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Hirohito Ichii

Associate Professor of Clinical Surgery, Surgery
School of Medicine

M.D., Kobe University school of Medicine


Ph.D., Kobe university graduate school of Medicine

Phone: (714) 456-8429
Email: hichii@uci.edu

University of California, Irvine
City Tower, Suite 1205, Rt. 19
Irvine, CA 92868

picture of Hirohito  Ichii

Research
Interests
Islet, Pancreas, kidney transplantation, islet isolation, Type I diabetes, Memory T cell, Immunosuppression
   
Appointments Postdoctoral associate Diabetes Research Institute, University of Miami scholl of Medicine
Transplant fellow, Miami Transplant institute, University of Miami scholl of Medicine
Research Assistant Professor, Diabetes Research Institute, University of Miami scholl of Medicine
   
Publications Book chapters
Ichii H, Pileggi A, Fraker C, Ricordi C. Islet transplantation and beta cell replacement therapy Chapter: Culture and transportation of islets between centers. 2007 251-268. Informa Healthcare
   
  1. Ichii H, Sakamoto A, Hatano M, Okada S, Toyama H, Taki S, Arima M, Kuroda Y, Tokuhisa T. Role for Bcl-6 in the generation and maintenance of memory CD8+ T cells. Nature Immunology. 2002 ;3(6):558-63.

2. Toyama H, Okada S, Hatano M, Takahashi Y, Takeda N, Ichii H, Takemori T, Kuroda Y, Tokuhisa T. Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells. Immunity. 2002 ;17(3):329-39.

3. Arima M, Toyama H, Ichii H, Kojima S, Okada S, Hatano M, Cheng G, Kubo M, Fukuda T, Tokuhisa T. A putative silencer element in the IL-5 gene recognized by Bcl6. Journal of Immunology. 2002 ;169(2):829-36.

4. Ichii H, Takada M, Kashiwagi R, Sakane M, Tabata F, Ku Y, Fujimori T, Kuroda Y. Three-dimensional reconstruction of biliary tract using spiral computed tomography for laparoscopic cholecystectomy. World Journal of Surgery. 2002 May ;26(5):608-11.

5. Ichii H, Sakamoto A, Tokuhisa T. Role for Bcl6 in T cell differentiation. Annual Review Immunology. 187-193, 2002.

6. Ichii H, Sakamoto A, Tokuhisa T. Bcl6 and memory CD8 T cell. Molecular Medicine vol.39, II. 2003.

7. Ichii H, Sakamoto A, Kuroda Y, Tokuhisa T. Bcl6 acts as an amplifier for the generation and proliferative capacity of central memory CD8+ T cells. Journal of Immunology. 2004 ;173(2):883-91.

8. Ichii H, Pileggi A, Molano RD, Baidal DA, Khan A, Kuroda Y, Inverardi L, Goss JA, Alejandro R, Ricordi C. Rescue purification maximizes the use of human islet preparations for transplantation. American Journal of Transplantation. 2005 Jan;5(1):21-30.

9. Klein D, Barbe-Tuana F, Pugliese A, Ichii H, Garza D, Gonzalez M, Molano RD, Ricordi C, Pastori RL. A functional CD40 receptor is expressed in pancreatic beta cells. Diabetologia. 2005 Feb; 48(2):268-76.

10. Mendoza V, Klein D, Ichii H, Ribeiro MM, Ricordi C, Hankeln T, Burmester T, Pastori RL. Protection of islets in culture by delivery of oxygen binding neuroglobin via protein transduction. Transplantation Proceedings. 2005; 37(1):237-40.

11. Pileggi A, Molano RD, Berney T, Ichii H, San Jose S, Zahr E, Poggioli R, Linetsky E, Ricordi C, Inverardi L. Prolonged allogeneic islet graft survival by protoporphyrins. Cell Transplantation. 2005; 14(2-3):85-96.

12. Ichii H, Inverardi L, Pileggi A, Molano RD, Cabrera O, Caicedo A, Messinger S, Kuroda Y, Berggren PO, Ricordi C. A novel method for the assessment of cellular composition and beta-cell viability in human islet preparations. American Journal of Transplantation. 2005; 5(7):1635-45

13. Ichii H. Islet Transplantation in U.S.A. Transplantation Now. 2005, 8(4):394-400.

14. Froud T, Ricordi C, Baidal DA, Hafiz MM, Ponte G, Cure P, Pileggi A, Poggioli R, Ichii H, Khan A, Ferreira JV, Pugliese A, Esquenazi VV, Kenyon NS, Alejandro R. Islet transplantation in type 1 diabetes mellitus using cultured islets and steroid-free immunosuppression: Miami experience. American Journal of Transplantation. 2005 Aug;5(8):2037-46.

15. Ichii H, Wang X, Messinger S, Alvarez A, Fraker C, Khan A, Kuroda Y, Inverardi L, Goss JA, Alejandro R, Ricordi C. Improved Human Islet Isolation Using Nicotinamide. American Journal of Transplantation. 2006; 6(9): 2060-68.

16. Barbé-Tuana FM, Klein D, Ichii H, Berman-Weinberg D, Coffey L, Kenyon NS, Ricordi C, Pastori RL. CD40-CD40 ligand interaction in pancreatic islets activates pro-inflammatory pathways. Diabetes. 2006; 55(9):2437-45.

17. Fraker C, Timmins MR, Guarino RD, Haaland PD, Ichii H, Molano D, Pileggi A, Poggioli R, Presnell SC, Inverardi L, Zehtab M, Ricordi C. The Use of the BD Oxygen Biosensor System to Assess Isolated Islets of Langerhans: Oxygen Consumption as a Potential Measure of Islet Potency. Cell Transplantation. 2006;15(8-9):745-58.

18. Fornoni A, Cobianchi L, Sanabria N, Antonello P, Molano DR, Ichii H, Inverardi L, Ricordi C, Pastori R. The L isoform but not any D modification of c-jun N-terminal kinase (JNK) inhibitory peptide improves beta cell mass and function. Biochem Biophys Res Commun. Mar 2;354(1):227-33. 2007

19. Ichii H, Sakamoto A, Arima M, Hatano M, Kuroda Y, Tokuhisa T. Bcl6 is essential for the generation of long-term memory CD4+ T cells. International Immunology. 2007 Apr;19(4):427-33

20. Ichii H, Sakuma Y, Pileggi A, Fraker C, Alvarez A, Montelongo J, Szust J, Khan A, Inverardi L, Naziruddin B, Levy MF, Klintmalm GB, Goss JA, Alejandro R, Ricordi C. Shipment of Human Islets for Transplantation. American Journal of Transplantation. 2007 April 7(4):1010-20.

21. Ponte GM, Pileggi A, Messinger S, Alejandro A, Ichii H, Baidal DA, Khan A, Ricordi C, Goss JA, Alejandro R. Toward maximizing the success rates of human islet isolation: Influence of donor and isolation factors. Cell Transplantation. 2007;16(6):595-607.

22. Yamamoto T., Ricordi C, Messinger S, Sakuma Y, Miki A., Rodriguez R,. Haertter R, Khan A, Alejandro R, Ichii H. Deterioration and Variability of Highly Purified Collagenase Blends used in Clinical Islet Isolation. Transplantation 2007 Oct 27;84(8):997-1002.

23. Fornoni A, Pileggi A, Molano DR, Sanabria N, Tejada T, Gonzalez-Quintana J, Ichii H, Inverardi L, Ricordi C, Pastori R. Inhibition of c-jun N terminal kinase (JNK) improves functional ?-cell mass in human pancreatic islets and leads to AKT and GSK-3 phosphorylation. Diabetologia. 2008 Feb;51(2):298-308.

24. Zahr E, R. Molano RD, Pileggi A, Ichii H, Jose SS, Bocca N, An W, Gonzalez-Quintana J, Faker C, Ricordi C Inverardi L. Rapamycin impairs the proliferation of islet beta-cells. Transplantation 2007 Dec 27;84(12):1576-83.

25. Miki A. Ricordi C. Yamamoto T. Mita A. Barker S. Khan A. Alejandro R. Ichii H. Effect of Human Islet Rescue Gradient Purification on Islet yield and Fractional Beta cell Viability. Transplantation Proceedings. 2008 Mar;40(2):360-1 PMCID: PMC2614214

26. Yamamoto T, Ricordi C, Miki A, Sakuma Y, Mita A, Barker S, Molano RS, Fornoni A, Pileggi A, Inverardi L, Ichii H. Beta-cell Specific Cytoprotection by Prolactin on Human Islet. Transplantation Proceedings. 2008 Mar;40(2):382-3. PMCID: PMC2614218

27. Sakuma Y, Ricordi C, Miki A, Yamamoto T, Pileggi A, Khan A, Alejandro R , Inverardi L, Ichii H. Factors Affecting Human Islet Isolation. Transplantation Proceedings. 2008 Mar;40(2):343-5.PMCID: PMC2614209

28. Zahr E, R. Molano RD, Pileggi A, Ichii H, Jose SS, Bocca N, An W, Gonzalez-Quintana J, Faker C, Ricordi C Inverardi L. Rapamycin Impairs beta-Cell Proliferation In Vivo. Transplantation Proceedings. 2008 Mar;40(2):436-7.

29. Mita A, Ricordi C, Miki A, Barker S, Haertter R, Hashikura Y , Miyagawa S , Burke GW , Inverardi L, Ichii H. Anti-Pro-Inflammatory Effects of Sirolimus on Human Islet Preparations. Transplantation. 2008 Jul 15;86(1):46-53.PMCID:PMC2650480

30. Klein D, Timoneri F, Ichii H, Ricordi C, Pastori RL. CD40-CD40L interaction in human islets induces mostly proinflammatory genes. Diabetologia. 2008 Oct;51(10):1853-61.

31. Ichii H, Miki A, Yamamoto T, Baker S, Mita A, Rodriguez-Diaz R, Molano DR, Klein D, Pastori RL, Alejandro R, Inverardi L, Pileggi A, Ricordi C. Characterization of Pancreatic Ductal Cell in Human Islet Preparations. Laboratory Investigation. 2008 Nov;88(11):1167-77.

32. Varona-Santos JL, Pileggi A, Molano RD, Sanabria N, Ijaz A, Ichii H, Pastori RL, Inverardi L, Ricordi C, Fornoni A. Lack of JNK1 but not JNK2 facilitates pancreatic islet function, viability and graft survival after transplantation. Diabetologia. 2008 Dec;51(12):2271-80.

33. Fenjves ES, Ochoa MS, Cechin S, Gay-Rabinstein C, Pérez-Alvarez I, Ichii H, Mendez A, Ricordi C, Curran MA. Protection of Human Pancreatic Islets Using a Lentiviral Vector Expressing two Genes; cFLIP and GFP. Cell Transplantation. 2008;17(7):793-802.

34. Ichii H, Ricordi C. Current Status of Islet Cell Transplantation. J Hepatobiliary Pancreat Surgery. 2009;16(2):101-12. PMCID: PMC3777531

35. Mita A, Ricordi C, Miki A, Barker S, Khan A, Alvarez A, Hashikura Y , Miyagawa S , Ichii H. The purification method using iodixanol based density gradient significantly reduces cytokine/chemokine production from human islet preparations, leading to prolong beta-cell survival during pre-transplant culture. Transplantation Proceedings. 2009, Jan-Feb;41(1):314-5.PMCID: PMC3780973

36. Takahashi H, Ruiz P, Ricordi C, Miki A, Mita A, Barker S, Tzakis A, Ichii H. In situ quantitative immunoprofiling of regulatory cells using Laser Scanning Cytometry. Transplantation Proceedings. 2009 Jan-Feb;41(1):238-9. PMCID:PMC3777540

37. Sakuma Y, Ricordi C, Miki A, Yamamoto T, Mita A, Barker S, Molano DR, Pileggi A, Yasuda Y, Yada T, Ichii H. The Effect of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Islet Transplantation. Transplantation Proceedings. 2009, Jan-Feb;41(1):343-5. PMCID: PMC3777528

38. Yamamoto T, Horiguchi A, ItoM, Nagata H, Ichii H, Miyakawa S . Quality control for clinical islet transplantation: Organ procurement and preservation, Islet processing facility and Islet potency test. J Hepatobiliary Pancreat Surg. 2009;16(2):131-6.

39. Burgess MD, Moore KD, Carter GM, Alli AA, Granda CS, Ichii H, Ricordi C, Gower, Jr. W.R. C-Type Natriuretic Peptide Receptor (NPR-C) Expression in Pancreatic Alpha Cells. Histochem Cell Biol. 2009 Jul;132(1):95-103.

40. Pileggi A, Ribeiro MM, Hogan AR, Molano RD, Cobianchi L, Ichii H, Embury J, Inverardi L, Fornoni A, Ricordi C, Pastori RL. Impact of Pancreatic Cold Preservation on Islet Recovery and Function. Transplantation. 2009, May 27; 87(10): 1442-1450.

41. Miki A. Ricordi C, Messinger S, Yamamoto T, Mita A, Barker S, Khan A, Alejandro R,. Ichii H Toward Improving Human Islet Isolation from Younger Donors; Rescue Purification is More Efficient for Trapped Islets. Cell Transplantation. 2009, 18(1), 13-22.PMCID: PMC3777447

42. Pileggi A, Ribeiro MM, Hogan AR, Molano RD, Embury JE, Ichii H, Cobianchi L, Fornoni A, Ricordi C, Pastori RL. Effects of pancreas cold ischemia on islet function and quality Transplantation Proceedings. 2009 Jun;41(5):1808-9.

43. Vendrame F, Pileggi A, Laughlin E, Martin-Pagola A, Molano RD, Allende G, Diamantopoulos S, Standifer N, Ichii H, Takahashi H, Mendez A, Geubtner K, Reijonen H, Ruiz P, Sageshima J, Ciancio G, Ricordi C, Nepom GT, Burke GW, Pugliese A. Type 1 diabetes recurrence after simultaneous pancreas-kidney transplantation despite immunosuppression. Diabetes 2010 Apr; 59(4):947-57. PMCID: PMC2844842

44. Yamamoto T, Mita A, Ricordi C , Miki A, Sakuma Y, Timoneri F, Barker S, Fornoni A, MolanoRD, Inverardi L, Pileggi A, Ichii H. PRL Supplementation to Culture Medium Improves Beta-Cell Survival. Transplantation 2010 Jun 15;89(11):1328-35.PMCID: PMC3780980

45. Mita A, Ricordi C ,Messinger M, Miki A, Misawa R, Barker S, Molano RD, Haertter R, Khan A, Miyagawa S, Pileggi A, Inverardi L, Alejandro R, Hering BJ, Ichii H. Anti-proinflammatory Effects of Iodixanol (OptiPrep)-Based Density Gradient Purification on Human Islet Preparations. Cell transplantation 2010;19(12):1537-46. PMCID: PMC3777530

46. Ohtsuka H, Sakamoto A, Pan J, Inage S, Horigome S, Ichii H, Arima M, Hatano M, Okada S, Tokuhisa T. Bcl6 is required for the development of mouse CD4+ and CD8alpha+ dendritic cells. Journal of Immunology 2011 Jan 1;186(1):255-63.

47. Lamb M, Storrs R, Li S, Liang O, Laugenour K, Dorian R, Chapman D, Ichii H, Imagawa D, Foster C 3rd, King S, Lakey JR. Function and viability of human islets encapsulated in alginate sheets: in vitro and in vivo culture. Transplantation Proceedings. 2011 Nov;43(9):3265-6.

48. Misawa R, Ricordi C, Miki A, Barker S, Molano RD, Khan A, Miyagawa S, Inverardi L, Alejandro R, Pileggi A, Ichii H. Evaluation of Viable ?-cell Mass is Useful for Selecting Collagenase for Human Islet Isolation: Comparison of Collagenase NB1 and Liberase HI. Cell Transplantation. Cell Transplantation 2012; 21(1):39-47. PMCID: PMC3777446

49. Takahashi H, Ruiz P, Ricordi C, Miki A, Mita A, Misawa R, Barker S, Burke GW, Tzakis AG , Ichii H. Quantitative In Situ Analysis of FoxP3+ T Regulatory Cells on Transplant Tissue Using Laser Scanning Cytometry. Cell Transplantation 2012; 21(1):113-25. PMCID: PMC3777543

50. Iglesias I, Valiente L, Shiang KD, Ichii H, Kandeel F, Al-Abdullah IH. The Effects of Digestion Enzymes on Islet Viability and Cellular Composition. Cell Transplantation 2012 Jan 10. [Epub ahead of print]

51. Foster CE 3rd, Weng RR, Piper M, Laugenour K, Ichii H, Lakey J,.Malinoski D. Induction therapy by anti-thymocyte globulin (rabbit) versus basiliximab in deceased donor renal transplants and the effect on delayed graft function and outcomes.. Transplantation Proceedings. 2012 Jan;44(1):164-6.

53. Ichii H, Masuda Y, Hassanzadeh T, Saffarian M, Gollapudi S, Nosratola D, Vaziri ND. Iron Sucrose Impairs Phagocytic Function and Promotes Apoptosis in Polymorphonuclear Leukocytes. American Journal of Nephrology 2012 Jun 19;36(1):50-57.

54. Klein D, Bravo-Egana V, Misawa R, Vargas N, Rosero S, Ichii H, Umland O, Zhijie J, Tsinoremas N, Ricordi C, Inverardi L, Domínguez-Bendala J, Pastroi RL. MicroRNA expression in alpha and beta cells of human pancreatic islets. Plos One 2013;8(1):e55064. doi: 10.1371/journal.pone.0055064. PMCID: PMC3558471

55. Vaziri ND, Yuan J, Khazaeli M, Masuada Y, Ichii H, Liu S. Oral activated charcoal adsorbent (AST-120) ameliorates CKD-induced intestinal epithelial barrier disruption. American Journal of Nephrology 2013;37(6):518-25. doi: 10.1159/000351171.

56. Robles L, Vaziri ND, Ichii H. Role of oxidative stress in the pathogenesis of pancreatitis: Effect of antioxidant therapy. Pancreatic disorders & Therapy 2013. 3: 112. doi:10.4172/2165-7092.1000112

57. Molnar MZ, Ichii H, Lineen J, Foster CE, Mathe Z, Schiff J, Kim J, Pahl MV, Amin AN, Kalantar-Zadeh K, Kovesdy CP. Timing of Return to Dialysis in Patients with Failing Kidney Transplants. Semin Dial. 2013 Sep 9. doi: 10.1111/sdi.12129. [Epub ahead of print]
   
Grants 5U01DK70460-02 NIH Strategies to Improve Long Term Islet Graft Survival
   
5U42R016603-03 NIH Islet Cell Resource (ICR) for Diabetes Research and Treatment
   
5R01DK025802-23 NIH Pancreatic Transplantation and Diabetes Mellitus
   
5R01DK59993-04 NIH Novel Strategies to Improve Viability of Islets
   
5U42R016603-06 NIH Islet Cell Resource (ICR) Cellular Composition Assessment Core
   
4-2004-361 JDRF Center for Islet Transplantation at the University of Miami – Diabetes Research Institute
   
17-2011-609 JDRF Explore a role of Nrf2-Keap1 pathway in human pancreatic beta cells (09/01/11-08/31/13)
   
UL1 TR000153, KL2 TR000147 NCRR, NIH Institute for Clinical and Translational Science (ICTS), KL-award (12/01/10-03/31/13)
   
Professional
Societies
American Society of Transplantation
Cell Transplant society
Japanese Society of Surgery
• Japanese Society of Gastroenterological Surgery
• Japanese Gastroenterological Endoscopy Society
   
Graduate Programs Transplantation Surgery

   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=5744
   
Last updated 10/07/2013