Lan Huang

Professor, Physiology & Biophysics
School of Medicine

B.S., Nanjing University, China, 1986, Chemistry


Ph.D., University of Florida, 1995, Analytical Chemistry

Phone: (949) 824-8548
Fax: 949-824-8540
Email: lanhuang@uci.edu

University of California, Irvine
D233 Medical Science I
Mail Code: 4560
Irvine, CA 92697

picture of Lan  Huang

Research
Interests
biological mass spectrometry/proteomics, ubiquitin-proteasome degradation pathways, protein complexes, posttranslational modifications, protein-protein interaction
   
URL Huang lab web page
   
Appointments 1996-1997 postdoctoral fellow, Mass Spectrometry Facility, Department of Pharmaceutical Chemistry, University of California, San Francisco
1997-2003 Research specialist, Department of Pharmaceutical Chemistry, Mass Spectrometry Facility, University of California, San Francisco
2003-2009 Assistant Professor, Depts. of Physiology & Biophysics and Developmental & Cell Biology
2009-2012 Associate Professor, Depts. of Physiology & Biophysics and Developmental & Cell Biology
7/2012- Professor, Dept of Physiology & Biophysics
   
Research
Abstract
The 26S Proteasome is a macromolecular machine responsible for ubiquitin/ATP dependent protein degradation in both cytosol and nucleus. Of the two distinct sub-complexes, the 20S proteasome complex is responsible for various proteolytic activities while the 19S regulatory complex is believed to render ATP-dependent proteolysis of ubiquitinated substrates. Ubiquitin-proteasome dependent protein degradation plays critical roles in numerous essential cellular processes, including cell cycle progression, apoptosis, DNA repair, etc. Recognition and degradation of ubiquitinated substrates including cell cycle regulators, tumor suppressors and transcription factors by the 26S proteasome are tightly regulated to maintain normal cell growth. Because of that, disruption of normal proteasomal degradation pathways can lead to a wide range of human disease, including forms of cancer and neurological degeneration. Recently, the proteasome has become an attractive therapeutic target for the treatment of various cancers. To enrich our understanding of ubiquitin-proteasome degradation pathway for future cancer treatment, we are interested in developing and employing mass spectrometry-based proteomic approaches to identify and characterize the dynamics of both yeast and human 26S proteasome complexes in various biological and pathological processes. The proteomic information obtained in this research will help us understand the mechanisms of ubiquitin-proteasome degradation pathway. In addition, it may provide molecular linkages between various biological processes that are regulated by the ubiquitin-proteasome dependent degradation. Furthermore, the methods developed for the proteasome complex can be applied to the studies of other macromolecular protein complexes.
   
Available Technologies
Publications See Huang lab website
   
Graduate Programs Cancer Biology

Biomedical Engineering

Cell Biology

Cellular and Molecular Biosciences

   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=5268
   
Last updated 07/19/2012