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Michael J. Buchmeier

Professor Div. of Infectious Diseases, Dept. of Medicine, Dept. of Molecular Biology and Biochemistry, Center for Virus Research

Ph.D., McMaster University, 1976, Virology and Immunology


M.S., Washington State University, 1973, Bacteriology and Public health


B.S., Washington State University, 1970, Bacteriology and Public health

Phone: (949) 824-5781
Fax: 949-824-1714
Email: m.buchmeier@uci.edu

University of California, Irvine
3205 Mc Gaugh Hall
University of California Irvine
Mail Code: 3900
Irvine, CA 92697

picture of Michael J. Buchmeier

Research
Interests
Arenaviruses, Coronaviruses, Biology of RNA Viruses, Viral Pathogenesis, Structural Biology of Viruses, Biology of Zoonotic and Emerging Viruses, Biodefense
   
URL buchmeierlab.bio.uci.edu
   
Academic
Distinctions
1979-1984 Recipient of Established Investigator Award No. 79-102 from American Heart Association
1992-1994 ASM Foundation Lecturer
1995-1996 Chair-Elect, Division T (RNA Viruses), American Society for Microbiology
1996-1997 Chair, Division T (RNA Viruses), American Society for Microbiology
1997-1998 Alternate Councilor (RNA Viruses), American Society for Microbiology
2000 Divisional Councilor (RNA Viruses), American Society for Microbiology
1996- Fellow of the American Association for the Advancement of Science
1999-2000 ASM-Burroughs -Wellcome Professor 1999/2000
2005- Fellow of the American Academy of Microbiology
2007- Associate editor PLoS Pathogens
2006- Editor, Microbiology and Molecular Biology Reviews
2001-2009 Editorial Board, J. Virology
1996- Associate Editor, Virology
2000- Editorial Board, Viral Immunology
2000- Associate Editor, BMC Microbiology
2004- Editorial Board, Virology Journal (BMC)
1985 NATO Visiting Investigator-University of London (LSHTM)
   
Appointments NRSA Postdoctoral Fellow in Experimental Pathology, Scripps Clinic and Research Foundation,La Jolla, CA., July 1976-June 1979.
   
Research
Abstract
Professor Buchmeier's laboratory is interested in the pathogenesis and control of viral infections. Viral diseases are among the most common environmental factors which influence human health and manifest in a variety of acute and chronic scenarios. These may include acute viral infections of various organ systems including the CNS and respiratory systems, and may result in a range of effects. My group is interested primarily in two classes of RNA Viruses that affect the CNS. These are the murine and human coronaviruses and the Arenaviruses. We study the structure and function of these viruses, and the contributions of the viral proteins and glycoproteins to the viral life cycle and disease, We are also engaged in antiviral drug design in, and the mechanisms by which viruses interact with the host during acute and persistent infection. The consequences of these virus-host interactions contributes to variety of autoimmune and neurodegenerative diseases, and we try to determine the host and viral events which result in disease.
   
Publications Human CD8 and CD4 T cell memory to lymphocytic choriomeningitis virus infection.
Kotturi MF, Swann JA, Peters B, Arlehamn CL, Sidney J, Kolla RV, James EA, Akondy RS, Ahmed R, Kwok WW, Buchmeier MJ, Sette A.
J Virol. 2011 Nov;85(22):11770-80. Epub 2011 Sep 7.
   
  Development of peptide-conjugated morpholino oligomers as pan-arenavirus inhibitors.
Neuman BW, Bederka LH, Stein DA, Ting JP, Moulton HM, Buchmeier MJ.
Antimicrob Agents Chemother. 2011 Oct;55(10):4631-8. Epub 2011 Aug 8.
   
  Conserved residues in Lassa fever virus Z protein modulate viral infectivity at the level of the ribonucleoprotein.
Capul AA, de la Torre JC, Buchmeier MJ.
J Virol. 2011 Apr;85(7):3172-8. Epub 2011 Jan 12.
   
  A structural analysis of M protein in coronavirus assembly and morphology.
Neuman BW, Kiss G, Kunding AH, Bhella D, Baksh MF, Connelly S, Droese B, Klaus JP, Makino S, Sawicki SG, Siddell SG, Stamou DG, Wilson IA, Kuhn P, Buchmeier MJ.
J Struct Biol. 2011 Apr;174(1):11-22. Epub 2010 Dec 3.
   
  Glycosylation modulates arenavirus glycoprotein expression and function.
Bonhomme CJ, Capul AA, Lauron EJ, Bederka LH, Knopp KA, Buchmeier MJ.
Virology. 2011 Jan 20;409(2):223-33. Epub 2010 Nov 5.
   
  A multivalent vaccination strategy for the prevention of Old World arenavirus infection in humans.
Botten J, Whitton JL, Barrowman P, Sidney J, Whitmire JK, Alexander J, Kotturi MF, Sette A, Buchmeier MJ.
J Virol. 2010 Oct;84(19):9947-56. Epub 2010 Jul 28.
   
  Polyfunctional CD4+ T cell responses to a set of pathogenic arenaviruses provide broad population coverage.
Kotturi MF, Botten J, Maybeno M, Sidney J, Glenn J, Bui HH, Oseroff C, Crotty S, Peters B, Grey H, Altmann DM, Buchmeier MJ, Sette A.
Immunome Res. 2010 May 17;6:4.
   
  A multivalent and cross-protective vaccine strategy against arenaviruses associated with human disease.
Kotturi MF, Botten J, Sidney J, Bui HH, Giancola L, Maybeno M, Babin J, Oseroff C, Pasquetto V, Greenbaum JA, Peters B, Ting J, Do D, Vang L, Alexander J, Grey H, Buchmeier MJ, Sette A.
PLoS Pathog. 2009 Dec;5(12):e1000695. Epub 2009 Dec 18.
   
  Nuclear magnetic resonance structure of the nucleic acid-binding domain of severe acute respiratory syndrome coronavirus nonstructural protein 3.
Serrano P, Johnson MA, Chatterjee A, Neuman BW, Joseph JS, Buchmeier MJ, Kuhn P, Wüthrich K.
J Virol. 2009 Dec;83(24):12998-3008. Epub 2009 Oct 14.
   
  Purification and electron cryomicroscopy of coronavirus particles.
Neuman BW, Adair BD, Yeager M, Buchmeier MJ.
Methods Mol Biol. 2008;454:129-36.
   
  Nuclear magnetic resonance structure shows that the severe acute respiratory syndrome coronavirus-unique domain contains a macrodomain fold.
Chatterjee A, Johnson MA, Serrano P, Pedrini B, Joseph JS, Neuman BW, Saikatendu K, Buchmeier MJ, Kuhn P, Wüthrich K.
J Virol. 2009 Feb;83(4):1823-36. Epub 2008 Dec 3.
   
  Lymphocytic choriomeningitis virus infection yields overlapping CD4+ and CD8+ T-cell responses.
Dow C, Oseroff C, Peters B, Nance-Sotelo C, Sidney J, Buchmeier M, Sette A, Mothé BR.
J Virol. 2008 Dec;82(23):11734-41. Epub 2008 Oct 1.
   
  New tools to battle emerging viruses.
Buchmeier MJ, Kuhn P.
Curr Opin Microbiol. 2008 Aug;11(4):360-1. Epub 2008 Aug 3. No abstract available.
   
  Proteomics analysis unravels the functional repertoire of coronavirus nonstructural protein 3.
Neuman BW, Joseph JS, Saikatendu KS, Serrano P, Chatterjee A, Johnson MA, Liao L, Klaus JP, Yates JR 3rd, Wüthrich K, Stevens RC, Buchmeier MJ, Kuhn P.
J Virol. 2008 Jun;82(11):5279-94. Epub 2008 Mar 26.
   
  Naive precursor frequencies and MHC binding rather than the degree of epitope diversity shape CD8+ T cell immunodominance.
Kotturi MF, Scott I, Wolfe T, Peters B, Sidney J, Cheroutre H, von Herrath MG, Buchmeier MJ, Grey H, Sette A.
J Immunol. 2008 Aug 1;181(3):2124-33.
   
  http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=buchmeier+mj
   
  Neurovirology: Viruses and the Brain
Michael J. Buchmeier and Iain L. Campbell, eds.
Academic Press, New York, 2001.
isbn 0-12-039856-7
   
Grant AI50840, AI065359 UCOP-MPRI #143226 HHSN266200400023
   
Professional
Societies
Fellow of the American Academy of Microbiology
Fellow of the AAAS
Fellow of the Pluto Society
American Society for Virology
International Committee on Virus Taxonomy
International Society for Neuroimmunology
American Association of Immunologists
   
Other Experience Scientific Advisory Board
Telik inc 1987—2003

Scientific Advisory Board
AVI Biopharma 2005—2008

Member, Recombinant Advisory Committee (RAC)
NIH 2008—2013

Member, Microbiology and Immunology Review Committee
NIH-NIAID 2000—2005

Member, Experimental Virology Study section
NIH 1991—1995

Graduate Research Fellowship Review Panel (Biology)
National Science Foundation 1999—2001

Peer Review Committee A
National Multiple Sclerosis Society 2000—2006

Graduate Programs Cellular and Molecular Biosciences

Virology

Immunology and Pathogenesis

   
Research Centers Center for Virus Research
   
Pacific Southwest Regional Center for Biodefense and Emerging Diseases
   
Institute for Immunology
   
Multiple Sclerosis Research Center
   
California Center for Antiviral Drug Discovery
   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=5519
   
Last updated 01/26/2012