabetes: Possibilities of combination therapy in the development of a comprehensive treatment. Biomedicine. 2022 Feb 17;10(2):472. doi: 10.3390/biomedicines10020472.
168. Hernandez LF, Eguchi N, Whaley D, Alexander M, Tantisattamo E, Ichii H. Anti-Oxidative Therapy in Diabetic Nephropathy. Frontiers in Bioscience-Scholar. 2022 May 9;Volume 12:Issue 2. Doi:10.31083/j.fbs1402014.
169. Eguchi N, Damyar K, Alexander M, Dafoe D, Lakey JRT, Ichii H. Anti-oxidative Therapy in Islet Cell Transplantation. Antioxidants. 2022 May 24;11(6):1038. doi: 10.3390/antiox11061038.
170. Rickels MR, Eggerman TL, Bayman L, Qidwai JC, Alejandro R, Bridges ND, Hering BJ, Markmann JF, Senior PA, Hunsicker LG; Clinical Islet Transplantation Consortium. Long-term Outcomes With Islet-Alone and Islet-After-Kidney Transplantation for Type 1 Diabetes in the Clinical Islet Transplantation Consortium: Aliva J, Begley B, .. Ichii H … et al. The CIT-08 Study. Diabetes Care. 2022 Oct 17:dc212688. doi: 10.2337/dc21-2688. Online ahead of print. PMID: 36250905
Book chapters
Ichii H, Pileggi A, Fraker C, Ricordi C. Islet transplantation and beta cell replacement therapy Chapter: Culture and transportation of islets between centers. 2007 251-268. Informa Healthcare
Ichii H, Pileggi A, Fraker C, Ricordi C. Islet transplantation and beta cell replacement therapy Chapter: Culture and transportation of islets between centers. 2007 251-268. Informa Healthcare
Grants
5U01DK70460-02 NIH Strategies to Improve Long Term Islet Graft Survival
5U42R016603-03 NIH Islet Cell Resource (ICR) for Diabetes Research and Treatment
5R01DK025802-23 NIH Pancreatic Transplantation and Diabetes Mellitus
5R01DK59993-04 NIH Novel Strategies to Improve Viability of Islets
5U42R016603-06 NIH Islet Cell Resource (ICR) Cellular Composition Assessment Core
4-2004-361 JDRF Center for Islet Transplantation at the University of Miami – Diabetes Research Institute
17-2011-609 JDRF Explore a role of Nrf2-Keap1 pathway in human pancreatic beta cells (09/01/11-08/31/13)
UL1 TR000153, KL2 TR000147
NCRR, NIH Institute for Clinical and Translational Science (ICTS), KL-award (12/01/10-03/31/13)
HCCA-205358 HITACHI CHEMICAL COMPANY, LTD. Development of urinary exosomal and microvesicles as renal cell specific biomarkers of transplant kidney injury
04/13/16- 08/31/2017
OPF-205728 OTSUKA PHARMACEUTICAL FACTORY, INC. DMF to reduce inflammatory response at the time of DIABECELL 06/29/16 – 01/31/18
OPF-205743 OTSUKA PHARMACEUTICAL FACTORY, INC. Research on the cell composition of DIABECELL, and measurement and evaluation of viability thereof 04/01/16 – 01/31/18
Subcontract UC4DK098085 NIDDK Integrated Islet Distribution Program (IIDP) - Data Coordinating Center (DCC) 04/01/2017- 3/31/2018
Viacyte Inc. An Open-Label, First-In-Human, Study Evaluating the Safety, Tolerability,
and Efficacy of VC-02™ Combination Product in Subjects with Type 1 Diabetes Mellitus and Hypoglycemia Unawareness”
Viacyte Inc. 07/03/2019-07/02/2021
NIAID, NIDDK, NIMHD APOL1 Long-term Kidney Transplantation Outcomes Network 03/28/2020- 05/31/2022
Professional Societies
American Society of Transplantation
Cell Transplant society
Japanese Society of Surgery
• Japanese Society of Gastroenterological Surgery
• Japanese Gastroenterological Endoscopy Society
Graduate Programs
Transplantation Surgery
Link to this profile
https://faculty.uci.edu/profile/?facultyId=5744
https://faculty.uci.edu/profile/?facultyId=5744
Last updated
10/23/2022
10/23/2022