Anthony B. Nesburn

Professor & Vice Chairman for Research, Ophthalmology
School of Medicine

M.D., Harvard Medical School Cum Laude, 1960, Medicine

Phone: 949) 824-6802
Fax: (949) 824-9626
Email: anesburn@uci.edu

University of California, Irvine
Gavin Herbert Eye Institute
843 Health Sciences Rd.
Rm. 2026
Mail Code: 4390
Irvine, CA 92697


Research
Interests
Herpes, vaccine, HSV-1, Herpes Simplex Virus type 1
   
Academic
Distinctions
B.A. UCLA, Magna Cum Laude, Phi Beta Kappa
M.D. Harvard Medical School, Cum Laude

Recipient, Fight for Sight Research Grant-in-Aid (1968-l970, 1971-1972)
Edward Sweebe Memorial Lecturer

Fellow of the American College of Surgeons (1977)
Visiting Professor of Ophthalmology:
Mayo Clinic, Rochester, Minnesota
Moorfields Eye Hospital, London, England
University of Rochester, Rochester, New York
Wilmer Eye Institute, John Hopkins University, Baltimore
LSU Eye Center, New Orleans, Louisianna
University of California at San Diego
American Academy of Ophthalmology Honor Award & Senior Honor Award
Organize three major symposia for the AAO Annual Meetings
1979 - "Virology Symposium" at AAO Jackson Memorial Lecture
1980 - "Refractive Surgery Symposium"
1982 - "Critical Evaluation of Human Refractive Surgery"
Robertson Memorial Lecturer
University of Texas Medical Branch at Galveston, April 15-16, 1983
Academy of Ophthalmology, Senior Honor Award 1991
National Advisory Eye Council, 1997-2000.
1995,1998,1999, 2001-2003, 2008 Best Doctors in America
Who’s Who in Medicine,
Loma Linda University, 71st Annual Postgraduate Convention, George Kambara Lecture, “What’s Really New in the World of Herpes Simplex?”
   
Available Technologies
Publications 1. Kaufman, H.E., Nesburn, A.B., and Maloney, E.D: IDU Therapy of Herpes Simplex. Arch. Ophthal. 67:583-591, 1962.
2. Kaufman, H.E., Maloney, E.D., Nesburn, A.B.: Comparison of Specific Antiviral Agents in Herpes Simplex Keratitis. Invest. Ophthal. 1:686-692, 1962.
3. Kaufman, H.E., Nesburn, A.B. and Maloney, E.D: Cure of Vaccinia Infection by 5-Indo-2'-Deoxyuridine. Virology 18:567-569, 1962.
4. Kaufman, H.E., Nesburn, A.B. and Maloney, E.D: Efficicite de la 5-Iodo-2'-Deoxyuridine Sur la Vaccine Experimentale. Pathologie et Biologie: January, 1964. (Solicited Article)
5. Williams, L.E., Nesburn, A.B. and Kaufman, H.E: Experimental Induction of Disciform Keratitis. Arch. Ophthal. 73:112-114, 1965.
6. Nesburn, A.B.: Progress Against Rubella (editorial). Arch. Ophthal. 77:425-426, 1967.
7. Nesburn, A.B., Elliott, J.M. and Leibowitz, H.M: Spontaneous Recurrence of Experimental Herpes Simplex Keratitis in Rabbits. Arch. Ophthal. 78:523-529, 1967.
8. Brown, D.C., Nesburn, A.B., Nauheim, J.S., Pavan-Langston, D. and Kaufman, H.E: Recurrent Herpes Simplex Conjunctivitis. Arch. Ophthal. 79:733-735, 1968.
9. Pavan-Langston, D. and Nesburn, A.B.: The Chronology of Primary Herpes Simplex Infection of the Eye and Adnexal Glands. Arch. Ophthal. 80:258-264, 1968.
10. Nesburn, A.B.: Isolation and Characterization of a Herpes-like Virus from New Zealand Albino Rabbit Kidney Cell Cultures: A Probable Reisolation of Virus III of Rivers. J. Virology 3:59-69, 1969.
11. Nesburn, A.B. and Ziniti, P.J: Effect of Long-Term Low Dosage Poly I:C on Chronic Ocular Herpes Simplex Infection in Rabbits. Interferon Sci. Memo. #381, May, 1970.
12. Nesburn, A.B. and Ziniti, P.J: Long-Term Topical Poly I:C in Experimental Chronic Ocular Herpes Infection. Amer. J. Ophthal. 72:821, 1971.
13. Stevens, J.G., Nesburn, A.B. and Cook, M.L: Recovery of Latent Herpes Simplex Virus from Trigeminal Ganglia of Rabbits with Recurrent Eye Infection. Nature New Biology 235:216-217, 1972.
14. Nesburn, A.B. and Wood, T.R: Virus Infection in Utero in Modern Ophthalmology, 2nd Edition, edited by Arnold Sorsby. Butterworth and Co., London, 1972.
15. Nesburn, A.B., Cook, M.L. and Stevens, J.G: Isolation of Herpes Simplex Virus - Isolation from Rabbit Trigeminal Ganglia Between Episodes of Recurrent Ocular Infection. Arch. Ophthal. 88:412-417, 1972.
16. Nesburn, A.B., Robinson, C. and Dickinson, R: Adenine Arabinoside Effect on Experimental Idoxuridine-Resistant Herpes Simplex Infection. Invest. Ophthal. 13:302-304, 1974.
17. Nesburn, A.B., Borit, A., Pentelei-Molnar, J. and Lazaro, R: Varicella Dendritic Keratitis. Invest. Ophthal. 13:764-770, 1974.
18. Nesburn, A.B.: Recurrence in Ocular Herpes Simplex Infection. Int'l. Ophthal. Clinic 15:101-110, 1975.
19. Kaufman, H.E., Meyer, R.F., Laibson, P.R, Waltman, S.R., Nesburn, A.B. and Shuster, J.J: Human Leukocyte Interferon for the Prevention of Recurrences of Herpetic Keratitis. J. Infect. Dis. 133 (June suppl.): Al65-Al68, 1976.
20. Nesburn, A.B. and Green, M.T: Recurrence in Ocular Herpes Simplex Infection (Editorial).Invest. Ophthal. 15:515-518, 1976.
21. Nesburn, A.B., Dickinson, R and Radnoti, M: The Effect of Trigeminal Nerve and Ganglion Manipulation on Recurrence of Ocular Herpes Simplex in Rabbits. Invest. Ophthal. 15:726-731, 1976.
22. Nesburn, A.B., Dickinson, R., Radnoti, M. and Green, M.T: Experimental Reactivation of Ocular Herpes Simplex in Rabbits. Survey of Ophthal. 21:185-190, 1976.
23. Ward, D.E. and Nesburn, A.B.: An artificial anterior chamber Amer. J.Ophthalmol. 82:796, 1976.
24. Nesburn, A.B., Green, M.T., Radnoti, M., Walker, B: A Reliable In Vivo Model for Latent HSV Reactivation with Peripheral Virus Shedding. Infec. Immun. 15(3):772-775, 1977.
25. Nesburn, A.B.: Extended Wear Contact Lenses in Aphakia. Ophthalmol. 85:73-79, 1978.
26. Nesburn, A.B.: Continuous Wear Contact Lenses. Western Journal of Medicine. 128:428-433, 1978.
27. Newton, M.J. and Nesburn, A.B.: Lack of Hydrophilic Lens Discoloration in Patients Using Dipivlyl Epinephrine for Glaucoma. Am J Ophthalmol 87:193-195, 1979.
28. Nesburn, A.B.: Contemporary Concepts of Ocular Herpes Simplex Recurrence Contact and Intraocular Lens Medical Journal.5:203-210, 1979.
29. Trousdale, M.D., Dunkel, E.C. and Nesburn, A.B.: Effect of Flurbiprofen on Herpes Simplex Keratitis in Rabbits. Invest. Ophthalmol. and Vis. Sci. 19:267-270, 1980.
30. Nesburn, A.B.: Extended Wear Contact Lenses in: Proceedings of The New Orleans Academy of Ophthalmology Symposium on the Cornea, C.V. Mosby Co., St. Louis, 1980.
31. Nesburn, A.B.: Recurrent Herpes Simplex Infection: Pathogenesis and Treatment in Barraquer, JI, et al (eds): 28th Annnal Symposium of the New Orleans Academy of Ophthalmology on Medical and Surgical Diseases of the Cornea. Missouri, C.V. Mosby Co., 1980, pp 48-68.
32. Nesburn, A.B., Smith, R.E. and Winthrop, S: Therapy of Stromal Herpes in Proceedings of the New Orleans Academy of Ophthalmology Symposium on the Cornea, C.V. Mosby Co., St. Louis, 1980.
33. Nesburn, A.B., Dunkel, E.C. and Trousdale, M.D: Enhanced HSV Recovery from Neuronal Tissues of latently Infected Rabbits. Proc. Soc. Exp. Biol. & Med. 163:398-401, 1980.
34. Nesburn, A.B.: Experience complications and success with extended wear. IN: Highlights of Ophthalmology, Silver Anniversary Edition, Boyd, B.F. (ed): Highlights of Ophthalmology, Panama, pp 860-866.
35. Trousdale, M.D., Dunkel, E.C., and Nesburn, A.B.: Effect of Acyclovir on Acute and Latent HSV Infections in the Rabbit. Invest Ophthalmol. and Vis. Sci. 19:1336-1341, 1980.
36. Nesburn, A.B.: Care of EW Lenses. Contact & IOL Med J 6:377-381, 1980.
37. Nesburn, A.B.: Common Viral Diseases and Latent Infections. Virology Symposium of the 1980 American Academy of Ophthalmology. Ophthalmology 87(12):1201-1207, 1980.
38. Maguen, E., Villasenor, R.A., Ward, D.E. and Nesburn, A.B.: A Modified Artificial Anterior Chamber for use in refractive keratoplasty. Amer. J. Ophthalmol. 89(5):742-744, 1980.
39. Smith, R.E., McDonald, H.R., Nesburn, A.B., Minckler, D.S: Penetrating keratoplasty: Changing indications. Arch Ophthal 98:1226-1229, 1980.
40. Trousdale, M.D., Nesburn, A.B. and Miller, C.A.: Assessment of Acyclovir on Acute Ocular Infection Induced by Drug Resistant Strains of HSV-1. Invest. Ophthal. and Vis. Sci. 20(2):230-235, 1981.
41. Nesburn, A.B. and Trousdale, M.D: Treatment of acute and chronic ocular herpes infection acyclovir. IN: Herpetic Eye Diseases Sundmacher, R. (ed), J.F. Bergmann, Verlag, Munchen, 1981.
42. Nesburn, A.B. and Maguen, E: Cosmetic Lenses. International Ophthalmology Clinics. Little, Brown and Co., Massachusett.21(2):209-219, 1981.
43. Nesburn, A.B.: Immunological aspects of ocular herpes simplex disease: Proceeding "Immunology of the eye; Workshop III." Suran, A., Gery, I. and Nussenblatt, R.B. (eds.) Sp. Supp. Immnnology Abstracts, 1981 pp 21-42.
44. Villasenor, R.A., Jester, J.V., Salz, J., Steel, D., Maguen, E., Nesburn, A.B., Krasnow, M.and Smith, R.E.: Preliminary Study of keratomileusis in primates (Macaca speciosa) Ophthalmology 88(8):724-728, 1981.
45. Salz, J., Lee, J.S., Jester, J.V., Steel, D., Villasenor, R.A., Nesburn, A.B. and Smith, R.E: Radial keratotomy in fresh human cadaver eyes. Ophthalmology 88(8):742-746, 1981.
46. Trousdale, M.D., Nesburn, A.B., Watanabe, K.A.and Fox, J.J: Evaluation of the antiherpetic activity of 2'-fluoro-5-iodo- ara-C in rabbit eyes and cell cultures. Invest Ophthalmol Vis. Sci. 21:826-832, 1981.
47. Shuster, J.J., Kaufman, H.E., Nesburn, A.B.: Statistical analysis of the rate of recurrence of herpesvirus ocular epithelial disease. Amer. J. Ophthalmol. 91(3):328-331, 1981.
48. Maguen, E. and Nesburn, A.B.: A new techniqne for lathing lyophilized cornea for refractive surgery. Arch. Ophthalmol. 100:119-121, 1982.
49. Maguen, E., Azen, S.P., Pinhas, S., Villasenor, R.A. and Nesburn, A.B.: Evaluation of sources of variation on the accuracy and reproducibility of microkeratome sections with the modified artificial anterior chamber. Ophthalmic Surgery 13(3):217-220, 1982.
50. Nesburn, A.B. and Maguen, E: Sauflon contact lenses for extended wear. IN: Extended Wear Lenses, Harstein, J. (ed) C. Mosby Co., St. Louis, 1982 pp 78-102.
51. Trousdale, M.D. and Nesburn, A.B.: Evaluation of the Antiherpetic Activity of Acyclovir in Rabbits. Amer. J. Med. 73(lA):155-160, 1982.
52. Schanzlin, D.J: Module 1: Herpes Simplex Eye Infection, IN: Focal Points: Clinical Modules for Ophthalmologists. Kaufman, H.E., Nesburn, A.B. (consultants). American Academy of Ophthalmology, 1982.
53. Nesburn, A.B., Willey, D.E., Trousdale, M.D: Effect of Intensive Acyclovir Therapy During Artificial Reactivation of Latent Herpes Simplex Virus. Soc. Exp. Bio. Med. 172:316-323, 1982.
54. Maguen, E., Nesburn, A.B., Espinosa, G. and Rosner, I: Long-term evaluation of Polycon contact lenses in advanced keratoconus. CLAO Journal 9(1):57-59, 1983.
55. Schanzlin, D.J.and Nesburn, A.B.:Refractive Kertoplasty, IN: the Cornea. Smolin, G. and Thoft, R.A., (eds), Boston/Toronto, Little, Brown and Company, 1983, pp. 453-464.
56. Maguen, E., Pinhas, S., Verity, S.M. and Nesburn, A.B.: Keratophakia with lyophilize cornea lathed at room temperature: New techniques and experimental results. Ophthalmic Surgery 14:759-762, 1983.
57. Nesburn, A.B., Mandelbaum, S., Trousdale, M.D., Maguen, E. and Ward, D.E.: A Specular microscopic viewing system for donor conrneas. Ophthalmology 90:686-691, 1983.
58. Trousdale, M.D., Nesburn, A.B., Su, .S., Lopez, C., Watanabe, K.A. and Fox, J.J: Activity of 1-(2'Fluoro-2'-Deoxy-Arabinofuranosyl) Thymine Against Herpes Simplex Virus in Cell Cultures and Rabbit Eyes. Antimicrobial Agents and Chemother 23:808-813, 1983.
59. Maguen, E., Nesburn, A.B. and Macy, J.I. The combined use of sodium hyaluronate and tissue adhesive in penetrating keratoplasty of corneal perforations. Ophthalmic Surgery 15:55-57, 1984.
60. Trousdale, M.D. and Nesburn, A.B.: Human interferon A or D and Trifluridine for treatment of acute herpetic keratitis in rabbits. Invest. Ophthalmol. Vis. Sci. 25:100-103, 1984.
61. Trousdale, M.D., Gordon, Y.J., Peters, A.C.B., Gropen, T.I., Nelson, E., Nesburn, A.B.: Evaluation of lithium as an antiherpetic agent in cell cultures and during reactivation of latent herpes infection in rabbits. Antimicrob. Agents Chemother. 25:522-523, 1984.
62. Willey, D.E., Nesburn, A.B. and Trousdale, M.D: Reactivation of murine latent HSV infection by epinephrine iontophoresis. Invest.Ophthalmol.Vis.Sci. 25:945-950, 1984.
63. Nesburn, A.B., Lowe, G.H., Lepoff, N.J., Maguen, E: Effect of topical trifluridine on Thygeson's superficial punctate keratitis. Ophthalmology, 91:1188-1192, 1984.
64. Willey, D.E., Maguen, E., Pinhas, S., Verity, S.M. and Nesburn, A.B.: Antibody response following implantation of xenogenic lenticules. Cornea, 3:33-36, 1984.
65. Trousdale, M.D., Nesburn, A.B., Willey, D.E. and Taaid, H: Efficacy of BW759 (9-2-hydroxy-1-(hydroxymethyl) ethoxy methyl guanine against herpes simplex virus Type 1 keratitis in rabbits. Current Eye Research, 3:1007-1015, 1984.
66. Maguen, E., Nesburn, A.B., Verity, S.M., Rosner, I.R: Myopic extended wear contact lenses in 100 patients: A retrospective study. CLAO Journal, 10:335- 340, 1984.
67. Maguen, E. and Nesburn, A.B.: Complications of therapeutic lenses, IN: Contact Lenses. Dabezies, 0. (ed.), New York, Grune & Stratton, Inc., 48.1-48.9, 1984.
68. Willey, D.E., Smith, M.D., Nesburn, A.B. and Trousdale, M: Sequential analysis of antibody response in serum, aqueous humor and tear film during latent and induced recurrent herpes simplex virus infection. Current Eye Research, 4(12):1235-1240, 1985.
69. Maguen, E., Nesburn, A.B., Jackman, N. and Macy, J.I:. Broken semiflexible intraocular lens implant. American Journal of Ophthalmology, 99(2):170-172, 1985.
70. Maguen, E. and Nesburn, A.B.: Extended-wear cosmetic lenses, International Ophthalmology Clinics ,IN: Contact Lenses and External Disease, 26(1):149-160, 1986.
71. Maguen, E., Isitt, J., Pinhas, S. and Nesburn, A.B.: Extraction of soluble proteins reduces rejection in rabbit porcine corneal xenografts. Cornea 5(3):163-166, 1986.
72. Maguen, E.M. and Nesburn, A.B.: Bilateral epikeratoplasty for variable diurnal vision and keratoglobus. J.Refrac.Surg. 3(1):12-16. 1987.
73. Rock,D.L., Nesburn, A.B., Ghiasi,H., Ong, J., Lewis, T.L., Lokensgard, J.R. and Wechsler, S.L: Detection of latency related viral RNAs (LR-RNAs) in trigeminal ganglia of rabbits latently infected with Herpes Simplex Virus Type 1. Journal of Virology, 61(12):3820-3826, 1987.
74. Maguen, E., Isitt, J. and Nesburn, A.B.: Efficacy of prewashing porcine lyophilized corneal lenticules for implant in the rabbit. Journal of Refractive Surgery 3:233-236, November/December 1987.
75. Wechsler, S.L. and Nesburn, A.B.: Recent advances in the molecular biology of herpes simplex latency: A short review. IN: The Cornea. Transactions of the World Congress on the Cornea III, H.D. Cavanagh (ed). Raven Presss, New York. Chapter 91, pp.511-516. 1988.
76. Maguen, E. and Nesburn, A.B.: Effects of Therapeutic Contact Lenses on the Cornea. IN: The Cornea, Kaufman, H.E., MacDonald, M., Waltman, S. (eds), New York, Churchill Livingstone, Inc. 1988.
77. Maguen, E. and Nesburn, A.B.: Bandage Soft Contact Lenses IN: The Cornea Kaufman, H.E., MacDonald, M., Waltman, S. (eds.), Churchill Livingstone, Inc., New York, pp. 647-669. 1988.
78. Maguen, E., Martinez, M., Grundfest, W., Papaioannou, T., Berlin, M. and Nesburn, A.B.: Excimer Laser Ablation of the Human Lens with a Fiber Driven Delivery System. J.Cataract & Refrac. Surg. July. 1988
79. Wechsler, S.L., Nesburn, A.B., Watson, R., Slanina, S.M. and Ghiasi, H: Fine mapping of the herpes simplex virus type 1 latency related gene: Alternative splicing produces distinct latency related RNAs containing open reading frames. J.Virol. 62:4051-4058. 1988.
80. Wechsler, S.L., Nesburn, A.B., Watson, R., Slanina, S.M. and Ghiasi, H: Fine mapping the herpes simplex virus type 1 latency related RNAs in human trigeminal ganglia. J.gen.Virol. 69:3101-3106. 1988.
81. Critchfield, W., Calandra, A., Nesburn, A.B. and Kenney, M.C: Keratoconus: Biochemical Studies. Exp. Eye Res. 46:953-963. 1988.
82. Maguen, E., Martinez, M., Grundfest, W., Papaioannou, T. and Berlin, M: Excimer Laser Ablation of the Human Lens at 308nm with a Fiber Delivery System. IN: Plastic Surgery and Neurosugery, Montorsi, M. and Granelli, P. (eds.). XI Monduzzi Editore, Bologna, Italy, pp. XI447-450. 1988
83. Wechsler, S.L., Nesburn, A.B., Zwaagstra, J. and Ghiasi, H: Sequence of the latency related gene of herpes simplex virus type 1. Virology 168:168-172. 1989.
84. Zwaagstra, J., Ghiasi, H., Nesburn, A.B. and Wechsler, S.L: In vitro promoter activity associated with the latency associated transcript gene of herpes simplex virus type 1. J.gen Virol. 70:2163-2169. 1989.
85. Nesburn, A.B., Ghiasi, H. and Wechsler, S.L: Ocular safety and efficacy of a HSV-1 gD vaccine during primary and latent infection. Invest. Ophthalmol. Vis. Sci. 31:1497-1502. 1990.
86. Zwaagstra, J.C., Ghiasi, H., Slanina, S, Nesburn, A.B., Wheatley, S.C., Lillycrop, K., Wood, J., Latchman, D.S., Patel, K. and Wechsler, S.L: Activity of Herpes simplex virus type 1 latency associated transcript (LAT) promoter in neuronal derived cells: Evidence for neuron specificity and for a large LAT precursor. J.Virol. 64:5019-5028. l990
87. Maguen, E., Martinez, M., Rosner, I.R., Caroline, P., Macy, J., and Nesburn, A.B.: The Use of Saturn II Lenses in Keratoconus. CLAO Journal 17(1):41-43. 1991.
88. Zwaagstra, J.C., Ghiasi, H., Nesburn, A.B. and Wechsler, S.L: Identification of a major regulatory sequence in the latency associated transcript (LAT) promoter of Herpes simplex virus type 1 (HSV-1). Virology 182:287-297. 1991.
89. Maguen, E., Tsai, J.C., Martinez, M., Rosner, I., Caroline, P., Macy, J.I. and Nesburn, A.B.: A Retrospective Study of Disposable Extended-Wear Lense in 100 Patients. Ophthalmology 98 (11):1685-1689. 1991.
90. Ghiasi, H., Nesburn, A.B. and Wechsler, S.L: Cell surface expression of Herpes simplex virus type 1 glycoprotein H in recombinant baculovirus-infected cells. Virology 185:187-194. 1991.
91. Ghiasi, H., Nesburn, A.B., Kaiwar, R. and Wechsler, S.L: Immunoselection of recombinant baculoviruses expressing high levels of biologically active Herpes simplex virus type 1 glycoprotein D. Arch.Virol. 121:163-178 1991.
92. Nesburn, A.B., Maguen, E. and Caroline, P.J: A method for sterile insertion of Soft Contact Lenses. Contact Lens Spectrum:19, Mar. l992.
93. Maguen, E., Salz, J.J. and Nesburn, A.B.: Pseudomonas corneal ulcer associated with rigid gas-permeable daily-wear lenses in a Patient infected with human immunodeficiency virus. Amer.J.Ophthal. 113(3):336-337. l992.
94. Ghiasi, H., Kaiwar, R., Nesburn, A.B. and Wechsler, S.L: Baculovirus-expressed glycoprotein H of Herpes simplex virus type 1 (HSV-1) induces neutralizing antibody and delayed type hypersensitivity responses, but does not protect immunized mice against lethal HSV-1 challenge. J. gen.Virol. 73:719-722. l992.
95. Ghiasi, H., Kaiwar, R., Nesburn, A.B. and Wechsler, S.L: Expression of herpes simplex virus type 1 glycoprotein B in insect cells: Initial analysis of its biochemical and immunological properties. Virus Res. 22: 25-39. l992.
96. Ghiasi, H., Kaiwar, R., Nesburn, A.B. and Wechsler, S.L: Expression of herpes simplex virus type 1 glycoprotein I in baculovirus: Preliminary biochemical characterization and protection studies. J. Virol. 66(4): 2505-2509. l992.
97. Ghiasi, H., Kaiwar, R., Nesburn, A.B., Salnina, S. and Wechsler, S.L: Baculovirus-expressed glycoprotein E (gE) of Herpes simplex virus type-1 (HSV-1) protects mice against lethal intraperitoneal and lethal ocular HSV-1 challenge. Virology 188: 469-476. 1992.
98. Ghiasi, H., Kaiwar, R., Nesburn, A.B. and Wechsler, S.L: Baculovirus expressed herpes simplex virus type 1 glycoprotein C protect mice from lethal HSV-1 infection. Antiviral Res. 18:291-302, l992.
99. Ghiasi H., Kaiwar R., Nesburn A.B., and Wechsler S.L:. 1992. Baculovirus-expressed glycoprotein G of herpes simplex virus type 1 partially protects vaccinated mice against lethal HSV-1 challenge. Virology 190:233-239.
100. Maguen, E., Caroline, P., Rosner, I., Macy, J. and Nesburn, A.B.: The use of the softperm lens for the correction of irregular astigmatism. CLAO J. 18(3):173-176, l992.
101. Salz, J., Maguen, E., Macy, J.I., Papaioannou, T., Hofbauer, J. and Nesburn, A.B.: One-year results of excimer laser photorefractive keratectomy for myopia. Refractive & Corneal Surgery, 8:269-273, l992.
102. Maguen, E., Berlin, M., Hofbauer, J., Macy, J., Nesburn, A.B., Papaioannou, T. and Salz, J: Preliminary results of VISX excimer-laser myopic phtorefractive keratectomy at Cedars-Sinai Medical Center. Proceedings of SPIE, vol. 1644: l992.
103. Maguen, E., Nesburn, A.B., Martinez, M.R., Rosner, I.R. and Macy, J.I.: A long-term evaluation of myopic extended wear lenses in a primary care non-referral population. Contact Lens Spectrum:45-50, Oct. 1992.
104. Maguen, E., Rosner, I., Caroline, P., Macy, J.I. and Nesburn, A.B.: A retrospective study of disposable extended wear lenses in 100 patients: Year 2. CLAO J. 18(4):229-231, 1992.
105. Maguen, E., Rosner, I., Caroline, P., Macy, J.I. and Nesburn, A.B.: A retrospective study of disposable extended wear lenses in 100 Patients: Year 2. CLAO J. 18(4):229-231, 1992.
106. Salz, J.J., Maguen, E., Nesburn, A.B., Warren, C., Macy, J.I., Hofbauer, J.D., Papaioannou, T., and Berlin, M: Two years experience with excimer laser photorefractive keratectomy (PRK) for myopia at the Ellis Eye Center, Cedars-Sinai Medical Center. Ophthalmology 100(6):873-882,1993.
107. Rabinowitz, Y.S., Nesburn, A.B. and McDonnell, P.J: Videokeratography of the fellow eye in unilateral keratoconus. Ophthalmology 100(2):181-186, 1993.
108. Horwitz, J. and Nesburn, A.B.: Ophthalmic research points way to improved treatments: Retinal disorders, cataract, glaucoma, AIDS, HSV, uveitis, children’s disease, dry eye. Ophthalmol Times 18(21):10-13, 114-115, 1993.
109. Nesburn, A.B. Study: Photoablatin appears to play little role in recurrent corneal erosion. Ocular Surg News 12(6):40 passim, 1994.
110. Ghiasi, H., Slanina, S., Nesburn, A.B. and Wechsler, S.L.: Characterization of baculovirus-expressed herpes simplex virus type 1 glycoprotein K. J. Virol. 68(4):2347-2354, 1994.
111. Ghiasi, H., Kaiwar, R., Nesburn, A.B., Slanina, S., and Wechsler, S.L.: Expression of seven herpes simplex virus type 1 glycoproteins (gB, gC, gC, gE, gG, gH, or gI): Comparative protectin against lethal challenge in mice. J. Virol. 68:2118-2126, 1994
112. Perng, G.C., Ghiasi, H., Kaiwar, R., Nesburn, A.B. and Wechsler, S.L.: Improved method for cloning portions of the repeat regions of Herpes simplex virus type 1. J. Virological. Methods. 46:111-116, 1994.
113. Perng, G.C., Zwaagstra, J.C., Ghiasi, H., Kaiwar, R., Brown, D.J., Nesburn, A.B. and Wechsler, S.L.: Similarities in regulation of the Herpes simplex virus type 1 LAT promoter in stromal keratocytes and neuronal cells. Invest. Ophthal. & Vis. Sci. 35:2981-2989, 1994.
114. Nesburn, A.B., Burke, R.L., Slanina, S., Bahri, S., Kaiwar, R., Ghiasi, H. and Wechsler, S.L.: Vaccine therapy for ocular herpes simplex virus (HSV) infection: Periocular vaccination reduces spontaneous ocular HSV type 1 shedding in latently infected rabbits. J. Virol. 68:5084-5092, 1994.
115. Maguen, E., Rosner, I.R., Caroline, P., Macy, J.I., Nesburn, A.B.: A retrospective study of disposable extended wear lenses in 100 patients - Year 3. CLAO J 20, 1994.
116. Maguen, E., Nesburn, A.B., Papaioannou, T., Salz, J.J., Macy, J.I., Warren, C.: Effect of nitrogen flow on recovery of vision after Excimer Laser Photorefractive Keratectomy without nitrogen flow. J.Refract. Corneal Surg. 10:321-326, 1994.
117. Maguen, E., Salz, J.J., Nesburn, A.B., Warren, C., Papaioannou, T., Macy, J.I., Hofbauer, J., and Berlin, M.: Results of excimer laser photorefractive keratectomy for the correction of myopia. Ophthalmology, 1994 IN PRESS.
118. Perng, G-C, Dunkel, E.C., Geary, P.A., Slanina, S., Ghiasi, H., Kaiwar, R., Nesburn, A.B. and Wechsler, S.L.: The latency associated transcript (LAT) gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontancous reactiviation of HSV-1 From latency. J. Virol. 68:8045-8055, 1994.
119. Ghiasi, H., Nesburn, A.B., Slanina, S. and Wechsler, S.L: Expression and characterization of baculovirus expressed herpes simplex virus type 1 glycoprotein L. Arch. Virol. 138:199-212, 1994.
120. Ghiasi, H., Wechsler, S.L., Kaiwar, R., Nesburn, A.B. and Hofman, F.M: Local expression of TNF-alpha and IL-2 correlate with protection against corneal scarring following HSV-1 ocular challenge of vaccinated mice. J. Virol. 69:334-340, 1995.
121. Perng, G-C, Thompson, R.L., Sawtell, N.M., Taylor, W.E., Slanina, S.M., Ghiasi, H., Kaiwar, R., Nesburn, A.B., Wechsler, S.L.: An avirulent ICP34.5 deletion mutant of Herpes Simplex Virus Type 1 is capable of in vivo spontaneous reactivation. J.Virol. 69(5):3033-3041. 1995
122. Terrell, J., Bechara, S.J., Nesburn, A., Waring, G.O., Macy, J and Malone, R.K: The effect of globe fixation on ablation zone centration in photrefractive keratectomy. Am. J. Ophthalmol. 119:612-619. 1995.
123. Nesburn, A.B., Bahri, S., Salz, J., Rabinowitz, Y.S., Maguen, E., Hofbauer, J., Berlin, M. and Macy, J.I.: Keratoconus detected by videokeratography in candidates for photrefractive keratectomy. J.Refrac.Surg. 11(3):194-201, 1995.
124. Ghiasi, H., Bahri, S., Salz, Nesburn, A.B. and Wechsler, S.L: Protection against Herpes simplex virus induced eye disease after vaccination with seven individually expressed Hereps simplex virus 1 glycoproteins. Invest.Ophthalmol.Vis.Sci., 36(7): 1352-1360, 1995.
125. Ghiasi, H., Cai, S., Slanina, S., Nesburn, A.B. and Wechsler, S.L: Vaccination of mice with herpes simplex virus type 1 glycoprotein D DNA produces low levels of protection against lethal HSV-1 challenge. Antiviral Research, 28:147-157, 1995.
126. Ghiasi, H., Nesburn, A.B. and Wechsler, S.L: Vaccination with a cocktail of 7 recombinantly expressed HSV-1 glycoproteins protects against ocular HSV-1 challenge more efficiently than vaccination with any individual glycoprotein. Vacine, 14:107-112. 1996.
127. Ghiasi, H., Perng, G-C, Cais, S., Nesburn, A.B. and Wechsler, S.l: The UL3 open reading frame of herpes simplex virus type 1 code for a phosphoprotein. Virus Res. 44:137-142. 1996
128. Perng, G-C, Chokephaibulkit, K., Thompson, R.L., Sawtell, N.M., Slanina, S., Ghiasi, H., Nesburn, A.B. and Wechsler, S.L: The region of the herpes simplex virus type 1 LAT gene that is colinear with the ICP34.5 gene is not involved in spontaneous reactivation. J. Virol., 70(1):282-291. 1996.
129. Ghiasi, H., Cai, S., Nesburn, A.B. and Wechsler, S.L: Vaccination with herpes simplex virus type 1 glycoprotein K impairs clearnace of virus from the trigeminal ganglia resulting in chronic infection. Virology, 224:330-333. 1996.
130. Perng, GC, Ghiasi, H, Slanina, SM, Nesburn, AB, and Wechsler, SL: 1996 The spontaneous reactivation function of the herpes simplex virus type 1 LAT gene resides completely within the first 1.5 kilobases of the 8.3-kilobase primary transcript. J.Virol. 70(2):976-984.
131. Perng, GC, Slanina, SM, Ghiasi, H, Nesburn, AB, and Wechsler, SL: 1996 A 371-nucleotide region between the herpes simplex virus type 1 (HSV-1) LAT promoter and the 2-kilobase LAT is not essential for efficient spontaneous reactivation of latent HSV-1. J.Virol. 70(3):2014:2018.
132. Perng, GC, Ghiasi, H, Slanina, SM, Nesburn, AB, and Wechsler, SL: 1996 High does ocular infection with a herpes simplex virus type 1 ICP34.5 deletion mutant produces no corneal disease or neurovirulence yet results in wild-type levels of spontaneous reactivation. J.Virol. 70(5):2883-2893.
133. Maguen, E., Nesburn, A.B. and Salz, J.J: Bilateral photorefractive keratectomy with intentional unilateral undercorrection in an aircraft pilot. J. Cataract Refract. Surg., 23:294-296, 1997.
134. Maguen, E., Salz, J.J. and Nesburn, A.B: Preliminary results of tracked photorefractive keratectomy (T-PRK) for mild to moderate myopia with the autonomous technologies excimer laser at Cedars-Sinai Medical Center. SPIE Proc. VOL. 2971, pps. 96-102, February, 1997.
135. Ghiasi, H., Cai, S., Slanina, S., Nesburn, A.B. and Wechsler, S.L. Nonneutralizing antibody against the glycoprotein K of herpes simplex virus type-1 exacerbates herpes simplex virus type-1 induced corneal scarring in various virus and mouse strain combinations. Invest. Ophthal. Vis. Sci. 38:1213-1221, 1997.
136. Ghiasi, H., Roppenian, D., Cai, S., Slanina, S., Nesburn, A.B. and Wechsler, S.L. The importance of MHC class I and MHC class II in protection of vaccinated mice against lethal HSV-1 challenge. Immunology. 91:430-435, 1997.
137. Ghiasi, H., Cai, S., Nesburn. A.B. and Wechsler, S.L. MHC-II but not MHC-I responses are required for vaccine-induced protection against ocular challenge with HSV-1. Curr. Eye Res. 16:1152-1158, 1997.
138. Nesburn, A.B., Burke, R.L. Ghiasi, H., Slanina, S.M., and Wechsler, S.L. A therapeutic vaccine that reduces recurrent herpes simplex virus corneal disease. Invest. Ophthal. Vis Sci. 39:1163-1170, 1998.
139. Nesburn, A.B., Slanina, S.M., Burke, R.L. Ghiasi, H., Bahri, S., and Wechsler, S.L. Local periocular vaccination protects against eye disease more effectively than systemic vaccination following primary ocular herpes simplex virus infection in rabbits. J. Virol. 72:7715-7721, 1998.
140. Ghiasi, H., Wechsler, S.L., Cai, S., Nesburn, A.B., and Hofman, F.M. The role of neutralizing antibody and T-helper subtypes in protection and pathogenesis of vaccinated mice following ocular HSV-1 challenge. Immunology 95:352-359, 1998.
141. Ghiasi, H., Nesburn, A.B., and Wechsler, S.L. The US5 open reading frame of herpes simplex virus type 1 does encode a glycoprotein (gJ). Intervirology 41:91-97, 1998.
142. Nesburn, A.B., Burke, R.L. Ghiasi, H., Slanina, S.M., and Wechsler, S.L. Therapeutic periocular vaccination with a subunit vaccine induces higher levels of herpes simplex virus specific tear sIgA than systemic vaccination and provides protection against recurrent spontaneous ocular shedding of virus in latently infected rabbits. Virology. 252:200-209, 1998.
143. Drolet, B.S., Perng, G.C., Cohen, J., Slanina, S.M., Yukht, A., Nesburn, A.B., and Wechsler, S.L. The region of the herpes simplex virus type 1 LAT gene involved in spontaneous reactivation does not encode a functional protein. Virology. 242:221-232, 1998.
144. The Hepetic Eye Disease Study Group: Acyclovir for the prevention of recurrent Herpes Simplex Virus Eye Disease. New England Journal of Medicine, 339(5):300-306.
145. Loutsch, J.M., Perng, G.C., Hill, J.M., Zheng, X., Marquart, M.E., Block, T.M., Ghiasi, H., Nesburn, A.B. and Wechsler, S.L. An identical 371 basepair deletion mutation in the LAT gene of herpes simplex virus type 1 (HSV-1) results in different in vivo reactivation phenotypes in HSV-1 strains McKrae and 17syn+. J Virol. 73:767-771, 1999.
146. Drolet, B.S., Perng, G.C., Villosis, R.J., Slanina, S.M., Nesburn, A.B., and Wechsler, S.L. Expression of the first 811 nucleotides of the herpes simplex virus type 1 latency associated transcript (LAT) partially restores wild type spontaneous reactivation to a LAT null mutant. Virology. 253:96-106, 1999.
147. Perng, G.C., Slanina, S.M., Yukht, A., Drolet, B.S., Keleher, W.Jr., Ghiasi, H., Nesburn, A.B., and Wechsler, S.L. A herpes simplex virus type 1 latency associated transcript (LAT) mutant with increased virulence and reduced spontaneous reactivation. J.Virol. 73:920-929, 1999.
148. Ghiasi H., Cai S., Perng G.C., Slanina S, Nesburn A.B., and Wechsler S.L: 1999. The role of IL-2 and IL-4 in herpes simplex virus type 1 ocular replication and eye disease. J. Infec. Dis.179:1086-1093.
149. Ghiasi H., Hofman F.M., Cai S., Nesburn A.B., and Wechsler S.L: 1999. Vaccination with Different HSV-1 glycoproteins Induces Different Patterns of Ocular Cytokine Responses Following HSV-1 Challenge of Vaccinated Mice. Vaccine, 17:2576-2582.
150. Ghiasi H., Cai S., Slanina, S.M., Perng G.C., Nesburn A.B., and Wechsler S.L: 1999. Specific and nonspecific immune stimulation of MHC-II-deficient mice results in chronic HSV-1 infection of the trigeminal ganglia following ocular challenge. Virology 258:208-216.
151. McDonald, M.B., Deitz, M.R., Frantz, M.J., Kraff, M.C., Krueger, R.R., Salz, J.J., Kraff, C.R., Maguen, E., Matta, C.S., Nesburn, A.B. and Piebenga, L.W: 1999 Photorefractive Keratectomy for Low-to-Moderate Myopia and Astigamtism with a Small-beam, Tracker-directed Excimer Laser. Ophthalmol. 106:1481-1489.
152. Ghiasi H., Cai S., Perng G.C., Nesburn A.B., and Wechsler S.L: 1999 Perforin pathway is essential for protection of mice against lethal ocular HSV-1 challenge but not corneal Scarring. Virus Res. 65:97-101.
153. Nesburn, A.B. and Kenney, M.C: 1999 Keratoconus 371.60 IN: Current Ocular Therapy: Fraunfelder, F.T., Roy, F.H. and Randall, J. (eds) Philadelphia, W.B. Saunders Company (a division of Harcourt Brace & Company), pp. 364-365.
154. Perng, GC, Slanina, SM, Yukht, A, Ghiasi, H, Nesburn, AB and Wechsler, SL: 1999 Herpes simplex virus type 1 serum neutralizing antibody titers increase during latency in rabbits latently infected with latency-associated transcript (LAT) positive but not LAT Negative viruses. J.Virol. 73(11):9669-9672.

155. Ghiasi, H., Cai, X, Perng, G-C., Nesburn, A.B. and Wechsler, S.L: 2000 Both CD4+ and CD8+ T cells are involved in protection against HSV-1 induce corneal scarring. Br.J.Ophthalmol. 84:408-412.
156. Ghiasi, H., Cai, X, Perng, G-C., Nesburn, A.B. and Wechsler, S.L: 2000 The role of natural killer cells in protection of mice against death and corneal scarring following ocular HSV-1 infection. Antiviral Res. 45:33-45.
157. Perng, G.C., Slanina, S.M., Yukht, A., Ghiasi, H., Nesburn, A.B. and Wechsler, S.L: 2000 The latency-associated transcript gene enhances establishment of herpes simplex virus type 1 latency in rabbits. J.Virol. 74:1885-1891.
158. Perng, G-C., Jones, C., Ciacci-Zanella, J., Henderson, G., Ykht, A., Slanina, S.M., Hofman, F.M., Ghiasi, H., Nesburn, A.B. and Wechsler, S.L: 2000 Virus-Induced Neuronal Apoptosis Blocked by the Herpes Simplex Virus Latency-Associated Transcript. Science 287:1500-1503
159. Ghiasi, H., Perng, G., Nesburn, A.B. and Wechsler, S.L. (2000). Antibody-dependent enhancement of HSV-1 infection by anti-gK sera. Virus Res. 68:137-44.
160. Ghiasi H, Hofman FM, Wallner K, Cai S, Perng GC, Nesburn AB, and Wechsler, S.L. (2000). Corneal macrophage infiltrates following ocular herpes simplex virus type 1 challenge vary in BALB/c mice vaccinated with different vaccines. Vaccine 19:1266-73.
161. Perng, GC, Slanina, SM, Ghiasi, H, Nesburn, AB, Wechsler, S.L. (2001) The effect of LAT (latency associated transcript) on the herpes simplex virus type 1 (HSV 1) latency-reactivation phenotype is mouse strain dependent. J.g.Virol. 82:1117-1122.
162. Samoto, K., Perng, GC, Ehtesham, M, Liu, Y, Wechsler, S.L., Nesburn, AB, Black, KL, and Yu, JS (2001) A herpes simplex virus type 1 mutant deleted for ?34.5 and LAT kills glioma cells in vitro and is inhibited for in vivo reactivation. Cancer Gene Therapy. 8:269-277.
163. Ghiasi,H., Osorio, Y., Perng, G-C., Nesburn, A.B., and Wechsler, S.L: (2001) Recombinant Herpes Simplex Virus Type 1 Expressing Murine Interleukin-4 Is less Virulent than Wild-Type Virus in Mice. J.Virol. 75:9029-9036.
164. Inman,M., Perng, G-C., Henderson,G., Ghiasi, H., Nesburn, A.B., Wechsler, S.L. and Jones, C: (2001) Region of Herpes Simplex Virus Type 1 Latency-iated Transcript Sufficient for Wild-Type Spontaneous Reactivation Promotes Cell Survival in Tissue Cutlure. J.Virol. 75:3636-3646.
165. Ljubimov, A.V., Atilano, S.R., Garner, M.H., Maguen, E., Nesburn, A.B. and Kenney, M.C: Extracellular Matrix and Na+, K+ -ATPase in Human Corneas Following Cataract Surgery. Cornea 21(1):74-80.
166. Perng, GC, Esmaili, D., Slanina, SM., Yukht, A., Ghiasi, H., Osorio, N., Mott, KR., Maguen, B., Jin, L., Nesburn, AB., and Wechsler, SL. (2001). Three HSV 1 LAT mutants with distinct asymmetric effects on virulence in mice compared to rabbits. J.Virol. 75(19);9018-9028
167. Ghiasi H, Hofman, FM, Wallner, K, Cai S, Perng GC, Nesburn AB, and Wechsler, S.L. (2001). Corneal macrophage infiltrates following ocular herpes simplex virus type 1 challenge vary in BALB/c mice vaccinated with different vaccines. Vaccine, 19:1266-1273.
168. Samoto, K, Ehtesham, M, Perng, GC, Hashizume, K, Wechsler, SL, Nesburn, AB, Black, KL and Yu, JS: 2002 A herpes simplex virus type 1 mutant with ?34.5 and LAT deletions effectively oncolyses human U87 glioblastomas in nude mice. Neurosurgery, Mar 50(3):599-606.


169. Perng GC, Maguen B, Jin L, Mott KR, Kurylo J, BenMohamed L, Yukht A, Osorio N, Nesburn AB, Henderson G, Inman M, Jones C, Wechsler SL. A novel herpes simplex virus type 1 transcript (AL-RNA) antisense to the 5' end of the latency-associated transcript produces a protein in infected rabbits. J Virol. 2002 Aug;76(16):8003-8010.

170. Samoto, K. Ehtesham M, Perng GC, Hashizume K, Wechsler SL, Nesburn AB, Black KL, Yu JS. A herpes simplex virus type 1 mutant with gamma 34.5 and LAT deletions effectively oncolyses human U87 glioblastomas in nude mice. Neurosurgery. 2002 Mar;50(3):599-605; discussion.

171. Ong, J.M., Aoki, A.M., Seigel, G.M., Sacerio, I., Castellon, R., Nesburn, A.B., and Kenney, M.C. 2002. Oxysterol-induced toxicity in R28 and ARPE-19 cells. Neurochemical Research 28(6):883-891.
172. Perng GC, Maguen B, Jin L, Mott KR, Osorio N, Slanina SM, Yukht A, Ghiasi H, Nesburn AB, Inman M, Henderson G, Jones C, Wechsler SL. A gene capable of blocking apoptosis can substitute for the herpes simplex virus type 1 latency-associated transcript gene and restore wild-type reactivation levels. J Virol. 2002 Feb;76(3):1224-1235.
173. Hamdi HK, Reznik J, Castellon R, Atilano SR, Ong JM, Udar N, Tavis JH, Aoki AM, Nesburn AB, Boyer DS, Small KW, Brown DJ, Cristina Kenney M. Alu DNA polymorphism in ACE gene is protective for age-related macular degeneration. Biochem Biophys Res Commun. 2002 Jul 19;295(3):668-72.
174. BenMohamed L, Wechsler SL, Nesburn AB. 2002 Lipopeptide vaccines--yesterday, today, and tomorrow. Lancet Infect Dis. 2(7):425-431.
175. Ljubimov AV, Atilano SR, Garner MH, Maguen E, Nesburn AB, Kenney MC. (2002) Extracellular matrix and Na+,K+-ATPase in human corneas following cataract surgery. Comparison with bullous keratopathy and Fuchs' dystrophy corneas. Cornea, 21:74-80.

176. Perng, G-C., Maguen, B., Lin, L., Mott, K. R. Kuryli, J., BenMohamed, L., Yukht, A., Osorio, A.B. Nesburn, Henderson, G., Inman, M., Jones C., and S. L. Wechsler. 2002. A novel Herpes Simplex Virus Type 1 transcript (AL-RNA) Antisense to the 5’ End of the Latency associated Transcripts produces a protein in infected Rabbits. J. Virology. 76(16):1-8.

177. Ghiasi H, Osorio, Y, Hedvat, Y, Perng GC, Nesburn AB, and Wechsler SL. 2002. Infection of BALB/c mice with a herpes simplex virus type 1 recombinant virus expressing IFN-g driven by the LAT promoter. Virology, 302:144-154.

178. Ghiasi H, Osorio, Y, Perng GC, Nesburn AB, and Wechsler SL. 2002. Over-expression of IL-2 by a recombinant HSV-1 attenuates pathogenicity and enhances antiviral immunity. J. Virology, 76(18):9069-9078.

179. Ghiasi H, Osorio, Y, Nesburn AB, and Wechsler SL. 2002. Enhanced clearance of herpes simplex virus type 1 and reduced herpetic eye disease in STAT6 knockout mice is associated with increased IL-2. Virology, 302:286-293
180. Perng GC, Mott KR, Osorio N, Yukht A, Salina S, Nguyen QH , Nesburn AB, and Wechsler SL. (2002). HSV 1 mutants containing the KOS strain ICP34.5 gene in place of the McKrae ICP34.5 gene have McKrae-like spontaneous reactivation but non Mckrae-like virulence. J. gen. Virol. 83:2933-2942.
181. Henderson G, Peng W, Jin L, Perng GC, Nesburn AB, Wechsler SL, and Jones C. (2002) Regulation of caspase 8- and caspase 9-induced apoptosis by the herpes simplex virus type 1 latency-associated transcript. J Neurovirol 8:103-111.

182. Osorio Y, Wechsler SL, Nesburn AB, and Ghiasi H. (2002) Reduced severity of HSV-1-induced corneal scarring in IL-12-deficient mice. Virus Res 90:317-26.

183. Ong, J.M., Aoki, A.M., Zorapapel, N.C., Brown, D.J., Nesburn, A.B., Rich, K.A., and Kenney, M.C. 2003 Impaired electorretinogram (ERG) response in apolipoprotein E-deficient mice. Current Eye Research, 27(1):15-24.

184. BenMohamed, L., Cory D. McNamara; Bertrand Georges; Helene Gras-Masse; Steven L. Wechsler; and Anthony B. Nesburn. 2003. Identification of Novel Potent CD4+ T Helper Immunogenic Peptides From The Herpes Simplex Virus Glycoprotein D That Confer Protective J. Virology. 77 (17):9463-9473.
185. Jin L, Peng W, Perng GC, Brick DJ, Nesburn AB, Jones C, and Wechsler SL (2003) Identification of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sequences That both Inhibit Apoptosis and Enhance the Spontaneous Reactivation Phenotype. J. Virol. 11:6556-6561.
186. Peng W, Henderson G, Perng GC, Nesburn AB, Wechsler SL, and Jones C (2003) The gene that encodes the herpes simplex virus type 1 latency associated transcript promotes the accumulation of transcripts (Bcl-xL and Bcl-xS) that encode apoptotic regulatory proteins. J. Virol. 77: 10714-10718.

187.Henderson G, Perng GC, Nesburn AB, Wechsler SL, and Jones C (2004) The latency related (LR) gene encoded by bovine herpesvirus 1 (BHV-1) can suppress caspase 3 and caspase 9 cleavage during productive infection. J Neurovirology. 10:64-70.

188. Jin L, Perng GC, Brick DJ, Naito J, Nesburn AB, Jones C, and Wechsler SL (2004) Methods for detecting the HSV-1 LAT anti-apoptosis activity in virus infected tissue culture cells. J.Virol.Methods. 118: 9-13.

189. Peng W, Jin L, Henderson G, Perng GC, Brick DJ, Nesburn AB, Wechsler SL, and Jones C (2004) Mapping herpes simplex virus type 1 latency associated transcript sequences that protect from apoptosis mediated by a plasmid expressing caspase-8. J. NeuroVirol. 10:260-265.

190. Nesburn AB, Ramos TV, Zhu X, Asgarzadeh H, Nguyen V, BenMohamed L. 2005 Local and systemic B-cell and Th1 responses induced following ocular mucosal delivery of multiple epitopes of Herpes Simplex Virus Type 1 glycoprotein D together with cytosine-phosphate-guanine adjuvant. Vaccine, 23(7):873-883.

191. Udar N, Kenney MC, Chalukya M, Anderson T, Seikhavandi S, Yellore V, Yelchits S, Reznik J, Brown D, Nesburn AB and Small KW. 2004 Keratoconus: No association with the BIGH3 gene. Cornea, 23:13-17.

192. Zhang X, Issagholian, A, Berg, EA, Fishman, JB, Nesburn, AB and BenMohamed, L: 2005 Th-Cytotoxic T-Lymphocyte Chimeric Epitopes Extended by N? – Palmitoyl Lysines Induce Herpes Simplex Virus Type 1-Specific Effector CD8+ Tc1, Responses and Protect Against Ocular Infection. J. Virology, 79(24):15289-15301.

193. Nesburn, AB, Ilham Bettahi, Xiuli Zhang, Xiaoming Zhu, Winston Chamberlain, Rasha E. Afifi, Steven L. Wechsler and L. BenMohamed. 2006 Topical/Mucosal Delivery of Sub-Unit Vaccines That Stimulate the Ocular Mucosal Immune System. The Ocular Surface. 4(4): 178-187

194.Udar N, Atilano SR, Brown DJ, Holguin B, Small K, Nesburn AB, Kenney MC. 2006
SOD1: A candidate gene for keratoconus. Invest Ophthalmol Vis Sci. 47 (8):3345-51.

195.Mott KR, Osorio Y, Maguen E, Nesburn AB, Wittek AE, Cai S, Chattopadhyay S, Ghiasi H. 2007
Role of anti-glycoproteins D (anti-gD) and K (anti-gk) IgGs in pathology of herpes stromal keratitis in humans. Invest. Ophthalmol Vis Sci. 48 (5): 2185-93.


196.Narayanan R, Butani V, Boyer DS, Atilano SR, Resende GP, Kim DS, Chakrabarti S, Kupperman BD, Khatibi N, Chwa M, Nesburn AB, Kenney MC. 2007 Complement factor H polymorphism in age-related macular degeneration. Ophthalmology 114 (7):1327-31.

197.Nesburn, AB, Bettahi I, Dasgupta G, Chentoufi AA, Zhang X, You S, Morishige N, Wahlert AJ, Brown DJ, Jester JV, Wechsler SL & BenMohamed L: 2007. Functional Foxp3+ CD4+CD25(Bright+) "Natural" Regulatory T Cells are Abundant in Rabbit Conjunctiva and Suppress Virus-Specific CD4+ and CD8+ Effector T Cells During Ocular Herpes Infection. J Virol. 81(14):7647-7661.

198.Bettahi, I; Nesburn AB., Yoon S; Mohebbi A; Sue V; Vanderberg V; Wechsler SL & BenMohamed L; 2007 Protective Immunity Against Ocular Herpes Infection and Disease Induced by Highly Immunogenic Self-Adjuvanting Glycoprotein D Lipopeptide Vaccines. IVOS, 48(10):4643-4653.

199.Chentoufi AA, Zhang X, Lamberth K, Dasgupta G, Bettahi I, Nguyen A, Wu M, Zhu X, Mohebbi A., Buss S, Wechsler SL, Nesburn AB, Benmohamed L. 2008 A-A*0201-restricted CD8+ cytotoxic T lymphocyte epitopes identified from herpes simplex virus glycoprotein D. J Virol. Jan 1;180 (1)
200.Chentoufi AA, Zhang X, Lamberth K, Dasgupta G, Bettahi I, Nguyen A, Wu M, Zhu X, Mohebbi A, Buus S, Wechsler SL, Nesburn AB, BenMohamed L. HLA-A*0201-restricted CD8+ cytotoxic T lymphocyte epitopes identified from herpes simplex virus glycoprotein D. Journal of Immunology. (2008). 180(1):426-37. PMID: 18097044.
201. Zhang X, Chentoufi AA, Dasgupta G, Nesburn AB, Wu M, Zhu X, Carpenter D, Wechsler SL, You S, BenMohamed L. A genital tract peptide epitope vaccine targeting TLR-2 efficiently induces local and systemic CD8(+) T cells and protects against herpes simplex virus type 2 challenge. Mucosal Immunology (Nature Publishing Group). (2009). 2(2):129-43. PMID: 19129756.
202. Dasgupta G., Chentoufi AA., Wechsler SL., Nesburn AB and BenMohamed L. Herpes Simplex Virus Vaccine Development: Notes and Challenges from a Battlefield. Expert Review Vaccine. (2009). 8(8):1023-35. PMID: 19627185.
203. Chentoufi AA., Nesburn AB and BenMohamed L. Recent Advances in Multivalent Self-Adjuvanting Glyco-lipopeptide Vaccine Strategies against Breast Cancer. Archivum Immunologiae et Therapiae Experimentalis. (2009). 57(6):409-23. PMID: 19866342.
204. Dasgupta G, Nesburn AB, Wechsler SL, BenMohamed L. Developing an asymptomatic mucosal herpes vaccine: the present and the future. Future Microbiology. (2010). 5:1-4. PMID: 20020824.
205. Chentoufi A.A., Dasgupta G., Azeem A. Choudhury Z., Christensen N, Wechsler SL., Nesburn AB & BenMohamed L. A Novel Human Leukocyte Antigen (HLA-A*0201) Transgenic Rabbit Model to Evaluate the Protective Efficacy of Human CD8+ T-Cell Epitopes against Ocular Herpes Infection and Disease. Journal of Immunology. (2010). In press. PMID: 20124097.


426-37.
   
Grant 1. NIH 1RO1, Grant EY09392, "Therapeutic Vaccines to Reduce Ocular HSV Recurrences." 1-1-03 to 12-31-04 2. NIH 1RO1, Grant EY015225, “Ocular Mucosol Immunity”. 8-1-04 to 6-30-08. 3. NIH 1R24 EY016663, “Vision Research Infrastructure Development Grant” 6-1-05 to 5-31-10 Dr. Nesburn has had funded grants as principal investigator NEI "almost" continuously since l972.
   
Professional
Societies
American Academy of Ophthalmology (Fellow)
American Association for the Advancement of Science
American College of Surgeons (Fellow)
American Intraocular Lens Implant Society
American Medical Association, California Medical
American Society for Microbiology
American Society of Virology
Association for Research in Vision and Ophthalmology
Association and Los Angeles County Medical Association
Los Angeles Research Study Club
Ocular Microbiology and Immunology Group
Society of Sigma Xi
   
Other Experience Medical Director
Discovery Eye Foundation 1983—Pres

Director, Ophthalmology Research
Cedars-Sinai Medical Center, Los Angeles 1985—2002

Graduate Programs Ophthalmology

   
Research Center University of California Irvine Medical Center
   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=5660
   
Last updated 08/12/2016