Rita S. Mehta
Associate Health Science Professor, Medicine
|Cancer Angiogenesis, Targeted/Individualized Therapeutic Options, Clinical and Translational Research|
M.B.B.S. Merit Scholarship(1977-82)
Hope Foundation/Ortho Biotech Young Investigator Workshop Award for SWOG(2001)
Avon Scholar (2001-03)
Orange County Physician of Excellence(2006-08)
Cancer Angiogenesis – She studied the p53 gene and its involvement in angiogenesis cascade. Data suggest that the level of expression of the p53 gene may be related to modulation of thrombospondin-1, an angiogenesis inhibitor, and that an angiogenesis index incorporating p53, thrombospondin-1 and angiogenesis has prognostic implications in breast, prostate, colorectal cancer. In this way an angiogenic capacity in cancer patients may be identified prior to treatment with a potential effective/ineffective antiangiogenic agent in an individual patient or in an individual cancer type. Recent approval of avastin is the substantiation of an important role of antiangiogeneic compounds in treatment of cancer.
Targeted/Individualized Therapeutic Options– In the era that is fast witnessing an increasing chemotherapeutic choice for cancers in general, individualized patient directed treatment with improved outcome seems plausible. Development of in vitro assays to predict clinical outcome in an individual patient is an ultimate goal. Acceptance of directed therapy in last several years, for example, using chemotherapy with Herceptin in breast cancer patient subgroup over-expressing Her-2 neu oncogene is the attestation of the success of individualized therapy.
Clinical and Translational Research – Dr. Mehta is one of the key contributors to clinical research activities within the Cancer Center at UCI. Her main focus has been on the development of hypothesis-driven, investigator-initiated trials in the area of breast cancer. Currently, Dr. Mehta is the UCI principal investigator for all NSABP breast cancer treatment trials and Lead Researcher of Southwest Oncology Group hormonal trial in advanced breast cancer-S022. She directs clinical research office in managing all breast cancer protocols.
Shieh MP, Mehta RS. Oligohydramnios associated with administration of weekly paclitaxel for triple-negative breast cancer during pregnancy.Ann Oncol. 2011 Sep;22(9):2151-2. Epub 2011 Jul 28
Roblyer D, Ueda S, Cerussi A, Tanamai W, Durkin A, Mehta R, Hsiang D, Butler JA, McLaren C, Chen WP, Tromberg B. Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment. Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14626-31. Epub 2011 Aug 18.
Chen JH, Bahri S, Mehta RS, Kuzucan A, Yu HJ, Carpenter PM, Feig SA, Lin M, Hsiang DJ, Lane KT, Butler JA, Nalcioglu O, Su MY. Breast Cancer: Evaluation of Response to Neoadjuvant Chemotherapy with 3.0-T MR Imaging. Radiology. 2011 Aug 30.
Lin M, Chen JH, Mehta RS, Bahri S, Chan S, Nalcioglu O, Su MY. Spatial shrinkage/expansion patterns between breast density measured in two MRI scans evaluated by non-rigid registration. Phys Med Biol. 2011 Sep 21;56(18):5865-75. Epub 2011 Aug 18.
Cerussi AE, Tanamai VW, Hsiang D, Butler J, Mehta RS, and Tromberg BJ. Diffuse optical spectroscopic imaging correlates with final pathological response in breast cancer neoadjuvant chemotherapy. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences (2011) 369: 4512
Chang DH, Chen JH, Lin M, Bahri S, Yu HJ, Mehta RS, Nie K, Hsiang DJ, Nalcioglu O, Su MY. Comparison of breast density measured on MR images acquired using fat-suppressed versus nonfat-suppressed sequences.Med Phys. 2011 Nov;38(11):5961.
Bear HD, Tang G, Rastogi P, Geyer CE Jr, Robidoux A, Atkins JN, Baez-Diaz L, Brufsky AM, Mehta RS et al. Bevacizumab added to neoadjuvant chemotherapy for breast cancer. N Engl J Med. 2012 Jan 26;366(4):310-20.www.nejm.org/doi/full/10.1056/NEJMoa1111097
Hsiang D, Yamamoto M, Mehta RS, Su MY, Baick CH, Lane KT, Butler JA. Predicting Nodal Status Using Dynamic Contrast Enhanced MRI and Breast Pathology in Patients with Locally Advanced Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy With and Without Sequential Trastuzumab. Archives of Surgery. 2007 Sep; 142(9):855-861.
Yamamoto M, Mehta RS, Bacik CH, Su MY, Lane K, Butler J, Hsiang, DJ. The Predictive Value of Sentinel Lymph Node Biopsy in Locally Advanced Breast Cancer Patients Who Have Undergone Neoadjuvant Chemotherapy. The American Surgeon. 2007 Oct; 73/10:977-980(4).
Chen JH, Carpenter, PM, Mehta RS, Nalcioglu O and Su, M-Y. Pathological Axillary Lymph Node Status in HER-2 Receptor Positive and Negative Breast Cancers. Ann Surg Oncol. 2008 Mar;15(3):941-2. Epub 2007 Nov 15.
Agrawal G, Chen JH, Baick CH, Hsiang SD, Mehta RS, Nalcioglu O, and Su, M-Y MR Imaging Features of Breast Cancer: A Correlation Study with HER-2 Receptor. Ann Oncol. 2007 Nov;18(11):1903-4.
Chen JH, Carpenter, PM, Mehta RS, Nalcioglu O and Su, M-Y. Triple Negative Breast Cancer: MR Imaging Features in 29 Patients. Ann Oncol. 2007 Dec;18(12):2042-3. Epub 2007 Nov 20.
Chen JH, Mehta RS, Carpenter, PM, Nalcioglu O, and Su, M-Y. MRI in Predicting Pathological Response of Triple Negative Breast Cancer Following Neoadjuvant Chemotherapy. J Clin Oncol. 2007 Dec 10;25(35):5667-9.
Chen JH, Feig B, Agrawal G, Yu H, Carpenter PM, Mehta RS, Nalcioglu O, Su
MY. MRI evaluation of pathologically complete response and residual tumors in breast cancer after neoadjuvant chemotherapy.Cancer. 2008 Jan 1;112(1):17-26.
Mehta RS. HER2 and response to paclitaxel in node-positive breast cancer. N Engl J Med. 2008 Jan 10;358(2):197-8; author reply 198.
Mehta RS; Schubbert T: Re: HER2 status and efficacy of adjuvant anthracyclines in early breast cancer: a pooled analysis of randomized trials. J Natl Cancer Inst. 2008 May 7;100(9):680; author reply 680-1. Epub 2008 Apr 29
Mehta RS: Hormone receptor, grade, human epidermal growth factor receptor 2, and topoisomerase II as predictors of response to chemotherapy. J Clin Oncol. 2008 May 20;26(15):2596; author reply 2596-7.
Baek HM, Chen JH, Yu HJ, Mehta R, Nalcioglu O, Su MY: Detection of choline signal in human breast lesions with chemical-shift imaging. J Magn Reson Imaging. 2008 May;27(5):1114-21.
Mehta RS. Dose-dense and/or metronomic schedules of specific chemotherapies consolidate the chemosensitivity of triple-negative breast cancer: a step toward reversing triple-negative paradox. J Clin Oncol. 2008 Jul 1; 26(19):3286-8; author reply 3288.
Mehta RS, Schubbert T, Wong K. Trastuzumab in inflammatory breast cancer.
Ann Oncol. 2008 Oct;19(10):1815-7.
Mehta RS, Schubbert T, Marshall J, Carpenter PM. Rational and successful use of carboplatin and albumin-bound paclitaxel in a patient with recurrent metaplastic carcinoma who presented with multi-organ tumor emboli. Clin Breast Cancer. 2009 Feb;9(1):56-9.
Zell JA, Tsang WY, Taylor TH, Mehta RS, Anton-Culver H Prognostic impact of human epidermal growth factor-like receptor 2 and hormone receptor status in inflammatory breast cancer (IBC): analysis of 2,014 IBC patient cases from the California Cancer Registry. Breast Cancer Res. 2009 Feb 19;11(1).
Chen JH, Feig BA, Hsiang DJ, Butler JA, Mehta RS, Bahri S, Nalcioglu O, Su MY. Impact of MRI-evaluated neoadjuvant chemotherapy response on change of surgical recommendation in breast cancer. Ann Surg. 2009 Mar;249(3):448-54.
Raj KP, Sanati H, Mehta RS, Zell JA. Need for a new treatment strategy: leptomeningeal carcinomatosis from gastric cancer. Anticancer Drugs. 2009 Apr;20(4):301-4.
Bahri S, Chen JH, Mehta RS, Carpenter PM, Nie K, Kwon SY, Yu HJ, Nalcioglu O, Su MY. Residual breast cancer diagnosed by MRI in patients receiving neoadjuvant chemotherapy with and without bevacizumab.Ann Surg Oncol. 2009 Jun;16(6):1619-28.
Mehta RS and Su M-Y: Continued Exploration of Bevacizumab in Breast Cancer. Ann Surg Oncol 2010 February; 17(2): INVITED LETTER
Chen JH, Mehta RS, Nalcioglu O, Su MY MR imaging evaluation of non-inflammatory breast cancer with skin involvement following neoadjuvant chemotherapy” (DOI 10.1245/s10434-010-0974-7) RS Mehta had an equal contribution as the first author, JH Chen. online February 24, 2010.
|Grant||Prediction of Neoadjuvant Chemo Pathological Response Using MRI Markers. Co-Investigator. (PI Su, L) R0-1 NCI, NIH, % Effort – 17%, 10/07-10/12: $3,070,694.00. Fundable score|
American Society for Clinical Oncology
Orange County Oncology Association
National Surgical Adjuvant Breast and Bowel Project
Southwest Oncology Research Group (SWOG)
SWOG 0226 presented at SABCS Dec 2011
Medical Director of the Breast Center
|Research Centers||Chao Family Comprehensive Cancer Center|
|Breast Cancer Research Group|
|Southwest Oncology Group|
|Link to this profile||http://www.faculty.uci.edu/profile.cfm?faculty_id=5537|