Adriana D. BriscoeAssociate Professor, Ecology & Evolutionary Biology |
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Research Interests |
Molecular evolution, evolutionary physiology | |
| URL | Lab web page | |
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Academic Distinctions |
1993 Fox Award for Outstanding Undergraduate Performance, Biological Sciences, Stanford University 1993-1998 Howard Hughes Medical Institute PreDoctoral Fellowship 2000-2001 Ford Foundation Postdoctoral Fellowship 2008 Federation of American Societies for Experimental Biology Diversity Award |
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Research Abstract |
My lab's research focuses around an interest in understanding what happens to gene products underlying physiological traits following the processes of gene duplication and functional diversification. We use insect eyes as model systems for examining how structural changes in the primary amino acid sequence of a protein (opsin) can lead to changes in its physiological properties (absorbance spectrum). Changes in the physiological properties of molecules may lead to changes at higher levels of biological organization. For instance, global changes in the spatial expression of light-absorbing photoreceptors in the retina has direct consequences for the organism in its behavioral interactions with the environment. As an example, we have shown that some butterflies may be red-green color-blind because they have not evolved a duplicated rhodopsin gene capable of detecting light in a red-shifted portion of the visible light spectrum, while other butterflies have. | |
| Publications |
Pohl N, Sison-Mangus MP, Yee EN, Liswi SW, Briscoe AD. 2009. Impact of duplicate gene copies on phylogenetic analysis and divergence time estimates in butterflies. BMC Evolutionary Biology, 9:99 Frentiu FD, Briscoe AD. 2008. A butterfly’s eye view of birds. BioEssays 30: 1151-1162. Briscoe AD. 2008. Reconstructing the ancestral butterfly eye: Focus on the opsins. Journal of Experimental Biology 211: 1805-1813. Sison-Mangus MP, Briscoe AD, Zaccardi G, Knüttel H, Kelber A. 2008. The lycaenid butterfly Polyommatus icarus uses a duplicated blue opsin to see green. Journal of Experimental Biology, 211: 361-369. Frentiu FD, Bernard GD, Sison-Mangus MP, Brower AVZ, Briscoe AD. 2007. Gene duplication is an evolutionary mechanism for expanding spectral diversity in the long wavelength photopigments of butterflies. Molecular Biology and Evolution 24:2016-2028. Frentiu FD, Bernard GD, Cuevas CI, Sison-Mangus MP, Prudic KL, Briscoe AD. 2007. Adaptive evolution of color vision as seen through the eyes of butterflies. Proc Natl Acad Sci U.S.A. 104 Suppl 1:8634-8640. Yuan Q, Metterville D, Briscoe AD, Reppert SM. 2007. Insect cryptochromes: gene duplication and loss define diverse ways to construct insect circadian clocks. Mol Biol Evol. 24:948-55. Sison-Mangus MP, Bernard GD, Lampel J, Briscoe AD. 2006. Beauty in the eye of the beholder: the two blue opsins of lycaenid butterflies and the opsin gene-driven evolution of sexually dimorphic eyes. J Exp Biol. 209:3079-90. Zaccardi G, Kelber A, Sison-Mangus MP, Briscoe AD. 2006. Color discrimination in the red range with only one long-wavelength sensitive opsin. J Exp Biol. 209:1944-55. Zhu H, Yuan Q, Briscoe AD, Froy O, Casselman A, Reppert SM. 2005. The two CRYs of the butterfly. Curr Biol. 15:R953-4. Erratum in: Curr Biol. 2006. 16:730. Briscoe, Adriana D [added]. Lampel J, Briscoe AD, Wasserthal LT. 2005. Expression of UV-, Blue-, Long Wavelength-Sensitive Opsins and Melatonin in Extraretinal Photoreceptors of the Optic Lobes of Hawkmoths. Cell and Tissue Research, 321:443-458. Spaethe J, Briscoe AD. 2005. Molecular Characterization and Expression of the UV Opsin in Bumblebees: Three Ommatidial Subtypes in the Retina and a New Photoreceptor Organ in the Lamina. Journal of Experimental Biology, 208: 2347-2361. Sauman I*, Briscoe AD*, Zhu H, Shi DD, Froy O, Stalleicken J, Yuan Q, Casselman A and Reppert SM. 2005. Connecting the Navigational Clock to Sun Compass Input in Monarch Butterfly Brain. Neuron, 46: 457-467. Briscoe AD, Bernard GD. 2005. Eyeshine and Spectral Tuning of Long Wavelength-Sensitive Rhodopsins: No Evidence for Red-Sensitive Photoreceptors Among Five Nymphaline Butterfly Species. Journal of Experimental Biology, 208: 687-696. Briscoe AD, White RH. 2005. Adult Stemmata of the Butterfly Vanessa cardui Express UV and Green Opsin mRNAs. Cell and Tissue Research, 319:175-9. Spaethe J, Briscoe AD. 2004. Early Duplication and Functional Diversification of the Opsin Gene Family in Insects. Molecular Biology and Evolution, 21: 1583-1594. Briscoe AD, Gaur C, Kumar S. 2004. The Spectrum of Human Rhodopsin Disease Mutations Through the Lens of Interspecific Variation. Gene, 332: 107-118. Briscoe AD, Bernard GD, Szeto AS, Nagy LM, White RH. 2003. Not All Butterfly Eyes are Created Equal: Rhodopsin Absorption Spectra, Molecular Identification and Localization of UV-, Blue- and Green-sensitive Opsins in the Retina of Vanessa cardui. Journal of Comparative Neurology, 458:334-349 Briscoe AD. 2002. Homology Modeling Suggests a Functional Role for Parallel Amino Acid Substitutions Between Bee and Butterfly Red- and Green-Sensitive Opsins. Molecular Biology and Evolution, 19 (6): 983-986. Briscoe AD. 2001. Functional Diversification of Lepidopteran Opsins Following Gene Duplication. Molecular Biology and Evolution, 18(12): 2270-2279 Briscoe AD and Chittka L. 2001. The Evolution of Color Vision in Insects. Annual Review of Entomology, 46: 571-510 Briscoe AD. 2000. Six Opsins from the Butterfly Papilio glaucus: Molecular Phylogenetic Evidence for Paralogous Origins of Red-sensitive Visual Pigments in Insects. Journal of Molecular Evolution, 51: 110-121 Pichaud F, Briscoe A, and Desplan C. 1999. Evolution of Color Vision. Current Opinion in Neurobiology, 9: 622-627 Briscoe AD. 1998. Molecular Diversity of Visual Pigments in the Butterfly Papilio glaucus. Naturwissenschaften, 85 (1): 33-35 |
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| Link to this profile | http://www.faculty.uci.edu/profile.cfm?faculty_id=5288 | |
| Last updated | 06/03/2009 | |