Mark E Linskey

Professor, Neurological Surgery
School of Medicine

B.A., Dartmouth College, 1982, Philosophy


M.D., Columbia University College of Physicians and Surgeons, 1986, Medicine

Phone: (714) 456-5533
Fax: (714) 456-8205
Email: mlinskey@uci.edu

University of California, Irvine
333 City Blvd West
8th Fl, Ste #810
Irvine, CA 92868

picture of Mark E Linskey

Research
Interests
Molecular epidemiology and biomarkers for brain tumors, Developmental glial biology, Radiobiology, Brain tumor clinical trials, Clinical outcomes studies
   
URLs Website
   
Department of Neurological Surgery Website
   
Brain Tumor Program - UCI Chao Family Comprehensive Cancer Center
   
Neurosurgery Services UC Irvine Medical Center
   
Academic
Distinctions
2008 – 2014 America’s Top Doctors, Castle Connolly Medical, Ltd (US News & World Report)

2006 – 2014 America’s Top Doctors for Cancer, Castle Connolly Medical, Ltd (US News & World Report) - Brain Tumors, Gamma Knife Surgery, and Skull Base Surgery

2006 – 2014 Physician of Excellence for Orange County, CA, Orange County Medical Association

2013 Nomination, 3rd Thomas Cesario Clinician of the Year Award, UC Irvine, SOM

2013 Nomination, 3rd Stanley van den Noort and Elliot Frohman Mentoring Award, UC Irvine, SOM

2012 Visiting Professor, Inova Health, Inova Fairfax Hospital, Virginia

2011 Distinguished Service Award, Congress of Neurological Surgeons

2011 Marianne Cinat MD, Heroes with Heart Award, Trauma Intervention Programs, Inc, Orange County Chapter

2011 Nomination, 1st Thomas Cesario Clinician of the Year Award, UC Irvine, SOM

2010 Visiting Professor, Department of Neurological Surgery, University of New Mexico

2010 Honored Guest, New Mexico State Neurosurgical Society Annual Meeting

2010 Stewardship Star, Health Affairs Advancement, UC Irvine

2009 Visiting Professor, Department of Neurological Surgery, Stanford University

2008 Leonard Tow Humanism in Medicine Award, The Arnold P. Gold Foundation, UCI SOM graduating medical student class of 2008

2008 Visiting Professor, Department of Neurological Surgery, University of Texas, San Antonio

2007 ARISE Award nominee, UCI MC,

2005 Visiting Professor, Department of Neurological Surgery, Loma Linda University, Loma Linda, CA

2003 UAMS Medical Center, Five Star Spirit Award

2002 Visiting Professor, Department of Neurological Surgery, University of California, Irvine, Irvine, CA

1998 Visiting Professor, Department of Neurological Surgery, Louisiana State University, Shreveport, LA

1998 Visiting Professor, Department of Neurological Surgery, University of Illinois, Chicago

1993 U.S. National Cancer Institute / European Organization for the Research and Treatment of Cancer Exchange Fellowship Award

1993 William P. van Wagenen Fellow, American Association of Neurological Surgeons

1992 Henry Bahnson Award for Basic Science Research, American College of Surgeons, Southwestern Pennsylvania Chapter

1992 Preuss Award for Brain Tumor Research, Joint Section on Tumors, (American Association of Neurological Surgeons / Congress of Neurological Surgeons)

1992 Pittsburgh Neuroscience Society Clinician Research Award

1992 Armed Forces Combat Casualty Care Course (6A-C4), Leadership Award, Class 174

1991 Competitive Medical Research Fund grant recipient, Presbyterian University Hospital, Pittsburgh, PA

1989 Acoustic Neuroma Association Scholarship Prize

1989 First Runner up - Oldendorf Award, American Society of Neuroimaging
   
Appointments 2012-present Professor of Neurological Surgery (Tenured), UC Irvine School of Medicine

2007-Present Center Associate , Reeve-Irvine Research Center, UC, Irvine, School of Medicine

2004-present Member, Neuro-Oncology Program, UCI Chao Family Comprehensive Cancer Center

2003-present Western Regional Director, Medical Advisory Board, TNA - The Facial Pain Association, Gainsville, FL

2008-2012 Program Director, Neurological Surgery Residency Training Program, UC Irvine School of Medicine

2004-20012 Surgical Co-Director, Neuro-Oncology Program, UCI Chao Family Comprehensive Cancer Center

2004-2009 Chairman, Department of Neurological Surgery, UC Irvine School of Medicine

2004-2009 Chief, Neurosurgical Service, UC Irvine MC

2004-2012 Associate Professor of Neurological Surgery (tenured), UC Irvine School of Medicine

1998-2004 Associate Professor of Neurological Surgery, University of Arkansas for Medical Sciences, Little Rock, AR

1998-2004 Co-Director, Gamma Knife Stereotactic Radiosurgery Center, University of Arkansas for Medical Sciences, Little Rock, AR

1998-2004 Co-Director, Neuro-Oncology Program, Arkansas Cancer Research Center, Little Rock, AR

1998-2004 Director, Brain Tumor Research Laboratory, Arkansas Cancer Research Center, Little Rock, AR

1998 – 1999 Acting Chief of Pediatric Neurosurgery, Arkansas Children's Hospital & University of Arkansas for Medical Sciences, Little Rock, AR

1999-2002 Assistant Chief of Pediatric Neurosurgery, Arkansas Children's Hospital & University of Arkansas for Medical Sciences, Little Rock, AR

1996-1998 Head, Division of Neurosurgery, Naval Medical Center, San Diego, CA

1995 Head, Department of Neurosurgery, Naval Medical Center, Oakland, CA

1994-1995 Division Officer, Neurosurgery Clinic, Naval Medical Center, Oakland, CA

1993-1994 Visiting Instructor, Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA
   
Research
Abstract
Clinician Scientist and Educator with focus on Surgical Neuro-Oncology, Skull base microsurgery, Endoscopic minimally invasive surgery, Image-guided surgery, Gamma Knife Stereotactic Radiosurgery, Stereotactic tumor surgery and cranial nerve disorder surgery (Trigeminal Neuralgia, Hemifacial Spasm, Glossopharyngeal Neuralgia). Experienced in building and leading academic departments and multidisciplinary clinical programs. Experienced in training medical students and residents as well as establishing and leading ACGME-accredited neurosurgery residency training programs. Clinical and basic science laboratory research interests focussed on glioma biology with translational emphasis. Experienced national neurosurgery organizer and leader with focus on evidence-based medicine clinical practice guideline development as well as socio-economic, health policy and regulatory issues as they relate to neurosurgery.
   
Publications PEER REVIEWED ARTICLES:

1. Linskey ME, Neugut AI, Hall E, Cox JD. A course in medical research study design and analysis. J Med Education 1987; 62:143-145

2. Linskey ME, Sekhar LN, Hirsch Jr W, Yonas H, Horton JA. Aneurysms of the intracavernous carotid artery: Clinical presentation, radiographic features, and pathogenesis. Neurosurgery 1990; 26:71-79

3. Linskey ME, Segal R. Median nerve injection injury from local steroid injection in carpal tunnel syndrome. Neurosurgery 1990; 26:512-515

4. Linskey ME, Lunsford LD, Flickinger J. Radiosurgery for acoustic neurinomas: Early experience. Neurosurgery 1990; 26:736-745

5. Linskey ME, Sekhar LN, Hirsch Jr W, Yonas H, Horton JA. Aneurysms of the intracavernous carotid artery: Natural history and indications for treatment. Neurosurgery 1990; 26: 933-938

6. Sekhar LN, Linskey ME, Sen CN, Altschuler E. Surgical Management of lesions within the cavernous sinus. Clin Neurosurg 1991; 37:440-489

7. Flickinger JC, Lunsford LD, Coffey RJ, Linskey ME, Bissonette DJ, Maitz AH, Kondziolka D. Radiosurgery of acoustic neurinomas. Cancer 1990; 67:345-353

8. Linskey ME, Jannetta PJ, Martinez AJ. A vascular malformation mimicking an intracanalicular acoustic neurilemoma. J Neurosurg 1991; 74(3):516-519

9. Linskey ME, Nuss D, Krieger D, Sekhar LN. Intraoperative electrophysiological monitoring of the
facial nerve in the presence of damage to the pre-parotid segment. Neurosurgery 1991; 28: 473-474

10. Linskey ME, Martinez AJ, Hogg J, Sekhar LN. Chondromyxoid fibromas of the neurocranium. Skull Base Surg 1991; 1:120-126

11. Linskey ME, Horton JA, Rao GR, Yonas H. Fatal rupture of the intracranial carotid artery during transluminal angioplasty for vasospasm induced by subarachnoid hemorrhage. J Neurosurg 1991; 74(6):985-990

12. Linskey ME, Sekhar LN, Horton JA, Yonas H, Hirsch Jr W. Aneurysms of the intracavernous carotid artery: A multidisciplinary approach to treatment. J Neurosurg 1991; 75(4):525-534

13. Linskey ME, Lunsford LD, Flickinger JC. Neuroimaging of acoustic nerve sheath tumors after stereotaxic radiosurgery. AJNR 1991; 12:1165-1175

14. Linskey ME, Sekhar LN. Cavernous sinus hemangiomas: A series, a review, and a hypothesis. Neurosurgery 1992; 30(1):101-107

15. Linskey ME, Lunsford LD, Flickinger JC, Kondziolka D. Stereotactic radiosurgery for acoustic tumors. Neurosurg Clin North Am 1992; 3:191-205

16. Sherer J, Linskey ME, Lunsford LD. Stereotactic radiosurgery for skull base tumors: Overview and nursing perspectives. ORL Head Neck Nurs 1992; 10:21-28

17. Lunsford LD, Linskey ME. Stereotactic radiosurgery in the treatment of patients with acoustic tumors. Otolaryngol Clin North Am 1992; 25:471-491

18. Linskey ME, Sekhar LN, Hecht ST. Emergency embolectomy for embolic occlusion of the middle cerebral artery after internal carotid artery balloon test occlusion. J Neurosurg 1992; 77:134-138

19. Yonas H, Linskey M, Johnson DW, Horton JA, Janecka IP, Witt JP, Jungreis C, Hirsch Jr WL, Sekhar LN. Internal carotid balloon test occlusion does require quantitative CBF. AJNR 1992; 13:1147-1148

20. Linskey ME, Lunsford LD, Flickinger JC. Tumor control after stereotactic radiosurgery in neurofibromatosis patients with bilateral acoustic tumors. Neurosurgery 1992; 31:829-839

21. Linskey ME, Stephanian E, Sekhar LN. Emergent middle cerebral artery embolectomy: A useful technique for cranial skull base surgery. Skull Base Surg 1993; 3:80-86

22. Linskey ME, Flickinger JC, Lunsford LD. Cranial nerve length predicts the risk of delayed facial and trigeminal neuropathies after acoustic tumor stereotactic radiosurgery. Int J Radiat Oncol Biol Phys 1992; Vol 25:227-233

23. Linskey ME, Martinez AJ, Kondziolka D, Flickinger JC, Maitz AH, Whiteside T, Lunsford LD. The radiobiology of human acoustic schwannoma xenografts after stereotactic radiosurgery evaluated in the subrenal capsule of athymic mice. J Neurosurg 1993; 78:645-653

24. Flickinger JC, Lunsford LD, Linskey ME, Duma CM, Kondziolka D. Gamma knife radiosurgery for acoustic tumors: Multivariate analysis of four year results. Radiother Oncol 1993; 27:91-98

25. Linskey ME, Jungreis CA, Yonas H, Hirsch Jr WL, Sekhar LN, Horton JA, Janosky JE. Stroke risk after abrupt internal carotid artery sacrifice: Accuracy of preoperative assessment with balloon test occlusion and stable Xenon-enhanced CT. AJNR 1994; 15:829-843

26. Linskey ME, Kondziolka D, Marion DW. Stereotactic localization and removal of a bullet in the third ventricular causing obstructive hydrocephalus after cerebral gunshot wound: Case Report. J Trauma 1994; 36:881-884

27. Linskey ME, Jho HD, Jannetta PJ. Microvascular decompression for trigeminal neuralgia caused by vertebrobasilar compression. J Neurosurg 1994; 81:1-9

28. Linskey ME, Gilbert MR. Glial differentiation: A review with implications for new directions in neuro-oncology. Neurosurgery 1995; 36:1-22

29. Linskey ME. Utilizing skull base techniques in the approach and exposure of intracranial aneurysms. Part I. Contemporary Neurosurgery 1995; 17(16):1-6

30. Linskey ME. Utilizing skull base techniques in the approach and exposure of intracranial aneurysms. Part II. Contemporary Neurosurgery 1995; 17(17):1-6

31. Noble M, Gutowski N, Bevan K, Engel U, Linskey M, Urenjak J, Bhakoo K, Williams S. From rodent
glial precursor cell to human glial neoplasia in the oligodendrocyte-type-2 astrocyte lineage. Glia 1995, 15:222-230

32. Linskey ME. Glial ontogeny and glial neoplasia: the search for closure. J Neuro-oncology 1997; 34: 5-2

33. Linskey ME. Developmental Glial Biology: The Key to Understanding Glial Tumors. Clin Neurosurg 2000; 47(3):46-71

34. Linskey ME. Multi-agent Cytostatic Treatment of “low-grade” Gliomas. Curr Oncology Rep 2000; 2: 454-462

35. Arnautovic KI, Husain MM, Linskey ME. Cranial nerve root entry zone primary cerebellopontine angle gliomas: A rare and poorly recognized subset of extraparenchymal tumors. J Neuro-Oncology 2000; 49:205-212

36. Linskey ME. Stereotactic radiosurgery versus stereotactic radiotherapy for patients with vestibular schwannoma: A Leksell Gamma Knife Society 2000 debate. J Neurosurg 2000; 93(Suppl 3):90-95

37. Gardner E, Linskey ME, Penagaricano JA, Hanna EY. Stereotactic radiosurgery for patients with cancer of the head and neck. Curr Oncology Rep 2003; 5:164-169

38. Elshihabi S, Ratanatharathorn V, Yan Y, Papanikolaou N, Penagaricano J, Linskey ME: Current principles for management of solid central nervous system metastases. Contemporary Neurosurgery 2003; 25(4): 1-10

39. Sawyer JR, Sammartino G, Husain M, Linskey ME. Constitutional t(16;22)(p13.3;q11.2 ~12) in a primitive neuroectodermal tumor of the pineal region. Cancer Genetics & Cytogenetics 2003; 142:73-76

40. Linskey ME, Johnstone P, O'Leary MO, Goetsch S. Radiation exposure of normal temporal bone structures during stereotactically guided gamma knife surgery for vestibular schwannomas. J Neurosurg 2003; 98:800-806

41. Linskey ME, Johnstone PA. Radiation tolerance of normal temporal bone structures: Implications for gamma knife stereotactic radiosurgery. Int J Radiat Oncol Biol Phys 2003; 57: 196-200

42. Elshihabi S, Husain M, Linskey M. Lipomatous medulloblastoma: A rare adult tumor variant with a uniquely favorable prognosis. Surg Neurol 2003; 60: 566-70

43. Barker FG II, Linskey ME. History of the Joint Section on Tumors and preface to the 20th anniversary Journal of Neuro-Oncology special issue. J Neuro-Oncology 2004; 69: 1-18

44. Linskey ME. The changing role of stereotaxis in surgical neuro-oncology. J Neuro-Oncology 2004; 69: 35-54

45. Penagaricano JA, Linskey ME, Ratanatharathorn V. Accelerated cerebral vasculopathy after radiation therapy to the brain. Neurology India 2004, 52:4, 477-81

46. Linskey ME, Davis SA, Ratanatharathorn V. Relative roles of microsurgery and stereotactic radiosurgery for the treatment of patients with cranial meningiomas: A single surgeon 4-year integrated experience using both modalities. J Neurosurg (suppl) 102:59-70, 2005

47. Zhou YH, Hess KE, Liu L, Linskey ME, Yung WKA. Modeling prognosis for patients with malignant astrocytic gliomas: Quantifying the expression of multiple genetic markers and clinical variables. Neuro-Oncology 2005; 7(4): 485-494

48. Raja AI, Linskey ME. In situ cranioplasty with methylmethacrylate and wire lattice. Br J Neurosurg October 2005; 19(5): 416-419.

49. Knisely JPS, Linskey ME. Less common indications for stereotactic radiosurgery or fractionated radiotherapy for patients with benign brain tumors. Neurosurg Clin North Am 17 (2006) 149-167.

50. Penagaricano JA, Yan Y, Shi C, Linskey ME, Ratanatharathorn V. Dosimetric comparison of Helical Tomotherapy and Gamma Knife stereotactic radiosurgery for single brain metastasis. Radiat Oncol. 2006 Aug 3;1:26.

51. Gibbs WN, Monuki ES, Linskey ME, Hasso AN. Pituicytoma: Diagnostic features on selective carotid angiography and MR imaging. Am J Neuroradiol. 27:1639-42, Sep 2006.

52. Vokes DE, Linskey ME, Armstrong WB. Propofol lipemia mimicking chyle leak during neck dissection. Head Neck. 2006 Dec;28(12):1147-1149.

53. Barnett GH, Linskey ME, Adler JR, Cozzens JW, Friedman WA, Heilbrun MP, Lunsford LD, Schulder M, Sloan AE, The American Association of Neurological Surgeons/Congress of Neurological Surgeons Washington Committee Stereotactic Radiosurgery Task Force. Stereotactic radiosurgery—an organized neurosurgery-sanctioned definition. J. Neurosurg. 2007 Jan:106:1-5.

54. Westhout FD, Paré LS, Linskey ME. Central causes of foot drop. Rare and underappreciated differential diagnoses. J Spinal Cord Med. 30(1):62-66 2007.

55. Westhout FD, Mathews M, Paré LS, Armstrong WB, Tully P, Linskey ME. Recognizing Schwannomatosis and distinguishing it from Neurofibromatosis Type 1 or 2. J Spinal Disord Tech. 20(4):329-332, 2007.

56. Linskey ME. Neurosurgery quality: Pay-for-performance, guidelines, and outcome measures. Clin Neurosurg. 54(27):157-179, 2007.

57. Abookasis D, Mathews MS, Lay C, Frostig RD, Linskey ME, Tromberg BJ. Measuring and Mapping Optical Properties and Chromophore Changes during brain injury in the near-infrared spectral range using spatial modulation of light: Initial results. Proceedings of 3rd International IEEE/EMBS Conference on Neural Engineering 2007:233-236.

58. Abookasis D, Mathews MS, Lay C, Cuccia DJ, Frostig RD, Linskey ME, Tromberg BJ. Mapping tissue chromophore changes in cerebral ischemia: A Pilot Study. Proc SPIE 2007; 6424:1-7.

59. Mathews MS, Linskey ME, Binder DK. William P. van Wagenen and the first corpus callosotomies for epilepsy. J Neurosurg 2008;108:608-613.

60. Westhout FD, Linskey ME. Obstructive hydrocephalus and progressive psychosis: rare presentations of neurosarcoidosis. Surg Neurol. 69 (2008):288-292

61. Mathews MS, Kim RC, Chang GY, Linskey ME. Klippel-Trenaunay syndrome and cerebral haemangiopericytoma: a potential association. Acta Neurochir 2008:150: 399-402.

62. Zakrzewska JM, Linskey M. Trigeminal neuralgia. BMJ Clin Evid 2008; 2(1207): 1-9.

63. Su J, Mathews MS, Nwagwu CI, Edris A, Nguyen BV, Heidari M, Linskey ME, Chen Z. Imaging treated brain aneurysms in vivo using optical coherence tomography. Proc. of SPIE, 2008; 6847: 684732: 1-7

64. Abookasis D, Mathews MS, Owen CM, Binder DK, Linskey ME, Frostig RD, Tromberg BJ. Using NIR spatial illumination for detection and mapping chromophore changes during cerebral edema. Proc SPIE 2008; 6842: 68422U: 1-6.

65. Mathews MS, Linskey ME, Hasso AN, Freuhauf JP. The effect of bevacizumab (Avastin) on neuroimaging of brain metastases. Surg Neurol 2008; 70(6):649-652

66. Linskey ME. The emergence of clinical practice parameter guidelines in neuro-oncology: Promise of utility tempered with caution. J Neuro Oncol 2008; 89:359-362.

67. Zakrzewska JM, Linskey ME. Neurosurgical interventions for the treatment of classical trigeminal neuralgia (Protocol). Cochrane Review ID 102. Cochrane Database of Systematic Reviews 2008, Issue 3. Art. No.: CD007312. DOI:10.1002/14651858.CD007312.

68. Linskey ME, Ratanatharathorn V, Penagaricano J. A prospective cohort study of microvascular
decompression and Gamma Knife surgery in patients with trigeminal neuralgia. J Neurosurg 2008; 109:160-172

69. Linskey ME. Hearing preservation in vestibular schwannoma stereotactic radiosurgery: what really matters? J Neurosurg 2008;109:129-136

70. Abookasis D, Lay CC, Mathews MS, Linskey ME, Frostig RD, Tromberg BJ. Imaging cortical absorption, scattering, and hemodynamic response during ischemic stroke using spatially modulated near-infrared illumination. J Biomed Opt 2009; 14(2): 024033, 1-9

71. Owen CM, Linskey ME. Frame-based stereotaxy in a frameless era: Current capabilities, relative role, and the positive- and negative predictive values of blood through the needle. J Neurooncology 2009; 93(1):139-149

72. Zakrzewska JM, Linskey ME. Trigeminal neuralgia. Clin Evid (online) 2009; Mar 12, pii, 1207

73. Scarrow AM, Linskey M, Asher AL, Anderson VC, Selden NR. Neurosurgeon transition to retirement: Results of the 2007 CNS consensus conference. Neurosurgery 2009; 65(2): 231-6

74. Linskey ME, Davis SA, Ratanatharathorn V. Relative roles of microsurgery and stereotactic radiosurgery for the treatment of patients with cranial meningiomas: A single surgeon 4-year integrated experience using both modalities. J Neurosurg 2009; 111: 127-138

75. Zhou YH, Hu Y, Mayes D, Siegel E, Kim JG, Mathews MS, Hsu N, Eskander D, Yu O, Tromberg
BJ, Linskey ME. PAX6 suppression of glioma angiogenesis and the expression of vascular endothelial growth factor A. J Neurooncology 2010 96: 191-200.

76. Linskey ME, Kalkanis SN. Evidence-linked, clinical practice guidelines—getting serious; getting professional. J Neurooncol, 2010; 96:1-5.

77. Linskey ME, Andrews D, Asher A, Burri S, Kondziolka D, Ammirati M, Cobbs C, Gaspar L, Gauld M, Henson J, Loeffler J, Mehta M, Mikkelsen T, Ryken T, McDermott M, Olson J, Paleologos N, Patchell R, Raina P, Robinson P, Santaguida L, Warnick R, Kalkanis S. The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncology 2010; 96: 45-68.

78. Kalkanis S, Linskey ME. Evidence-based clinical practice parameter guidelines for the treatment of patients with metastatic brain tumors: Introduction. J Neurooncology 2010; 96:7-10.

79. Robinson P, Kalkanis S, Linskey ME. Methodology used to develop the AANS/CNS management of brain metastases evidence-based clinical practice parameter guidelines. J Neurooncology, 2010; 96: 11-16.

80. Kalkanis S, Asher A, Burri S, Gaspar L, Kondziolka D, Cobbs C, Ammarati M, Andrews D, Gauld M, Henson J, Loeffler J, Mehta M, Mikkelsen T, Ryken T, McDermott M, Olson J, Paleologos N, Patchell R, Raina P, Robinson P, Santaguida L, Warnick R, Linskey ME,. The role of surgical resection in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncology 2010; 96: 33-43.

81. Paleologos N, Mikkelsen T, Ammirati M, Andrews D, Asher A, Burri S, Cobbs C, Gaspar L, Gauld M, Henson J, Kondziolka D, Linskey ME, Loeffler J, Mehta M, Olson J, Ryken T, McDermott M, Patchell R, Raina P, Robinson P, Santaguida L, Warnick R, Kalkanis S. The role of prophylactic anticonvulsants in the management of brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncology 2010; 96: 97-102

82. Ryken Y, McDermott M, Ammirati M, Andrews D, Asher A, Burri S, Cobbs C, Gaspar L, Gauld M, Henson J, Kondziolka D, Linskey ME, Loeffler J, Mehta M, Mikkelsen T, Olson J, Paleologos N, Patchell R, Raina P, Robinson P, Santaguida L, Warnick R, Kalkanis S. The role of steroids in the management of brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncology 2010; 96: 103-114.

83. Gaspar L, Burri S, Mehta M, Patchel R, Ammirati M, Andrews D Asher A, Cobbs C, Gauld M, Henson J, Kalkanis S, Kondziolka D, Linskey ME, Loeffler J, Mikkelsen T, Ryken T, McDermott M, Olson J, Paleologos N, Raina P, Robinson P, Santaguida L, Warnick R, Kalkanis S. The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline J Neurooncology 2010; 96: 17-32.

84. Mehta M, Mikkelsen T, Paleologos N, Ammirati M, Andrews D Asher A, Burri S, Cobbs C, Gaspar L, Gauld M, Henson J, Kondziolka D, Linskey ME, Loeffler J, Ryken T, McDermott M, Olson J, Patchell R, Raina P, Robinson P, Santaguida L, Warnick R, Kalkanis S. The role of chemotherapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncology 2010; 96: 71-83.

85. Ammarati M, Cobbs C, Linskey ME, Paleologos N, Ryken T, Asher A, Burri S, Loeffler J, Andrews D, Gaspar L, Gauld M, Henson J, Kalkanis S, Kondziolka D, Mehta M, Mikkelsen T, McDermott M, Olson J, Patchell R, Raina P, Robinson P, Santaguida L, Warnick R, Kalkanis S. The role of retreatment in the management of recurrent/progressive brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncology 2010; 96: 85-96.

86. Olson J, Paleologos N, Gaspar L, Ammirati M, Andrews D Asher A, Burri S, Cobbs C, Gauld M, Henson J, Kalkanis S, Kondziolka D, Linskey ME, Loeffler J, Mehta M, Mikkelsen T, Ryken T, McDermott M, Patchell R, Raina P, Robinson P, Santaguida L, Warnick, R Kalkanis S. The role of emerging and investigational therapies for metastatic brain tumors: a systematic review and evidence-based clinical practice guideline of selected topics. J Neurooncology 2010; 96: 115-142.

87. Linskey ME. Implementing traumatic cervical spine clearance clinical practice guidelines. J Trauma
2010; 68:1451-1452.

88. Linskey ME. Defining excellence in evidence based medicine clinical practice guidelines. Clin
Neurosurg; 2010; 57: 28-37.

89. Vogelbaum MA, Rogers CL, Linskey ME, Mehta MP. Opportunities for clinical research in meningioma. J Neuro-Oncology 2010; 99:417-422.

90. Zlotnick D, Kalkanis SN, Quinones-Hinojosa A, Chung K, Linskey ME, Jensen RL, DeMonte F,
Barker FG, Racine CA, Berger MS, Black PM, Cusimano M, Sekhar LN, Parsa A, Aghi M, McDermott MW. FACT-MNG: tumor site specific web-based outcome instrument for meningiomas patients. J Neuro-Oncology 2010; 99:423-431.

91. Zhou YH, Hess KR, Raj VR, Yu L, Liu L, Yung AW, Linskey ME. Establishment of prognostic
models for astrocytic and oligodendroglial brain tumors with standardized quantification of marker gene expression and clinical variables. Biomark Insights 2010; 5:153-168.

92. Bhangoo SS, Linskey ME, Kalkanis S. Evidence-based guidelines for the management of brain
metastases. Neurosurg Clin North Am 2011; 22:97-104

93. Gong X, Schwartz PH, Linskey ME, Bota DA. Neural Stem/Progenitors and Glioma Stem-like Cells
Have Differential Sensitivity to Chemotherapy. Neurology 2011; 76:1226-1234

94. Mathews MS, Su J, Heidari M, Levy EI, Linskey ME, Chen Z. Neuroendovascular optical coherence tomography imaging and histologic analysis. Neurosurgery 2011; 69:430-439

95. Mathews MS, Bota D, Kim RC, Hasso A, Linskey ME. Primary leptomeningeal plasmablastic lymphoma. J Neuro-Oncology 2011; J Neurooncol. 2011; 104:835-838

96. Hu Y, Pioli PD, Siegel E, Zhang Q, Nelson J, Chaturbedi A, Mathews MS, Ro DI, Alkafeef S, Hsu N, Hamamura M, Yu L, Hess KR, Tromberg BJ, Linskey ME, Zhou YH. EFEMP1 suppresses malignant glioma growth and exerts its action within the tumor extracellular compartment. Mol Cancer. 2011; Sep 28;10(1):123.

97. Chaturbedi A, Yu L, Linskey M, Zhou YH. Detection of 1p19q deletion by real-time comparative quantitative PCR. Biomark Insights 2012; 7:9-17.

98. Nashed M, Glantz MJ, Linskey ME, Bota DA. The access to specialized treatments for adult Hispanic brain tumor patients: Findings from a single institution retrospective study. Community Oncology 2012; 9:283-288

99. Mathews MS, Linskey ME. Neuroendovascular optical coherence tomography imaging for cerebrovascular disease: Current concepts and clinical potential. Curr Cardiol Rep 2012; 14:647-50

100. Fu B, Linskey ME, Bota DA. Retrospective study of bevacizumab and etoposide combination chemotherapy in patients with recurrent malignant gliomas who fail bevacizumab. Drug and Therapy Studies 2012; 2:e6. p26-28

101. Di K, Linskey ME, Bota DA. Trim-11 is over-expressed in high-grade gliomas and promotes
proliferation, invasion, migration and glial tumor growth. Oncogene 2013; 17;32:5038-47. PMID:23178488

102. Alexandru D, Linskey ME, Kim R, Bota DA. Undifferentiated sarcoma induced by BCNU [1,3-bis(2chloroethyl) -1 nitrosourea] wafers. J Interdiscipl Histopathol 2013; 1:163-7

103. Lin NU, Lee EQ, Aoyama H, Barani IJ, Baumert BG, Brown PD, Camidge R, Chang SM, Dancey J,
Gaspar LE, Harris GJ, Henson JW, Hodi FS, Kalkanis SN, Lambom KR, Linskey ME, Macdonald DR, Margolin K, Mehta MP, Schiff DS, Sneed PK, Soffietti R, Suh J, van den bent MA, Vogelbaum MA, Wefel JS, Wen PY. Response assessment in neuro-oncology (A report of the RANO group): Challenges relating to solid tumor brain metastases in clinical trials, Part 1: Patient population, response and progression. Lancet Oncology 2013; Sep;14(10):e396-406. doi: 10.1016/S1470-2045(13)70311-5. [Epubl ahead of print] PMID:23993384

104. Lin NU, Lee EQ, Aoyama H, Barani IJ, Baumert BG, Brown PD, Camidge R, Chang SM, Dancey J, Gaspar LE, Harris GJ, Henson JW, Hodi FS, Kalkanis SN, Lambom KR, Linskey ME, Macdonald DR, Margolin K, Mehta MP, Schiff DS, Sneed PK, Soffietti R, Suh J, van den bent MA, Vogelbaum MA, Wefel JS, Wen PY. Response assessment in neuro-oncology (A report of the RANO group): Challenges relating to solid tumor brain metastases in clinical trials, Part 2: Neurocognitive, neurological and quality of life outcomes. Lancet Oncology 2013; Sep;14(10):e407-16. doi: 10.1016/S1470-2045(13)70308-5. [Epubl ahead of print] PMID:23993385.

105. Kondziolka D, Parry PV, Lunsford LD, Flickinger JC, Rakfal S, Arai Y, Loeffler JS, Rush S,
Knisely J, Sheehan J, Friedman W, Tarhini A, Francis L, Lieberman F, Ahluwalia M, Linskey ME, McDermott M, Sperduto P, Stupp R. The accuracy of predicting survival in individual patients with cancer. J Neurosurg 2013; Oct 25 [Epubl ahead of print] PMID:24160479.

106. Hu Y, Ru N, Xiao H, Chaturbedi A, Hoa NT, Wang P, Zhang H, Yan F, Nelson J, Li Z, Yu L, Siegel
E, Zhang X, Jia Z, Jadus MR, Limoli CL, Linskey ME, Xing J, Zhou YH. Tumor-specific chromosome mis-segregation controls cancer plasticity by maintaining tumor heterogeneity. PLOS One 2013;8(11): Nov 25, e 80898, DOI: 10.1371/journal.pone.0080898.

107. Zakrzewska JM, Linskey ME. Trigeminal neuralgia. Br Med J 2014 (Accepted)

108. Zakrzewska JM, Linskey ME. Trigeminal neuralgia. Clin Evid (online) 2014 (Accepted)

OTHER ARTICLES:

1. Linskey ME. When cancer spreads to your brain. Arkansas Cancer Research Center. ACRC Spotlight. 2000

2. Linskey ME, Przybylski GJ. Launching NERVES: Neurosurgery taps a valuable resource – practice managers. AANS Bulletin 2002; 11(4): 22-23

3. Linskey ME, Ratanatharathorn V. Getting help for trigeminal neuralgia. Physician Digest, 2003

4. Linskey ME, Ratanatharathorn V. Patients with brain metastases - The outlook has changed. UAMS News, Fall 2003

5. Linskey ME. Violence takes one of our own. Robin Lynn Mitchell, M.D. remembered by many. Women in Neurosurgery Newsletter. Fall 2004: 2, 6

6. Linskey ME. Practice Guidelines-Why Bother? IOM, MedPAC and Others Call for Evidence-Based Quality Care. AANS Bulletin 2005; 14(1): 17

7. Linskey ME. Practice guidelines-Why bother? Neurosurgery News 2005; 6(3): 12-14

8. Linskey MW. When cancer spreads to your brain. UCI Department of Neurological Surgery. Neurological Surgery Newsletter. Fall 2005; 1(1)

9. Westhout F, Linskey ME. Gamma Knife stereotactic radiosurgery. UCI Department of Neurological Surgery. Neurological Surgery Newsletter. Fall 2005; 1(1)

10. Linskey ME. Practice guidelines: Current status in neurosurgery. Neurosurgery News 2005; 6(4): 6-8.

11. Linskey ME. Re-engineering the neurosurgery guidelines effort: A critical need in preparation for pay-for-performance. Neurosurgery News 2005; 6(5): 4.

12. Linskey ME. Trigeminal neuralgia. UCI Department of Neurological Surgery. Neurological Surgery Newsletter. Spring 2006; 1(2)

13. Linskey ME. Intra-operative Magnetic Resonance Imaging (IOMR) at UCI Medical Center. UCI Department of Neurological Surgery. Neurological Surgery Newsletter. Fall 2006; 2(1)

14. Linskey ME. Microvascular decompression. UCI Department of Neurological Surgery. Neurological Surgery Newsletter. Spring 2007; 2(2)

15. Linskey ME. New radiosurgery techniques at UC Irvine. UCI Department of Neurological Surgery. Neurological Surgery Newsletter. Fall 2007; 3(1)

16. Linskey ME. Guidelines committee update. Tumor News. AANS/CNS Tumor Section Newsletter Newsletter. Fall 2007; 4.

17. Linskey ME. Clinical practice parameter guidelines and neurosurgery. Congress Quarterly, Fall 2007; 19-21.

18. Linskey ME. Tumor Section Develops Evidence-Based Guidelines. Tumor News. AANS/CNS Tumor Section Newsletter Newsletter, Spring 2008; 3.

19. Linskey ME. New Neurosurgery Residency Training Program. UCI Department of Neurological Surgery. Neurological Surgery Newsletter. Spring 2008; 3(2)

20. Selden NR, Rezai AR, Rodts GE, Linskey ME, Asher AL. CNS consensus sessions and the annual meeting: We are listening. Congress Quarterly, Fall 2008; 10-11

21. Linskey ME, Kalkanis S. Tumor guidelines report. Tumor News. AANS/CNS Tumor Section Newsletter, Spring 2009; 10

22. Linskey ME, Groman R. The AANS/CNS joint guidelines committee. Congress Quarterly 2010; Winter, 2010; 12-14.

23. Linskey ME. Avoiding mythical traps and seductive diversions. TNA Quarterly Spring 2011; 1(1)

24. Linskey ME. TNA - the Facial Pain Association western regional conference. TNA Quarterly Summer 2011; 1(2)

25. Linskey ME. Clinical trials. Tumor News. AANS/CNS Tumor Section Newsletter, Fall 2011; 4-5

26. Jannetta PJ, Alksne JF, Barbaro NM, Barbaro JA, Burchiel KJ, Casey JF, Graff-Radford SB, Linskey ME, Nixdorf DR, Pollock BE, Sirois DA, Zakrzewska JM. Facial Pain Experts Establish a New Pain Classification. The Facial Pain Association and its Medical Advisory Board under the guidance of Dr. Peter J. Jannetta have concluded that the term atypical facial pain be replaced with the term “facial pain of obscure etiology”. TNA Quarterly Winter 2012; 1(2): 12

27. Linskey ME. First cranial module for N2QOD. Tumor News. AANS/CNS Tumor Section Newsletter Newsletter, Spring 2012; 3

28. Linskey ME. Locked out. AANS Neurosurgeon 2012; 21(3).

29. Linskey ME. The changing of the guard. Congress Quarterly Fall 2013; 14(4)

BOOKS, MONOGRAPHS, & JOURNAL VOLUMES:

1. Linskey ME, Rutigliano M, eds. Quality and Cost in Neurological Surgery. Volume 10 in Haines SJ, Nelson PB, eds. Concepts in Neurosurgery. Baltimore: Lippincott William & Wilkins, 2001

2. Linskey ME, Sawaya R, Guest Editors. Journal of Neuro-Oncology. Special volume celebrating the Section on Tumors (AANS/CNS) 20th anniversary. 2004; 69 (1-3): 1-354

3. Linskey ME. Trigeminal Neuralgia. American College of Physicians (ACP), Physician’ Information and Education Resource (PIER) module. 2012, December. Http://pier.acponline.org/physicians/diseases/d625/d625-pdf.htnl

BOOK CHAPTERS:

1. Linskey ME, Lunsford LD, Flickinger JC. Stereotactic radiosurgery for acoustic nerve sheath tumors. In: Lunsford LD, ed. Stereotactic Radiosurgery Update. New York: Elsevier, 1992, pp 321-334

2. Lunsford LD, Linskey ME, Flickinger JC. Stereotactic radiosurgery for acoustic nerve sheath tumors. In: Tos M, Thomsen J, eds. Acoustic Neuroma. New York: Kugler Publications, 1992, pp 279-287

3. Lunsford LD, Linskey ME, Flickinger JC. Stereotactic radiosurgery for acoustic tumors. In: Eldridge R, ed. NIH Consensus Development Conference: Acoustic Neuroma, Program and Abstracts. December 11-13, 1991. Bethesda: National Institutes of Health, 1992

4. Linskey ME, Sekhar LN, Sen C. Cerebral revascularization in cranial base surgery. In: Sekhar LN, Janecka IP, eds. Surgery of Cranial Base Tumors. New York: Raven Press, Ltd., 1993, pp 45-68

5. Kondziolka D, Lunsford LD, Linskey ME, Flickinger JC. Skull base radiosurgery. In: Alexander III E, Loeffler JS, Lunsford LD, eds. Stereotactic Radiosurgery. New York: McGraw Hill, Inc., 1993, pp 175-188

6. Kondziolka D, Linskey ME, Lunsford LD. Animal models in radiosurgery. In Alexander III E, Loeffler JS, Lunsford LD, eds. Stereotactic Radiosurgery. New York: McGraw Hill, Inc., 1993, pp 51-64

7. Sekhar LN, Linskey ME. Management of the internal carotid artery in cranial base neoplasms. In Johnson JT, Didolkar MS, eds. Head and Neck Cancers. Vol. 3. New York: Elsevier, 1993, pp 669-682

8. Sekhar LN, Linskey ME, Snyderman CH. Surgical management of neoplastic involvement of the internal carotid artery. In: Carter LP, Spetzler RF, eds. Neurovascular Surgery. New York: McGraw Hill, Inc., 1994, pp 1263-1299

9. Linskey ME. The developmental biology of glial cells and its relation to the study of glioma biology. In: Apuzzo MLJ, ed. Benign Cerebral Gliomas. Neurosurgical Topic Series. Park Ridge, IL: American Association of Neurological Surgeons, 1995, pp 13-57

10. Linskey ME. Advances in the study of glial lineage. In: Kornblith PL, Walker M, eds. Advances in Neuro-Oncology, Vol. II. N.Y.: Futura Publishing Co., 1997, pp 3-33

11. Linskey ME, Yonas H: Evaluation of collateral circulation. In: Eisenberg M, Al-Mefty O, eds. The Cavernous Sinus: A Comprehensive Text. Philadelphia: Lippincott William & Wilkins, 2000, 55-76

12. Linskey ME. Obstacles to implementing a quality philosophy in neurological surgery. In Linskey ME, Rutigliano M, eds. Quality and Cost in Neurological Surgery. Volume 10 in Haines SJ, Nelson PB, eds. Concepts in Neurosurgery. Baltimore: Lippincott William & Wilkins, 2001, pp 260-282

13. Linskey ME. Defining, standardizing, refining, and stabilizing processes. In Linskey ME, Rutigliano M, eds. Quality and Cost in Neurological Surgery. Volume 10 in Haines SJ, Nelson PB, eds. Concepts in Neurosurgery. Baltimore: Lippincott William & Wilkins, 2001, pp 123-134

14. Linskey ME. The total quality movement: A paradigm shift in leadership and management philosophy for neurological surgery and health care in general. In Linskey ME, Rutigliano M, eds. Quality and Cost in Neurological Surgery. Volume 10 in Haines SJ, Nelson PB, eds. Concepts in Neurosurgery. Baltimore: Lippincott William & Wilkins, 2001, pp 3-31

15. Linskey ME, Rutigliano MJ. Preface. In Linskey ME, Rutigliano M, eds. Quality and Cost in Neurological Surgery. Volume 10 in Haines SJ, Nelson PB, eds. Concepts in Neurosurgery. Baltimore: Lippincott William & Wilkins, 2001, pp vii-viii

16. Schwaiki A, Ratanatharathorn V, Hutchins LF, El-Shihabi S, Linskey ME. Management of CNS metastases from breast carcinoma. In Berger MS, Prados MD, eds. Textbook of Neuro-Oncology. Philadelphia: Elsevier, Inc, 2005, pp 404-429

17. Linskey ME. Evidence-based medicine for neurosurgeons: Introduction and methodology. In Pollock BE, Ed. Guiding Neurosurgery by Evidence. Prog Neurol Surg. Basel, Karger, 2006; 19:1-53.

18. Hanna E, Linskey M, Pieper D. Malignant tumors of the anterior cranial base. In Sekhar Laligam N, Fessler Richard G, eds. Atlas of Neurosurgical Techniques. Brain. New York: Thieme, 2006, pp 588-598.

19. Danner C, Dornhoffer J, Linskey M. Repair of cranial nerve VII. In Sekhar Laligam N, Fessler Richard G, eds. Atlas of Neurosurgical Techniques. Brain. New York: Thieme, 2006, pp 881-885.

20. Linskey ME. Neurosurgery: Diseases of the nervous system. In Lawrence Peter F, Ed. Essentials of Surgical Specialties, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins, 2007, pp 331-395.

21. Linskey ME. Cavernous sinus hemangiomas. In Hay Ian D, Turner H, Wass John AH, eds. Clinical Endocrine Oncology, 2nd Edition. Oxford: Blackwell Scientific Publications, 2008, pp 318-324.

22. Zakrzewska JM, Linskey M. Trigeminal neuralgia. In Zakrzewska JM, Ed. Orofacial Pain. London, Oxford University Press 2009, pp 119-134.

23. Linskey ME, Jannetta PJ. Differential diagnosis of trigeminal neuralgia: Look alike diseases and atypical trigeminal neuralgia. In Jannetta PJ, Ed. Trigeminal Neuralgia. London, Oxford University Press 2010, pp 74-86.

24. Linskey ME. Stereotactic radiosurgery for trigeminal neuralgia. In Jannetta PJ, Ed. Trigeminal Neuralgia. London, Oxford University Press 2010, pp 169-191.

25. Mathews MS, Binder DK, Linskey ME. Trigeminal neuralgia: Diagnosis and non-operative management. In Winn HR, Ed. Youmans Textbook of Neurological Surgery, 6th Ed, Volume 2. Philadelphia, Saunders 2011, pp 1776 - 1780

26. Linskey ME, Kuo J. General and historical considerations of radiotherapy and radiosurgery. In Winn HR, Ed. Youmans Textbook of Neurological Surgery, 6th Ed, Volume 3. Philadelphia, Saunders 2011, pp 2547-2555

27. Alexandru D, Bota D, Linskey ME. Epidemiology of brain metastases. In Lunsford LD, Ed. Current and Future Management of Brain Metastasis. Prog Neurol Surg. Basel, Karger 2012; 25:13-29

28. Linskey ME. Treatment of an arteriovenous malformation in eloquent areas. Gamma Knife radiosurgery. Chapter 17 In Al-Mefty O, Origitano TC, Harkey L. Controversies in Neurosurgery. Second Edition. New York, Thieme 2013, pp 305, and 309-310

29. Linskey ME. Stereotactic radiosurgery for single metastatic brain tumors. In Sheehan J, Gerszten P, eds. Controversies in Stereotactic Radiosurgery. New York, Thieme 2013 (In Press)
   
Grant RESEARCH GRANTS 2014-2016 NIH/NINDS Translational R21, (under review) 2014-2015 NIH/NINDS R43 (SBIR) – Revision (submitted) 2014-2015 UC Irvine Foundation Philanthropy Grant 2013-2014 UC Irvine Foundation Philanthropy Grant 2012-2013 UC Irvine Foundation Philanthropy Grant 2011-2012 UC Irvine Foundation Philanthropy Grant 2010-2011 UC Irvine Foundation Philanthropy Grant 2008-2010 Chao Family Comprehensive Cancer Center, Cancer Center Seed Grant 2008-2009 UC Irvine, Council on Research Computing and Libraries, Multi- Investigator Faculty Research Grant 2007-2008 UC, Irvine School of Medicine, Committee on Research Award 2003-2005 University of Arkansas for Medical Sciences, Tobacco Fund 2003-2004 University of Arkansas for Medical Sciences, Medical Research Endowment Fund 1998-1999 Clinical Investigation Department, Naval Medical Center San Diego, CID # S-95-L000000-094 1996-1998 Clinical Investigation Department, Naval Medical Center San Diego, CID # S-96-L000000-062 1993-1994 European Organization for the Research and Treatment of Cancer / U.S. National Cancer Institute (EORTC/NCI) International Exchange Fellowship Grant 1993-1994 van Wagenen Fellowship Research Grant, American Association of Neurological Surgeons 1991-1992 Competitive Medical Research Fund, Presbyterian University Hospital, Pittsburgh, PA 1991-1992 Copeland Fund, Department of Neurological Surgery, University of Pittsburgh School of Medicine 1991-1992 Copeland Fund, Department of Neurological Surgery, University of Pittsburgh School of Medicine 1991-1992 Copeland Fund, Department of Neurological Surgery, University of Pittsburgh School of Medicine 1990-1991 Copeland Fund, Department of Neurological Surgery, University of Pittsburgh School of Medicine 1990-1991 Copeland Fund, Department of Neurological Surgery, University of Pittsburgh School of Medicine
   
Professional
Societies
Brd Dir, Am Assoc Neurol Surgeons
Congress of Neurol Surgeons
Chair, Counc State Neurosurg Soc
Washington Com (AANS/CNS)
Jnt Guidelines Com (AANS/CNS)
Exec Counc, Tumor Section (AANS/CNS)
Society of Neuro-Oncology
N Am Skull Base Society
Leksell Gamma Knife Soc
Int Stereotact Radiosurg Soc
Society Neurological Surgeons
Cerebrovascular Sect (AANS/CNS)
Society Univ Neurosurgeons
Western Neurosurg Society
CA Assoc Neurol Surgeons
OC Medical Association
Am Medical Association
Society for Neuroscience
   
Other Experience Neuro-Oncology Research Fellowship
Pittsburgh Cancer Institute 1994—1996

Neuro-Oncology Research fellowship
Ludwig Inst Cancer Research, London 1993—1994

Graduate Programs Neurological Surgery

   
Research Center Brain Tumor Research Laboratory, Med Sci 1, C214 & C356
   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=5322
   
Last updated 12/08/2013