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Mathew Blurton-Jones

Assistant Professor, Neurobiology and Behavior
School of Biological Sciences

Member, Institute for Memory Impairments and Neurological Disorders (UCI MIND)

Member, Sue and Bill Gross Stem Cell Research Center


Ph.D., University of California, San Diego, 2002, Neuroscience

Phone: (949) 824-5243
Email: mblurton@uci.edu

University of California, Irvine
3014 Gross Hall
Mail Code: 1705
Irvine, CA 92697

picture of Mathew  Blurton-Jones

Research
Interests
Stem Cells, Parkinson Disease, Alzheimer Disease, Neurogenesis, Differentiation, Learning and Memory, Neurodegeneration, Neurotrophins
   
Academic
Distinctions
2006-2007 Postdoctoral Fellowship in Stem Cell Biology (California Institute for Regenerative Medicine)
2002-2004 NIA Neurobiology of Aging Training Grant (PI: C Cotman, annually awarded)
1997-2001 NIA Neuroplasticity of Aging Training Grant (PI: F Gage, annually awarded)
2001 Merck fellowship/Neurosciences Graduate Training Program
2000 Teaching Excellence Award, UC San Diego Cognitive Science Department
1997 Markey Fellowship, University of California, San Diego
   
Appointments 2005-2007 Postgraduate Researcher
Department of Neurobiology and Behavior
University of California, Irvine
Irvine, CA 92697-4545
Mentor: Frank LaFerla, Ph.D.

2002-2005 Postgraduate Researcher
Department of Neurobiology and Behavior
University of California, Irvine
Irvine, CA 92697-4545
Mentor: Carl Cotman, Ph.D.

July 2002 Ph.D. in Neurosciences
University of California, San Diego
Thesis Advisor: Mark Tuszynski, M.D.,Ph.D.
   
Research
Abstract
My research is focused on the application of stem cells to examine the underlying molecular mechanisms that mediate neurodegenerative disease and to identify novel therapeutic approaches to treat these disorders. Many of my studies have focused on the most common age-related neurodegenerative disorder, Alzheimer disease. However, building upon these studies we are examining the use of stem cells to study and treat related neurological disorders such as Parkinson disease (PD), and Dementia with Lewy Bodies (DLB). We are also adapting molecular biological techniques for the study of embryonic and adult stem cells and to facilitate the purification, analysis, and transplantation of distinct neuronal and glial cell populations.
   
Publications 1. Melega WP, Raleigh MJ, Stout DB, DeSallas AA, Cherry SR, Blurton-Jones M, Morton GG, Huang SC, and Phelps ME (1996) Longitudinal Behavioral and 6-[18F]Fluoro-L-DOPA-PET Assessment of MPTP-Hemiparkinsonian Monkeys. Experimental Neurology. 141: 318-329.

2. Blurton-Jones M, Roberts J, and Tuszynski MH (1999) Estrogen Receptor Immunoreactivity in the Adult Primate Brain: Neuronal Distribution and Association with p75, trk A, and Choline Acetyltransferase. Journal of Comparative Neurology. 405:529-542.

3. Blurton-Jones M and Tuszynski MH (2001) Reactive astrocytes express estrogen receptors in the injured primate brain. Journal of Comp. Neurology. 433:115-123.

4. Taber KH, Murphy DD, Blurton-Jones M, and Hurley RA (2001) An Update on Estrogen: Higher Cognitive Function, Receptor Mapping, Neurotrophic Effects. Journal of Neuropsychiatry and Clinical Neuroscience.13:313-317.

5. Blurton-Jones M and Tuszynski MH (2002) Estrogen receptor-? co-localizes extensively with parvalbumin-labeled inhibitory neurons in the cortex, amygdala, basal forebrain, and hippocampal formation of intact and ovariectomized adult rats. Journal of Comparative Neurology. 452: 276-287.

6. Blurton-Jones M, Kuan PN, and Tuszynski MH (2004) Anatomical evidence for transsynaptic influences of estrogen on brain derived neurotrophic factor expression. Journal of Comparative Neurology. 468: 347-360.

7. Rissman RA*, Poon WW*, Blurton-Jones M*, Oddo S, Torp R, Vitek MP, LaFerla FM, Rohn TT, Cotman CW (2004) Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. Journal of Clinical Investigation. 114: 121-130. * RR, WP, & MBJ contributed equally to this work.

8. Cribbs DH, Poon WW, Rissman RA, Blurton-Jones M. (2004) Caspase-mediated degeneration in Alzheimer’s disease. American Journal of Pathology. 165:353-355.

9. Cotman CW, Poon WW, Rissman RA, Blurton-Jones M. (2005) The role of caspase cleavage of tau in alzheimer's disease neuropathology. Journal of Neuropathology and Experimental Neurology. 64:104-112.

10. Taylor AM*, Blurton-Jones M*, Rhee SW, Cribbs DH, Cotman CW, Jeon NL (2005) A Microfluidic Neuronal Culture Platform for CNS Axonal Injury, Regeneration and Transport. Nature Methods. 2:599-605 *AMT & MBJ contributed equally to this work.

11. Blurton-Jones M and Tuszynski MH (2006) Estradiol-induced modulation of estrogen receptor-? and GABA within the adult neocortex: a potential trans-synaptic mechanism for estrogen modulation of BDNF. J. Comp. Neurology. 499: 603-612.

12. Blurton-Jones M, LaFerla, FM. (2006) Pathways by which Aß facilitates tau pathology. Current Alzheimer Research. 3:437-448.

13. Parachikova A, Agadjanyan MG, Cribbs DH, Blurton-Jones M, Perreau V, Rogers J, Beach TG, Cotman CW (2007) Inflammatory changes parallel the early stages of Alzheimer’s disease. Neurobiology of Aging. 28(12): 1821-33.

14. Shapiro LA, Ng K, Kinyamu R, Whitaker-Azmitia P, Geisert EE, Blurton-Jones M, Korn MJ, Zhou QY, Ribak C. (2007) Origin, migration and fate of newly generated neurons in the adult rodent piriform cortex. Brain Structure and Function. 212(2):133-148.

15. Yamasaki TR, Blurton-Jones M, Morrissette DA, Kitazawa M, Oddo S and LaFerla FM (2007) Neural Stem Cells Improve Memory in an Inducible Mouse Model of Neuronal Loss. Journal of Neuroscience. 27(44):11925-33.

16. Tseng BP, Green KN, Chan JL, Blurton-Jones M, LaFerla FM (2008) A? inhibits the proteasome and enhances amyloid and tau accumulation. Neurobiology of Aging. 29(11):1607-1618. PMCID2664168

17. Poon WW, Blurton-Jones M, Tu CH, Feinberg LM, Chabrier MA, Harris JW, Jeon NL, Cotman CW (2009) ?-amyloid impairs axonal BDNF retrograde trafficking. Neurobiology of Aging: Jun 18. PMCID3038182.

18. McAlpine FE, Lee JK, Harms AS, Ruhn KA, Blurton-Jones M, Hong J, Das P, Golde TE, LaFerla FM, Oddo S, Blesch A, Tansey MG. (2009). Inhibition of soluble TNF signaling in a mouse model of Alzheimer’s disease prevents pre-plaque amyloid-associated neuropathology. Neurobiology of Disease 34: 163-177. PMID: 19320056

19. Lopes JP, Blurton-Jones M, Yamazaki TR, Agostinho P and LaFerla F.M. (2009) Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not A? and tau pathology. J Alzheimer’s Disease 16: 541-9.

20. Clinton LK*, Blurton-Jones M*, Myczek K*, Trojanowski JQ, LaFerla FM. (2010). Synergistic Interactions Among A?, Tau, and ?-Synuclein: Acceleration of Neuropathology and Cognitive Decline. Journal of Neuroscience. 30(21):7281-7289. *MBJ, CLK, & MK contributed equally to this work. PMC Journal - In Process.

21. Koike MA, Green KN, Blurton-Jones M¬, LaFerla FM. (2010) Oligemic Hypoperfusion Differentially Affects Tau and Amyloid-?. American Journal of Pathology. 177(1):300-10.

22. Blurton-Jones M, Kitazawa M, Martinez-Coria H, Castello N, Muller FJ, Loring JF, Yamasaki T, Poon WW, Green KN, LaFerla FM. (2009) Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proceedings of the National Academy of Sciences USA. 106:13594-13599. PMCID2715325.

23. Freude KK, Penjwini M, Davis JL, Laferla FM, Blurton-Jones M. (2011) Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells. Journal of Biological Chemistry. 286(27):24264-74. PMID:21606494.

24. Walls KC, Coskun P, Gallegos-Perez JL, Zadourian N, Freude K, Rasool S, Blurton-Jones M, Green KN, and LaFerla FM. Swedish Alzheimer's mutation induces mitochondrial dysfunction mediated by HSP60 mislocalization of APP and beta-amyloid. Journal of Biological Chemistry. Jun 29. [Epub ahead of print]. PMID:22753410

25. Marsh SE, Blurton-Jones M. (2012) Examining the mechanisms that link beta-amyloid and alpha-synuclein pathologies. Alzheimer’s Research & Therapy. 4(2):11. PMID:22546279.

BOOK CHAPTERS:

1. Blurton-Jones M, Yamasaki TR, LaFerla FM. (2009). Improving Memory with Stem Cell Transplantation. Regulatory Networks in Stem Cells, Eds. VK Rajesekhar & MC Vemuri. Humana Press.

2. Blurton-Jones M, Nerhus, J, LaFerla FM. (2012). Transplanting stem cells into the brain. Human Stem Cell Manual 2nd edition, Eds. J Loring & S Peterson. Elsevier. In Press
   
Grants K01 AG-029378 (Blurton-Jones) 04/15/08 - 03/31/13 NIH/NIA The Role of Beta-Amyloid Assembly States in Tau Pathology and Cognitive Decline
   
Alzheimer Disease Research Center (ADRC) Project 05/01/10 - 04/31/15 NIH/NIA Using neural stem cells to promote plasticity and improve cognition in AD transgenic mice.
   
Professional
Societies
2006-present International Society for Stem Cell Research
1998-present Society for Neuroscience
   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=5530
   
Last updated 01/17/2013