Sudhanshu Agrawal

Picture of Sudhanshu Agrawal
M.S., M.S. University, 1988, Biotechnology
Phone: (949) 824-5268
Email: sagrawal@uci.edu
University of California, Irvine
Irvine, CA 92697
Research Interests
Immunology
Research Abstract
•American Academy of Allergy Asthma & Immunology 2013, 2014.
•Keystone symposia on Innate Immunity 2003, Type II immunity 2013.
•American Age association 2011.
•American Association of Immunologist 2010.
•Gordan Research on Aging 2009.
•Experimental Biology 2004, 2005, 2006, 2007.
•American Association of Cancer Research Proceedings 2001 & 2002, EORTC-NCI-AACR 2002.
•Immunization of Melanoma patients with Dendritic cells Loaded with an Allogenic Cell Lysate.
•Annual Meeting of American Society of Hematology 2002.
•International Congress of Immunology 2001.
Publications
1. Ghoneum M , Felo N , Agrawal S , Agrawal A . A novel kefir product (PFT) activates dendritic cells to induce CD4+T and CD8+T cell responses in vitro Int J of Immunopathol Pharmacol DOI: 10.1177/0394632015599447.

2. Agrawal S, Prakash S, Gupta S, Peterson E, Agrawal A. Dendritic Cells from Aged Subjects Display Enhanced Inflammatory Responses to Chlamydophila pneumoniae. Mediators of Inflammation. 2014 doi:10.1155/2014/436438.

3. Gollapudi SV, So C, Formica M, Agrawal S, Agrawal A. Safety and efficacy of Polydioxanone Nano-Fibers as anti-inflammatory agents. Journal of Nanomedicine & Biotherapeutic Discovery. 2014. 4: 127. doi:10.4172/2155-983X.1000127.

4. Ghoneum M, Agrawal S. MGN-3/biobran enhances generation of cytotoxic CD8+ T cells via upregulation of DEC-205 expression on dendritic cells. Int J of Immunopathol Pharmacol. 2014 Oct-Dec;27(4):523-30.

5. Yasharpour M, Agarwal S , Jerome D and Yel L . Is It Hyper IgE Syndrome Or Something Else? MOJ Immunol 2014, 1(2): 00010.

6. Prakash S, Agrawal S , Vahed H , Ngyuen M, BenMohamad L , Gupta S , Agrawal A . Dendritic cells from aged subjects contribute to chronic airway inflammation by activating bronchial epithelial cells under steady state. Mucosal Immunology doi:10.1038/mi.2014.28.

7. Bozoghalanin V, Agrawal S, Gupta S. Comprehensive Immunological and Clinical features of Common Variable Immunodeficiency (CVID). J Allergy and Clin Immunol Volume 133, Issue 2, February 2014, AB7.

8. Louis A, Agrawal S, Gupta S. Immunological Analysis of Primary IgM Deficiency in Adults. J Allergy and Clin Immunol Volume 133, Issue 2, February 2014, AB12.

9. Cook KA, Agrawal S, Gupta S. In vitro effect of Intravenous Immunoglobulin (IVIG) on Natural Antibody producing Human B1 Cells. J Allergy and Clin Immunol Volume 133, Issue 2, February 2014, AB183.

10. Agrawal S, Gollapudi G, Gupta S, Agrawal A. Dendritic cell from elderly display an intrinsic defect in production of IL-10 in response to lithium chloride. Exp. Gerontology 2013 Aug 26;48(11):1285-1292. doi: 10.1016/j.exger.2013.08.006.

11. Gupta S, Agrawal S, Gollapudi G. Increased activation and cytokine secretion in B cells stimulated with leptin in aged humans Immunity Ageing 2013 Jan 23;10(1):3. doi: 10.1186/1742-4933-10-3.

12. Manoukian K, Agrawal S, Gupta S Immune Responses to Allopurinol in A Patient with DRESS Syndrome J Allergy and Clin Immunol Volume 131, Issue 2, Supplement, February 2013, Pages AB211.

13. Agrawal A, Su H, Chen J, Osann K, Agrawal S, Gupta S. Increased IL-21 secretion by aged CD4+T cells is associated with prolonged STAT-4 activation and CMV seropositivity Aging (Albany NY). 2012 Sep;4(9):648-59.

14. Prakash S, Agrawal S, Cao, JN, Gupta S, Agrawal A. Impaired Secretion of Interferons by Dendritic Cells from Aged Subjects to Influenza: Role of Histone Modifications. AGE. 2012 DOI: 10.1007/s11357-012-9477-8.

15. Gupta S, Agrawal S, Gollapudi G. Selective IgM Deficiency with T Cell Defects and Mycobacterium Avium Complex (MAC) Infection The Open Immunology Journal, 2012, 5, 8-12.

16. Gupta S, Samra D, Yel L, Agrawal S. T- and B-cell Deficiency Associated with Yellow Nail Syndrome. Scand. J of Immunol. 2012 Mar;75(3):329-35.

17. Ghoneum M , Agrawal S. Activation of human monocyte derived Dendritic cells in vitro by the biological responses modifier Arabinoxylan rice bran ( MGN-3/biobran) Intl. J of Immunopathol & Phrarmacol. 2011 Oct-Dec;24(4):941-8.

18. Hsieh H, Agrawal S, Yel L and Gupta S. Autoimmune Pancreatitis: An Autoimmune or Immunoinflammatory Disease? The Open Autoimmunity Journal, 2011, 3, 10-16

19. Agrawal S, Gollapudi S, Su H, Gupta S. Leptin Activates Human B Cells to Secrete TNF-a, IL-6, and IL-10 via JAK2/STAT3 and p38MAPK/ERK1/2 Signaling Pathway J Clin Immunol. 2011 31:472–478.

20. Agrawal S, Gupta S. TLR1/2, TLR7, and TLR9 Signals Directly Activate Human Peripheral Blood Naive and Memory B Cell Subsets to Produce Cytokines, Chemokines, and Hematopoietic Growth Factors J Clin Immunol. 2011 Jan;31(1):89-98.

21. Sridharan A, Esposo M, Kaushal K, Tay J, Osann K, Agrawal S, Gupta S, Agrawal A. Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity. AGE (Dordr). 2011 Sep;33(3):363-76.

22. Agrawal S, Gupta S , Agrawal A, Human dendritic cells activated via Dectin-1 are efficient at priming Th17, cytotoxic CD8 T and B cell responses PLoS ONE 2010 Oct 18;5(10):e13418.

23. Nyugen J, Agrawal S, Gollapudi S, Gupta S. Impaired Functions of Peripheral Blood Monocyte Subpopulations in Aged Humans. J Clin Immunol. 2010 Nov;30(6):806-13..

24. Gupta S, Samra D, Agrawal S. Adaptive and Innate Immune Responses in Autism: Rationale for Therapeutic Use of Intravenous Immunoglobulin J Clin Immunol. (2010) 30 (Suppl 1):S90–S96.

25. Hong R, Agrawal S, Gollapudi S, Gupta S. Impaired pneumovax-23-induced monocyte-derived cytokine production in patients with common variable immunodeficiency. J Clin Immunol. 2010 May;30(3):435-41.

26. Abrahamian F, Agrawal S, Gupta S. Immunological and clinical profile of adult patients with selective immunoglobulin subclass deficiency: response to intravenous immunoglobulin therapy. Clin Exp Immunol. 2010 Mar;159(3):344-50.

27. Agrawal S, Gollapudi P, Elahimehr R, Pahl MV, Vaziri ND. Effects of end-stage renal disease and haemodialysis on dendritic cell subsets and basal and LPS-stimulated cytokine production. Nephrol Dial Transplant.2010 Mar;25(3):737-46.

28. Agrawal A, Tay J, Yang GE, Agrawal S, and Gupta S. Age-associated epigenetic modifications in human DNA increase its immunogenicity AGING, 2010 Mar 20;2(2):93-100.

29. Ghoneum M, Seto Y, Agrawal S. Activation of human monocyte-derived dendritic cells in vitro by Thymax, a gross thymic extract. Anticancer Res.2009 Nov;29(11):4367-71.

30. Anshu Agrawal, Sudhanshu Agrawal , Sudhir Gupta Role of Dendritic cells in Aging Handbook on Immunosenescence 2009.

31. Gupta S , Agrawal S , Gollapudi S Differential effect of HHV-6A on cell division and apoptosis among Naïve and Central and Effector memory CD4+ and CD8+ T cells subsets. J Virol. 2009 Jun;83(11):5442-50.

32. Agrawal A, Tay J, Ton S, Agrawal S, Gupta S Increased reactivity of dendritic cells from aged subjects to self-antigen, the human DNA. J Immunol 2009 Jan 15;182(2):1138-45.

33. Agrawal S, Gupta S ,Agrawal A Vaccinia virus proteins activate human dendritic cells to induce T cell responses in vitro Vaccine 2009 Jan 1;27(1):88-92.

34. Agrawal A ,Agrawal S, Tay J , Gupta S Biology of dendritic cells in aging. J Clin Immunol (2008) 28:14–20.

35. Agrawal A, Agrawal S, Cao J.N, Su H, Osann K, and Gupta S, Altered Innate Immune Functioning of Dendritic Cells in Elderly Humans: A Role of the Phosphoinositide 3-Kinase-Signaling Pathway. J Immunol.2007 June 1, 178;

36. Agrawal A, Agrawal S, Gupta S . Dendritic cells in human aging. Exp Gerontol. 2007 May; 42(5):421-6.

37. Ghoneum M, Wang L, Agrawal S, Gollapudi S. Yeast therapy for the treatment of breast cancer: A nude mice model. In Vivo 2007 Mar-Apr;21(2):251-8.

38. Agrawal A, Kaushal P, Agrawal S, Gollapudi S, Gupta S. Thimerosal induces TH2 responses via influencing cytokine secretion by human dendritic cells. J Leukoc Biol. 2007, 81:474-482 .

39. Gupta S, Agrawal A , Agrawal S, Su H, Gollapudi S . A paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis. Immun Ageing. 2006 May 19;3(1):5.

40. Agrawal S , Dillon S , Banerjee K, Letterio J , O-Ritcher K , Kasprowicz DJ, Keller K , Pare J, Van Dyke T, Ziegler S , Unutmaz D , Pulendran B. Yeast Zymosan, Ligand for TLR-2 and Dectin-1, induce regulatory antigen-presenting cells and Immunological tolerance. J. Clin. Invest. 2006 Apr 3;116(4):916-928.

41. Agrawal S, Zughaier S, Stephens DS and Pulendran B. Hexa-acylation and KDO2-glycosylation determine the specific immunostimulatory activity of Neisseria meningitidis lipid A for human monocyte derived dendritic cells. Vaccine 2006 Feb 27;24(9):1291-7.

42. Bali Pulendran , Anshu Agrawal, Stephanie Dillon , Sudhanshu Agrawal Dendritic cells: Target of Immune Modulation by Microbes and Immunologist. Vaccine Adjuvants -Immunological and Clinical Principles. Dec 2005. 25-38. ( Humana Press).

43. Gupta S, Su H, Bi R, Agrawal S, Gollapudi S Life and Death of Lymphocytes: A key to Immunosenescence. Immun Ageing. 2005 Aug 23;2(1):12.

44. Barrou B, Benolt G, Ouldkaci M, Cussenot O, Salcedo M, Agrawal S, Massicard S, Bercovici N, Ericson M, Thiounn N. Vaccination of Prostatectomized Prostate Cancer Patients in Biochemical Relapse with Autologous Dendritic Cells pulsed with Ex vivo with Recombinant Human PSA. Cancer Immunol. Immunother.2004 53; 453-460.

45. Agrawal S, Agrawal A, Doughty B, Gerwitz A, Van Dyke T, Pulendran B. Cutting edge: Different TLR Agonist Instruct Dendritic Cells to Induce Diverse T helper Responses, via Differential Activation of MAP Kinases. Cutting edge J Immunol.2003 15 Nov; 171(10)4984-4989.

46. Jotwani R, Pulendran B, Agrawal S, Cutler CW. Human Dendritic cells Respond to Porphyromonas gingivalis LPS by Promoting TH2 effector response In Vitro. Eur. J Immunol. 2003.33:2980-2986.

47. Agrawal A, Lingappa J, Leppla SH, Agrawal S, Jabbar A, Quinn C, Pulendran B. Impairment of Dendritic cells and Adaptive immunity by Anthrax lethal factor. Nature 2003 17 July; 424:329-334.

48. Mahanty S, Hutchinson K, Agarwal S, Mcrae M, Pulendran B. Cutting edge: Impairment of Dendritic cells and Adaptive immunity by Ebola and Lassa Viruses. J Immunol. 2003 Mar 15; 170(6):2797-801.

49. Dendritic cells loaded with melanoma cell lysate induce T cell responses against melanoma shared antigens in vitro and in melanoma patients J of Immunotherapy: Volume 24(5) Sep/Oct 2001 pp S1-S26.

50. Dendritic cells generated in presence of IL-13 and GM-CSF in GMP large scale production process are potent tumor antigen stimulators and are well tolerated by cancer patient Eur J of cancer 37 Sup3 Sep 2001 page S35.

51. Bercovici N, Duffour MT, Agrawal S, Salcedo M, Abastado JP. New methods to assess T cell responses in basic and clinical immunology Clin. Diagn. Lab. Immunol. 2000 Nov; 7(6): 859-864.

52. Mereyala HB, Gadikota RR, Joe M, Arora SK, Dastidar SG, Agarwal S. Synthesis and antitumor activity of goniofufurone analogues Bioorg Med Chem. 1999 Sep;7(9):2095-103.
Other Experience
Senior Research Project Coordinator
Emory Vaccine Center, Emory University 2002—2004
Scientist
Immuno-Designed Molecules , Paris , France 1999—2001
Scientist
Ranbaxy Lab Ltd , New Delhi , India 1994—1999
Manger
BIBCOL , India 1989—1994
Last updated
08/17/2015