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Paolo Sassone-Corsi

Director, Center for Epigenetics and Metabolism (joint with BioSci)
School of Medicine

Donald Bren Professor, Biological Chemistry
School of Medicine

Joint Appointment, Microbiology & Molecular Genetics
School of Medicine

Joint Appointment, Pharmaceutical Sciences
College of Health Sciences

Ph.D., University of Naples, Italy, 1979

Phone: (949) 824-4540
Fax: (949) 824-2078
Email: psc@uci.edu

University of California, Irvine
Department of Biological Chemistry
324 Sprague Hall
Mail Code: 1700
Irvine, CA 92697

picture of Paolo  Sassone-Corsi

Research
Interests
signal transduction, gene expression, oncogenesis, circadian clock
   
URLs Biological Chemistry Home Page
   
See below for selected publications or click here for additional publication listings available via PubMed
   
Academic
Distinctions
1977 - Philips European Award for Young Investigators

1990 - Member of the European Molecular Biology Organization

1994 - EMBO Gold Medal

1996 - Rosen Prize (Fondation de la Recherche Médicale), France

1997 - Grand Prix Liliane Bettencourt pour la Recherche, France

2001 - Segerfalk Award Lecture, Lund University, Sweden

2003 - Grand Prix Charles-Léopold Mayer de l’Académie des Sciences, Paris

2003 - ISI Highly Cited

2004 - Edwin B. Astwood Award Lecture of The Endocrine Society, USA

2004 - The Umesono Memorial Award Lecture, The Salk Institute, San Diego, USA.

2004 - CNRS Silver Medal, Paris

2010 - Athalie Clarke Achievement Award from the Research Associates, a community-based support group for the University of California, Irvine, School of Medicine

2010 - Appointed Donald Bren Professor, established to support outstanding faculty members and to enhance scholarship, research and creative achievement

2011 - Roy O. Greep Award Lecture for outstanding contributions to research in endocrinology

April 2011 - The 2012 Transatlantic Medal, The Society of Endocrinology, for significant contributions to the discipline and to promote connections between endocrinology in the United Kingdom and North America.

June 2011 - Selected as an external member of the Max Planck Society, one of the world's most prestigious scientific groups.
   
Research
Abstract
Dr. Sassone-Corsi's major interest is concentrated on the mechanisms of signal transduction able to modulate nuclear functions and, in particular gene expression, chromatin remodeling and epigenetic control. These events have important consequences for the understanding of cellular proliferation, oncogenesis and differentiation. The stimulation of intracellular pathways and the activation of specific protein kinases lead to transcriptional regulation by changes in the phosphorylation state of nuclear factors. These act as final targets of different pathways and modulate expression from specific regulatory sites. The strength of these studies is particularly evident within physiological settings which have been investigated by this lab, the molecular control of circadian rhythms and the differentiation of male germ cells.
   
Publications Relevant Publications:

Whitmore, D., Foulkes, N. S., Strähle, U. and Sassone-Corsi, P. (1998) Zebrafish Clock rhythmic expression reveals independent peripheral circadian oscillators. Nature Neurosci. 1, 701-708 .

Fimia, G. M., De Cesare, D. and Sassone-Corsi, P. (1999) CBP-independent activation of CREM and CREB by the LIM-only protein ACT. Nature 398, 165-169.

Sassone-Corsi, P., Mizzen, C. A., Cheung, P., Crosio, C., Monaco, L., Jacquot, S., Hanauer, A. and Allis, C. D. (1999) Requirement of Rsk-2 for Epidermal Growth Factor-activated phosphorylation of Histone H3. Science 285, 886-891.

Whitmore, D., Foulkes, N. S. and Sassone-Corsi, P. (2000) Light acts directly on organ cells in culture to set the vertebrate circadian clock. Nature 404, 87-91

Cheung, P., Allis, C. D. and Sassone-Corsi, P. (2000) Signaling to chromatin through histone modifications. Cell 103, 263-271.

Crosio, C., Cermakian, N., Allis, D. C. and Sassone-Corsi, P. (2000) Light induces chromatin modification in cells of the mammalian circadian clock. Nature Neurosci. 3, 1241-1247

Sassone-Corsi, P. (2002) Unique chromatin remodeling and transcriptional regulation in spermatogenesis. Science 296, 2176-2178.

Pando, M. P., Morse, D., Cermakian, N. and Sassone-Corsi, P. (2002) Phenotypic Rescue of a Peripheral Clock Genetic Defect via SCN Hierarchical Dominance. Cell 110, 107-117.

Macho, B., Brancorsini, S., Fimia, G. M., Setou, M., Hirokawa, N. and Sassone-Corsi, P. (2002) CREM-Dependent Transcription in Male Germ Cells Controlled by a Kinesin. Science 298, 2388-2390.

Yanagimachi, R., Wakayama, T., Kishikawa, H., Fimia, G. M., Monaco, L. and Sassone-Corsi, P. (2004) Production of fertile offspring from genetically infertile mice. Proc. Natl. Acad. Sci. USA 101, 1691-1695.

Kimmins, S. and Sassone-Corsi, P. (2005) Chromatin remodeling and epigenetic features of germ cells. Nature 434, 583-589.

Hirayama, J., Cardone, L., Doi, M. and Sassone-Corsi, P. (2005) Common Pathways in Circadian and Cell Cycle Clocks: Light-dependent Activation of Fos/AP-1 in Zebrafish Controls CRY-1a and WEE-1. Proc. Natl. Acad. Sci. USA 102, 10194-10199.

Cardone, L., Hirayama, J., Giordano, F., Tamaru, T., Palvimo, J. J. and Sassone-Corsi, P. (2005) Circadian clock control by SUMOylation of BMAL1. Science 309, 1390-1394.

Monaco, L., Kolthur-Seetharam, U., Loury, R., Ménissier-de Murcia, J., de Murcia, G. and Sassone-Corsi, P. (2005) Inhibition of Aurora-B kinase activity by poly(ADP-ribosyl)ation in response to DNA damage. Proc. Natl. Acad. Sci. USA 102, 14244-14248.

Doi, M., Hirayama, J. and Sassone-Corsi, P. (2006) Circadian regulator CLOCK is a Histone Acetyltransferase. Cell 125, 497-508.

Hirayama, J., Sahar, S., Grimaldi, B., Tamaru, T., Takamatsu, K., Nakahata, Y. and Sassone-Corsi, P. (2007) CLOCK-mediated acetylation of BMAL1 controls circadian function. Nature 450, 1086-1090.

Nakahata, Y., Kaluzova, M., Grimaldi, B., Sahar, S., Hirayama, J., Chen , D., Guarente, L.P. and Sassone-Corsi, P. (2008) The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell 134, 329-340

Borrelli, E., Nestler, E. J., Allis, C. D. and Sassone-Corsi, P. (2008) Decoding the Epigenetic Language of Neuronal Plasticity. Neuron 60, 961-974.

Nakahata, Y., Sahar, S., Astarita, G., Kaluzova, M. and Sassone-Corsi, P. (2009) Circadian control of the NAD+-salvage pathway by CLOCK-SIRT1. Science 324, 654-657.

Eckel-Mahan, K. and Sassone-Corsi, P. (2009) Metabolism control of the circadian clock and vice versa. Nature Struct. Mol. Biol. 16, 462-467.

Tamaru, T., Hirayama, J., Isojima, Y., Nagai, K., Norioka, S.,Takamatsu, K. and Sassone-Corsi, P. (2009) CK2a phosphorylates BMAL1 to regulate the mammalian clock. Nature Struct. Mol. Biol. 16, 446-448.

Sahar, S. and Sassone-Corsi, P. (2009) The intriguing links between the circadian clock, metabolism and cancer. Nature Rev. Cancer (in press)
   
Grants National Institute of General Medical Sciences (NIGMS) R01 GM081634, 08/01/07-07/31/12, $1,054,346 direct costs, Chromatin remodeling and circadian clock control (Role: P.I.).
   
Angelini Pharmaceuticals, Inc., ANG-48184, 09/01/09-06/30/10 and 01/01/11-09/30/11, $84,314 and $71,895 direct costs, Molecular details of mechanisms of action of Bindarit and other Angelini MCP-1 inhibitors (Role: P.I.).
   
Institut National de la Santé et de la Recherche Médicale (INSERM) INSERM-44790, 01/01/08-12/31/11, $602,056 direct costs, Epigenetic control of neuronal plasticity (Role: Co-Director of UCI-INSERM Research Unit. Director: Dr. Emiliana Borrelli).
   
National Institute of Diabetes & Digestive Kidney Diseases (NIDDK) F32 DK083881, 05/01/10-04/30/12, $98,080 direct costs, CLOCK regulation of liver metabolism via modulation of HNF-4a (Role: Sponsor for Postdoctoral Fellow, Kristin Mahan).
   
Sirtris Pharmaceuticals, Inc., SP-48984, 05/01/10-04/30/12, $313,726 direct costs, SIRT1 in circadian biology and cellular metabolism (Role: P.I.).
   
National Institute of General Medical Science (NIGMS) F32 GM097899, 09/01/11-08/31/13, $102,628 direct costs, The role of SIRT6 in modulating circadian expression (Role: Sponsor for Postdoctoral Fellow, Selma Masri).
   
National Institute of Aging (NIA) R21 AG041504, 09/15/11-08/31/13, $275,000 direct costs, SIRT1 and MLL1 interplay in circadian clock function (Role: P.I.).
   
Associazione Italiana per la Recerca sul Cancro (AIRC) AWD #TBD, 11/01/11-10/31/13, $121,902 direct costs, Role of the circadian clock in oncogene-induced senescence and tumorigenesis (Role: Sponsor for Postdoctoral Fellow, Gabriele Sulli).
   
Institut Merieux, AWD #TBD, 01/01/12-12/31/14, $300,000 Euros (approx $408,000 US) total costs, Nutrition and metabolism: the epigenetic circadian link (Role: P.I.).
   
Professional
Societies
Member of the European Molecular Biology Organization
Member of the European Cellular Biology Organization
Member of the Endocrine Society (USA)
Member of the American Society for Photobiology (USA)
   
Other Experience
Chair, Department of Pharmacology
University of California, Irvine 2006—2011

Graduate Programs Cellular and Molecular Biosciences

Interdepartmental Neuroscience Program

Medicinal Chemistry and Pharmacology

   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=5402
   
Last updated 02/15/2012