Michael J. Buchmeier

Professor Div. of Infectious Diseases, Dept. of Medicine, Dept. of Molecular Biology and Biochemistry, Center for Virus Research

Associate Director, Center for Viral Research


Ph.D., McMaster University, 1976, Virology and Immunology


M.S., Washington State University, 1972, Bacteriology and Public health


B.S., Washington State University, 1970, Bacteriology and Public health

Phone: (949) 824-5781
Fax: 949-824-1714
Email: m.buchmeier@uci.edu

University of California, Irvine
3205 Mc Gaugh Hall
University of California Irvine
Office: 2222 Bio Sci 3
Mail Code: 3900
Irvine, CA 92697

picture of Michael J. Buchmeier

Research
Interests
Arenaviruses, Coronaviruses, Biology of RNA Viruses, Viral Pathogenesis, Structural Biology of Viruses, Biology of Zoonotic and Emerging Viruses, Biodefense
   
URL buchmeierlab.bio.uci.edu
   
Academic
Distinctions
1979-1984 Recipient of Established Investigator Award No. 79-102 from American Heart Association
1992-1994 ASM Foundation Lecturer
1995-1996 Chair-Elect, Division T (RNA Viruses), American Society for Microbiology
1996-1997 Chair, Division T (RNA Viruses), American Society for Microbiology
1997-1998 Alternate Councilor (RNA Viruses), American Society for Microbiology
2000 Divisional Councilor (RNA Viruses), American Society for Microbiology
1996- Fellow of the American Association for the Advancement of Science
1999-2000 ASM-Burroughs -Wellcome Professor 1999/2000
2005- Fellow of the American Academy of Microbiology
2007- Associate editor PLoS Pathogens
2006- Editor, Microbiology and Molecular Biology Reviews
2001-2009 Editorial Board, J. Virology
1996- Associate Editor, Virology
2000- Editorial Board, Viral Immunology
2000- Associate Editor, BMC Microbiology
2004- Editorial Board, Virology Journal (BMC)
1985 NATO Visiting Investigator-University of London (LSHTM)
   
Appointments NRSA Postdoctoral Fellow in Experimental Pathology, Scripps Clinic and Research Foundation,La Jolla, CA., July 1976-June 1979.
   
Research
Abstract
Professor Buchmeier's laboratory is interested in the pathogenesis and control of viral infections. Viral diseases are among the most common environmental factors which influence human health and manifest in a variety of acute and chronic scenarios. These may include acute viral infections of various organ systems including the CNS and respiratory systems, and may result in a range of effects. My group is interested primarily in two classes of RNA Viruses that affect the CNS. These are the murine and human coronaviruses and the Arenaviruses. We study the structure and function of these viruses, and the contributions of the viral proteins and glycoproteins to the viral life cycle and disease, We are also engaged in antiviral drug design in, and the mechanisms by which viruses interact with the host during acute and persistent infection. The consequences of these virus-host interactions contributes to variety of autoimmune and neurodegenerative diseases, and we try to determine the host and viral events which result in disease.
   
Publications http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=buchmeier+mj

Casadevall A, Bertuzzi S, Buchmeier MJ, Davis RJ, Drake H, Fang FC, Gilbert J,
Goldman BM, Imperiale MJ, Matsumura P, McAdam AJ, Pasetti MF, Sandri-Goldin RM,
Silhavy T, Rice L, Young JH, Shenk T. ASM Journals Eliminate Impact Factor
Information from Journal Websites. mSystems. 2016 Jul 11;1(4). pii: e00088-16.
PubMed PMID: 27822548; PubMed Central PMCID: PMC5069964.


Postler TS, Clawson AN, Amarasinghe GK, Basler CF, Bavari S, Benko M, Blasdell
KR, Briese T, Buchmeier MJ, Bukreyev A, Calisher CH, Chandran K, Charrel R, Clegg
CS, Collins PL, Juan Carlos T, Derisi JL, Dietzgen RG, Dolnik O, Dürrwald R, Dye
JM, Easton AJ, Emonet S, Formenty P, Fouchier RA, Ghedin E, Gonzalez JP, Harrach
B, Hewson R, Horie M, Jiang D, Kobinger G, Kondo H, Kropinski AM, Krupovic M,
Kurath G, Lamb RA, Leroy EM, Lukashevich IS, Maisner A, Mushegian AR, Netesov SV,
Nowotny N, Patterson JL, Payne SL, PaWeska JT, Peters CJ, Radoshitzky SR, Rima
BK, Romanowski V, Rubbenstroth D, Sabanadzovic S, Sanfaçon H, Salvato MS,
Schwemmle M, Smither SJ, Stenglein MD, Stone DM, Takada A, Tesh RB, Tomonaga K,
Tordo N, Towner JS, Vasilakis N, Volchkov VE, Wahl-Jensen V, Walker PJ, Wang LF,
Varsani A, Whitfield AE, Zerbini FM, Kuhn JH. Possibility and Challenges of
Conversion of Current Virus Species Names to Linnaean Binomials. Syst Biol. 2016
Oct 22. pii: syw096. doi: 10.1093/sysbio/syw096. [Epub ahead of print] PubMed
PMID: 27798405.


Neuman BW, Buchmeier MJ. Supramolecular Architecture of the Coronavirus
Particle. Adv Virus Res. 2016;96:1-27. doi: 10.1016/bs.aivir.2016.08.005. Review.
PubMed PMID: 27712621.


Radoshitzky SR, Bào Y, Buchmeier MJ, Charrel RN, Clawson AN, Clegg CS, DeRisi
JL, Emonet S, Gonzalez JP, Kuhn JH, Lukashevich IS, Peters CJ, Romanowski V,
Salvato MS, Stenglein MD, de la Torre JC. Past, present, and future of arenavirus
taxonomy. Arch Virol. 2015 Jul;160(7):1851-74. doi: 10.1007/s00705-015-2418-y.
PubMed PMID: 25935216.


Knopp KA, Ngo T, Gershon PD, Buchmeier MJ. Single nucleoprotein residue
modulates arenavirus replication complex formation. MBio. 2015 Apr
28;6(3):e00524-15. doi: 10.1128/mBio.00524-15. PubMed PMID: 25922393; PubMed
Central PMCID: PMC4436057.


Bederka LH, Bonhomme CJ, Ling EL, Buchmeier MJ. Arenavirus stable signal
peptide is the keystone subunit for glycoprotein complex organization. MBio. 2014
Oct 28;5(6):e02063. doi: 10.1128/mBio.02063-14. PubMed PMID: 25352624; PubMed
Central PMCID: PMC4217180.


Neuman BW, Angelini MM, Buchmeier MJ. Does form meet function in the
coronavirus replicative organelle? Trends Microbiol. 2014 Nov;22(11):642-7. doi:
10.1016/j.tim.2014.06.003. Review. PubMed PMID: 25037114.


Angelini MM, Neuman BW, Buchmeier MJ. Untangling membrane rearrangement in the
nidovirales. DNA Cell Biol. 2014 Mar;33(3):122-7. doi: 10.1089/dna.2013.2304.
PubMed PMID: 24410069; PubMed Central PMCID: PMC3942677.


Puccini JM, Ruller CM, Robinson SM, Knopp KA, Buchmeier MJ, Doran KS, Feuer R.
Distinct neural stem cell tropism, early immune activation, and choroid plexus
pathology following coxsackievirus infection in the neonatal central nervous
system. Lab Invest. 2014 Feb;94(2):161-81. doi: 10.1038/labinvest.2013.138.
PubMed PMID: 24378643.


Angelini MM, Akhlaghpour M, Neuman BW, Buchmeier MJ. Severe acute respiratory
syndrome coronavirus nonstructural proteins 3, 4, and 6 induce double-membrane
vesicles. MBio. 2013 Aug 13;4(4). pii: e00524-13. doi: 10.1128/mBio.00524-13.
PubMed PMID: 23943763; PubMed Central PMCID: PMC3747587.


Neuman BW, Kiss G, Al-Mulla HM, Dokland T, Buchmeier MJ, Weikl T, Schley D.
Direct observation of membrane insertion by enveloped virus matrix proteins by
phosphate displacement. PLoS One. 2013;8(2):e57916. doi:
10.1371/journal.pone.0057916. PubMed PMID: 23469104; PubMed Central PMCID:
PMC3585246.


Bonhomme CJ, Knopp KA, Bederka LH, Angelini MM, Buchmeier MJ. LCMV
glycosylation modulates viral fitness and cell tropism. PLoS One.
2013;8(1):e53273. doi: 10.1371/journal.pone.0053273. PubMed PMID: 23308183;
PubMed Central PMCID: PMC3538765.


Kotturi MF, Swann JA, Peters B, Arlehamn CL, Sidney J, Kolla RV, James EA,
Akondy RS, Ahmed R, Kwok WW, Buchmeier MJ, Sette A. Human CD8? and CD4? T cell
memory to lymphocytic choriomeningitis virus infection. J Virol. 2011
Nov;85(22):11770-80. doi: 10.1128/JVI.05477-11. PubMed PMID: 21900169; PubMed
Central PMCID: PMC3209290.


Neuman BW, Bederka LH, Stein DA, Ting JP, Moulton HM, Buchmeier MJ.
Development of peptide-conjugated morpholino oligomers as pan-arenavirus
inhibitors. Antimicrob Agents Chemother. 2011 Oct;55(10):4631-8. doi:
10.1128/AAC.00650-11. PubMed PMID: 21825302; PubMed Central PMCID: PMC3186971.


Capul AA, de la Torre JC, Buchmeier MJ. Conserved residues in Lassa fever
virus Z protein modulate viral infectivity at the level of the ribonucleoprotein.
J Virol. 2011 Apr;85(7):3172-8. doi: 10.1128/JVI.02081-10. PubMed PMID: 21228230;
PubMed Central PMCID: PMC3067847.


Neuman BW, Kiss G, Kunding AH, Bhella D, Baksh MF, Connelly S, Droese B,
Klaus JP, Makino S, Sawicki SG, Siddell SG, Stamou DG, Wilson IA, Kuhn P,
Buchmeier MJ. A structural analysis of M protein in coronavirus assembly and
morphology. J Struct Biol. 2011 Apr;174(1):11-22. doi: 10.1016/j.jsb.2010.11.021.
PubMed PMID: 21130884; PubMed Central PMCID: PMC4486061.


Bonhomme CJ, Capul AA, Lauron EJ, Bederka LH, Knopp KA, Buchmeier MJ.
Glycosylation modulates arenavirus glycoprotein expression and function.
Virology. 2011 Jan 20;409(2):223-33. doi: 10.1016/j.virol.2010.10.011. PubMed
PMID: 21056893; PubMed Central PMCID: PMC3053032.


Botten J, Whitton JL, Barrowman P, Sidney J, Whitmire JK, Alexander J,
Kotturi MF, Sette A, Buchmeier MJ. A multivalent vaccination strategy for the
prevention of Old World arenavirus infection in humans. J Virol. 2010
Oct;84(19):9947-56. doi: 10.1128/JVI.00672-10. PubMed PMID: 20668086; PubMed
Central PMCID: PMC2937778.


Kotturi MF, Botten J, Maybeno M, Sidney J, Glenn J, Bui HH, Oseroff C, Crotty
S, Peters B, Grey H, Altmann DM, Buchmeier MJ, Sette A. Polyfunctional CD4+ T
cell responses to a set of pathogenic arenaviruses provide broad population
coverage. Immunome Res. 2010 May 17;6:4. doi: 10.1186/1745-7580-6-4. PubMed PMID:
20478058; PubMed Central PMCID: PMC2880318.
2: Botten J, Whitton JL, Barrowman P, Sidney J, Whitmire JK, Alexander J, Kotturi
MF, Sette A, Buchmeier MJ. A multivalent vaccination strategy for the prevention
of Old World arenavirus infection in humans. J Virol. 2010 Oct;84(19):9947-56.
doi: 10.1128/JVI.00672-10. PubMed PMID: 20668086; PubMed Central PMCID:
PMC2937778.


Bonhomme CJ, Capul AA, Lauron EJ, Bederka LH, Knopp KA, Buchmeier MJ.
Glycosylation modulates arenavirus glycoprotein expression and function.
Virology. 2011 Jan 20;409(2):223-33. doi: 10.1016/j.virol.2010.10.011. PubMed
PMID: 21056893; PubMed Central PMCID: PMC3053032.


Neuman BW, Kiss G, Kunding AH, Bhella D, Baksh MF, Connelly S, Droese B, Klaus
JP, Makino S, Sawicki SG, Siddell SG, Stamou DG, Wilson IA, Kuhn P, Buchmeier MJ.
A structural analysis of M protein in coronavirus assembly and morphology. J
Struct Biol. 2011 Apr;174(1):11-22. doi: 10.1016/j.jsb.2010.11.021. PubMed PMID:
21130884; PubMed Central PMCID: PMC4486061.


Capul AA, de la Torre JC, Buchmeier MJ. Conserved residues in Lassa fever
virus Z protein modulate viral infectivity at the level of the ribonucleoprotein.
J Virol. 2011 Apr;85(7):3172-8. doi: 10.1128/JVI.02081-10. PubMed PMID: 21228230;
PubMed Central PMCID: PMC3067847.
   
  Neurovirology: Viruses and the Brain
Michael J. Buchmeier and Iain L. Campbell, eds.
Academic Press, New York, 2001.
isbn 0-12-039856-7
   
Grant AI50840, AI065359 UCOP-MPRI #143226 HHSN266200400023
   
Professional
Societies
Fellow of the American Academy of Microbiology
Fellow of the AAAS
Fellow of the Pluto Society
American Society for Virology
International Committee on Virus Taxonomy
International Society for Neuroimmunology
American Association of Immunologists
   
Other Experience Scientific Advisory Board
AVI Biopharma 2005—2008

Member, Recombinant DNA Advisory Committee (RAC)
NIH 2008—2013

Member, Microbiology and Immunology Review Committee
NIH-NIAID 2000—2005

Member, Experimental Virology Study section
NIH 1991—1995

Graduate Research Fellowship Review Panel (Biology)
National Science Foundation 1999—2001

Peer Review Committee A
National Multiple Sclerosis Society 2000—2006

Scientific Advisory Board,
Terripin Technologies 1987—1992

Scientific Advisory Board,
Telik, inc 1993—2003

Scientific Advisory Committee Synbiotics Corp.
Synbiotics Corp. 1986—1989

Scientific Advisory Committee Synbiotics Corp.
Synbiotics Corp. 1986—1989

Editor in Chief, Microbiology and Molecular Biology Reviews
American Society for Microbiology Press 2015—2020

Graduate Programs Cellular and Molecular Biosciences

Virology

Immunology and Pathogenesis

   
Research Centers Center for Virus Research
   
Pacific Southwest Regional Center for Biodefense and Emerging Diseases
   
Institute for Immunology
   
Multiple Sclerosis Research Center
   
California Center for Antiviral Drug Discovery
   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=5519
   
Last updated 01/12/2017