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Karen Todd Lane

Clinical Director, Breast Health Center, Surgery
School of Medicine

Associate Professor of Clinical Surgery, Surgery
School of Medicine

B.S., University of California, Los Angeles, 1989, Psychobiology


M.D., University of California, Los Angeles, 1993

Phone: (714) 456-8505
Fax: (714) 456-7461
Email: klane@uci.edu

University of California, Irvine
101 The City Drive South
Bldg. 23, 3rd. Floor, Room 320
Mail Code: 5376
Orange, CA 92868

picture of Karen Todd Lane

Research
Interests
outcomes, survivorship, high risk
   
Academic
Distinctions
University Women's Scholarship 1984
Alumni Scholar 1984
Regent's Scholar 1984-1988
Dean's Honor List 3 quarters
Graduated Cum Laude 1989
American Federation for Clinical Research: Med Student Award 6/92
Elected to Alpha Omega Alpha--California Delta Chapter 10/92
Janet P. Glasgow Award 5/93
Hewlett-Packard Top Medical Graduate Award 5/93
Longmire Medal for Outstanding Surgery Student 5/93
Dean's Scholar 5/93
Nominated for the Leah J. Dickstein Award 2/93
UCLA Second Year Resident of the Year 1994-1995
UCLA Wilma Miley Morton Research Award 2000
Haile Debas Excellence in Teaching Award 9/05
Orange County Physician of Excellence 9/2007
NAWBO Remarkable Women Award 10/2007
   
Publications Book Chapters

1. Todd KE, Reber HA. Pancreatic neoplasms. Current Opinion in Gastroenterology, Owyang C (ed); Rapid Science Publ, Philadelphia 1996, 12:436-441.

2. Todd KE, Lane JS, Reber HA. Questions most commonly asked regarding pancreatic cancer. Problems in General Surgery. Traverso W (ed); Lippincott-Raven, Philadelphia 1997; 141:27-32.

3. Todd KE, Reber HA. Pancreatic neoplasms. Current Opinion in Gastroenterology; Owyang C (ed). Rapid Science Publ, Philadelphia 1997, 13:392-397.

4. Todd KE, Reber HA. Pancreaticoduodenectomy in the United States. Pancreaticoduodenectomy. Hanyu F, Takasaki K (eds); Springer-Verlag, New York 1997, 381-387.

5. Todd KE, Reber HA. Adenocarcinoma of the Pancreas. Textbook of Clinical Gastroenterology; Brandt LJ (ed); Current Medicine, Philadelphia 1998, 139:1201-1206.

6. Todd KE, Reber HA. Indications for surgery in chronic pancreatitis. Problems in General Surgery. Prinz R, Deziel D (eds); Lippincott – Raven Publ, Philadelphia 1998, 15(1):48-53.

7. Gloor B, Hines OJ, Blinman TA, Rigberg DA, Todd KE, Lane JS, Reber HA. Role of Kupffer Cells in Acute Pancreatitis. Falk Symposium 113, Andus T, Rogler G, Schlottmann K, Frick E (eds); Kluwer Academic Publ, Boston 1999, 365-371.

8. Todd KE, Gloor B, Reber HA. Pancreatic adenocarcinoma. Textbook of Gastroenterology, Yamada T, et al (eds); Lippincott-Raven Publ, Philadelphia 1999,Volume 2: 2178-2193.

9. Todd KE and Chang H. Breast cancer risk factors and prevention. Cancer Prevention and Early Diagnosis in Women, Manetta A (ed); Elsevier Sci, Philadelphia 2001, 48-68.

10. Reber HA, Todd KE. Surgical management of cancer of the pancreas. Surgical Oncology: Multidisciplinary approach to difficult problems. Silberman AW, Silberman H (eds); Oxford Univ Press, New York 2002, 556-569.
   
  Peer-Reviewed Articles

1. Todd K, Wiley F, Landaw E, Gajewski J, Bellamy P, Harrison R, Brill J, Feig S. Survival outcome among 54 intubated pediatric bone marrow transplant patients. Crit Care Med 1994, 22(1):171-176.

2. Todd K, Kleinman R, Millis M, Brunicardi F.C. The influence of pre-operative donor factors on the performance of the isolated perfused human pancreas. Journal of Surg Res 1994, 56(2):141-145.

3. Todd K, Kleinman R, Brunicardi F.C. Influence of preoperative donor factors on the performance of the isolated perfused human pancreas. Transplantation Proc 1994, 26(2):552.

4. Lewis MPN, Kusske AM, Todd K, Toyama MT, Ashley SW, Reber HA. An endothelin ETa/ETb receptor antagonist improves the severity of experimental pancreatitis in rats. Surgical Forum 1996, 47:135-137.

5. Todd KE, Reber HA. The surgical approach to severe acute pancreatitis. Journal of Hep Bil Pancr Surg 1996, 3:241-246.

6. Todd KE, Lewis MPN, Gloor B, Lane JS, Ashley SW, Reber HA. An ETa/ETb endothelin antagonist ameliorates systemic inflammation in a murine model of acute hemorrhagic pancreatitis (AHP). Surgery 1997, 122(2):443-450.

7. Todd KE, Lewis MPN, Gloor B, Kusske AM, Ashley SW, Reber HA. Management decisions for unusual periampullary tumors. Am Surg 1997, 63:927-932.

8. Lane JS, Todd KE, Lewis MPN, Gloor B, Reber HA, McFadden DW, Chandler CF. Interleukin-10 (IL-10) reduces the systemic inflammatory response in a murine model of intestinal ischemia/reperfusion. Surgery 1997, 122:288-294.

9. Gloor B, Todd KE, Reber HA. Surgical therapy for pancreatic pseudocysts. J Gastrointest Surg 1997, 1:203-204.

10. Gloor B, Todd KE, Reber HA. Diagnostic workup of patients with suspected pancreatic carcinoma: the University of California-Los Angeles approach. Cancer 1997, 79(9):1780-1786.

11. Lane JS, Todd KE, Lewis MPN, Gloor B, Ashley SW, Reber HA, McFadden DW, Chandler CF. Interleukin-10 reduces the systemic inflammatory response in a murine model of intestinal ischemia-reperfusion. Surgical Forum 1997, 122(2):288-294.

12. Todd KE, Gloor B, Lane JS, Isacoff WH, Reber HA. Resection of locally advanced pancreatic cancer after downstaging with continuous infusion 5-FU, Mitomycin C, Leucovorin (LV) and Persantine. J Gastrointest Surg 1998, 2(5): 159-166.

13. Lane JS, Kwan DK, Chandler CF, Alexander P, Todd KE, McFadden DW, Ashley SW. Diverting loop versus end ileostomy during ileoanal pull-through procedure for ulcerative colitis. Am Surg 1998, 64(10):979-982.

14. Gloor B, Todd KE, Lane JS, Lewis MPN, Reber HA. Hepatic Kupffer cell blockade reduces mortality in acute hemorrhagic pancreatitis in mice. J Gastrointest Surg 1998, 2(5):430-435.

15. Gloor B, Todd KE, Lane JS, Rigberg DA, Reber HA. Mechanism of increased lung injury after acute pancreatitis in IL-10 knockout mice. J Surg Res 1998, 80(1): 110-114.

16. Lewis MPN, Reber PU, Kusske AM, Toyama MT, Todd KE, Ashley SW, Reber HA. Intragastric alcohol causes endothelin release from feline pancreas. Dig Dis Sci 1998, 43(5):927-930.

17. Lane JS, Todd KE, Rigberg DA, Gloor B, Kau A, Ashley SW, McFadden DW, Reber HA, Chandler CF. Endothelin antagonism reduces the systemic inflammatory response in a murine model of intestinal ischemia-reperfusion. Surgical Forum 1998, 48:119-122.

18. Lewis MP, Lo SK, Reber PU, Patel A, Gloor B, Todd KE, Toyama MT, Sherman S, Ashley SW, Reber HA. Endoscopic measurement of pancreatic tissue perfusion in patients with chronic pancreatitis and control patients. Gastrointest Endosc 2000, 51(2): 195-199.

19. Gloor B, Blinman TA, Rigberg DA, Todd KE, Lane JS, Hines OJ, Reber HA. Kupffer cell blockade reduces hepatic and systemic cytokine levels and lung injury in hemorrhagic pancreatitis in rats. Pancreas 2000, 21(4): 414-420.

20. Lane JS, Todd KE, Gloor B, Chandler CF, Kau AW, Ashley SW, Reber HA, McFadden DW. Platelet activating factor antagonism reduces the systemic inflammatory response in a murine model of acute pancreatitis. J Surg Res 2001, 99:365-370.

21. Maggard MA, O’Connell JB, Lane KT, Liu JH, Etzioni DA, Ko CY. Do young breast cancer patients have worse outcomes? J Surg Res 2003, 113(1):109-113.

22. Butterfield LH, Ribas A, Meng WS, Dissette VB, Amarnani S, Vu Huong, Seja E, Todd K, Glaspy J, McBride WH, Economou JS. T-Cell responses to HLA-A*0201 immunodominant peptides derived from -Fetoprotein in patients with hepatocellular cancer. Clin Ca Res 2003, 9(16 Pt1):5902-5908.

23. Lang JE, Esserman LJ, Ewing CA, Rugo HS, Lane KT, Leong SP, Hwang S. Accuracy of selective sentinel lymphadenectomy after neoadjuvant chemotherapy: Effect of clinical node status at presentation. J Am Coll Surg 2004, 199:856-862.

24. Lane KT, Esserman LJ. Sentinel Lymph Node Dissection in Early-Stage Breast Cancer: Standards, Controversies and Future Considerations; Oncology Exchange 2004, 3(3):6-13.

25. Maggard, MA, Lane KT, O’Connell JB, Nanyakkara DD, Ko CY. Beyond the clinical trials: How often is sentinel lymph node dissection performed for breast cancer? Ann Surg Oncol 2005, 12(1):41-47.

26. Foster RD, Hansen SL, Esserman LJ, Hwang ES, Ewing C, Lane K, Anthony JP. Safety of immediate transverse rectus abdominis myocutaneous breast reconstruction for patients with locally advanced disease. Arch Surg 2005, 140:196-200.

27. Tan YY, Wu CT, Fan YG, Hwang S, Ewing C, Lane K, Esserman L, Lu Y, Treseler P, Morita E, Leong SP. Primary tumor characteristics predict sentinel lymph node macrometastases in breast cancer. Breast J 2005, 11(5):338-343.

28. Lane JS, Vittinghoff E, Lane KT, Hiramoto JS, Messina LM. Risk factors for premature peripheral vascular disease: Results for the National Health and Nutritional Survey 1999-2002. J Vasc Surg 2006, 44:319-325.

29. Datrice N, Narula N, Butler JA, Hsiang D, Baick C, Lane KT, Do Breast Columnar Cell Lesions with Atypia Need to be Excised? The American Surgeon 2007 Oct;73(10):984-986

30. Hsiang D, Yamamoto M, Mehta R, Baick C, Lane K, Butler J; Predicting nodal status using dynamic contrast-enhanced magnetic resonance imaging in patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy with and without sequential trastuzumab. Archives of Surgery. 2007 Sep;142(9):855-61

31. Yamamoto M, Mehta RS, Baick CH, Su MY, Lane KT, Butler JA, Hsiang DJ. The predictive value of sentinel lymph node biopsy in locally advanced breast cancer patients who have undergone neoadjuvant chemotherapy. Am Surg. 2007 Oct;73(10):977-80.

32. Lane K, Kempf A, Magno C, Lane J, Butler J, Hsiang D, Greenfield S, Jakowatz J, Regional Differences in the Use of Sentinel Lymph Node Biopsy for Melanoma: A Potential Quality Measure. Am Surg. 2008 Oct;74(10):981-4.

33. Lane JS, Magno CP, Lane KT, Chan T, Hoyt DB, Greenfield S. Nutrition impacts the prevalence of peripheral arterial disease in the United States. J Vasc Surg. 2008 Oct;48(4):897-904. Epub 2008 June 30.

34. Ninh T. Nguyen, Cheryl P. Magno, Karen T. Lane, et. al., Association of Hypertension, Diabetes, Dyslipidemia, and Metabolic Syndrome with Obesity: Findings from the National Health and Nutrition Examination Survey, 1999 to 2004. JACS December 2008; 207(6) 928-934.
   
  Published Abstracts

1. Toyama MT, Kusske AM, Reber PU, Lewis MPN, Todd K, Reber HA, Ashley SW. Administration of a nitric oxide donor decreases the severity of acute pancreatitis. Pancreas 1995, 11(4):451.

2. Todd KE, Lane JS, McFadden DW, Ashley SW, Reber HA. Interleukin-10 Reduces Cytokine Levels in a Murine Model of Pancreatitis and Sepsis. Pancreas 1996, 13(4):458.

3. Kusske AM, Rongione AJ, Lewis MPN, Todd K, Menon S, Xu Y, Ashley SW, McFadden DW, Reber HA. Interleukin-10 (IL-10) reduces the severity of acute hemorrhagic pancreatitis in rats. Gastroenterology 1996, 110(4):A407.

4. Kusske AM, Lewis MPN, Todd K, Toyama MT, Ashley SW, Reber HA. Platelet activating factor (PAF) antagonism markedly reduces pancreas and lung neutrophil accumulation in a caerulein model of acute pancreatitis (AP) in rats. Gastroenterology 1996, 110(4):A1399.

5. Lewis MPN, Kusske AM, Todd K, Toyama MT, Rongione AJ, Ashley SW, Reber HA. Improvement of experimental acute pancreatitis (AP) by an endothelin ETa/ETb receptor antagonist. Gastroenterology 1996, 110(4):A4

6. Toyama MT, Lewis MPN, Kusske AM, Todd K, Ashley SW, Reber HA. The isolated perfused pancreas/liver. A new model for the study of free radical production and systemic manifestations of acute pancreatitis. Gastroenterology 1996, 110(4):A438.

7. Lane JS, Todd KE, McFadden DW, Reber HA, Ashley SW. Interleukin-10 reduces severity early in the course of pancreatitis. Pancreas 1996, 13(4):445.

8. Lewis MPN, Gloor B, Todd KE, Sampogna S, Ashley SW, Reber HA. Human chronic pancreatitis is associated with ductal and vascular endothelial immunostaining for endothelin-1. Pancreas 1996, 13(4):447.

9. Gloor B, Todd KE, Lane JS, Lewis MPN, Reber HA. Kupffer cell activation increases serum cytokines in a model of acute pancreatitis. Gastroenterology 1997, 112:A444.

10. Todd KE, Lane JS, Gloor B, Chandler CF, Kwan DK, McFadden DW, Reber HA. Increased severity of acute pancreatitis in IL-10 knockout mice. Gastroenterology 1997, 112:A487.

11. Gloor B, Todd KE, Lane JS, Lewis MPN, Reber HA. Hepatic Kupffer cell blockade reduces mortality in acute hemorrhagic pancreatitis in mice. Gastroenterology 1997, 112:A1444.

12. Lane JS, Whang EE, Todd KE, Kwan D, Newton T, Diamond J, Zinner MJ, McFadden DW, Ashley SW. Paracellular pathway plays a minor role in jejunal glucose transport in the unanesthetized dog. Gastroenterology 1997, 112:A378.

13. Lane JS, Schew WA, Todd KE, Chandler CF, Diamond J, Ashley SW. Growth hormone increases mucosal nutrient transport efficiency following intestinal resection. Gastroenterology 1997, 112:A378.

14. Todd KE, Gloor B, Lane JS, Isacoff WH, Reber HA. Resection of locally advanced pancreatic cancer after downstaging with continuous infusion 5-FU, Mitomycin C, Leucovorin (LV) and Persantine. Gastroenterology 1997, 112: A1479.

15. Lane JS, Todd KE, Gloor B, Chandler CF, Kau AD, Ashley SW, Reber HA, McFadden DW. Platelet activating factor (PAF) antagonism reduces the systemic inflammatory response in a murine model of acute pancreatitis. Gastroenterology 1997, 112:A1454.

16. Hines OJ, Gloor B, Thakur A, Todd KE, Kwon R, Reber HA. Pancreaticoduodenectomy (PD): Changes in clinical management and their fiscal implications. Gastroenterology 1998, 114:A1392.

17. Lane JS, Todd KE, Rigberg DA, Gloor B, Kau AD, Ashley SW, McFadden DW, Reber HA, Chandler CF. Endothelin antagonism reduces the systemic inflammatory response in a murine model of intestinal ischemia-reperfusion. Gastroenterology 1998, 114:A1404.

18. Lewis MPN Gloor B, Todd KE, Lane JS, Reber HA. Ethanol causes in vitro release of endothelin from isolated rat pancreatic acini. Gastroenterology 1998, 114:A478.

19. Gloor B, Blinman TA, Rigberg DA, Todd KE, Lane JS, Hines JO, Reber HA. Hepatic contribution to circulating cytokine levels in severe acute pancreatitis in rats. Gastroenterology 1998, 114:A462.

20. Gloor B, Blinman TA, Rigberg DA, Todd KE, Lane JS, Hines JO, Reber HA. Kupffer cell blockade reduces hepatic and systemic cytokine levels and lung injury in hemorrhagic pancreatitis in rats. Gastroenterology 1998, 114:A462.

21. Maggard, Melinda, Lane, KE, O’Connell, Jessica, Ko, Clifford, Do racial disparities exist for receipt of reconstructive surgery for breast cancer? Poster presentation SCACS, January 2004

22. Maggard, Melinda, Lane, KE, O’Connell, Jessica, Ko, Clifford, Beyond the clinical trials: How prevalent are sentinel lymph node biopsies performed for breast cancer? Oral Presentation March 2004, New York, N.Y.

23. Esserman L, Lane KT, Ewing CA, Hwang ES. Innovations in Breast Cancer Care. Johns Hopkins Advanced Studies in Medicine 2005 Vol 5(6):294-305.

24. Hsiang D, Yamamoto M, Mehta R, Baick C, Lane K, Butler J; Predicting nodal status using dynamic contrast-enhanced magnetic resonance imaging in patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy with and without sequential trastuzumab. Archives of Surgery. 2007 Sep;142(9):855-61

25. Yamamoto M, Mehta RS, Baick CH, Su MY, Lane KT, Butler JA, Hsiang DJ. The predictive value of sentinel lymph node biopsy in locally advanced breast cancer patients who have undergone neoadjuvant chemotherapy. Am Surg. 2007 Oct;73(10):977-80.

26. Datrice N, Narula N, Butler JA, Hsiang D, Baick C, Lane KT, Do Breast Columnar Cell with Atypia Need to be Excised? The American Surgeon 2007 Oct;73(10):984-986

27. Ashley Kempf, BS, Karen Lane, MD, Cheryl Magno, MPH, et. al., Regional Differences in the use of Sentinel Lymph Node Biopsy for Melanoma: A Potential Quality Measure. Am Surg. 2008 Oct;74(10):981-4.

28. Karen Lane, MD, Nicole Datrice, MD, Cheryl Magno, MPH, Edith Smith, NP, John Butler, MD, David Hsiang, MD, Sheldon Greenfield, MD, Lari Wenzel, PhD. Evaluating the Quality of Follow-up Care in Breast Cancer Survivors. SCCACS 2009 January, 17 Santa Barbara, CA.
   
  Invited Articles, Critiques, Commentaries, Introductions

1. Lane KT, Esserman LJ. Sentinel lymph node dissection in early stage breast cancer: Current standards, controversies, and future considerations. Oncology Exchange 2004, 3(3):6-13.

2. Esserman L, Lane KT, Ewing CA, Hwang ES. Innovations in breast cancer care. Adv Stud Med 2005, 5(6):228-240.

3. Lane KT. Invited critique on: Litvak DA, Arora R. Treatment of Elderly Breast Cancer Patients in a Community Hospital Setting. Archives of Surgery Vol 141, October 2006

4. Lane KT. Improving quality of care for breast cancer survivors. Breast Diseases: A Yearbook Quarterly; Vol 17, No 4, 2007

5. Lane, KT; Clinical Challenges in Breast Disease. Seminars In Breast Disease: Diagnostic Imaging, Medical Oncology, Pathology, Radiation Oncology, Surgery; September 2007

6. Kempf A, Lane KT. Unusual Breast Lesions. Seminars in Breast Disease; 10:110-114; September 2007

7. Lane KT, Butler JA. Commentary on: Silberman H. Surgical Options for Stage I and II Breast Cancer (In Press Sept 2009)
   
Professional
Societies
Alpha Omega Alpha Medical Honor Society
Association of Women Surgeons
Longmire Surgical Society
Fellow, American College of Surgeons
Society of Surgical Oncology
American Society of Breast Diseases
American Society of Breast Surgeons
National Association of Women Business Owners
Southern California Chapter: American College of Surgeon
National Consortium of Breast Centers
National Association of Women Business Owners
Orange County Young Adult Cancer Program
   
Other Experience Clinical Instructor
University of California, Los Angeles, Division of Surgical Oncology 2000—2002

Assistant Professor in Residence
University of California, San Francisco School of Medicine 2002—2005

Research Center Center for Health Policy Research
   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=5615
   
Last updated 07/09/2009