Argyrios ZiogasAssociate Adjunct Professor, Epidemiology |
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Research Interests |
Biostatistics, Statistical Genetics, Epidemiology | |
| URLs | Dept. of Epidemiology | |
| UC Irvine Genetic Epidemiology Research Institute | ||
| Appointments |
Assoc. Adj. Professor, UCI, (1996 - present) Lecturer,UCLA School of Public Health (1996) |
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Research Abstract |
My main research is in the development of statistical methodology of doing family studies. I am concentrating on three important areas: 1) statistical models for analysis in genetic (family based) data; 2) development of statistical methods that deal with ascertainment bias; and 3) the examination of gene-environment and gene-gene interactions that may be involved in the etiology of breast, colorectal, or prostate cancer. Applications of my research include the use of efficient designs that allow for the testing of hypotheses concerning gene-environment interactions or effect modifications related to the etiology of breast, ovarian, and colon cancer; estimation of the frequency of susceptibility or metabolic genes in the general population; and the estimation of the attributable risk of genetic and environmental factors for breast, ovarian, and colorectal cancer. In particular, I am interested in the development of efficient sampling for the analysis of case-control and cohort studies as applied to the genetic epidemiology. These designs include nested case-control, case-cohort, and counter-match case control designs. My interest is in determining the efficiency of such designs and comparing the relative efficiency across different study designs. Other research interests include developing methods of correction for measurement error in case-control and cohort studies. In particular, I am concerned with situations where information on exposure data (measured and true) exists in part of the subjects but not in all participants. Another area related to the above is my interest in developing statistical methods for family validation studies. | |
| Publications |
Dugel P.U., Liggett P.E., Lee M.B., Ziogas A., Forster D.J., Smith R.E., Rao N.A. Repair of retinal detachment caused by cytomegalovirus retinitis in patients with the Acquired Immunodeficiency Syndrome. American Journal of Ophthalmology, 112:235-242, 1991 Blackhall L.J., Ziogas A., Azen S.P. Low survival rate after cardiopulmonary resuscitation in a county hospital. Archives of Internal Medicine, 152: 2045-2048, 1992. 3. Faucett C., Gauderman W.J., Thomas D., Ziogas A., Sobel E. Combined segregation and linkage analysis of late onset Alzheimer's disease in Duke families using Gibbs Sampling. Genetic Epidemiology, 10: 489-494, 1993. Lerner S.P., Skinner D.G., Lieskovsky G., Boyd S.D., Groshen S.L., Ziogas A., Skinner E., Nichols P., Hopwood B. The rationale for en block pelvic lymph node dissection for bladder cancer patients with nodal metastases: long-term results. The Journal of Urology, 149: 758-765. 1993 Moreira H., Kolahdouz-Isfahani A.H., Englanoff J.S., Fasano A.P., Ziogas A., Villaseñor R., McDonnell P.J. Retrospective comparison of simultaneous and non-simultaneous bilateral radial keratotomy. Journal Refract. Corneal Surg, 10(50):545-9, 1994 Sharpe K.P., Rao S., Ziogas A. Evaluation of the effectiveness of the Minerva cervicothoracic orthosis. Spine, 20(13): 1475-9, 1995. Stanczyk FZ, Gentzschein E, Ary BA, Kojima T, Ziogas A, Lobo RA. Urinary progesterone and pregnanediol: use for monitoring progesterone treatment. Journal of Reproductive Medicine, 42(4):216 22, 1997. Janezic S., Ziogas A, Krumroy LM, Krasner M, Plummer SJ, Cohen P, Gildea M, Barker D, Haile R, Casey G, Anton Culver H. Germline BRCA1 alterations in a population based series of ovarian cancer cases. Human Molecular Genetics, 8(5): 889 897, 1999. Brewster WR, DiSaia PJ, Ziogas A., Monk BJ, Yamada SD, Anton-Culver H. Young age as a prognostic factor in cervical cancer: Results of a population based analysis. American Journal of Obstetrics & Gynecology 180(6 Pt 1):1467-7, 1999. Kolodner R, Tytell J, Schmeits J, Kane MF, Gupta RD, Wahlberg S, Fox EA, Garber JE, Syngal S, Peel D, Ziogas A, Anton-Culver H, Li FP. Germline msh6 mutations in colorectal cancer families. Cancer Research, 59: 5068-5074, 1999. Ziogas A, Gildea M, Cohen P, Bringman D, Taylor TH, Seminara D, Barker D, Casey G, Haile R, Liao SY, Thomas D, Noble B, Kurosaki T, and Anton-Culver H. Cancer risk estimates for family members of a population-based family registry for breast and ovarian cancer. Cancer Epidemiology, Biomarkers and Prevention. Vol. 9, 103-11, Jan. 2000. Anton-Culver, H., Cohen, PE, Ziogas, A. Characteristics of BRCA1 mutations in a population-based case series of breast and ovarian cancer. European Journal of Cancer 36(2000) 1200-08. Peel D., Ziogas A., Li F., Fox E., Gildea M. Laham B., Clements E., Kolodner R., and Anton-Culver H. Characterization of Hereditary Nonpolyposis Colorectal Cancer families from a Population-Based Series of Cases. Journal of the National Cancer Institute, Vol. 92, No 18, Sep 20, 2000 Theuer, C., Kurosaki, T., Ziogas, A., Butler, J., Anton-Culver, H. Asian gastric cancer patients in America exhibit unique clinical features and superior overall and cancer specific survival. Cancer 2000 89:1883-1892. Brewster WR, Monk BJ, Ziogas A, Anton-Culver, H. Yamada SD, Berman ML. Intent-to-treat analysis of stage Ib and Ia cervical cancer in the United States: radiotherapy or surgery 1988-1995. Obstetrics & Gynecology 2001, 97:248-254. DiSaia PJ, Brewster WR, Ziogas A, Anton-Culver H. Breast cancer survival and hormone replacement therapy. A Cohort Analysis. Amer. Journal of Clinical Oncology 2000, 23(6):541-545 Langholz B., Ziogas A., Thomas D., Huberman M., Faucett C., and Goldstein L. Ascertainment bias ratio estimation from case-sibling control studies of variable age-at-onset diseases. Biometrics 55, 1129-1136, 1999. Semenza J, Ziogas A, Largent J, Peel D, Anton-Culver H. Gene-environment interactions in renal cell carcinoma. Am J Epidemiology. 2001, May 1:153(9):851-859. Anton-Culver H, Peel D, Ziogas A. Proportion of HNPCC in the general population, Response to Evans. (Correspondence regarding Peel et. al, Characterization of HNPCC families from a population based series of cases, published JNCI Reports 2000; 92(18):1517-1522.) Journal of the National Cancer Institute, vol. 93, no. 9, May 2, 2001: 717-718. Parada K.S., Peng R., Erickson RA., Hawes R., Sahai A.V., Ziogas A., Chang K.J. A resource utilization projection study of EUS. Gastrointest Endosc. 2002 Mar;55(3):328-334. Brewster WR, Anton-Culver H, Ziogas A, Largent J, Howe S, Hubbell FA, Manetta A. Recruitment strategies for cervical cancer prevention study. Gynecol Oncol. 2002 May;85(2):250-4. Horn-Ross PL, Hoggatt KJ, West DW, Krone MR, Stewart SL, Anton-Culver H, Bernstein L, Deapen D, Peel D, Pinder R, Reynolds P, Ross RK, Wright W, Ziogas A. Recent diet and breast cancer risk: the California Teachers Study. Cancer Causes and Control 13:407-415, 2002. Theuer CP, Campbell BS, Peel DJ, Lin F, Carpenter P, Ziogas A, Butler JA. Microsatellite instability in Japanese vs European American patients with gastric Cancer.Arch Surg. 2002 Aug;137(8):960-5; discussion 965-6. Bernstein, L. Allen, M., Anton-Culver, H., Deapen, D., Horn-Ross, PL., Peel, D., Pinder, R. Reynolds, P., Sullivan-Halley, J., West, D., Wright, W., Ziogas, A., Ross, RK. High Breast Cancer Incidence Rates Among California Teachers: Results from the California Teachers Study. In press: Cancer Causes and Control, 2002. Hoggatt KJ, Bernstein L, Reynolds P, Anton-Culver H, Deapen D, Peel D, Pinder R, Ross RK, West DW, Wright W, Ziogas A, Horn-Ross P. Correlates of vitamin supplement use in the United States: data from the California Teachers Study cohort. Cancer Causes & Control 13:735-740; 2002 Ziogas A, Anton-Culver H. Validation of family history data in cancer family registries. Am J Prev Med 24(2):190-198; Feb. 2003. Semenza JC, Delfino RJ, Ziogas A, Anton-Culver H. Breast cancer risk and methylenetetrahydrofolate reductase polymorphism. Breast Cancer Res Treat. Feb 2003;77(3):217-23. Marshall SF, Deapen D, Allen M, Anton-Culver H, Bernstein L, Horn-Ross PL, Peel D, Pinder R, Reynolds P, Ross RK, West D, Ziogas A. Validating California teachers study self-reports of recent hospitalization: comparison with California hospital discharge data. Am J Epidemiology. 2003 Nov 15;158(10):1012-20. Reynolds P, Hurley S, Goldberg DE, Anton-Culver H, Bernstein L, Deapen D, Horn-Ross PL, Peel D, Pinder R, Ross RK, West D, Wright WE, Ziogas A. Active smoking, household passive smoking, and breast cancer: evidence from the California Teachers Study.J Natl Cancer Inst. 2004 Jan 7;96(1):29-3 Horn-Ross PL, Canchola AJ, West DW, Stewart SL, Bernstein L, Deapen D, Pinder R, Ross RK, Anton-Culver H, Peel D, Ziogas A, Reynolds P, Wright W. Patterns of alcohol consumption and breast cancer risk in the California Teachers Study cohort.Cancer Epidemiol Biomarkers Prev. 2004 Mar;13(3):405-11. Quintana PJ, Delfino RJ, Korrick S, Ziogas A, Kutz FW, Jones EL, Laden F, Garshick E. Adipose tissue levels of organochlorine pesticides and polychlorinated biphenyls and risk of non-Hodgkin's lymphoma.Environ Health Perspect.2004Jun;112(8):854-61. John EM, Hopper JL, Beck JC, Knight JA, Neuhausen SL, Senie RT, Ziogas A, Andrulis IL, Anton-Culver H, Boyd N, Buys SS, Daly MB, O'Malley FP, Santella RM, Southey MC, Venne VL, Venter DJ, West DW, Whittemore AS, Seminara D; Breast Cancer Family Registry. The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancer. Breast Cancer Res. 2004;6(4):R375-89. Epub 2004 May 19. Anton-Culver H, Ziogas A, Bowen D, Finkelstein D, Griffin C, Hanson J, Isaacs C, Kasten-Sportes C, Mineau G, Nadkarni P, Rimer B, Schildkraut J, Strong L, Weber B, Winn D, Hiatt R, Nayfield S. The Cancer Gentics Network: recruitment results and pilot studiesCommunity Genet. 2003;6(3):171-7 Reynolds P, Hurley SE, Goldberg DE, Yerabati S, Gunier RB, Hertz A, Anton-Culver H, Bernstein L, Deapen D, Horn-Ross PL, Peel D, Pinder R, Ross RK, West D, Wright WE, Ziogas A. Residential proximity to agricultural pesticide use and incidence of breast cancer in the California Teachers Study cohort.Environ Res. 2004 Oct;96(2):206-18. Reynolds P, Hurley SE, Hoggatt K, Anton-Culver H, Bernstein L, Deapen D, Peel D, Pinder R, Ross RK, West D, Wright W, Ziogas A, Horn-Ross PL. Correlates of active and passive smoking in the California Teachers Study cohort.J Womens Health (Larchmt). 2004 Sep;13(7):778-90. Reynolds P, Hurley S, Goldberg DE, Anton-Culver H, Bernstein L, Deapen D, Horn-Ross PL, Peel D, Pinder R, Ross RK, West D, Wright WE, Ziogas A. Regional variations in breast cancer among california teachers.Epidemiology. 2004 Nov;15(6):746-54. Choudhary SK, Choudhary NR, Kimbrell KC, Colasanti J, Ziogas A, Kwa D, Schuitemaker H, Camerini D . R5 HIV-1 Infection of Fetal Thymic Organ Culture Induces Cytokine and CCR5 Expression J Virol. 2005 Jan;79(1):458-71. Hurley SE, Reynolds P, Goldberg DE, Hertz A, Anton-Culver H, Bernstein L, Deapen D, Peel D, Pinder R, Ross RK, West D, Wright WE, Ziogas A, Horn-Ross PL. Residential mobility in the California Teachers Study: implications for geographic differences in disease rates.Soc Sci Med. 2005 Apr;60(7):1547-55. Milne RL, Knight JA, John EM, Dite GS, Balbuena R, Ziogas A, Andrulis IL, West DW, Li FP, Southey MC, Giles GG, McCredie MR, Hopper JL, Whittemore AS. Oral contraceptive use and risk of early-onset breast cancer in carriers and noncarriers of BRCA1 and BRCA2 mutations.Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):350-6. Ewart-Toland A, Dai Q, Gao YT, Nagase H, Dunlop MG, Farrington SM, Barnetson RA, Anton-Culver H, Peel D, Ziogas A, Lin D, Miao X, Sun T, Ostrander EA, Stanford JL, Langlois M, Chan JM, Yuan J, Harris C, Bowman E, Clayman GL, Lippman SM, Lee JJ, Zheng W, Balmain A. urora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types.Carcinogenesis. 2005 Mar 31; Lindor NM, Rabe K, Petersen GM, Haile R, Casey G, Baron J, Gallinger S, Bapat B, Aronson M, Hopper J, Jass J, LeMarchand L, Grove J, Potter J, Newcomb P, Terdiman JP, Conrad P, Moslein G, Goldberg R, Ziogas A, Anton-Culver H, de Andrade M, Siegmund K, Thibodeau SN, Boardman LA, Seminara D. Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X.JAMA. 2005 Apr 27;293(16):1979-85. Marshall SF, Bernstein L, Anton-Culver H, Deapen D, Horn-Ross PL, Mohrenweiser H, Peel D, Pinder R, Purdie DM, Reynolds P, Stram D, West D, Wright WE, Ziogas A, Ross RK. Nonsteroidal anti-inflammatory drug use and breast cancer risk by stage and hormone receptor status.J Natl Cancer Inst. 2005 Jun 1;97(11):805-12. Largent JA, Ziogas A, Anton-Culver H. Effect of reproductive factors on stage, grade and hormone receptor status in early-onset breast cancer.Breast Cancer Res. 2005;7(4):R541-54. Epub 2005 May 16 Knight JA, John EM, Milne RL, Dite GS, Balbuena R, Shi EJ, Giles GG, Ziogas A, Andrulis IL, Whittemore AS, Hopper JL; Breast Cancer Family Registry. An inverse association between ovarian cysts and breast cancer in the breast cancer family registry.Int J Cancer. 2006 Jan 1;118(1):197-202 Brewster WR, Hubbell FA, Largent J, Ziogas A, Lin F, Howe S, Ganiats TG, Anton-Culver H, Manetta A. Feasibility of management of high-grade cervical lesions in a single visit: a randomized controlled trial.JAMA. 2005 Nov 2;294(17):2182-7 Zell JA, Ou SH, Ziogas A, Anton-Culver H. Epidemiology of bronchioloalveolar carcinoma: improvement in survival after release of the 1999 WHO classification of lung tumors.J Clin Oncol. 2005 Nov 20;23(33):8396-40 Crawford NP, Ziogas A, Peel DJ, Hess J, Anton-Culver H, Hunter KW. Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer.Breast Cancer Res. 2006;8(2): Theuer CP, Al-Kuran R, Akiyama Y, Okumura M, Ziogas A, Carpenter PM. Increased epithelial cadherin expression among Japanese intestinal-type gastric cancers compared with specimens from American patients of European descent.Am Surg. 2006 Apr;72(4):332-8. Zell JA, Ou SH, Ziogas A, Anton-Culver H. Long-term survival differences for bronchiolo-alveolar carcinoma patients with ipsilateral intrapulmonary metastasis at diagnosis. Ann Oncol. 2006 Aug;17(8):1255-62. Zell, JA, Ou, S-HI, Ziogas, A, Anton-Culver, H.In Reply.J Clin Oncol 2006 April; 24(12):1963-1964. Largent JA, McEligot AJ, Ziogas A, Reid C, Hess J, Leighton N, Peel D, Anton-Culver H. Hypertension, diuretics and breast cancer risk.J Hum Hypertens. 2006 Aug 3 |
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| Crawford NP, Qian X, Ziogas A, Papageorge AG, Boersma BJ, Walker RC, Lukes L, Rowe WL, Zhang J, Ambs S, Lowy DR, Anton-Culver H, Hunter KW. Rrp1b, a new candidate susceptibility gene for breast cancer progression and metastasis.PLoS Genet. 2007 Nov 30;3(11):e214. | ||
| Grants | “Hereditary Breast Cancer: Genetic and Molecular Studies” Funding Agency NIH/NCI, Project 2 U01 CA58860-10 Hoda Anton-Culver Ph.D. (P.I), Brief Description:To maintain and follow-up an existing family resource of 1250 breast and 262 ovarian cancer probands. As Co-PI, I am responsible for providing statistical support for the characterization of BRCA mutations in breast and ovarian cancer families, and determine whether there is molecular genetic evidence for the aggregation of breast and colorectal cancer in a subgroup of the existing high risk breast cancer families. | |
| “Enhanced Single Visit Cervical Cancer Screening Program” Funding Agency NIH/NCI, Project R01 CA76502-06, Al Manetta M.D. (P.I), This grant takes an innovative approach to screen women for cervix cancer and provide early treatment for severe cervix dysplasia in a single-visit program in a Latino/Hispanic community. This renewal grant is designed to further increase the effectiveness of the single-visit program.As Co-PI, I am responsible for providing technical expertise regarding statistical analysis in the project. | ||
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Professional Societies |
American Statistical Association Institute of Mathematical Statistics International Biometric Society |
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| Graduate Programs |
Epidemiology |
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| Research Center | Genetic Epidemiology Research Institute | |
| Link to this profile | http://www.faculty.uci.edu/profile.cfm?faculty_id=5229 | |
| Last updated | 03/13/2009 | |