Associate Project Scientist, Epidemiology
School of Medicine

Cancer epidemiology, genetic epidemiology, age-related disparities

Dept. of Epidemiology - School of Medicine

My research interests are within the area of cancer epidemiology. Specifically, I am interested in the impact of young age on disease characteristics and prognosis. When people are diagnosed with cancer at a young age the course of disease tends to be different than it is for people diagnosed in later years. Hormonal exposures vary by age and may be influencing the progression and prognosis of some cancers in young people. The proportion of disease attributed to genetic factors also differs by age. Furthermore, some issues faced by young cancer survivors including fertility, effects on family and young children of cancer patients, and quality of life are unique. My research goals are to gain a better understanding of age-related disparities and the role of hormonal, genetic and other risk factors in cancer development and survival in young people, so that targeted interventions may be developed to reduce morbidity and improve the quality of life among young cancer patients.

Knight JA, Bernstein L, Largent J, Capanu M, Begg C, Mellemkjær L, Lynch CF, Malone KE, Reiner AS, Liang X, Haile RW, Boice Jr. JD, WECARE Study Collaborative Group, Bernstein JL. Alcohol intake and cigarette smoking and risk of a contralateral breast cancer in the Women's Environmental Cancer and Radiation Epidemiology Study. American Journal of Epidemiology 2009 Apr 15;169(8):962-8.

Templeman C, Marshall SF, Clarke CA, Delellis Henderson K, Largent J, Neuhausen S, Reynolds P, Ursin G, Bernstein L. Risk factors for surgically removed fibroids in a large cohort of teachers. Fertil Steril. 2008 Nov 17. [Epub ahead of print]

Largent JA, Capanu M, Bernstein L, Langholz B, Mellemkjær L, Malone KE, Begg C, Haile RW, Anton-Culver H, Lynch CF, Thomas D, Wolitzer A, Bernstein JL. Reproductive history and risk of second primary breast cancer: the WECARE Study. Cancer Epidemiology, Biomarkers & Prevention, 16: 906-911, 2007.

McEligot AJ, Largent J, Ziogas A, Peel D, Anton-Culver H. Dietary fat, fiber, vegetable, and micronutrients are associated with overall survival in postmenopausal women diagnosed with breast cancer. Nutrition and Cancer, 55(2), 132-140, 2006.

Largent JA, McEligot AJ, Ziogas A, Reid C, Hess J, Leighton N, Peel D, Anton-Culver H. Hypertension, diuretics and breast cancer risk. Journal of Human Hypertension, advance online publication, 3 Aug 2006.

Brewster WR, Hubbell A, Largent J, Ziogas A, Lin F, Howe S, Ganiats TG, Anton-Culver H, Manetta A. Feasibility of management of high-grade cervical lesions in a single visit: a randomized controlled trial. JAMA, 294(17), 2005.

Largent J, Ziogas A, Anton-Culver H. Effect of reproductive factors on stage, grade, and hormone receptor status in early onset breast cancer Breast Cancer Research 2005, 7:R541-R554

Chang KJ, Parasher G, Christie C, Largent J, Anton-Culver H. Risk of pancreatic adenocarcinoma: Disparity between African-Americans and other race/ethnic groups. Cancer, Jan 15;103(2):349-57, 2005.

McEligot AJ, Wenzel L, Largent J, Ziogas A, Anton-Culver H. Factors associated with complementary and alternative medicine (CAM) use among breast cancer patients with and without a family history of breast or ovarian cancer. Journal of Cancer Integrative Medicine. 2004, 2:31 - 37.

Brewster WR, Anton-Culver H, Ziogas A, Largent J, Howe S, Hubbell FA, Manetta A. Recruitment strategies for cervical cancer prevention study. Gynecological Oncology, May;85(2):250-4, 2002.

Semenza JC, Ziogas A, Largent J, Peel D, and Anton-Culver H. Gene-environment interactions in renal cell carcinoma. American Journal of Epidemiology, 153(9):851-9, 2001.

Society for Epidemiologic Research

Epidemiology

Link to this profile
https://faculty.uci.edu/profile/?facultyId=5485

Last updated
04/09/2009