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Michael R. Rose

Professor & Director of NERE, Ecology & Evolutionary Biology
School of Biological Sciences

Ph.D., University of Sussex, 1979, Biology

Phone: (949) 824-8121, 8198
Fax: (949) 824-2181
Email: mrrose@uci.edu

University of California, Irvine
Ecology and Evolutionary Biology
School of Biological Sciences
Mail Code: 2525
Irvine, CA 92697

picture of Michael R. Rose

Research
Interests
Experimental Evolution; Aging; Biological Immortality; Drosophila; Human Evolution; Evolution of Sex
   
URL The Rose Laboratory Website
   
Academic
Distinctions
British Commonwealth Scholar, 1976-1979
NATO Science Fellow, 1979-1981
NSERC of Canada University Research Fellow, 1981-1988
President's Prize (with others) American Society of Naturalists, 1992
Excellence in Teaching Award, UCI Biological Sciences, 1996
Busse Prize, World Congress of Gerontology, 1997
   
Appointments NATO Science Fellow: Laboratory of Genetics, University of
Wisconsin, Madison, 1979-1981

Dalhousie University: Assistant
Prof. of Biology, 1981-1985; Associate
Professor of Biology, 1985-1988

University of California, Irvine:
Associate Professor of Biology, 1986-1990;
Professor of Biology, 1990-

University of California, Systemwide:
Director, Intercampus Research Program
on Experimental Evolution, 2004-2005;
Director, Network for Experimental Research on Evolution,
A University of California Multicampus Research Program, 2006-
   
Research
Abstract
On receiving a British Commonwealth Scholarship in 1976, Michael Rose proceeded to the University of Sussex for his doctoral studies under the supervision of Brian Charlesworth and John Maynard Smith. The subject of his doctoral research was the quantitative genetics of aging in Drosophila melanogaster. A N.A.T.O. Science Fellowship took Rose to the University of Wisconsin - Madison, in 1979, to work with James F. Crow at the Department of Genetics. During this period, he began to work out some of the theoretical population genetics behind the evolution of life-histories, particularly the concept of "antagonistic pleiotropy", a term of his coinage

A federally-funded research faculty position took Rose to Canada in 1981, where he became an Assistant Professor in the Department of Biology, Dalhousie University, Halifax, Nova Scotia. There he set up a Drosophila laboratory, as well as continuing with theoretical work. He was promoted to Associate Professor and tenured in 1985. In addition, Rose published Quantitative Ecological Theory, in 1987. While at Dalhousie, Rose pursued postponed aging, beginning with the organismal physiology involved, particularly energetic metabolism. This work extended aging research in an influential new direction, combining physiology with evolution. In particular, Rose and his students showed that resistance to various stresses was a key factor in postponed aging; flies with the genetic capacity to live longer are better able to resist stress at every adult age. This work has opened up new avenues of research on aging, with collaborations between physiologists and evolutionists of increasing importance.

In 1987, Rose returned to the United States to become an Associate Professor at the University of California, Irvine. In 1990, Rose was promoted to Professor. In 1991, his Evolutionary Biology of Aging appeared, a book that ranged from mathematical genetics to cell biology. This work offered a view of aging that was a complete departure from the views that had dominated the aging field since 1960. The journal Evolution described the field of gerontology as having become "after Rose". In 1997, Rose received the Busse Prize of the World Congress of Gerontology. In 1998, his book Darwin’s Spectre was published, a popular introduction to the history and significance of evolutionary biology. In 2004, a compendium of his laboratories' research findings was published as Methuselah Flies. His latest books are Experimental Evolution (with T. Garland) and Does Aging Stop? (with L.D. Mueller and C.L. Rauser).
   
Publications Curriculum Vitae: (PDF)

Selected Publications (From 277)

Books (selected)

L.D. Mueller, C.L. Rauser, & M.R. Rose. Does Aging Stop? Oxford University Press, New York.

T. Garland & M.R. Rose, Eds. 2009. Experimental Evolution. University of California Press, Berkeley.

M.R. Rose and L.D. Mueller. 2006. Evolution and Ecology of the Organism. Prentice-Hall, Upper Saddle River, New Jersey.

M.R. Rose. 2005. The Long Tomorrow; How Advances in Evolutionary Biology Can Help Us Postpone Aging. Oxford University Press, New York.

M.R. Rose, H.B. Passananti, and M. Matos, Editors. 2004. Methuselah Flies: A Case Study in the Evolution of Aging. World Scientific Publishing, Singapore.

M.R. Rose. 1998. Darwin's Spectre, Evolutionary Biology in the Modern World. Princeton University Press, Princeton, N.J.

M.R. Rose and G.V. Lauder, Editors. 1996. Adaptation. Academic Press, New York.

M.R. Rose and C.E. Finch, Editors. 1994. Genetics and Evolution of Aging. Kluwer Academic Publishers, Dordrecht, the Netherlands.

M.R. Rose. 1991. Evolutionary Biology of Aging. Oxford University Press, New York.

Reviewed Articles (selected)

M.R. Rose. 2011. Gods and Darwinists. Quarterly Review of Biology 84(4): 323-328. (PDF)

M.R. Rose, L.D. Mueller, and M.K. Burke. 2011. New experiments for an undivided genetics.
Genetics 188: 1-10. (PDF)

M.K. Burke, J.P. Dunham, P. Shahrestani, K.R. Thornton, M.R. Rose, and A.D. Long. 2010. Genome-wide analysis of a long-term evolution experiment with Drosophila. Nature, in press. Nature 467:
587-590. Covered in NY Times article by Nicholas Wade, September 20, 2010: “Natural Selection Cuts Broad Swath Through Fruit Fly Genome.” (PDF)


H. Teotónio, I.M. Chelo, M. Bradi?, M.R. Rose & A.D. Long. 2009. Experimental evolution reveals natural selection on standing genetic variation. Nature Genetics 41: 251-257. Covered in News and Views feature in same issue: Reverse evolution and evolutionary memory. M.M. Desai, Nature Genetics 41: 142-143. (PDF)


P. Shahrestani, L.D. Mueller, & M.R. Rose. 2009. Does aging stop? Current Aging Science 2: 3-11. (PDF)


M.R. Rose & J.P. Phelan. 2009. Gods inside. In Voices of Disbelief (Ed. R. Blackford & U. Schuklenk, Wiley-Blackwell Press, New York). (PDF)


M.R. Rose & T. Garland. 2009. Darwin’s other mistake. In Experimental Evolution (Garland, T., and Rose, M.R., Eds., University of California Press). (PDF)


C.L. Rauser, L.D. Mueller, M. Travisano, & M.R. Rose. 2009. Evolution of aging and late life. In Experimental Evolution (Garland, T., and Rose, M.R., Eds., University of California Press). (PDF)


M.K. Burke & M.R. Rose. 2009. Experimental evolution with Drosophila. American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology 296: R1847-R1854. (PDF)


M.R. Rose. 2009. Adaptation, Aging, and Genomic Information. Aging 1: 444-50. (PDF)


M.R. Rose, M.K. Burke, P. Shahrestani, & L.D. Mueller. 2008. Evolution of ageing since Darwin. Journal of Genetics 87: 363-371. (PDF)


S. Sepulveda, P. Shojaeian, C. L. Rauser, M. Jafari, L. D. Mueller, & M. R. Rose. 2008. The Relationship between Injury, Stress, and Aging in Drosophila melanogaster. Experimental Gerontology 43: 136-145. (PDF)


M.R. Rose and T.H. Oakley. 2007. The new biology: Beyond the Modern Synthesis. Biology Direct 2: epub, 30. (PDF)


M.R. Rose, C.L. Rauser, G. Benford, M. Matos, & L.D. Mueller. 2007. Hamilton’s Forces of Natural Selection after forty years. Evolution 61: 1265-1276. (PDF)


M.A. Archer, T.J. Bradley, L.D. Mueller & M.R. Rose. 2007. Using experimental evolution to study the physiological mechanisms of desiccation resistance in Drosophila melanogaster. Physiological and Biochemical Zoology 80: 386-398. (PDF)


L.D. Mueller, C.L. Rauser, & M.R. Rose. 2007. An evolutionary heterogeneity model of late-life fecundity in Drosophila. Biogerontology 8: 147-161. (PDF)


W. Van Voorhies, J.W. Curtsinger, & M.R. Rose. 2006. Do longevity mutants always show trade-offs? Experimental Gerontology 41: 1055-1058. (PDF)


J.L. Graves & M.R. Rose. 2006. Against racial medicine. Patterns of Prejudice 40: 481-493. (PDF)


M. R. Rose, C.L. Rauser, L.D. Mueller, & G. Benford. 2006. A revolution for aging research. Biogerontology 7: 269-277. (PDF)


C.L. Rauser, L.D. Mueller, & M.R. Rose. 2006. The evolution of late life. Aging Research Reviews 5: 14-32. (PDF)


C.L. Rauser, J.J. Tierney, S. M. Gunion, G. M. Covarrubias, L. D. Mueller, and M. R. Rose. 2006. Evolution of late-life fecundity in Drosophila melanogaster. Journal of Evolutionary Biology 19: 289-301. (PDF)


M. R. Rose, C.L. Rauser & L.D. Mueller. 2005. Late life: A new frontier for physiology. Physiological and Biochemical Zoology 78: 869-878. (PDF)


C.L. Rauser, Y. Abdel-Aal, J.A. Shieh, C.W. Suen, L.D. Mueller & M.R. Rose. 2005. Lifelong heterogeneity in fecundity is insufficient to explain late-life fecundity plateaus in Drosophila melanogaster. Experimental Gerontology 40: 660-670. (PDF)

M.R. Rose, H.B. Passananti, A.K. Chippindale, J.P. Phelan, M. Matos, H. Teotónio, & L.D. Mueller. 2005. The effects of evolution are local: Evidence from experimental evolution in Drosophila. Integrative and Comparative Biology 45: 486-491. (PDF)


J.P. Phelan & M.R. Rose. 2005. Why dietary restriction substantially increases longevity in animal models but won’t in humans. Aging Research Reviews 4: 339-350. (PDF)


C.L. Rauser, J.S. Hong, M.B. Cung, K.M. Pham, L.D. Mueller, and M.R. Rose. 2005. Testing whether male age or high nutrition causes the cessation of reproductive aging in female Drosophila melanogaster populations. Rejuvenation Research 8: 86-95. (PDF)


H. Teotónio, M. Matos, and M.R. Rose. 2004. Quantitative genetics of functional characters in Drosophila melanogaster populations subjected to laboratory selection. J. Genet. 83: 265-277. (PDF)


M. Matos, P. Simões, A. Duarte, C. Rego, T. Avelar, and M.R. Rose. 2004. Convergence to a novel environment - Comparative method versus experimental evolution. Evolution 58: 1503–1510. (PDF)

A.K. Chippindale, A.L. Ngo, & M.R. Rose. 2003. The devil in the details of life history evolution: Instability and reversal of genetic correlations during selection on Drosophila development. Journal of Genetics 82: 133-145. (PDF)


J. P. Phelan, M.A. Archer, K.A. Beckman, A.K. Chippindale, T.J. Nusbaum, & M.R. Rose. 2003. Breakdown in Correlations During Laboratory Evolution. I. Comparative Analyses of Drosophila Populations. Evolution 57: 527-535. (PDF)


M.A. Archer, J.P. Phelan, K.A. Beckman, & M.R. Rose. 2003. Breakdown in Correlations During Laboratory Evolution. II. Selection on Stress Resistance in Drosophila Populations. Evolution 57: 536-543. (PDF)


L.D. Mueller, M.D. Drapeau, C.S. Adams, C.W. Hammerle, K.M. Doyal, A. J. Jazayeri, T. Ly, S.A. Beguwala, A.R. Mamidi, & M.R. Rose. 2003. Statistical tests of demographic heterogeneity theories. Experimental Gerontology 38: 373-386. (PDF)


M.R. Rose, M.D. Drapeau, P.G. Yazdi, K.H. Shah, D.B. Moise, R.R. Thakar, C. L. Rauser, & L. D. Mueller. 2002. Evolution of late-life mortality in Drosophila melanogaster. Evolution 56: 1982-1991. (PDF)


H. Teotónio, M. Matos, & M.R. Rose. 2002. Reverse evolution of fitness in Drosophila melanogaster. J. of Evolutionary Biology 15: 608-617. (PDF)


M. Matos, T. Avelar, & M.R. Rose. 2002. Variation in the rate of convergent evolution: adaptation to a laboratory environment in Drosophila subobscura. J. of Evolutionary Biology 15: 673-682. (PDF)


H. Teotónio & M.R. Rose. 2001. Perspective: Reverse evolution. Evolution 55: 653-660. (PDF)


M.R. Rose & L.D. Mueller. 2000. Ageing and immortality. Philosophical Transactions of the Royal Society, London 355: 1657-1662. (PDF)


H. Teotónio & M.R. Rose. 2000. Variation in the reversibility of evolution. Nature 408: 463-466. (PDF)


M.D. Drapeau, E.K. Gass, M.D. Simison, L.D. Mueller, & M.R. Rose. 2000. Testing the heterogeneity theory of late-life mortality plateaus by using cohorts of Drosophila melanogaster. Experimental Gerontology 35: 71-84. (PDF)


M.R. Rose. 1999. Genetics of aging in Drosophila. Experimental Gerontology 34: 577-85. (PDF)


T.J. Bradley, A.E. Williams, & M.R. Rose. 1999. Physiological responses to selection for desiccation resistance in Drosophila melanogaster. American Zoologist 39: 337-45. (PDF)


T.J. Nusbaum & M.R. Rose. 1999. The effects of nutritional manipulation and laboratory selection on lifespan in Drosophila melanogaster. Journal of Gerontology: Biological Sciences 54A: B192-B198. (PDF)


M.R. Rose. 1998. Darwinian anti-aging medicine. Journal of Anti-Aging Medicine 1: 105-108. (PDF)


M.R. Rose & T.J. Bradley. 1998. Evolutionary physiology of the cost of reproduction. OIKOS 83: 443-451. (PDF)


A.K. Chippindale, A.G. Gibbs, M. Sheik, K.J. Yee, M. Djawdan, T.J. Bradley, & M.R. Rose. 1998. Resource acquisition and the evolution of stress resistance in Drosophila melanogaster. Evolution 52: 1342-52. (PDF)


M.R. Rose & L.D. Mueller. 1998. Evolution of human lifespan: past, future, and present. American Journal of Human Biology 10: 409-420. (PDF)


A.K. Chippindale, J.A. Alipaz, H-W. Chen, and M.R. Rose. 1997. Experimental evolution of accelerated development in Drosophila. 1. Larval development speed and survival. Evolution 51: 1536-1551. (PDF)


A.K. Chippindale, A.M. Leroi, H. Saing, D.J. Borash & M.R. Rose. 1997. Phenotypic plasticity and selection in Drosophila life-history evolution. 2. Diet, mates and the cost of reproduction. Journal of Evolutionary Biology 10: 269-293. (PDF)


D.J. Deckert-Cruz, R.H. Tyler, J.E. Landmesser & M.R. Rose. 1997. Allozymic differentiation in response to laboratory demographic selection of Drosophila melanogaster. Evolution 51: 865-872. (PDF)


A.G. Gibbs, A.K. Chippindale & M.R. Rose. 1997. Physiological mechanisms of
evolved desiccation resistance in Drosophila melanogaster. Journal of Experimental Biology 200: 1821-1832. (PDF)


L.D. Mueller & M.R. Rose. 1996. Evolutionary theory predicts late-life mortality plateaus. Proc. Natl. Acad. Sci. USA 93: 15249-15253. (PDF)


M. Djawdan, T. Sugiyama, L. Schlaeger, T.J. Bradley, & M.R. Rose. 1996. Metabolic aspects of the trade-off between fecundity and longevity in Drosophila melanogaster. Physiological Zoology 69:1175-1195. (PDF)


T.J. Nusbaum, L.D. Mueller, & M.R. Rose. 1996. Evolutionary patterns among measures of aging. Experimental Gerontology 31:507-516. (PDF)


A.K. Chippindale, T.J.F. Chu & M.R. Rose. 1996. Complex trade-offs and the evolution of starvation resistance in Drosophila melanogaster. Evolution 50:753-66. (PDF)


L.D. Mueller, T.J. Nusbaum & M.R. Rose. 1995. The Gompertz equation as a predictive tool in demography. Experimental Gerontology 30:553-569. (PDF)


C.E. Finch & M.R. Rose. 1995. Hormones and the physiological architecture of life-history evolution. Quarterly Review of Biology 70: 1-52. (PDF)


A.K. Chippindale, D.T. Hoang, P.M. Service & M.R. Rose. 1994. The evolution of development in Drosophila melanogaster selected for postponed senescence. Evolution 48: 1880-1899. (PDF)


A.M. Leroi, A.K. Chippindale & M.R. Rose. 1994. Long-term laboratory evolution of a genetic trade-off in Drosophila melanogaster. I. The role of genotype x environment interaction. Evolution 48: 1244-1257. (PDF)


A.M. Leroi, W.R. Chen & M.R. Rose. 1994. Long-term laboratory evolution of a genetic trade-off in Drosophila melanogaster. II. Stability of genetic correlations. Evolution 48: 1258-1268. (PDF)


A.M. Leroi, S.B. Kim & M.R. Rose. 1994. The evolution of phenotypic life-history trade-offs: an experimental study using Drosophila melanogaster. American Naturalist 144:661-676. (PDF)


M.R. Rose & T.J. Nusbaum. 1994. Prospects for postponing human aging. FASEB Journal 8: 925-928. (PDF)


T.J. Nusbaum & M.R. Rose. 1994. Aging in Drosophila. Comparative Biochemistry and Physiology 109A: 33-38. (PDF)


J.E. Fleming, G.S. Spicer, R.C. Garrison & M.R. Rose. 1993. Two dimensional protein electrophoretic analysis of postponed aging in Drosophila. Genetica 91: 183-198. (PDF)


L.D. Mueller, J.L. Graves, & M.R. Rose. 1993. Interactions between density-dependent and age-specific selection in Drosophila melanogaster. Functional Ecology 7:469-479. (PDF)


G.V. Lauder, A.M. Leroi & M.R. Rose. 1993. Adaptations and history. Trends in Ecology and Evolution 8:294-297. (PDF)


A.K. Chippindale, A.M. Leroi, S.B. Kim, & M.R. Rose. 1993. Phenotypic plasticity and selection in Drosophila life-history evolution. I. Nutrition and the cost of reproduction. J. Evol. Biology 6:171-193. (PDF)


M.R. Rose, L.N. Vu, S.U. Park, & J.L. Graves. 1992. Selection for stress resistance increases longevity in Drosophila melanogaster. Exp. Gerontol. 27: 241-250. (PDF)


J.L. Graves, E.C. Toolson, C. Jeong, L.N. Vu, & M.R. Rose. 1992. Desiccation, flight, glycogen, and postponed senescence in Drosophila melanogaster. Physiol. Zool. 65:268-286. (PDF)


T.B.L. Kirkwood & M.R. Rose. 1991. Evolution of senescence: late survival sacrificed for reproduction. Phil. Trans. R. Soc. B 332: 15 24. (PDF)


E.W. Hutchinson & M.R. Rose. 1991. Quantitative genetics of postponed aging in Drosophila melanogaster. I. Analysis of outbred populations. Genetics 127: 719 727. (PDF)


E.W. Hutchinson, A.J. Shaw & M.R. Rose. 1991. Quantitative genetics of postponed aging in Drosophila melanogaster. II. Analysis of selected lines. Genetics 127: 729 737. (PDF)


M.R. Rose. 1989. Genetics of increased lifespan in Drosophila. Bioessays 11: 132 135. (PDF)


M.R. Rose & J.L. Graves. 1989. What evolutionary biology can do for gerontology. J. Gerontology: B27-B29. (PDF)


P.M. Service, E.W. Hutchinson, & M.R. Rose. 1988. Multiple genetic mechanisms for the evolution of senescence in Drosophila melanogaster. Evolution 42: 708-716. (PDF)


D.E. Edmonds & M.R. Rose. 1988. Reproductive wastage and the evolution of genetic systems. J. Theor. Biol. 132: 247-250. (PDF)


M. Krieber & M.R. Rose. 1986. Males, parthenogenesis, and the maintenance of anisogamous sex. J. Theor. Biol. 122: 421-440. (PDF)


C. Tremblay & M.R. Rose. 1985. Population dynamics of gene transfer. Theor. Pop. Biol. 28: 359-381. (PDF)


M.R. Rose. 1985. Life-history evolution with antagonistic pleiotropy and overlapping generations. Theor. Pop. Biol. 28: 342-358. (PDF)


P.M. Service, E.W. Hutchinson, M.D. MacKinley, & M.R. Rose. 1985. Resistance to environmental stress in Drosophila melanogaster selected for postponed senescence. Physiol. Zool. 58: 380-389. (PDF)


P.M. Service & M.R. Rose. 1985. Genetic covariation among life history components: the effect of novel environments. Evolution 39: 943-945. (PDF)


R.J. Wassersug & M.R. Rose. 1984. A reader's guide and retrospective to the 1982 Darwin centennial. Q. Rev. Biol. 59: 417-437. (PDF)


M.R. Rose. 1984. Laboratory evolution of postponed senescence in Drosophila melanogaster. Evolution 38: 1004-1010. (PDF)


M.R. Rose. 1984. The evolution of animal senescence. Can. J. Zool. 62: 1661-1667. (PDF)


M.R. Rose, M.L. Dorey, A.M. Coyle & P.M. Service. 1984. The morphology of postponed senescence in Drosophila melanogaster. Can. J. Zool. 62: 1576-1580. (PDF)


M.R. Rose. 1984. Artificial selection on a fitness-component in Drosophila melanogaster. Evolution 38: 516-526. (PDF)


M.R. Rose. 1984. Genetic covariation in Drosophila life history: untangling the data. Am. Nat. 123: 565-569. (PDF)


M.R. Rose & W.F. Doolittle. 1983. Molecular biological mechanisms of speciation. Science 220: 157-162. (PDF)


M.R. Rose. 1983. The contagion mechanism for the origin of sex. J. Theor. Biol. 101: 137-146. (PDF)


M.R. Rose. 1983. Theories of life-history evolution. Am. Zool. 23: 15-23. (PDF)


M.R. Rose. 1983. Hominid evolution and social science. J. Soc. Biol. Struct. 6: 29-36. (PDF)


M.R. Rose. 1982. A physiological barrier for the maintenance of anisogamous sex. J. Theor. Biol. 94: 801-813 (PDF)


M.R. Rose. 1982. Antagonistic pleiotropy, dominance, and genetic variation. Heredity 48: 63-78. (PDF)


M.R. Rose & B. Charlesworth. 1981. Genetics of life-history in Drosophila melanogaster. II. Exploratory selection experiments. Genetics 97: 187-196. (PDF)


M.R. Rose & B. Charlesworth. 1981. Genetics of life-history in Drosophila melanogaster. I. Sib analysis of adult females. Genetics 97: 173-185. (PDF)


M.R. Rose & R. Harmsen. 1981. Ecological outbreak dynamics and the cusp catastrophe. Acta Biotheoretica 30: 239-263. (PDF)


M. Rose & B. Charlesworth. 1980. A test of evolutionary theories of senescence. Nature 287: 141-142. (PDF)


M.R. Rose. 1980. The mental arms race amplifier. Human Ecol. 8: 285-293. (PDF)


J. Haigh & M.R. Rose. 1980. Evolutionary game auctions. J. Theor. Biol. 85: 381-397. (PDF)

M.R. Rose. 1978. Cheating in evolutionary games. J. Theor. Biol. 75: 21-34. (PDF)
   
Professional
Societies
Member, Society for the Study of Evolution
Fellow, AAAS
   
Research Center Director of the Network for Experimental Research on Evolution (NERE), A University of California Multicampus Research Program
   
   
Link to this profile http://www.faculty.uci.edu/profile.cfm?faculty_id=5261
   
Last updated 02/13/2012