Young Jik Kwon

Professor, Pharmaceutical Sciences

Professor (Joint), Chemical Engineering & Materials Science

Professor (Joint), Biomedical Engineering

Professor (Joint), Molecular Biology and Biochemistry

Ph.D., University of Southern California, 2003, Chemical Engineering

M.S., University of Southern California, 2000, Chemical Engineering

B.S., Inha University, South Korea, 1998, Biological Engineering

Phone: (949) 824-8714

University of California, Irvine
132 Sprague Hall
Mail Code: 3905
Irvine, CA 92697

picture of Young Jik  Kwon

Gene therapy, drug delivery, cancer-targeted therapeutics, combined molecular imaging and therapy, cancer vaccine
URL BioTherapeutics Engineering Laboratory (BioTEL)
Brain Pool scholar and visiting professor, Chemical and Biomolecular Engineering, Korea University, Korea (2015 – 2016)

Special visiting research fellow (Science without Borders Scholar), College of Pharmacy, Federal University of Minas Gerais, Brazil (2015 – 2017)

Top downloaded article award in 2014, Journal of Materials Chemistry, Royal Society of Chemistry Publishing (2015)

Top-cited article award, FEBS Journal, Wiley (2013)

Medical Research Award, Gabrielle's Angel Foundation for Cancer Research (2011)

Faculty Early Career Development (CAREER) Award, National Science Foundation (2010)

Faculty Career Development Award, UC Irvine (2008)

M. Frank and Margaret Domiter Rudy Assistant Professor of Biomedical Engineering in Cancer Research, Case Western Reserve University (2006-2007)
Appointments Postdoc, Chemistry, UC Berkeley (2003-2005)
Available Technologies
Publications Since joined UCI:

Soo Kyung Cho, Chris Dang, Xi Wang, Regina Ragan, Young Jik Kwon.* Mixing-sequence-dependent nucleic acid complexation and gene transfer efficiency by polyethylenimine. Biomaterials Science 3, 1124-1133 (2015).

Shirley Wong, Young Jik Kwon.* Facile synthesis of high-molecular-weight acid-labile polypeptides using urethane derivatives. Journal of Polymer Science A: Polymer Chemistry 53, 280-286 (2015).

Genesis Zamora, Frederick Wang, Chung-Ho Sun, Anthony Trinidad, Young Jik Kwon, Soo Kyung Cho, Kristian Berg, Steen Madsen, Henry Hirschberg*. Photochemical internalization mediated nonviral gene transfection: polyamine core-shell nanoparticles as gene carrier. Journal of Biomedical Optics 19, 105009 (2014).

Julius Edson, Young Jik Kwon*. RNAi for silencing drug resistance in microbes toward development of nanoantibiotics. Journal of Controlled Release 189, 150-157 (2014).

Frederick Wang,* Genesis Zamora, Chung-Ho Sun, Anthony Trinidad, Changho Chun, Young Jik Kwon, Kristian Berg, Steen J. Madsen, Henry Hirschberg. Increased sensitivity of glioma cells to 5-fluorocytosine following photo-chemical internalization enhanced nonviral transfection of the cytosine deaminase suicide gene. Journal of Neurooncology 118, 29-37 (2014).

Shirley Wong, Min Suk Shim, Young Jik Kwon*. Synthetically designed peptide-based biomaterials with stimuli-responsive and membrane-active properties for biomedical applications. Journal of Materials Chemistry B 2, 595-615 (2014).

Min Suk Shim, Seong-Sil Chang, Young Jik Kwon*. Efficient gene silencing in tumor via systemic delivery of stimuli-responsive siRNA carriers. Biomaterials Science 2, 35-40 (2014).

Soo Kyung Cho, Ali Pedram, Ellis R. Levin*, Young Jik Kwon*. Acid-degradable core-shell nanoparticles for reversed tamoxifen-resistance in breast cancer by silencing manganese superoxide dismutase (MnSOD). Biomaterials 34, 10228-10237(2013).

Chang Soo Kim, Wenjuan Qi, Jun Zhang, Young Jik Kwon*, Zhongping Chen*. Imaging and quantifying Brownian motion of micro- and nanoparticles using phase resolved Doppler variance optical coherence tomography. Journal of Biomedical Optics 18, 030504 (2013).

Min Sun Song, Seung Phill Choi, Young Jik Kwon, Sang Jun Sim*. Real time, sensitive, and specific detection of promoter-polymerase interactions in gene transcription using a nanoplasmonic sensor. Advanced Materials 25, 1265-1269 (2013) (Cover article).

Soo Kyung Cho, Young Jik Kwon*.Synthetically engineered viruses: Can synthetic chemistry tame the nature? Current Opinion in Solid State & Materials Science 16, 276-286 (2012) (Invited review).

Marlon Mathews*, En-Chung Shih, Genesis Zamora, Chung-Ho Sun, Soo Kyung Cho, Young Jik Kwon, Henry Hirschberg. Glioma cell growth inhibition following photochemical internalization enhanced PTEN gene transfection. Lasers in Surgery and Medicine 44, 746-754 (2012) (Best Young Investigator Research Award by the journal for 2012).

Min Suk Shim, Young Jik Kwon*. Ketalized poly(amino ester) for stimuli-responsive and biocompatible gene delivery. Polymer Chemistry 3, 2570-2577 (2012).

Suk Shim, Shirley Wong, Young Jik Kwon*. siRNA as a conventional drug in the clinic? Challenges and Current Technologies. Drug Discovery Today Technologies 9, 167-173 (2012) (Invited review).

Suk Shim, Young Jik Kwon*. Stimuli-responsive gene delivery and combined imaging. Advanced Drug Delivery Reviews 64, 1046-1059 (2012) (Invited review).

Young Jik Kwon*. Before and after endosomal escape: Roles of stimuli-converting siRNA/polymer interactions in determining gene silencing efficiency. Accounts of Chemical Research 45, 1077-1088 (2012) (Invited review) (Ranked to be #1 article in siRNA delivery published in 2012; BioMedLb,

Soo Kyung Cho, Young Jik Kwon*. Simultaneous gene transduction and silencing using stimuli-responsive viral/nonviral chimeric nanoparticles. Biomaterials 33, 3316-3323 (2012).

Ae Jung Huh, Young Jik Kwon*. Nanoantibiotics: A new paradigm for treating infectious diseases using nanomaterials in the antibiotics resistant era. Journal of Controlled Release 156, 128-145 (2011).

Soo Kyung Cho, Young Jik Kwon*. Polyamine/DNA polyplexes with acid-degradable polymeric shell as structurally and functionally virus-mimicking nonviral vectors. Journal of Controlled Release 150, 287-297 (2011).

Min Suk Shim, Young Jik Kwon*. Dual mode-degradable polyspermine for plasmid DNA and siRNA delivery in vitro and in vivo: Effects of acid-degradability. Biomaterials 32, 4009-4020 (2011).

Shirley Wong, Young Jik Kwon*. Synthetically functionalized retroviruses produced from the bioorthogonally engineered cell surface. Bioconjugate Chemistry 22, 151-155 (2011).

Min Suk Shim, Young Jik Kwon*. Efficient and targeted delivery of siRNA in vivo. FEBS Journal 277, 4814-4827 (2010)

Min Suk Shim, Xi Wang, Regina Ragan, Young Jik Kwon*. Dynamics of nucleic acid/cationic polymer complexation and disassembly under biologically simulated conditions using in situ atomic force microscopy. Microscopy Research and Technique 73, 845-856 (2010).

Chang Soo Kim, Yeh-Chan Ahn, Petra Wilder-Smith, Seajin Oh, Zhongping Chen*, Young Jik Kwon*. Efficient and facile delivery of gold nanoparticles in vivo using dissolvable microneedles for contrast-enhanced optical coherenece tomography. Biomedical Optics Express 1, 106-113 (2010).

Min Suk Shim, Chang Soo Kim, Yeh-Chan Ahn, Zhongping Chen, Young Jik Kwon*. Combined multi-modal optical imaging and targeted gene silencing using stimuli-transforming nanotheragnostics. Journal of the American Chemical Society 132, 8316-8324 (2010).

Yoon Kyung Kim, Young Jik Kwon*. Separation and recovery of nucleic acids with improved biological activity by acid-degradable polyacrylamide gel electrophoresis. Electrophoresis 31, 1656-1661 (2010).

Min Suk Shim, Young Jik Kwon*. Acid-transforming polypeptide micelles as efficient, biocompatible, and versatile nonviral gene carriers. Biomaterials 31, 3404-3413 (2010).

Yoon Kyung Kim, Young Jik Kwon*. Isolation of intact proteins from acid-degradable polyacrylamide gel. Proteomics 9, 3765-3771 (2009) (Highlighted article by the editor).

Chang Soo Kim, Petra Wilder-Smith, Yeh-Chan Ahn, Lih-Huei Liaw, Zhongping Chen*, Young Jik Kwon*. Enhanced detection of early stage oral cancer in vivo by optical coherence tomography using multi-modal delivery of gold nanoparticles. Journal of Biomedical Optics 14, 034008 (2009).

Min Suk Shim, Young Jik Kwon*. Acid-responsive linear polyethylenimine for efficient, specific, and biocompatible siRNA delivery. Bioconjugate Chemistry 20, 488-499 (2009).

Min Suk Shim, Young Jik Kwon*. Controlled cytoplasmic and nuclear localization of plasmid DNA and siRNA by differentially tailored polyethylenimine. Journal of Controlled Release 133, 206-213 (2009).

In Kap Ko, Assem Ziady, Shwei Lu, Young Jik Kwon*. Acid-degradable cationic methacrylamide polymerized in the presence of plasmid DNA as tunable non-viral gene carrier. Biomaterials 29, 3872-3881 (2008).

Min Suk Shim, Young Jik Kwon*. Controlled delivery of plasmid DNA and siRNA to intracellular targets using ketalized polyethylenimine. Biomacromolecules 9, 444-455 (2008). (The 2nd most accessed article from Biomacromolecules for the first quarter of 2008 by the American Chemical Society).

For a complete list check the lab webpage listed above.
American Chemical Society
Amecian Institute of Chemical Engineers
American Society for Gene and Cell Therapy
Controlled Release Society
Graduate Programs Chemical Engineering

Medicinal Chemistry and Pharmacology

Biomedical Engineering

Cellular and Molecular Biosciences

Research Centers Onco-Imaging and Biotechnology Program, The Chao Family Comprehensive Cancer Center
Institute for Immunology
Center for Virus Research
Link to this profile
Last updated 09/20/2015