Young Jik KwonAssistant Professor, Pharmaceutical Sciences Assistant Professor, Chemical Engineering & Materials Science Assistant Professor, Biomedical Engineering |
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Research Interests |
Gene therapy, drug delivery, cancer-targeted therapeutics, combined molecular imaging and therapy, nanobiotechnology, tissue engineering | |
| URL | BioTherapeutics Engineering Laboratory (BioTEL) | |
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Academic Distinctions |
M. Frank and Margaret Domiter Rudy Assistant Professor of Biomedical Engineering in Cancer Research, Case Western Reserve University (2006-2007) Faculty Career Development Award, UC Irvine (2008) |
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| Appointments |
Postdoc, Chemistry, UC Berkeley (2003-2005) Assistant Professor, Biomedical Engineering, Case Western Reserve University (2005-2007) |
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| Publications | Min Suk Shim, Young Jik Kwon*. Acid-transforming polypeptide micelles as efficient, biocompatible, and versatile nonviral gene carriers. Submitted. | |
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Yoon Kyung Kim, Young JIk Kwon. Isolation of intact proteins from acid-degradable polyacrylamide gel. Proteomics 9, 3765-3771 (2009). Chang Soo Kim, Petra Wilder-Smith, Yeh-Chan Ahn, Lih-Huei Liaw, Zhongping Chen, Young Jik Kwon. Enhanced detection of early stage oral cancer in vivo by optical coherence tomography using multi-modal delivery of gold nanoparticles. Journal of Biomedical Optics 14, 034008 (2009) Min Suk Shim, Young Jik Kwon. Acid-responsive linear polyethylenimine for efficient, specific, and biocompatible siRNA delivery. Bioconjugate Chemistry 20, 488-499 (2009) Min Suk Shim, Young Jik Kwon. Controlled cytoplasmic and nuclear localization of plasmid DNA dnd siRNA by differentially tailored polyethylenimine. Journal of Controlled Release 133, 206-213 (2009) Young Jik Kwon, Ching-An Peng. Differential interaction of retroviral vector with target cell: Quantitative effect of cellular receptor, soluble proteoglycan, and cell type on gene delivery efficiency. Tissue Engineering 14, 1497-1506 (2008) In Kap Ko, Assem Ziady, Shiwei Lu, Young Jik Kwon. Acid-degradable cationic methacrylamide polymerized in the presence of plasmid DNA as tunable non-viral gene carrier. Biomaterials 29, 3872-3881 (2008). Min Suk Shim, Young Jik Kwon. Controlled delivery of plasmid DNA and siRNA to intracellular targets using ketalized polyethylenimine. Biomacromolecules, 9, 444-455 (2008) Stephany M. Standley, Ines Mende, Sarah L. Goh, Young Jik Kwon, Tristan Beaudette, Edgar G. Engleman, Jean M. J. Fréchet. Incorporation of CpG oligonucleotide ligand into protein-loaded particle vaccines promotes antigen-specific CD8 T cell immunity. Bioconjugate Chemistry, 18, 77-83 (2007) Young Jik Kwon, Edward James, Nilabh Shastri, Jean M. J. Fréchet. In vivo targeting of dendritic cells for activation of cellular immunity using vaccine carriers based on pH-responsive microparticles. Proceedings of the National Academy of Sciences in USA, 102, 18264-18268 (2005) Young Jik Kwon, Stephany M. Standley, Sara L. Goh, Jean M. J. Fréchet. Enhanced antigen presentation and immunostimulation of dendritic cells using acid-degradable cationic nanoparticles. Journal of Controlled Release, 105, 199-212 (2005) Young Jik Kwon, Ching-An Peng. High-yield retroviral production using temperature modulated two-stage operation. Biotechnology and Bioengineering 90, 365-372 (2005) Young Jik Kwon, Stephany M. Standley, Andrew P. Goodwin, Elizabeth R. Gillies, Jean M. J. Fréchet. Directed antigen presentation using polymeric microparticulate carriers degradable at lysosomal pH for controlled immune responses. Molecular Pharmaceutics 2, 83-91 (2005) Stephany M. Standley, Young Jik Kwon, Niren Murthy, Jun Kunisawa, Nilabh Shastri, Jean M. J. Fréchet. Acid-Degradable Particles for protein-based vaccines: Enhanced survival rate for tumor-challenged mice using ovalbumin model. Bioconjugate Chemistry 15, 1281-1288 (2004) Young Jik Kwon, Gene Hung, W. French Anderson, Ching-An Peng, Hong Yu. Determination of Infectious retrovirus concentration from colony-forming assay with quantitative analysis. Journal of Virology 77, 5712-5720 (2003) Young Jik Kwon, Ching-An Peng. Evaluation of retroviral production systems using quantitative analysis. Biotechnology Progress 19, 528-537 (2003) Young Jik Kwon, Ching-An Peng. Calcium-alginate gel bead crosslinked with gelatin as potential microcarrier for anchorage-dependent cell culture. BioTechniques 33, 212-218 (2002) (Selected as a BioSpotlight of the issue) Young Jik Kwon, Ching-An Peng. Engineering analysis of ex vivo retroviral transduction systems. Annals of Biomedical Engineering 30, 731-742 (2002) Young Jik Kwon, Ching-An Peng. Transduction rate constant as more reliable index quantifying efficiency of retroviral gene delivery. Biotechnology and Bioengineering 77, 668-677 (2002) Young Jik Kwon, Ching-An Peng. Impact of cell growth morphology on retroviral transduction: Effect of contact inhibition. Biotechnology Progress 17, 240-246 (2001) Young Jik Kwon, Hong Yu, Ching-An Peng. Enhanced retroviral transduction of 293 cells cultured on liquid-liquid interface. Biotechnology and Bioengineering 72, 331-338 (2001) |
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Professional Societies |
American Chemical Society Amecian Institute of Chemical Engineers American Society for Gene Therapy Controlled Release Society |
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| Graduate Programs |
Chemical Engineering Biomedical Engineering Medicinal Chemistry and Pharmacology |
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| Research Centers | Translational Oncology Program, The Chao Family Comprehensive Cancer Center | |
| Center for Immunology | ||
| Link to this profile | http://www.faculty.uci.edu/profile.cfm?faculty_id=5498 | |
| Last updated | 07/31/2009 | |