Todd C. Holmes

Professor, Vice-Chair, Physiology & Biophysics
School of Medicine

Ph.D., Massachusetts Institute of Technology, 1994, Neurobiology

Phone: (949) 824-0006

University of California, Irvine
D340 Medical Science I
Department of Physiology and Biophysics
Mail Code: 4560
Irvine, CA 92697

picture of Todd C. Holmes

ion channels, cellular physiology, neural circuits and behavior; circadian and visual circuits
Whitehead Faculty Fellowship (1999), NSF CAREER Award (2001)
My laboratory has developed pioneering approaches for understanding neural circuits and whole animal behavior. We focus on unraveling the functional operations of neurons in vivo with the goal of understanding integrative neural function from molecules to behavior. Recently, we have discovered a novel phototransduction mechanism that occurs directly in neurons that rapidly modulates electrical excitability. Other recent projects include modeling human neurodegenerative diseases using Drosophila as a model system.
Available Technologies
Publications Fogle, K.J., Parson, K.G. and Holmes. T.C., (2011) Cryptochrome is a blue light sensor that rapidly regulates neuronal firing rate. Science. 331:1409-1413, published online March 3, 2011 (see also Perspective, Im, S.H. and Taghert, P.H., Science, 331:1394-1395.)
  Sheeba, V., Fogle, K.J., and Holmes. T.C., (2010) Persistence of morning Anticipation Behavior and High Amplitude Morning Startle Response Following Functional Loss of Small Ventral Lateral Neurons. PLoS One, 5:e11628.

Sheeba, V., Fogle, K.J., Kaneko, M., Rashid, S., Chou, Y.T., Sharma, V.K., and Holmes. T.C., (2008) Large ventral lateral neurons modulate arousal and sleep in Drosophila. Current Biology, 18:1537-1545., published online September 4, 2008.

Sheeba, V., Sharma, V.K., Gu, H., Chou, Y.T., O’Dowd, D.K., and Holmes, T.C. (2008) Pigment Dispersing Factor-Dependent and -Independent Circadian Locomotor Behavioral Bouts. J.Neuroscience, 28:217-227.

Sheeba, V., Gu, H., Sharma, V.K., O’Dowd, D.K., and Holmes, T.C. (2008) Circadian- and light-dependent regulation of resting membrane potential and spontaneous action potential firing of Drosophila melanogaster large ventral lateral circadian pacemaker neurons. J. Neurophysiology, 99:976-988, published Online, December 12, 2007.

Nitabach, M.N., Wu, Y., Sheeba, V., Lemon, W., Strumbos, J., Zelensky, P., White, B.H., and Holmes, T.C. (2006) Electrical hyperexcitation of lateral ventral pacemaker neurons desynchronizes downstream circadian oscillators in the fly circadian circuit and induces multiple behavioral periods. J. Neuroscience, 26: 479-489.

Nitabach, M.N., Blau, J. and Holmes, T.C. (2002) Electrical silencing of central pacemaker neurons stops the central molecular clock. Cell 109:485-495 (see also van den Pol and Obrietan, Nature Neuroscience, 5: 616-618, News and Views).

Holmes, T.C., de Lacalle, S., Su, X., Liu, G., Rich, A. and Zhang, S. (2000) Extensive neurite outgrowth and active synapse formation on transportable self-complimentary oligopeptide matrices. Proc. Natl. Acad. Sci. USA 97:6728-6733 (see also Schachner, M. 2000, Nature, 405: 747-748, News and Views).

Holmes, T.C., Fadool, D.A., Ren, R. and Levitan, I.B. (1996) Direct association of Src tyrosine kinase with the human Kv1.5 potassium channel mediated by src homology 3 domain. Science 274:2089-2091.
Grant Grants from the NIH and NSF
Society for Neuroscience
Graduate Programs Cellular and Molecular Biosciences

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Last updated 10/25/2011