Young Jik Kwon
Associate Professor, Pharmaceutical Sciences
Associate Professor (Joint), Chemical Engineering & Materials Science
Associate Professor (Joint), Biomedical Engineering
Associate Professor (Joint), Molecular Biology and Biochemistry
|Gene therapy, drug delivery, cancer-targeted therapeutics, combined molecular imaging and therapy, cancer vaccine|
|URL||BioTherapeutics Engineering Laboratory (BioTEL)|
Medical Research Award, Gabrielle's Angel Foundation for Cancer Research (2011)
Faculty Early Career Development (CAREER) Award, National Science Foundation (2010)
Faculty Career Development Award, UC Irvine (2008)
M. Frank and Margaret Domiter Rudy Assistant Professor of Biomedical Engineering in Cancer Research, Case Western Reserve University (2006-2007)
Assistant Professor, Biomedical Engineering, Case Western Reserve University (2005-2007)
Postdoc, Chemistry, UC Berkeley (2003-2005)
Since joined UCI:
Min Suk Shim, Young Jik Kwon*. Stimuli-responsive polymers and nanomaterials for gene delivery and imaging applications. Advanced Drug Delivery Reviews (2012) (in press).
Min Suk Shim, Shirley Wong, Young Jik Kwon*. siRNA as a conventional drug in the clinic? Challenges and Current Technologies. Drug Discovery Today Technologies (2012) (in press).
Young Jik Kwon*. Before and after endosomal escape: Roles of stimuli-converting siRNA/polymer interactions in determining gene silencing efficiency. Accounts of Chemical Research (2012) (in press).
Soo Kyung Cho, Young Jik Kwon*. Simultaneous gene transduction and silencing using stimuli-responsive viral/nonviral chimeric nanoparticles. Biomaterials 33, 3316-3323 (2012).
Ae Jung Huh, Young Jik Kwon*. Nanoantibiotics: A new paradigm for treating infectious diseases using nanomaterials in the antibiotics resistant era. Journal of Controlled Release 156, 128-145 (2011).
Soo Kyung Cho, Young Jik Kwon*. Polyamine/DNA polyplexes with acid-degradable polymeric shell as structurally and functionally virus-mimicking nonviral vectors. Journal of Controlled Release 150, 287-297 (2011).
Min Suk Shim, Young Jik Kwon*. Dual mode-degradable polyspermine for plasmid DNA and siRNA delivery in vitro and in vivo: Effects of acid-degradability. Biomaterials 32, 4009-4020 (2011).
Shirley Wong, Young Jik Kwon*. Synthetically functionalized retroviruses produced from the bioorthogonally engineered cell surface. Bioconjugate Chemistry 22, 151-155 (2011).
Min Suk Shim, Young Jik Kwon*. Efficient and targeted delivery of siRNA in vivo. FEBS Journal 277, 4814-4827 (2010)
Min Suk Shim, Xi Wang, Regina Ragan, Young Jik Kwon*. Dynamics of nucleic acid/cationic polymer complexation and disassembly under biologically simulated conditions using in situ atomic force microscopy. Microscopy Research and Technique 73, 845-856 (2010).
Chang Soo Kim, Yeh-Chan Ahn, Petra Wilder-Smith, Seajin Oh, Zhongping Chen*, Young Jik Kwon*. Efficient and facile delivery of gold nanoparticles in vivo using dissolvable microneedles for contrast-enhanced optical coherenece tomography. Biomedical Optics Express 1, 106-113 (2010).
Min Suk Shim, Chang Soo Kim, Yeh-Chan Ahn, Zhongping Chen, Young Jik Kwon*. Combined multi-modal optical imaging and targeted gene silencing using stimuli-transforming nanotheragnostics. Journal of the American Chemical Society 132, 8316-8324 (2010).
Yoon Kyung Kim, Young Jik Kwon*. Separation and recovery of nucleic acids with improved biological activity by acid-degradable polyacrylamide gel electrophoresis. Electrophoresis 31, 1656-1661 (2010).
Min Suk Shim, Young Jik Kwon*. Acid-transforming polypeptide micelles as efficient, biocompatible, and versatile nonviral gene carriers. Biomaterials 31, 3404-3413 (2010).
Yoon Kyung Kim, Young Jik Kwon*. Isolation of intact proteins from acid-degradable polyacrylamide gel. Proteomics 9, 3765-3771 (2009) (Highlighted article by the editor).
Chang Soo Kim, Petra Wilder-Smith, Yeh-Chan Ahn, Lih-Huei Liaw, Zhongping Chen*, Young Jik Kwon*. Enhanced detection of early stage oral cancer in vivo by optical coherence tomography using multi-modal delivery of gold nanoparticles. Journal of Biomedical Optics 14, 034008 (2009).
Min Suk Shim, Young Jik Kwon*. Acid-responsive linear polyethylenimine for efficient, specific, and biocompatible siRNA delivery. Bioconjugate Chemistry 20, 488-499 (2009).
Min Suk Shim, Young Jik Kwon*. Controlled cytoplasmic and nuclear localization of plasmid DNA and siRNA by differentially tailored polyethylenimine. Journal of Controlled Release 133, 206-213 (2009).
In Kap Ko, Assem Ziady, Shwei Lu, Young Jik Kwon*. Acid-degradable cationic methacrylamide polymerized in the presence of plasmid DNA as tunable non-viral gene carrier. Biomaterials 29, 3872-3881 (2008).
Min Suk Shim, Young Jik Kwon*. Controlled delivery of plasmid DNA and siRNA to intracellular targets using ketalized polyethylenimine. Biomacromolecules 9, 444-455 (2008). (The 2nd most accessed article from Biomacromolecules for the first quarter of 2008 by the American Chemical Society).
For a complete list check the lab webpage listed above.
American Chemical Society
Amecian Institute of Chemical Engineers
American Society for Gene and Cell Therapy
Controlled Release Society
Medicinal Chemistry and Pharmacology
Cellular and Molecular Biosciences
|Research Centers||Onco-Imaging and Biotechnology Program, The Chao Family Comprehensive Cancer Center|
|Institute for Immunology|
|Center for Virus Research|
|Link to this profile||http://www.faculty.uci.edu/profile.cfm?faculty_id=5498|