Paolo Sassone-CorsiDistinguished Professor & Chair, Pharmacology Joint Appointment, Microbiology & Molecular Genetics Joint Appointment, Pharmaceutical Sciences |
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Research Interests |
signal transduction, gene expression, oncogenesis, circadian clock | |
| URLs | Pharmacology Home Page | |
| Dr. Sassone-Corsi's Lab | ||
| See below for selected publications or click here for additional publication listings available via PubMed | ||
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Academic Distinctions |
1977 - Philips European Award for Young Investigators 1990 - Member of the European Molecular Biology Organization 1994 - EMBO Gold Medal 1996 - Rosen Prize (Fondation de la Recherche Médicale), France 1997 - Grand Prix Liliane Bettencourt pour la Recherche, France 2001 - Segerfalk Award Lecture, Lund University, Sweden 2003 - Grand Prix Charles-Léopold Mayer de l’Académie des Sciences, Paris 2003 - ISI Highly Cited 2004 - Edwin B. Astwood Award Lecture of The Endocrine Society, USA 2004 - The Umesono Memorial Award Lecture, The Salk Institute, San Diego, USA. 2004 - CNRS Silver Medal, Paris |
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Research Abstract |
Dr. Sassone-Corsi's major interest is concentrated on the mechanisms of signal transduction able to modulate nuclear functions and, in particular gene expression, chromatin remodeling and epigenetic control. These events have important consequences for the understanding of cellular proliferation, oncogenesis and differentiation. The stimulation of intracellular pathways and the activation of specific protein kinases lead to transcriptional regulation by changes in the phosphorylation state of nuclear factors. These act as final targets of different pathways and modulate expression from specific regulatory sites. The strength of these studies is particularly evident within physiological settings which have been investigated by this lab, the molecular control of circadian rhythms and the differentiation of male germ cells. | |
| Publications |
Relevant Publications: Whitmore, D., Foulkes, N. S., Strähle, U. and Sassone-Corsi, P. (1998) Zebrafish Clock rhythmic expression reveals independent peripheral circadian oscillators. Nature Neurosci. 1, 701-708 . Fimia, G. M., De Cesare, D. and Sassone-Corsi, P. (1999) CBP-independent activation of CREM and CREB by the LIM-only protein ACT. Nature 398, 165-169. Sassone-Corsi, P., Mizzen, C. A., Cheung, P., Crosio, C., Monaco, L., Jacquot, S., Hanauer, A. and Allis, C. D. (1999) Requirement of Rsk-2 for Epidermal Growth Factor-activated phosphorylation of Histone H3. Science 285, 886-891. Whitmore, D., Foulkes, N. S. and Sassone-Corsi, P. (2000) Light acts directly on organ cells in culture to set the vertebrate circadian clock. Nature 404, 87-91 Cheung, P., Allis, C. D. and Sassone-Corsi, P. (2000) Signaling to chromatin through histone modifications. Cell 103, 263-271. Crosio, C., Cermakian, N., Allis, D. C. and Sassone-Corsi, P. (2000) Light induces chromatin modification in cells of the mammalian circadian clock. Nature Neurosci. 3, 1241-1247 Sassone-Corsi, P. (2002) Unique chromatin remodeling and transcriptional regulation in spermatogenesis. Science 296, 2176-2178. Pando, M. P., Morse, D., Cermakian, N. and Sassone-Corsi, P. (2002) Phenotypic Rescue of a Peripheral Clock Genetic Defect via SCN Hierarchical Dominance. Cell 110, 107-117. Macho, B., Brancorsini, S., Fimia, G. M., Setou, M., Hirokawa, N. and Sassone-Corsi, P. (2002) CREM-Dependent Transcription in Male Germ Cells Controlled by a Kinesin. Science 298, 2388-2390. Yanagimachi, R., Wakayama, T., Kishikawa, H., Fimia, G. M., Monaco, L. and Sassone-Corsi, P. (2004) Production of fertile offspring from genetically infertile mice. Proc. Natl. Acad. Sci. USA 101, 1691-1695. Kimmins, S. and Sassone-Corsi, P. (2005) Chromatin remodeling and epigenetic features of germ cells. Nature 434, 583-589. Hirayama, J., Cardone, L., Doi, M. and Sassone-Corsi, P. (2005) Common Pathways in Circadian and Cell Cycle Clocks: Light-dependent Activation of Fos/AP-1 in Zebrafish Controls CRY-1a and WEE-1. Proc. Natl. Acad. Sci. USA 102, 10194-10199. Cardone, L., Hirayama, J., Giordano, F., Tamaru, T., Palvimo, J. J. and Sassone-Corsi, P. (2005) Circadian clock control by SUMOylation of BMAL1. Science 309, 1390-1394. Monaco, L., Kolthur-Seetharam, U., Loury, R., Ménissier-de Murcia, J., de Murcia, G. and Sassone-Corsi, P. (2005) Inhibition of Aurora-B kinase activity by poly(ADP-ribosyl)ation in response to DNA damage. Proc. Natl. Acad. Sci. USA 102, 14244-14248. Doi, M., Hirayama, J. and Sassone-Corsi, P. (2006) Circadian regulator CLOCK is a Histone Acetyltransferase. Cell 125, 497-508. Hirayama, J., Sahar, S., Grimaldi, B., Tamaru, T., Takamatsu, K., Nakahata, Y. and Sassone-Corsi, P. (2007) CLOCK-mediated acetylation of BMAL1 controls circadian function. Nature 450, 1086-1090. Nakahata, Y., Kaluzova, M., Grimaldi, B., Sahar, S., Hirayama, J., Chen , D., Guarente, L.P. and Sassone-Corsi, P. (2008) The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell 134, 329-340 Borrelli, E., Nestler, E. J., Allis, C. D. and Sassone-Corsi, P. (2008) Decoding the Epigenetic Language of Neuronal Plasticity. Neuron 60, 961-974. Nakahata, Y., Sahar, S., Astarita, G., Kaluzova, M. and Sassone-Corsi, P. (2009) Circadian control of the NAD+-salvage pathway by CLOCK-SIRT1. Science 324, 654-657. Eckel-Mahan, K. and Sassone-Corsi, P. (2009) Metabolism control of the circadian clock and vice versa. Nature Struct. Mol. Biol. 16, 462-467. Tamaru, T., Hirayama, J., Isojima, Y., Nagai, K., Norioka, S.,Takamatsu, K. and Sassone-Corsi, P. (2009) CK2a phosphorylates BMAL1 to regulate the mammalian clock. Nature Struct. Mol. Biol. 16, 446-448. Sahar, S. and Sassone-Corsi, P. (2009) The intriguing links between the circadian clock, metabolism and cancer. Nature Rev. Cancer (in press) |
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| Grants | American-Italian Cancer Foundation (AICF) AICF-44386, 12/15/08-12/15/09, $35,000 direct costs, CLOCK mediated regulation of cell cycle (Role: Sponsor for Postdoctoral Fellow, Loredana Zocchi). | |
| Angelini Pharmaceuticals, Inc., ANG-48184, 09/01/09-06/30/10, $84,314 direct costs, Molecular details of mechanisms of action of Bindarit and other Angelini MCP-1 inhibitors (Role: P.I.). | ||
| Phi Beta Psi Sorority PBPS-45405, 08/01/09-07/31/10, $55,350 direct costs, Potential for novel cancer therapeutic strategy revealed by the molecular link between the circadian clock and tumorigenesis (Role: P.I.). | ||
| National Institute on Aging (NIA) R21 AG033888, 03/01/09-02/28/11, $225,500 direct costs, Epigenetics and circadian clock: Deciphering the physiological and molecular pathways of CLOCK-mediated acetylation of HNF4 (Role: P.I.). | ||
| National Institute of General Medical Sciences (NIGMS) R01 GM081634, 08/01/07-07/31/11, $1,000,000 direct costs, Chromatin remodeling and circadian clock control (Role: P.I.). | ||
| Institut National de la Santé et de la Recherche Médicale (INSERM) INSERM-44790, 01/01/08-12/31/11, $652,364 direct costs, Epigenetic control of neuronal plasticity (Role: Co-Director of UCI-INSERM Research Unit. Director: Dr. Emiliana Borrelli). | ||
| National Institute of Diabetes & Digestive Kidney Diseases (NIDDK) F32 DK083881, 05/01/10-04/30/12, $96,472 direct costs, CLOCK regulation of liver metabolism via modulation of HNF-4a (Role: Sponsor for Postdoctoral Fellow, Kristin Mahan). | ||
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Professional Societies |
Member of the European Molecular Biology Organization Member of the European Cellular Biology Organization Member of the Endocrine Society (USA) Member of the American Society for Photobiology (USA) |
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| Other Experience | ||
| Graduate Programs |
Cellular and Molecular Biosciences Pharmacology and Toxicology Interdepartmental Neuroscience Program Medicinal Chemistry and Pharmacology |
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| Link to this profile | http://www.faculty.uci.edu/profile.cfm?faculty_id=5402 | |
| Last updated | 10/30/2009 | |