Vice Chair, Department of Pharmaceutical Sciences
Joint Appointments, Pharmacolyg and Ecology/Evolutionary Biology
|The Impact of Botanical Extracts and Dietary Supplements on Longevity and Health, Anti-Aging Pharmacology, and Preventive Medicine|
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UCI Distinguished Professor Award for Teaching
The Greater Los Angeles Federal Executive Board Public Service Team Accomplishment Award for FDA/UCI Internship Program
The FDA Collaboration Award for the FDA/UCI Internship Program
UCI Distinguished Professor Award
UCI Department of Pharmaceutical Sciences “Most Inspiring Professor” Award
UCI Department of Pharmaceutical Sciences “Overall Outstanding Professor Award”
UCI Susan Samueli Center for Integrative Medicine “Discovery Award”
UCI Chancellor’s Award for Excellence in Fostering Undergraduate Research
UCI Distinguished Assistant Professor Award for Teaching
“20 Women to Watch in Orange County”, OC Metro Business Magazine
- Healthspan Pharmacology-
Consumption of natural products claimed to have anti-aging properties is high in the US population. While some studies show an impact on age-related diseases such as cancer, heart disease and neurodegenerative disorders, there are large gaps in our knowledge about the mechanisms through which these products modulate aging.
- Screening Candidate Anti-Aging Compounds -
We need appropriate methodologies to study the pharmacology of aging in model species, if experimental findings with such systems are to be extrapolated to the treatment of human aging. Using Drosophila as our model system, we have developed a number of bioassay to address this issue. These assays constitute a general testing protocol for anti-aging pharmacology.
- Molecular Mechanisms of Anti-Aging -
We hypothesize that botanicals extend life span and enhance health span by modulating one or more of the major pathways of aging: mitochondrial bioenergetics/oxidative stress, insulin signaling, sirtuins, and target of rapamycin (TOR). Using cell culture, Drosophila and mice as our model systems, we use standardized botanical extracts to address the following questions: 1) Do the botanicals that attenuate aging also improve health span? 2) Do these botanicals alter mitochondrial function, reduce free radicals, and/or protect against oxidative stress?; and 3) Do these botanicals act through the major pathways or proteins associated with aging?
- Selected Publications in Aging (Since 2006)-
Jafari, M. and Rose, M.R. 2006. Rules for the Use of Model Organisms in Anti-Aging Pharmacology. Aging Cell. 5:17-22.
Jafari M, Long AD, Mueller LD and Rose MR.. 2006. Pharmacology of aging in Drosophila. Current Drug Targets. (7), 1479-1483.
Mathieu, C. and Jafari, M. 2006 Immunomodulation by 1,25-dihydroxyvitamin D3: Therapeutic implications in autoimmunity and transplantation. Clinical Nephrology. 66(4): 275-283.
Mahtab Jafari, Behnood Khodayari, Jeffrey Felgner, Irvin I. Bussel, Michael R. Rose, and Laurence D. Mueller. 2007 Pioglitazone: An Anti-Diabetic Compound with Anti-Aging Properties. Biogerontology 8:639-651.
Mahtab Jafari, Jeffrey Felgner, Behnood Khodayari, Anthony Hutchili, Irvin I. Bussel, Concordia Vince-Cruz, Michael R. Rose, and Laurence D. Mueller. 2007 Rhodiola: A Promising Anti-Aging Chinese Herb. Rejuvenation Research. 10 (4): 1-16.
Sepulveda S., P. Shojaeian, C. L. Rauser, M. Jafari, L. D. Mueller, M. R. Rose. 2008. Interactions between Injury, Stress, and Aging in Drosophila melanogaster. Experimental Gerontology. 43(3):136-45.
Mahtab Jafari, Asghar Zarban, Steven Chang, and Thomas Wang. 2008 Rosa damascena decreases mortality in adult Drosophila. Journal of Medicinal Foods. 11 (1): 9-13.
Bussel, I.I, Joseph, M., Lewis, V., Jafari, M. 2008 Caffeine supplementation increases mortality in female Drosophila melanogaster without reproductive or metabolic impairment. Drosophila Information Services. Volume 91. December 2008.
Avanesian A, Khodayari B, Felgner J.S, Jafari M. 2009 Lamotrigine Extends Lifespan but Compromises Health Span in Drosophila melanogaster. Biogerontology. 11(1): 45-52.
Samuel E Schriner, Agnesa Avanesian, Yanxia Liu, Hendrik Luesch, and Mahtab Jafari. 2009 Protection of human cultured cells against oxidative stress by Rhodiola rosea without activation of antioxidant defenses. Free Radical Biology and Medicine. 47: 577-584
Samuel E. Schriner, Ani Abrahamyan, Agnesa Avanesian, Irvin Bussel, Maral Gazarian, Marissa A. Holmbeck, and Mahtab Jafari. 2009 Decreased mitochondrial superoxide levels and enhanced protection against paraquat in Drosophila melanogaster supplemented with Rhodiola rosea. Free Radical Research. 43(9): 836-843
Agnesa Avanesian, Sahar Semnani and Mahtab Jafari. 2009 Can Drosophila melanogaster Represent a Model System for the Detection of Reproductive Adverse Drug Reactions? Drug Discovery Today. 14 (15/16): 761-766.
Mahtab Jafari. 2010 Drosophila Melanogaster as a Model System for Evaluating Anti-aging Compounds. FLY 4 (3): 1-5
Kyu-Sun Lee, Byung-Sup Lee, Sahar Semnani, Agnesa Avanesian, Se-Yoon Um, Hyun-Jin Jeon, Kwon Yu, Kyung-Jin Min*, and Mahtab Jafari* (*equal contribution made by these authors). 2010 Curcumin Extends Lifespan, Improves Heal Span, and Modulate Aging Related Genes in Drosophila Melanogaster. Rejuvenation Research 13 (5): 1-10.
Zhongbo Liu, Xuesen Li, Anne R. Simoneau, Mahtab Jafari, and Xiaolin Zi. 2011. Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy. Molecular Carcinogenesis. April 22, 2011 (ePub)
Schriner SE, Katoozi NS, Pham KQ, Garzarian M, Zarban A, Jafari M. 2012. Extension of Drosophila lifespan by Rosa damascena associated with an increased sensitivity to heat. Biogerontology. 13(2):105-117.
Kislukhin, Galina; Murphy, Maura L.; Jafari, Mahtab; Long, Anthony D. 2012. Chemotherapy-induced toxicity is highly heritable in Drosophila melanogaster. Pharmacogenetics and Genomics. 22 (4): 285–289
Seyed Fazel Nabavi, Solomon Habtemariam, Mahtab Jafari, Antoni Sureda, and Seyed Mohammad Nabavi. 2012. Protective Role of Gallic Acid on Sodium Fluoride Induced
Oxidative Stress in Rat Brain. Bulleting of Enviromental Contamination and Toxicology. 89(1): 73-77.
Seyed Fazel Nabavi, Seyed Mohammad Nabavi, Solomon Habtemariam , Antoni Sureda , Mahtab Jafari , Fatemeh Abolhasani, and Akbar Hajizadeh Moghaddam. 2013. Hepatoprotective effect of gallic acid isolated from Peltiphyllum peltatum against sodium fluoride-induced oxidative stress. Industrial Crops and Products. 44:50-55.
Samuel E. Schriner, Kevin Lee, Stephanie Truong, Kathyrn T. Salvadora, Steven Maler, Alexander Nam, Thomas Lee, and Mahtab Jafari. 2013. Extension of Drosophila lifespan by Rhodiola rosea through a mechanism independent from dietary restriction. PLoS ONE 8(5): e63886
Lopez T, Schriner SE, Okoro M, Lu D, Chiang BT, Huey J, Jafari M. 2014. Green Tea Polyphenols Extend the Lifespan of Male Drosophila melanogaster While Impairing Reproductive Fitness J Med Food. 17(12):1314-1321.
Samuel E. Schriner, Steven Kuramada, Terry E. Lopez, Stephanie Truong, Andrew Pham, and Mahtab Jafari. 2014. Extension of Drosophila lifespan by cinnamon through a sex-specific dependence on the insulin receptor substrate chico. Experimental Gerontology. 60(C): 220-230.
Kil, Yun-Seo, Choi, Seul-Ki, Lee, Yun-Sil, Jafari, Mahtab, Seo, Eun-Kyoung. 2015. Chalcones from Angelica keiskei: Evaluation of Their Heat Shock Protein Inducing Activities. Journal of Natural Products. 78; 2481-2487.
Mahtab Jafari. Healthspan Pharmacology. 2015. Rejuvenation Research. 18(6): 573-80.
Terry E. Lopez, Hoang M. Pham, Julia Barbour, Phillip Tran, Sean P. Hogan, Benjamin Van Nguyen, Richelle L. Homo, Volkan Coskun, Samuel E. Schriner, and Mahtab Jafari. The impact of green tea polyphenols on development and reproduction of Drosophila melanogaster. 2016. Journal of Functional Foods. 20: 556–566
Samuel E. Schriner, Volkan Coskun, Sean P. Hogan, Terry E. Lopez, and Mahtab Jafari. Extension of Drosophila lifespan by Rhodiola rosea Depends on Dietary Carbohydrate and Caloric Content in a Simplified Diet. 2016. Journal of Medicinal Food. 19 (3): 318–323
Terry E Lopez; Hoang M Pham; Yerazik Tahmasian; Benjamin V Nguyen; Shannon Ramsden; Volkan Coskun; Samuel E Schriner, and Mahtab Jafari. Green Tea Polyphenols Require the Mitochondrial Iron Transporter, mitoferrin, for Lifespan Extension in Drosophila melanogaster. 2016. Archives of Insect Biochemistry and Physiology. 93(4): 210-221.
Yun-Seo Kil, Sally T. Pham, Eun Kyoung Seo,and Mahtab Jafari. Angelica keiskei, an emerging medicinal herb with various bioactive constituents and biological activities. Archives of Pharmacal Research. In press.
|Grants||National Institute of General Medical Sciences (NIGMS), R01 GM085251, 3/01/2009–2/28/2013, Drosophila as a Model for Chemotherapy Pharmacogenomics Role: Co-Investigator (PI: Anthony Long).|
|Ellison Medical Foundation, AG-NS-0495-08, 08/1/2008–07/31/2012, The Role of Mitochondrial Superoxide in Aging, Role: Supervisor (PI: Samuel E. Shriner).|
|National Center for Complementary & Alternative Medicine (NCCAM), R21 AT004987, 4/01/2010-3/31/2013, Botanicals, Mitochondrial Bioenergetics, and Aging Pathways, Role: PI.|
|National Cancer Institute (NCI), R21 CA152804, 03/08/2011-02/28/2013, Rhodiola Rosea Extracts, Salidroside and Bladder Cancer Chemoprevention, Role: Co-Investigator (PI: Xiaolin Zi).|
Medicinal Chemistry and Pharmacology
|Link to this profile||http://www.faculty.uci.edu/profile.cfm?faculty_id=5313|